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Ethyl 2,4-Dibromobutyrate

    • Product Name Ethyl 2,4-Dibromobutyrate
    • Alias Ethyl 2,4-dibromobutanoate
    • Einecs 214-334-4
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
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    Specifications

    HS Code

    589363

    Product Name Ethyl 2,4-Dibromobutyrate
    Cas Number 52451-25-3
    Molecular Formula C6H10Br2O2
    Molecular Weight 273.95 g/mol
    Appearance Colorless to pale yellow liquid
    Boiling Point 110-115°C at 16 mmHg
    Density 1.778 g/cm3 at 25°C
    Refractive Index 1.489-1.492 at 20°C
    Melting Point -4°C
    Solubility Soluble in organic solvents such as ethanol and ether
    Purity Typically ≥98%
    Synonyms 2,4-Dibromobutyric acid ethyl ester

    As an accredited Ethyl 2,4-Dibromobutyrate factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Ethyl 2,4-Dibromobutyrate, 25g, supplied in a sealed amber glass bottle with tamper-evident cap and hazard labeling.
    Shipping Ethyl 2,4-Dibromobutyrate should be shipped in tightly sealed containers, compliant with local and international regulations for hazardous chemicals. It requires labeling as a harmful and potentially environmentally hazardous substance. Transport should be in a cool, dry, well-ventilated area, avoiding exposure to heat, flames, and incompatible materials. Handle with appropriate protective measures.
    Storage Store **Ethyl 2,4-Dibromobutyrate** in a tightly sealed container, away from moisture, heat, and direct sunlight. Keep in a cool, dry, well-ventilated area, separated from incompatible substances such as strong oxidizers and bases. Use storage conditions as recommended in the Safety Data Sheet. Proper labeling and secondary containment are advised to prevent leaks or accidental exposure.
    Application of Ethyl 2,4-Dibromobutyrate

    Applications of Ethyl 2,4-Dibromobutyrate in Industrial Manufacturing

    Ethyl 2,4-Dibromobutyrate serves as a specialized intermediate for several chemical synthesis sectors. As a manufacturer, we supply this material directly to downstream producers whose processes demand consistency, high purity, and regulatory conformity. Below, we outline key industrial application areas based on real downstream use cases.

    1. Pharmaceutical Active Ingredient Synthesis

    Pharmaceutical manufacturers employ Ethyl 2,4-Dibromobutyrate in the multi-step synthesis of anti-epileptic API precursors, particularly for bromine-functionalized molecules. It participates as a building block in the preparation of intermediates for drugs like Levetiracetam and analogs, where the controlled introduction of bromine atoms is essential for target activity. Downstream users select the compound for its reliable reactivity under anhydrous or semi-aqueous conditions, supporting batch-wise and continuous flows. Quality assurance, traceability, and compliance with international pharmacopoeias remain essential during procurement, processing, and subsequent scale-up.

    Industry compliance standards

    • ICH Q7 GMP (Good Manufacturing Practice for APIs)
    • EU GMP Annex 8 (Raw Materials Policy)
    • US FDA 21 CFR Part 210/211 (Drug Manufacturing Controls)
    • European Pharmacopoeia (EP) specification check for starting materials

    Typical usage ratio

    • 0.10–0.25 molar equivalents per batch, adjusted by reaction scale and desired selectivity
    • Variations depend on target intermediate and downstream yield optimization

    Downstream process integration

    • Introduced in early-stage alkylation as a nucleophilic partner
    • Used in protected-phase synthesis, often under inert gas and controlled temperature
    • Followed by hydrolysis or further halogenation in closed reactor systems

    Final product types

    • Active pharmaceutical ingredient intermediates
    • Anti-epileptic drug molecule building blocks
    • Reference standards for brominated APIs
    • Synthons for further heterocyclic compound production

    2. Agrochemical Intermediate Production

    Agrochemical formulators utilize Ethyl 2,4-Dibromobutyrate as an intermediate for the synthesis of specific pre-emergence herbicides and insecticidal agents that rely on bromoethyl substituents. This application leverages the compound’s reactivity for creating carbon-bromine bonds critical to crop protection effectiveness. Production lines must uphold sector-specific residue thresholds and manage cross-contamination risks. Downstream facilities rely on the consistent purity level of this intermediate to maintain finished product quality, subject to both local and export compliance audits.

