P-Bromoanisole is a high-purity compound, offered under the CAS number 104-92-7, that plays a pivotal role in the synthesis of various pharmaceutical intermediates. Recognized within the industrial and pharmaceutical sectors for its consistent quality and reliability, P-Bromoanisole is available in stock to support immediate project and manufacturing requirements. This fine chemical is ideal for demanding synthetic processes where precise performance is essential.
As a halogenated aromatic ether, P-Bromoanisole’s molecular formula is C7H7BrO, and it possesses a molecular weight of 187.04 g/mol. Its structure features a para-positioned bromine substituent on an anisole (methoxybenzene) ring, which imparts a unique combination of electron-withdrawing and electron-donating character. This duality makes the compound particularly reactive towards a variety of cross-coupling and electrophilic aromatic substitution reactions. P-Bromoanisole’s reactivity and selectivity render it highly effective as a building block in the preparation of complex pharmaceutical molecules, especially where methoxy substitution is critical for the efficacy or pharmacokinetics of the final drug candidate.
With regard to its physicochemical properties, P-Bromoanisole has a density of 1.499 g/cm³ at 25°C, a boiling point of 238–239°C, and a melting point of 10–13°C. The compound’s flash point is recorded at 101°C, and its partition coefficient (logP) is 2.8, which indicates moderate hydrophobicity useful in both aqueous and organic synthesis environments. Purity is assured with an assay typically at or above 99%, and water content remains below 0.1% to minimize the risk of hydrolysis or unwanted side reactions during storage and use.
P-Bromoanisole finds its principal application as a key intermediate in the synthesis of active pharmaceutical ingredients, especially for drugs developed via stepwise arylation or O-alkylation routes. Its strong utility comes to the fore in Suzuki, Heck, and Buchwald–Hartwig coupling reactions—chemistries widely deployed in pharmaceutical process development and scale-up. Additionally, the compound is leveraged in the continuous manufacturing of aryl ethers, where its high reactivity supports productive flow chemistry operations leading to minimal waste and scalable output. Beyond its direct utility in intermediate production, P-Bromoanisole serves in the manufacture of specialty fine chemicals, agrochemical intermediates, and advanced materials for electronic applications due to its functional versatility and well-characterized behavior under diverse reaction conditions. In research settings, it is also employed as a standard substrate to assess catalyst performance or to establish reaction benchmarking in etherification studies.
For packaging, P-Bromoanisole is supplied in 25 kg high-density polyethylene drums under a nitrogen-purged headspace to prevent oxidative degradation and moisture uptake. The drums conform to best practices for industrial chemical logistics, ensuring both material safety and preservation of product integrity during extended storage and international transit. Recommended storage conditions are in a cool, dry, and well-ventilated facility away from sources of ignition or incompatible substances. When handled and stored as directed, P-Bromoanisole offers a shelf life exceeding 24 months. Each batch is accompanied by a certificate of analysis (COA) to document compliance with quality standards and traceability for regulatory documentation.
Related Articles
