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Product Name: 7-Acca
Chemical Name: 7-Amino-3-chloro-3-cephem-4-carboxylic acid
Synonyms: 7-ACA, 7-Aminocephalosporanic Acid
CAS Number: 2453-00-7
Use: Intermediate for cephalosporin antibiotics
Manufacturer Information: Licensed chemical suppliers and pharmaceutical manufacturers provide their contact information on product labels and shipping documents.
Emergency Contact: Local poison control center, company safety department.
Physical Hazards: No major flammability or reactivity hazard under normal conditions.
Health Hazards: Possible skin and eye irritation; inhalation of dust can cause respiratory discomfort; ingestion may cause gastrointestinal upset and allergic reactions in sensitized individuals.
Environmental Hazards: May pose a moderate risk to aquatic life on significant or repeated exposure.
Label Elements: Pictograms for irritant and health hazard categories.
Signal Word: Warning
Hazard Statements: May cause allergy or asthma symptoms or breathing difficulties if inhaled; may cause serious eye irritation.
Chemical Identity: 7-Amino-3-chloro-3-cephem-4-carboxylic acid
Purity: Typically over 98%
Impurities: Related cephalosporin intermediates and minor organic contaminants, content less than 2%
Ingredient Notes: No significant additives or stabilizers present in the bulk active intermediate.
Inhalation: Move the exposed person to fresh air; give artificial respiration if not breathing; seek medical attention if symptoms develop.
Skin Contact: Remove contaminated clothing; rinse affected skin thoroughly with water and soap; consult medical help if irritation persists.
Eye Contact: Rinse cautiously with water for at least 15 minutes; remove contact lenses; obtain medical attention if redness or pain continues.
Ingestion: Rinse mouth with water; do not induce vomiting unless directed by medical personnel; seek immediate medical care if large amounts are swallowed or if allergic reactions appear.
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Specific Hazards: Thermal decomposition can generate toxic fumes, including nitrogen oxides and halogenated compounds
Protective Equipment: Firefighters require self-contained breathing apparatus and protective clothing to prevent contact with materials and smoke
Special Precautions: Evacuate area; avoid breathing combustion products; use water spray to cool adjacent containers if exposed to heat or flames
Personal Precautions: Avoid inhalation; use appropriate respiratory protection if dust forms; wear gloves and goggles
Environmental Precautions: Prevent release into waterways and drains; contain spillage with absorbent materials
Cleanup Methods: Use a HEPA-filtered vacuum or damp sweeping to collect powder; transfer material to a labeled container for disposal
Decontamination: Wash area with plenty of water after complete removal of bulk material
Handling: Use in well-ventilated areas; avoid generation and inhalation of dust; do not eat, drink, or smoke during use; utilize proper personal protective equipment
Storage: Store in tightly sealed original containers in a dry, cool, and well-ventilated storeroom; protect from sunlight, moisture, and incompatible substances (strong oxidizers); keep away from unauthorized personnel
Storage Temperature: Recommended temperature range is 2-8°C
Special Packaging Considerations: Use corrosion-resistant, labeled containers; check regularly for signs of damage or leaks
Exposure Limits: No established occupational exposure limits; minimize exposure by good industrial hygiene practice
Engineering Controls: Local exhaust ventilation and enclosed handling systems for powder transfer; HEPA filtration; eye wash stations and safety showers in proximity
Personal Protection Equipment: Nitrile or latex gloves, splash-resistant goggles, disposable lab coats or coveralls, and particulate respirators for significant dust levels
Hygiene Measures: Wash hands and exposed skin after handling; avoid touching face and mucous membranes
Control of Environmental Exposure: Procedures to minimize release to air, water, and soil
Appearance: White to off-white crystalline powder
Odor: Practically odorless
Melting Point: 220-225°C (decomposition)
Solubility: Slightly soluble in water, soluble in dilute acid or alkali
Boiling Point: Not applicable (decomposes before boiling)
Vapor Pressure: Negligible at room temperature
Density: Approximately 1.7 g/cm³
pH (1% solution): 3.5-5.0
Partition Coefficient (n-octanol/water): Not applicable for this intermediary compound
Flash Point: Not flammable under normal laboratory conditions
Chemical Stability: Stable under recommended handling and storage conditions
Conditions to Avoid: High temperature, humidity, exposure to light
Incompatible Materials: Strong oxidizing agents, strong acids, strong bases
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride, carbon oxides on thermal breakdown
Polymerization: Not expected under normal use conditions
Acute Toxicity: Low acute oral, dermal, and inhalation toxicity in animal studies; LD50 (oral, rat) > 2000 mg/kg
Skin Irritation: Possible mild irritation; not classified as a skin corrosive
Eye Irritation: May cause moderate reversible irritation
Respiratory Sensitization: Rare but possible in individuals sensitized to beta-lactam structures
Chronic Effects: Long-term exposure data limited; no conclusive evidence of carcinogenicity, mutagenicity, or reproductive toxicity
Allergic Reactions: Occupational asthma and hypersensitivity possible, especially among pharmaceutical workers
Other Effects: No significant impact expected on organs outside target routes
Ecotoxicity: Moderate hazard to aquatic organisms if released in significant quantities due to antibiotic properties
Persistence and Degradability: Slowly biodegradable in surface environments; not persistent under strong sunlight and microbial conditions
Bioaccumulation Potential: Low bioaccumulation expected due to hydrophilic structure
Soil Mobility: Fairly mobile in moist soils; risk to groundwater minimal if not released in bulk
Other Environmental Risks: Effluent controls recommended to protect wastewater microbiota
Disposal Methods: Unused material and waste residues require incineration by licensed chemical waste contractors; avoid landfill and direct release to sewers
Contaminated Packaging: Triple-rinse containers; dispose through regulated chemical waste stream
Environmental Impact: Inform local environmental protection authorities prior to large-scale disposal
Regulatory Considerations: Compliance with local, state, and federal environmental regulations necessary for final disposal method
UN Number: Not classified as a dangerous good under international transport regulations
Transport Hazard Class: Not subject to ADR, IMDG, IATA restrictions
Packing Group: None assigned
Marine Pollutant: Not designated; spill control needed near water bodies
Special Transport Precautions: Protect containers from spillage, crush, excessive heat, and moisture during transit
International Inventories: Listed on major chemical inventories, including US TSCA, EU REACH under intermediates
Occupational Safety Standards: Managed under workplace exposure policies for pharmaceutical intermediates
Labeling Requirements: Hazard communication as per global harmonized system (GHS)
Other Regulations: Requirements for control of workplace dust exposure, medical surveillance for those handling beta-lactam intermediates, emergency planning for spills and accidental exposures
