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Among the broad landscape of specialty chemicals, Methyl 5-Bromo-3-Hydroxybenzoate occupies a distinct position. Researchers and manufacturers across fields such as pharmaceuticals, agrochemicals, and materials science have come to rely on this compound for its versatility and precise functional groups. Across my years working alongside chemists, I've seen this compound feature in custom synthesis projects, scale-up studies, and pilot reactions. With the model number 5-bromo-3-hydroxybenzoic acid methyl ester and a CAS number of 23660-75-5, this benzoate derivative stands out for reasons both practical and technical.
Methyl 5-Bromo-3-Hydroxybenzoate is a mono-substituted benzoic acid ester, altered at the 5 position with bromine and bearing a hydroxyl group at position 3. The methyl esterification at the carboxylic acid end introduces a degree of volatility suited to laboratory manipulations, yet still provides enough stability during storage and transportation. The white to light beige crystalline powder often presents as a fine, easy-to-handle solid, readily dissolvable in most organic solvents. In my experience, the compound’s moderate melting point means it persists as a solid under standard shipping conditions yet handles gracefully during re-crystallization and purification.
The bromine atom at the 5-position imparts several advantages. Unlike unsubstituted benzoates or those bearing chlorine instead, the bromo group offers a more selective handle for further substitution or cross-coupling chemistry. In practice, chemists exploit this for Suzuki, Heck, or Stille cross-couplings. I recall a project where switching from a chloro to a bromo analog improved coupling yields and reduced unwanted byproducts. The structure also places the hydroxy group meta to the methyl ester, which can influence reactivity—electronic effects distribute in a way that opens doors to regioselective modifications, especially when you need orthogonal protection of functional groups.
Outside academic curiosity, the real power of Methyl 5-Bromo-3-Hydroxybenzoate emerges in application. Many medicinal chemists use this intermediate in the synthesis of biologically active heterocycles, exploring new lead compounds for inflammation, oncology, and central nervous system conditions. The structure serves as a modular core scaffold for molecules bearing kinase inhibitory activity; unexplored analogs built from this starting point occasionally surprise with their biological potency.
Agrochemical researchers have also found value in benzoic acid derivatives bearing both a hydroxy and halogen group. The precise control over substitution allows for the construction of herbicide and fungicide analogs with optimized environmental or toxicological profiles. From a practical standpoint, having a methyl ester instead of a free acid streamlines purification steps and often boosts solubility in organic solvents, a useful trait when scaling reactions beyond a few grams in the lab.
Looking across catalogs, dozens of benzoate esters and their halogenated or hydroxylated cousins populate the chemical landscape. Direct comparisons with ortho- or para-substituted analogs highlight clear differences. The meta-hydroxy group offers hydrogen bonding without overly activating the ring toward unwanted side reactions, as seen with ortho arrangements. Bromination at the 5-position toggles electron distribution, changing the usual rules of reactivity. In a series of methylated 5-halobenzoates, only the 5-bromo, 3-hydroxy analog reliably delivered high yields in palladium-catalyzed couplings in our hands.
Purchasers might ask whether to use a 5-chloro variant, hoping for a lower cost or more widespread availability. In actual practice, the difference isn’t subtle: bromo-substituted compounds react more smoothly in transition metal-catalyzed transformations and minimize the harsh conditions needed for further derivatization. Cost differences often even out after factoring in improved reaction efficiency and cleaner downstream processing.
Consistency and purity matter, particularly for research chemists who count on reproducible results. Over the years, I’ve learned that small-batch synthesis sometimes introduces trace impurities—byproducts or unreacted starting materials—that may confound sensitive reactions downstream. Top suppliers pay close attention to spectral purity (NMR, LC-MS), moisture content (Karl Fischer titration helps here), and melting point consistency. In large-scale applications, users appreciate reliable flow properties and minimal dust generation; a well-grained product shortens transfer time and reduces waste.
Packaging also plays a role in user satisfaction. Moisture- and light-resistant packaging helps preserve chemical integrity, especially for research teams without advanced storage facilities. From personal experience, what looks like a minor difference in packaging quality can lead to loss of potency or troublesome decomposition; even slight discoloration from exposure can signal underlying issues. This brings up the importance of transparent lot testing and relevant certificates of analysis.
Researchers working with Methyl 5-Bromo-3-Hydroxybenzoate notice immediately its cooperative handling profile. Low bulk density and fine particle size allow rapid weighing, but care must be taken to avoid static cling during transfer. The compound generally exhibits low hygroscopicity, which means it doesn’t clump or degrade quickly in humid environments. In gram-to-kilogram synthesis, filtering and drying steps proceed without bottlenecks.
