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Product Name: Ampicillin Sodium
Chemical Name: Sodium 6-(D(-)-α-aminophenylacetamido)penicillanate
Synonyms: Sodium ampicillin salt
CAS Number: 69-52-3
Recommended Use: Pharmaceutical antibiotic
Manufacturer Information: Refer to specific supplier
Emergency Contact: Provided by local distributor or manufacturer
Hazard Classification: May cause allergic skin reaction, target organ effects, respiratory sensitization
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms if inhaled; can cause eye, skin, and respiratory irritation; may provoke allergic reactions in sensitive individuals
Precautionary Statements: Wear protective gloves, clothing, and eye protection; avoid breathing dust, fumes, or spray; in case of inadequate ventilation, use respiratory protection
Label Elements: Exclamation mark, health hazard pictograms
Other Hazards: Occupational exposure can heighten risk of antibiotic sensitization in lab and production environments
Chemical Identity: Ampicillin Sodium
Concentration: ≥98% pure
Impurities: <1% (by manufacturer specification)
Molecular Formula: C16H18N3NaO4S
Molecular Weight: 371.39 g/mol
Inhalation: Remove from exposure, move to fresh air promptly; seek medical advice for persistent symptoms (shortness of breath, wheezing)
Skin Contact: Wash skin with generous amounts of water and soap; remove contaminated clothing; medical attention recommended if rash, burning, or irritation occurs
Eye Contact: Flush immediately with running water for at least 15 minutes; hold eyelids apart; obtain medical attention if discomfort, irritation, redness persists
Ingestion: Rinse mouth thoroughly; drink water if victim is conscious; never induce vomiting unless instructed by a physician; seek immediate medical attention, especially for allergic individuals
Chronic Effects: Sensitization, periodic dermatitis, respiratory symptoms in exposed workers
Suitable Extinguishing Media: Use water spray, foam, carbon dioxide, or dry chemical
Unsuitable Extinguishing Media: None known for the pure compound
Special Hazards: Emits toxic, irritating fumes such as sulfur oxides, nitrogen oxides, and carbon oxides when heated sharply
Protective Equipment: Full protective gear and self-contained breathing apparatus
Fire Fighting Guidance: Keep containers cool with water spray; do not let run-off from firefighting enter drains or waterway
Personal Precautions: Use personal protection as recommended—gloves, mask, protective eyewear
Environmental Precautions: Do not allow product to penetrate drains, waterways, or soil
Containment: Stop the source of leakage if safe; avoid dust formation; ventilate area
Cleanup Method: Sweep or vacuum without raising dust, collect in a suitable, closed, and clearly labeled container for proper disposal; wash affected area with water and soap
Handling: Minimize dust generation; use in well-ventilated area or approved fume hood; avoid direct contact with eyes, skin, or clothing; wash hands thoroughly after handling
Storage: Keep container tightly closed, dry, and away from incompatible substances; ideally stored at 2–8°C (refrigerated) and protected from light; avoid strong oxidizers and acids; ensure storage facility is secure and properly labeled
Engineering Controls: Use process enclosures, local exhaust ventilation, or other engineering controls to maintain airborne levels below recommended exposure limits
Personal Protection: Lab coat, gloves (nitrile or latex), safety goggles, dust mask or respirator if airborne levels are high
Hygiene Measures: Do not eat, drink, or smoke in areas where this substance is handled; always wash hands after use
Occupational Limits: No established exposure limits by OSHA, ACGIH, or NIOSH, though prudent practices suggest minimizing exposure due to sensitization and antibiotic effects
Physical State: Crystalline powder
Color: White to off-white
Odor: Weak characteristic odor
pH (1% solution): 8.0–10.0
Melting Point: Decomposes above 190°C
Solubility: Freely soluble in water
Boiling Point: Not applicable (decomposes)
Flash Point: Not determined (not flammable under normal conditions)
Bulk Density: Approx. 0.7–0.8 g/cm³
Stability: Stable under recommended storage and handling; moisture, light, and elevated temperature promote decomposition
Reactivity: Reacts with strong acids, oxidizers
Decomposition Products: Releases carbon oxides, nitrogen oxides, sulfur oxides along with other irritating or toxic substances
Polymerization: Will not occur under normal laboratory conditions
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (rat, oral): 6850 mg/kg
Skin Sensitization: Documented cases of allergic reactions in pharmaceutical workers
Chronic Effects: Development of sensitization and potential allergic reactions, including anaphylaxis in susceptible individuals; repeated or long-term inhalation can trigger respiratory conditions like asthma
Symptoms of Overexposure: Rash, itching, swelling, difficulty breathing, gastrointestinal upset, rarely severe immune reaction
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Toxicity: Antibiotic properties may cause adverse effects in aquatic and soil organisms; may promote antibiotic resistance in microbial populations
Persistence and Degradability: Partially biodegradable; some metabolites may persist in environment
Bioaccumulation: Potential not identified as significant
Mobility in Soil: Moderate due to solubility in water
Other Adverse Effects: Risk of promoting antibiotic resistance in natural microbial communities
Disposal Method: Dispose of as hazardous pharmaceutical waste; incinerate in approved facility or use authorized collection; never release to sewer or environment
Contaminated Packaging: Treat as hazardous; dispose in line with local, regional, and national regulations
Regulatory Codes: Check local environmental regulations for medicinal or hazardous chemical waste
UN Number: Not regulated globally for transport; check local restrictions
Proper Shipping Name: May be shipped as non-hazardous for air/land/sea but verify latest guidelines
Packing Group: Not applicable
Special Transport Precautions: Keep container sealed, protect from moisture and light during transit
FDA: Approved for pharmaceutical use under prescription control
OSHA: No specific exposure standards; general duty to protect workers
WHMIS: Classified as controlled product in some regions
REACH: Not on SVHC list
Other Regulations: Monitor for updates on disposal and transport of antibiotic waste; duty of care to limit environmental release and occupational exposure
