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Chemical Name: 2,4,6-Trimethylpyridine
Common Synonyms: Collidine
CAS Number: 108-75-8
Molecular Formula: C8H11N
Appearance: Clear, colorless to light yellow liquid
Odor: Strong, pungent, resembling pyridine with a bitter edge
Uses: Organic synthesis, solvent in chemical reactions, intermediate in pharmaceuticals and agrochemicals
Boiling Point: Around 172°C
Flash Point: Around 54°C (closed cup)
Solubility: Moderately soluble in water, mixes well with organic solvents
Hazard Classifications: Flammable liquid, Acute toxicity, Skin and eye irritant
Physical Hazards: Releases flammable vapors at room temperature, forms explosive mixtures with air
Health Hazards: Harmful if inhaled or swallowed, irritating to eyes, nose, throat, skin; vapor may cause central nervous system effects including headache, dizziness, drowsiness
Environmental Hazards: Toxic to aquatic organisms, risk of long-term adverse effects in aquatic environment
GHS Symbols: Flame, Exclamation Mark, Environment
Chemical Name: 2,4,6-Trimethylpyridine
Concentration: Typically >98%
Impurities: May contain minor concentrations of other alkylpyridines or related organic compounds due to manufacturing source
Inhalation: Move affected person to fresh air immediately, keep at rest in comfortable position, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, consult physician if irritation develops
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek medical attention if eye irritation occurs
Ingestion: Do not induce vomiting, rinse mouth with water if conscious, call for medical help right away
Protection for First Responders: Wear gloves, goggles, and appropriate respirator when entering contaminated area
Extinguishing Media: Use dry chemical powder, foam, carbon dioxide; avoid water jets which can spread fire
Special Hazards: Highly flammable vapors, can travel offsite and ignite back to source, produces toxic gases such as nitrogen oxides when burning
Protective Equipment: Full protective suit, self-contained breathing apparatus
Advice: Remove people from area, combat fire from a safe distance, cool surrounding containers with water spray to prevent rupture
Personal Precautions: Ventilate area, eliminate ignition sources, use non-sparking tools, prevent skin and eye contact
Environmental Precautions: Stop leak if safe, prevent entry into drains and waterways, contain spillage with sand or inert absorbent material
Methods for Cleaning Up: Absorb with sand or special absorbent pads, shovel into appropriate container for disposal, clean surfaces with detergent and water
Handling: Only use under fume hood or with proper ventilation, keep away from open flames, sources of static, avoid breathing vapor
Storage: Store in tightly closed container, away from sources of heat and direct sunlight, in dry, well-ventilated place, separate from oxidizers and acids
Specific Use Notes: Label area and containers, ensure spill control equipment is readily available
Engineering Controls: Ensure local exhaust ventilation in working area, monitor vapor levels
Personal Protection Equipment: Wear chemical-resistant gloves, safety goggles, lab coat, use appropriate respirator if vapor concentrations rise
Hygiene Measures: Do not eat or drink near chemical, wash hands thoroughly after use, remove contaminated clothing before leaving work area
Occupational Exposure Limits: Consult local regulatory guidelines for workplace limits on pyridine compounds
Form: Liquid at ambient temperatures
Color: Colorless to pale yellow
Odor: Strong and pungent
Density: About 0.92 g/cm³
Boiling Point: 172°C
Melting Point: -15°C
Vapor Pressure: Moderate
Vapor Density: Heavier than air
Solubility in Water: Limited
Partition Coefficient (log Kow): Approximately 2.3
Viscosity: Low
Flash Point: About 54°C
Autoignition Temperature: Around 410°C
Chemical Stability: Stable under recommended handling and storage conditions
Conditions to Avoid: Exposure to heat, open flames, sparks, static discharge, direct sunlight
Incompatible Materials: Strong oxidizers, acids, alkali metals
Hazardous Decomposition Products: Toxic smoke, nitrogen oxides, carbon monoxide, carbon dioxide
Polymers: Does not polymerize under normal circumstances
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Eye and skin irritation, respiratory discomfort, headaches, nausea, drowsiness, central nervous system depression at high doses
Acute Toxicity: Swallowing or inhaling can cause harmful effects, including vomiting, confusion, or coordination loss
Chronic Effects: Prolonged or repeated exposure may lead to liver or kidney disorders based on animal studies with related methylpyridine compounds
Carcinogenicity: No evidence of human carcinogenicity found in major regulatory reviews
Aquatic Toxicity: Toxic to aquatic organisms, may cause long-lasting effects in water environments
Mobility: Moderate mobility in soil and water, potential for groundwater contamination if released
Persistence and Degradability: Likely to degrade slowly in environment
Bioaccumulation: Potential for accumulation in aquatic organisms remains moderate
Advice: Prevent release into surface water or sewage systems
Disposal Methods: Incinerate in approved chemical incinerator, dispose of in accordance with local, regional, and national regulations
Packaging Disposal: Empty container retains product residue and vapor, handle as hazardous waste
Do Not: Discharge to surface waters or general waste system
UN Number: 1993 (for flammable liquids, if regulated)
Proper Shipping Name: Flammable Liquid, n.o.s. (contains trimethylpyridine)
Hazard Class: 3 (flammable liquid)
Packing Group: III
Transport by Road/Rail/Sea/Air: Adhere to international and local transport regulations, label containers appropriately, secure against tipping or leakage
Special Precautions: Avoid transport with incompatible materials, keep away from oxidizers, ensure ventilation in transport compartment
Labeling: Must include standard hazard and safety warnings for flammable and toxic substances
Regulation: Subject to chemical safety obligations under global systems such as GHS and REACH in the European Union, TSCA reporting in the United States
Restrictions: Use, storage, and disposal may be restricted or monitored in some jurisdictions due to environmental and health risks
Worker Safety: Requires adequate training, access to safety data, and protective equipment per occupational regulations
