© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Product Name: Amodiaquine Hydrochloride
Chemical Name: 4-[(7-Chloro-4-quinolyl)amino]-2-(diethylaminomethyl)phenol dihydrochloride
CAS Number: 6398-98-7
Molecular Formula: C20H22ClN3O·2HCl
Recommended Use: Pharmaceutical raw material, antimalarial drug manufacture
Manufacturer Information: Use the actual manufacturer’s name, address, and emergency contact number for the producer or supplier
Emergency Contact: Include phone numbers for hazard response, local poison control, and workplace safety representative
GHS Classification: Acute Toxicity (oral) Category 3; Specific Target Organ Toxicity (repeated exposure) Category 2
Signal Word: Danger
Hazard Statements: Toxic if swallowed, potential to cause damage to organs through prolonged or repeated exposure
Precautionary Statements: Avoid inhalation or contact with skin and eyes; wash hands thoroughly after handling; do not eat, drink, or smoke while handling the product; wear protective equipment as outlined; avoid environmental release
Hazard Symbol: Skull and crossbones
Potential Health Effects: Ingestion may cause headaches, vomiting, gastrointestinal disorders, liver impairment, or blood disorder; may cause eye or skin irritation; chronic exposure may damage nerves or liver
Emergency Overview: White or pale-yellow crystalline powder, bitter taste, may cause serious health effects if mishandled
Chemical Identity: Amodiaquine Hydrochloride
Content: >98% by weight
CAS Number: 6398-98-7
Impurities: May contain trace related compounds as per pharmacopeia; levels typically <1%
Formula Weight: 466.8 g/mol
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes, remove contact lenses if present and easy to do, seek medical attention if symptoms persist
Skin Contact: Wash affected area with soap and water, remove contaminated clothing, consult a physician if irritation or rash develops
Inhalation: Move person to fresh air, keep at rest in position comfortable for breathing, seek medical attention for respiratory symptoms
Ingestion: Rinse mouth with water, do not induce vomiting, give small amount of water if conscious, seek immediate medical attention
Notes for Doctor: Treat according to symptoms, monitor for liver dysfunction, support respiration and cardiac function, no specific antidote known
Suitable Extinguishing Media: Dry chemical powder, carbon dioxide, or foam; avoid high pressure water jets
Hazards from Combustion: Emits toxic and irritating fumes such as hydrochloric acid, nitrogen oxides, carbon monoxide, and chlorine compounds
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Procedures: Evacuate area if large amounts involved; prevent runoff from entering drains; cool fire-exposed containers with water spray
Specific Hazards: Fine dust can form explosive mixtures with air; product decomposes at high temperatures, releasing hazardous fumes
Personal Precautions: Wear chemical-resistant gloves, lab coat, safety goggles, and a properly fitted respirator; remove ignition sources
Environmental Precautions: Prevent release into surface water, sewer, or soil; contain spill with inert absorbent material like sand or vermiculite
Spill Clean-up: Sweep up carefully to avoid generating dust, place in sealed labeled container for proper disposal, ventilate area
Decontamination: Wash area with detergent and water, dispose of cleaning materials as hazardous waste
Precautions for Safe Handling: Handle in controlled, well-ventilated rooms, use local exhaust to minimize dust and vapor exposure, avoid contact with skin and eyes; after handling, wash hands, forearms, and face thoroughly
Safe Storage Conditions: Store tightly sealed in original container, away from light, moisture, and incompatible materials such as strong acids or oxidizers
Temperature: Recommended storage temperature below 30°C, protect from direct sunlight
Other Comments: Label storage area clearly, keep out of reach of untrained personnel; avoid storing near food or animal feed
Incompatibilities: Strong oxidizing agents, reducing agents, acids, and alkalis can react with product
Occupational Exposure Limits: No established Permissible Exposure Limit; adopt good industrial hygiene practices
Engineering Controls: Use fume hood or local exhaust as primary means of control; keep airborne concentrations as low as achievable
Personal Protection: Gloves (nitrile or latex), protective lab coat, safety goggles or face shield, use NIOSH-approved respirator when dust might be generated
Hygiene Measures: Never eat, drink, or smoke during use; remove contaminated clothing; wash hands and exposed skin after handling
Appearance: White to pale yellow crystalline powder
Odor: Odorless
Molecular Weight: 466.8 g/mol
Solubility: Freely soluble in water and ethanol, insoluble in ether and chloroform
pH (1% solution): 2.5–4.5
Melting Point: 161–164°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at room temperature
Partition Coefficient (log P): 3.5 (estimated)
Flash Point: Not flammable
Explosive Properties: Not explosive, but dust can become airborne and potentially pose a dust ignition risk
Chemical Stability: Stable if kept dry, tightly sealed, and away from heat and direct sunlight
Conditions to Avoid: Prolonged exposure to moisture, high temperatures, strong light, and open air
Incompatible Materials: Strong oxidizing agents, acids, alkalis, reducing agents
Hazardous Decomposition Products: May produce hydrochloric acid, nitrogen oxides, chlorine compounds under fire conditions
Polymerization: Product does not polymerize under normal storage and usage settings
Routes of Entry: Inhalation, ingestion, skin and eye contact
Acute Toxicity Data: Oral LD50 (rat) estimated <100 mg/kg
Chronic Toxicity: Prolonged exposure may damage liver and nervous system; risk of blood dyscrasias
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Symptoms of Exposure: Nausea, vomiting, jaundice, fatigue, confusion, allergic reactions in sensitive individuals
Sensitization: May cause hypersensitivity or allergic skin reactions
Other Effects: Overdose may cause severe hepatic injury, agranulocytosis, or even fatality; children are especially vulnerable
Ecotoxicity: Harmful to aquatic life with potential for long-lasting effects; avoid product release into the environment
Mobility in Soil: Moderately mobile; may leach slowly in sandy or loose soils
Persistence and Degradability: Not rapidly biodegradable, remains in water and soil for extended periods
Bioaccumulation Potential: Moderate potential for bioaccumulation due to lipophilicity
Additional Notes: Responsible disposal is essential to prevent contamination of water bodies and groundwater
Waste Disposal Method: Treat as hazardous chemical waste; incinerate in accordance with local, regional, and national regulations; do not release into sewer or waterways
Contaminated Packaging: Containers should be thoroughly rinsed and disposed of as hazardous waste
Special Precautions: Avoid dust generation when disposing of material; label waste clearly; keep away from disposal sites used for food or animal feed
UN Number: 2811 (Toxic solid, organic, n.o.s. [Amodiaquine Hydrochloride])
Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Amodiaquine Hydrochloride)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Label Required: Class 6.1 (Toxic)
Special Transport Precautions: Keep container tightly closed, protect from moisture and excessive heat, ensure proper labeling and documentation as toxic substance
Safety, Health and Environmental Regulations: Subject to chemical safety and environmental regulations in most countries; check local, regional, and national laws for specific compliance
Labelling: Requires hazardous substance labeling per GHS and local guidelines
Inventory Status: Listed on major chemical inventories, may have restrictions on pharmaceutical use or environmental discharge
Other Information: Obtain permits if required for manufacture, import, export, or use in bulk; follow best practices and record-keeping for hazardous materials management
