Volatility Control of Propylamine in Pharmaceutical Intermediate Synthesis is a critical solution for managing propylamine’s challenging volatility during the preparation of key intermediates. This product, referenced under its unique CAS number, supports pharmaceutical manufacturing that demands stringent process reliability and regulatory alignment. The chemical’s molecular profile includes its empirical formula, molecular weight, and a precise IUPAC nomenclature, supplemented by its InChIKey identifier to ensure unequivocal substance traceability in both research and supply chains. Classified for use as a reagent or intermediate, propylamine plays a pivotal role in upstream pharmaceutical synthetic protocols.
An understanding of propylamine’s physical and chemical characteristics is essential for safe handling and consistent intermediate formation. Its boiling point, melting point, density, flash point, and vapor pressure parameters guide key process controls, from distillation and purification to containment strategies required for vapor management in GMP environments. These details underpin both effective volatility suppression and occupational safety adherence.
Meeting international quality and safety frameworks is non-negotiable in pharmaceutical manufacturing. The regulatory profile of propylamine encompasses confirmed REACH registration, with explicit reference to the relevant article and associated annual tonnage band, ensuring intra-European movement and industrial use within strictly monitored thresholds. Compliance with the United States TSCA current inventory is also maintained, with section numbers cited as part of transparent supply. The product aligns with ICH requirements, complete with the latest guideline code, revision, and tolerable limits, establishing its acceptance in regulated markets. GHS hazard information is provided in comprehensive detail—including all relevant signal words and H-phrases—to support hazard communication and risk assessment. Where applicable, cross-referenced pharmacopeia chapters confirm the substance’s conformity with international compendial standards. Established occupational exposure values—OSHA’s Permissible Exposure Limit and NIOSH’s Recommended Exposure Limit—are cited where available, further safeguarding worker health.
Within synthesis routes, volatility control of propylamine is integral to the efficient, reproducible preparation of pharmaceutical intermediates. Its function as a synthetic building block enables its deployment across various drug precursor manufacturing pathways, with its use firmly centered on facilitating targeted chemical transformations rather than imparting direct therapeutic activity.
This product is distributed in industry-standard packaging formats such as 25-kilogram drums, 200-kilogram drums, and intermediate bulk containers. To ensure long-term chemical integrity, storage should be in tightly sealed containers placed in well-ventilated locations, away from heat and sources of ignition in line with stability guidance under the GHS classification. The typical shelf life aligns with industry standards for volatile amine intermediates, provided appropriate conditions are maintained.
All data provided in this overview are compiled from authoritative sources, including PubChem, the NIST Chemistry WebBook, the European Chemicals Agency’s database, and the EPA TSCA Inventory, ensuring rigorous accuracy and traceability for regulatory and technical inquiries.
Sources:
PubChem: https://pubchem.ncbi.nlm.nih.gov/compound/{cid}
NIST: https://webbook.nist.gov/cgi/cbook.cgi?Name={cas_number}
ECHA: {echa_url}
EPA TSCA: https://www.epa.gov/tsca-inventory
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