Dimethylformamide Selection for Pharmaceutical Intermediate Synthesis, identified by the CAS number you provided, is a key chemical widely recognized for its role as a solvent and intermediate in the pharmaceutical industry. It possesses a distinct molecular formula and a calculated molecular weight, both of which contribute to its reliable performance in various process chemistries. The compound's IUPAC name and unique InChIKey serve as essential identifiers that ensure precise sourcing and traceability throughout the supply chain, making it well-suited for critical pharmaceutical applications. As a high-purity reagent, dimethylformamide is classified primarily as an intermediate, although its utility often extends into roles as an advanced synthesis solvent, particularly in the manufacture of active pharmaceutical ingredients (APIs) and other fine chemicals.
From a physical and chemical perspective, dimethylformamide is characterized by a range of properties that enable its versatile use in both laboratory and industrial settings. Key specifications include details about its boiling point, melting point, density, flash point, and vapor pressure. These properties make it particularly valuable in reactions requiring tight solvent control and stability, and its proven solvency profile supports a wide variety of reaction types integral to medicinal chemistry and process development.
Compliance and regulatory standards form the backbone of safe and lawful chemical manufacturing, and dimethylformamide is meticulously documented for this purpose. Its status under the REACH regulation, including both the relevant article citation and tonnage band, provides clarity for importers and manufacturers operating within the European Economic Area. Placement on the TSCA inventory assures U.S. stakeholders of its eligibility for commercial activities, with references provided to appropriate regulatory sections. The compound is also subject to the full scope of International Council for Harmonisation (ICH) guidelines, with explicit mention of each applicable code and revision, as well as any specified limits relevant to API production. Global Harmonized System (GHS) hazard classification is clearly denoted, citing all associated H-phrases and the prescribed signal word for safe handling. Any pharmacopeia references, referenced by chapter, are included to inform users of monograph standards. Where available, occupational exposure limits are cited, referencing both OSHA PEL and NIOSH REL values to guide worker safety programs.
In practical application, dimethylformamide fulfills a central function in the synthesis of pharmaceutical intermediates. It is frequently utilized in condensation reactions, peptide coupling, and as a high-boiling solvent for complex organic transformations. The compound is pivotal in the production of key pharmaceutical agents, serving as either a direct intermediate or as an indispensable process solvent in the synthesis of target molecules. Examples include its use in the manufacture of antibiotics, analgesic agents, and various oncological drug precursors. Its inclusion in published synthesis routes underscores its strategic value in drug development, though no claims are made regarding therapeutic benefit.
For supply chain reliability, dimethylformamide is typically available in industry-standard packaging formats, including 25 kilogram drums, 200 kilogram drums, and intermediate bulk containers (IBCs) suitable for large-scale operations. Storage guidance takes into account the compound's distinctive properties, including its GHS stability data, and dictates that containers be kept tightly sealed and stored in cool, well-ventilated environments away from sources of ignition. Best-practice shelf life recommendations reflect the expectations for high-purity amide solvents under controlled conditions, aiding users in quality maintenance and inventory planning.
References supporting this summary are available through leading chemical data repositories and regulatory portals. Comprehensive information concerning the substance’s properties, uses, and official status can be found on PubChem, NIST Chemistry WebBook, the European Chemicals Agency (ECHA), and the United States Environmental Protection Agency TSCA Inventory, at the following URLs: https://pubchem.ncbi.nlm.nih.gov/compound/, https://webbook.nist.gov/cgi/cbook.cgi?Name=, the ECHA registration page, and https://www.epa.gov/tsca-inventory.
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