For scale-up, I’ve watched teams move from exploratory synthesis all the way through pilot production, often remarking that this benzoate’s solubility in a broad range of organic solvents cuts down on solvent-swapping steps. Simple filtration and avoidance of extensive vacuum drying streamlines workflow. Safe handling still demands the usual personal protective equipment; brominated organics sometimes irritate skin or mucous membranes, so prudent lab technique never goes out of style.
Increasing concern over chemical sustainability has led to deeper scrutiny on intermediates that enter the environment at any stage, from accidental spills to process wastewater. Methyl 5-Bromo-3-Hydroxybenzoate, while non-volatile and relatively stable under ambient conditions, should be managed to prevent unnecessary release. By choosing greener solvents in reaction and workup steps—ethyl acetate, for example, over dichloromethane—one can reduce environmental footprint. Waste streams containing the compound respond well to standard organic treatment methods. While halogenated aromatics usually spark regulatory questions, this specific compound, in research-scale use, has posed fewer challenges given responsible disposal practices and robust data packages manufacturers submit to regulators.
Comparatively, the hydroxy function allows for potential biodegradation not available to simple halobenzoates, although the methyl esterification introduces some persistence. In industry, batch records and traceability help ensure that finished goods remain free of residues, and regular reviews align with shifting regulation. We’ve seen the value of partnerships between suppliers and academic teams for staying ahead of emerging limits and finding ways to document safe handling.
Researchers in drug discovery often look to methylated benzoic acids like this for their modularity. The arrangement of functionalities—bromo, hydroxy, and methyl ester—enables flexible synthesis planning. In a typical route, chemists employ the bromo group in cross-couplings to install complex aryl or alkyl side chains, making way for new pharmacophores. De-esterification at later stages restores the free acid for salt formation or final prodrug manufacturing.
Something I've seen often is that groups will specifically choose the 3-hydroxy, 5-bromo configuration over other positional isomers based on the electronic effects and downstream synthetic options. It expands the chemical space for structure-activity relationship (SAR) studies, allowing teams to move rapidly from hit identification to viable lead candidates. The hydroxy group not only serves as a synthetic handle (for example, in etherification or acylation) but also directly contributes to biological binding in some targets.
Beyond pharmaceuticals, the intermediate steps in dye and pigment manufacture regularly feature this compound. The electronic and solubility properties aid stability of certain colorant precursors. Research chemists prize the reproducibility in scaling up from milligram to multikilogram batches, an attribute not always guaranteed with less-characterized substitutes.
Anyone with experience in process chemistry knows that bench-scale success does not always translate to kilo-scale reliability. Methyl 5-Bromo-3-Hydroxybenzoate, unlike some multi-functional aromatics, maintains predictable behavior across scales. Its moderate melting point and solution stability simplify the switch to jacketed reactors, with minimal foaming or caking during reaction or isolation. Teams report smooth filtration and drying under nitrogen, seldom encountering runaway reactions or sticky residues.
From my time troubleshooting plant upsets, I learned that this compound’s low volatility curbs risk of emissions or odor complaints, easing health and safety burdens. Crude batches clean up reliably using standard recrystallization, and purification by silica gel chromatography—tedious as it might be on the pilot scale—proceeds without demanding exotic solvents or column conditions.
Oddly enough, storage stability often differentiates workable intermediates from those that lose value after a few months. Properly sealed, this compound remains unchanged for well over a year under ambient conditions, and large lots preserve their particle size and color without clumping. Facility managers appreciate these features when ordering inventory ahead for seasonal product runs.
Supply chain disruptions have brought renewed focus to sourcing specialty chemicals. Methyl 5-Bromo-3-Hydroxybenzoate enjoys a healthy market, produced by several well-established suppliers, but not all sources prove equal in quality or documentation. I’ve watched procurement teams compare chromatography data and batch histories, then consult with technical representatives to gauge consistency between batches. The better manufacturers routinely disclose IR, NMR, or high-resolution mass spec data, along with impurity profiles—reassuring partners who must meet strict regulatory standards.
Thin margins and increasing global demand sometimes tempt buyers toward lower-cost imports, but I’ve seen long-term cost savings eroded by issues with batch-to-batch variability or shipping delays. Transparency in how each lot is produced, packaged, and analyzed leads to the best outcomes. Research alliances between manufacturers and academic labs speed up troubleshooting and innovation, since both sides contribute real-world feedback.
