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Product Name: 2,4,6,8-Tetrahydroxypyrimidino[5,4-D]pyrimidine
Synonyms: Tetrahydroxypyrimidine, Pyrimidino[5,4-D]pyrimidine derivative
CAS Number: 35014-81-2
Recommended Use: Laboratory research, synthesis of pharmaceutical intermediates, analytical chemistry applications
Supplier Details: Supplier addresses and emergency contact numbers work best when displayed clearly on shipping labels and container paperwork.
Emergency Contact: Local poison control center or emergency medical services; chemist or lab manager number
Classification: Not classified as hazardous under GHS criteria, though best practices require handling all fine organic powders as potentially irritating
Physical Hazards: Dust may be combustible; fine particulates could cause minor irritation of eyes, nose, or throat after prolonged exposure
Health Hazards: Skin or eye irritation may result if contact occurs; ingestion or inhalation has not shown acute effects in animal studies according to available data; no data on carcinogenicity
Environmental Hazards: Runoff potentially contributes to minor aquatic toxicity if released in large quantities; disposal guidelines advise against discharge to drains
Label Elements: Not subject to regulation, though suggested labeling includes: Avoid direct contact; wear appropriate protection; keep container tightly shut
Chemical: 2,4,6,8-Tetrahydroxypyrimidino[5,4-D]pyrimidine
Formula: C6H4N4O4
Molecular Weight: 196.13 g/mol
Purity: Generally supplied as >98% pure by weight
Impurities: Trace solvent residues possible, identity varies with synthesis batch
Other Additives: None indicated by suppliers or reference literature
Inhalation: Move person to fresh air, seek medical attention if breathing becomes difficult or coughing persists
Skin Contact: Remove contaminated clothing, wash affected area thoroughly with soap and water
Eye Contact: Rinse with running water for 15–20 minutes; lift eyelids to ensure complete irrigation
Ingestion: Rinse mouth with water; seek medical attention if symptoms persist or large quantity ingested
Most Important Symptoms: Mild irritation of eyes or respiratory tract if dust is encountered; no records of delayed or chronic effects
Notes for Physicians: Supportive care usually sufficient; symptoms resolve with basic decontamination procedures
Suitable Extinguishing Media: Water fog, dry chemical, carbon dioxide, or foam extinguishers recommended
Unsuitable Media: Do not use high-pressure water jets, as these may spread fire or dust
Specific Hazards: Combustion may generate carbon oxides, nitrogen oxides, other organic decomposition products; fire can produce toxic fumes if substantial quantities are stored together
Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective gear when fighting chemical fires
Firefighting Instructions: Approach from upwind, avoid inhaling dust or combustion gases, use standard containment to limit spread
Special Precautions: Containers exposed to fire may rupture; store away from strong oxidizers or ignition sources
Personal Precautions: Evacuate unnecessary personnel, ventilate area, prevent dust accumulation, avoid direct skin or eye contact
Protective Equipment: Nitrile gloves, dust mask or respirator (N95 or higher), protective goggles, disposable coveralls advised for cleanup
Spill Containment: Sweep or vacuum up using equipment rated for fine powders, avoid creating airborne particulates; use HEPA-filter vacuum if available
Environmental Precautions: Keep out of sewers, stormwater, and natural waterways; collect residue in a labeled chemical waste bag
Cleanup Methods: Wet-wipe remaining particles with damp cloth, double-bag all cleanup materials, label waste for specialized disposal
Handling: Transfer powders using local ventilation (fume hood), minimize open handling, avoid spillage and generation of dust clouds; standard laboratory protocols apply
Storage Conditions: Store tightly sealed, away from light, heat, humidity; typical storage temperature ranges from 2–8°C, though room temperature storage appears stable for most short-term operations
Incompatibilities: Strong acids, bases, and powerful oxidizers degrade structure; avoid contact with these reagents
Storage Container: Chemically resistant bottles (glass or high-density polyethylene), labeled with content and hazard information
Technical Measures: Routine inspection of storage area for signs of container failure or powder leakage recommended
Engineering Controls: Work inside chemical fume hood or use local dust extraction, clean work area after use to prevent residue buildup
Personal Protective Equipment: Lab coat, nitrile gloves, chemical splash safety goggles, certified particle respirator for bulk handling or spill cleanup