In practice, larger organizations build lasting relationships with suppliers who consistently deliver product hitting tight specifications. Flexibility in packaging—drums for manufacturing, jars for R&D—helps reduce handling mistakes and keeps projects on schedule.
While Methyl 5-Bromo-3-Hydroxybenzoate does not present the acute hazards of some reactive or highly toxic compounds, working chemists remain vigilant. Even moderate irritants demand careful handling—proper gloves, goggles, and fume hoods ensure no surprises. Fast cleanup of any spills and clear labeling reduce accidental exposures, especially in shared lab spaces. As protocols and data sheets evolve, training keeps up with evolving best practices.
Long-term safety studies guide industry use; available toxicology data shows low acute toxicity for related esters, with typical handling risks stemming more from dust generation or skin contact than from chronic effects. Factory and warehouse environments benefit from automated handling and dedicated disposal streams for expired or off-spec materials.
As research and manufacturing evolve, so does the push to improve specialty chemicals like Methyl 5-Bromo-3-Hydroxybenzoate. Real gains come from incremental refinements—higher purity, more robust packaging, and improved documentation. Investment in greener synthetic routes, including enzymatic or continuous flow methods, reduces waste and boosts sustainability. Peer-reviewed studies highlighting more efficient coupling reactions using renewable solvents or catalysts continue to expand the toolkit available to chemists.
A collaborative approach among manufacturers, university-based researchers, and end-users brings better solutions. Shared analytical data, open discussions about supply chain risks, and regular feedback loops have led to more uniform product quality and transparency in pricing. The spread of digital quality management systems means fewer errors, better traceability, and enhanced recall ability should issues arise.
Educating new scientists about both the utility and the responsibility involved in handling benzoate intermediates builds a culture of safe and innovative chemistry. Training remains key: with the right preparation, users extract maximum value while controlling risks.
The global footprint of specialty benzoates reflects shifting trends in pharmaceuticals and fine chemicals. Demand for unique building blocks for the expanding biological therapies sector continues to climb, with analogs serving as API intermediates or as coupling partners for more intricate molecules. Methyl 5-Bromo-3-Hydroxybenzoate enjoys a solid reputation as an enabler for rapid diversification and analog synthesis.
Departments in charge of sourcing track not only price per kilogram but supplier reputation for transparency and consistent quality. This matters especially for regulated industries where every incoming lot must pass scrutiny. A clear understanding of contaminant profiles and synthetic heritage reduces risk both for buyers and downstream stakeholders.
The growth of custom synthesis businesses globally has also led to a broader base of demand. Companies serving niche sectors now rely on reliable sources for specialty intermediates, including this one, to keep development timelines on track. Markets in Asia, Europe, and North America all contribute to steady consumption, with new opportunities emerging alongside innovations in synthetic methodology.
As technologies evolve, the horizons for compounds like Methyl 5-Bromo-3-Hydroxybenzoate continue to expand. Next-generation synthesis relies ever more on clean, atom-efficient processes. The trend toward greener chemistry—using renewable feedstocks, reducing energy demands, and minimizing hazardous byproducts—reshapes supplier offerings. Researchers continually publish new methods for activating or transforming bromoaromatics under milder conditions, opening possibilities for more sensitive biological applications.
The compound’s adaptability serves not only advanced small-molecule therapeutics but also material sciences, where functionalized aromatics form the backbone of polymers, sensors, or coatings with unique properties. Each year, presentations at major chemistry conferences showcase new work leveraging this scaffold for completely unanticipated uses, from smart materials to targeted drug delivery vehicles.
The ongoing shift toward digitalization in chemical research further bolsters confidence in specialty intermediates. Retrosynthetic planning software and machine learning models increasingly draw on high-quality, vendor-provided datasets, ensuring more reliable predictions for yield and reactivity. This means investments in analytical documentation and clarity in batch records matter as much as the reagent itself.
Methyl 5-Bromo-3-Hydroxybenzoate’s standing in the chemical toolkit relies not just on its intrinsic reactivity or purity but on the practices that surround its sourcing, handling, and continual improvement. Years of on-the-bench experience and close collaboration with researchers and suppliers show just how much careful attention to detail—from packaging to documentation to safety—pays off in successful research and manufacturing. For all the technical distinctions among specialty benzoates, the importance of consistency, transparency, and adaptability stands out. As scientific demands push toward ever-more complex targets, core intermediates like this will keep fueling innovation, provided the entire community invests in smart, responsible stewardship and continuous learning.