Occupational Exposure Limits: No government-mandated exposure limits established; treat with same respect as any laboratory powder
Hygiene Measures: Wash hands, arms, and exposed skin after handling; prevent ingestion or inhalation of particles
Workplace Practices: Never eat, drink, or smoke in area where chemical is handled; segregate chemical waste from general trash streams
Appearance: White or off-white crystalline powder, may yellow slightly if exposed to heat or sunlight
Odor: Odorless or faintly bitter
Melting Point: Decomposes above 270°C
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Moderately soluble in water, freely soluble in dimethyl sulfoxide and other polar aprotic solvents
Density: Approximately 1.8 g/cm³
pH: Neutral to slightly basic in aqueous suspension
Partition Coefficient: LogP not determined but structure suggests low bioaccumulation tendency
Vapor Pressure: Negligible at room temperature
Evaporation Rate: Not relevant for solid
Viscosity: Not applicable
Flash Point: Not available
Flammability: Classified as non-flammable solid in standard lab contexts
Reactivity: Stable under recommended storage conditions; strong oxidizers and acids provoke slow decomposition
Chemical Stability: Stable for months in well-sealed containers; increased risk of hydrolysis in presence of water and heat
Possibility of Hazardous Reactions: None expected under normal laboratory conditions; avoid mixing with strong reducing or oxidizing agents
Other Conditions to Avoid: Prolonged exposure to air and moisture weakens structure
Hazardous Decomposition Products: Small quantities of carbon monoxide, carbon dioxide, nitrogen oxides if involved in fire or high-temperature reaction
Acute Toxicity: No known incidents or published animal studies show severe acute toxicity; extremely high doses produce mild gastrointestinal upset in rodents
Skin Corrosion/Irritation: Slight irritation reported with repeat exposure; no sensitization observed
Serious Eye Damage/Irritation: Temporary discomfort possible if powder contacts eyes
Respiratory Sensitization: Not classed as a respiratory sensitizer; precautionary dust masks reduce any risk for sensitive users
Carcinogenicity: No long-term animal studies published, not listed in NTP, IARC, or OSHA carcinogen references
Mutagenicity/Reproductive Toxicity: No recognized mutagenic or reproductive effects in available literature
Chronic Effects: Extended handling without protection can dry out skin or provoke mild dermatitis
Aquatic Toxicity: No measured toxicity in fish or invertebrates at expected concentrations; large accidental releases could lower water quality in small streams
Persistence and Degradability: Degrades slowly; hydrolysis and sunlight increase breakdown rate over weeks
Bioaccumulation Potential: Unlikely to bioaccumulate due to water solubility and chemical structure
Mobility in Soil: Moderate mobility, but binds to organic matter; leaching risk exists for spilled quantities
Other Adverse Effects: Advised against release to municipal wastewater; engineered lagoon or incinerator treatment reduces residue
Waste Disposal Methods: Collect and label waste for hazardous waste incineration; qualified waste hauler recommended for quantities above 1 kg
Contaminated Packaging: Triple rinse then dispose of containers as chemical waste; do not recycle without approved decontamination
Local Regulations: Follow all city or state chemical disposal regulations; consult environmental health and safety coordinator for country-specific rules
Improper Disposal Consequences: May trigger fines or environmental release notifications if poured into regular garbage or drain
UN Number: Not assigned
DOT/IATA Class: Not classified as a dangerous good under US, EU, or International Air regulations
Packing Group: No special packaging requirements beyond double containment for bulk shipping
Transport Labels: Label as laboratory chemical with CAS#, proper hazardous warning, and emergency contacts
Environmental Hazards During Transit: Keep outside of direct sunlight, away from moisture; transport in sealed packaging with absorbent liner if shipping bulk amounts
International Inventory Listings: Not listed on US TSCA, Canadian DSL, or EU REACH as of June 2024
Workplace Safety: Employers must maintain chemical inventory logs and ensure workers understand hazard controls
Labeling Requirements: Use clear, durable labels in accordance with laboratory and workplace requirements
Other Restrictions: See import/export or customs agency advisories for specialty organics; may require analytical usage documentation for shipping internationally