    Industry compliance standards

    • OECD Guidelines for the Testing of Chemicals (Residue Analysis)
    • FAO/WHO Good Laboratory Practice (GLP) for Pesticide Raw Materials
    • REACH Regulation (EC No 1907/2006) for intermediates
    • ISO 9001:2015 Quality Management System for agrochemical manufacturing

    Typical usage ratio

    • 0.08–0.15 molar equivalents relative to final active compound mass
    • Ratio varies with targeted molecule and integrated yield calculation

    Downstream process integration

    • Added during intermediate bromination phase
    • Maintains reactivity in closed reactor systems to prevent volatilization loss
    • Processes monitored by GC-MS for bromine content validation

    Final product types

    • Pre-emergence herbicide intermediates
    • Active insecticidal agents with bromoalkyl side chains
    • Building blocks for fungicide synthesis
    • Intermediate for specialized seed treatment chemistry

    3. Fine Chemical Synthesis for Flavor and Fragrance Precursors

    Leading fine chemical producers incorporate Ethyl 2,4-Dibromobutyrate in controlled syntheses that yield bromo-containing esters, allowing for the subsequent production of aroma compounds, especially in high-stability flavor encapsulation products. The ingredient’s inclusion supports the formation of specialty lactones and aliphatic chain-modified esters critical for nuanced taste and scent profiles in high-end food and fragrance applications. Industry buyers require detailed Certificate of Analysis (COA), absence of non-permitted solvents, and documented batch-to-batch reproducibility.

    Industry compliance standards

    • FCC (Food Chemicals Codex) reference for raw material acceptability
    • IFRA Standards (International Fragrance Association guidelines)
    • US FDA 21 CFR Part 172 (Food Additives Permitted for Direct Addition to Food)
    • ISO 22000 Food Safety Management for ingredient traceability

    Typical usage ratio

    • Up to 0.12 molar equivalents per controlled batch synthesis
    • Adjusted to ensure downstream flavor precursor purity and minimize residual bromine

    Downstream process integration

    • Participates in key esterification and ring-closing steps
    • Utilized with phase-transfer catalysts to boost yield
    • Downstream purification by fractional distillation or preparative chromatography

    Final product types

    • Specialty ester intermediates for flavor manufacture
    • Lactone and macrocycle precursors for fragrance synthesis
    • Aliphatic bromederivatives for encapsulated flavor systems
    • Non-GMO, food-grade aroma additives

    4. Polymer Modification and Additives Manufacturing

    In polymer chemistry, Ethyl 2,4-Dibromobutyrate introduces functional bromine groups in specialty copolymer synthesis, supporting the development of fire retardant and surface-modified resins. These modifications enable downstream producers to enhance flame resistance, alter polarity, or create chemically reactive side chains for subsequent grafting. The production environment must avoid contamination, control emissions, and document material flows for regulatory reporting. The input ratio and timing of raw material addition play a decisive role in achieving target polymer characteristics.

    Industry compliance standards

    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances)
    • UL 94 (Standard for Flammability of Plastic Materials)
    • ISO 14001 Environmental Management for chemical processing
    • EN 13501-1 (Fire classification of construction products and building elements)

    Typical usage ratio

    • 0.04–0.10 mole per mole of base polymer monomer
    • Adjusted per flame retardancy and solubility requirements

    Downstream process integration

    • Added in pre-polymerization functionalization
    • Integrated into melt-blend or solution polymerization processes under inert atmosphere
    • Excess neutralized and removed via post-reaction washing

    Final product types

    • Flame retardant copolymers
    • Surface-reactive resins for composite laminates
    • Modified acrylics or vinyls for adhesives
    • Intermediate compounds for wire/cable sheath material
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    Certification & Compliance
    More Introduction

    Introducing Ethyl 2,4-Dibromobutyrate: A Closer Look at Its Role and Advantages

    In specialty chemical production, every compound tells its own story. Ethyl 2,4-Dibromobutyrate stands out not just for its unique structure, but for the way it brings precision and reliability to a range of industrial and research applications. If you've worked in organic synthesis or explored the nitty-gritty of advanced chemical processes, you might already know how crucial intermediates like this one can be. Marketed under the model name Ethyl 2,4-Dibromobutyrate or simply by its molecular formula C6H10Br2O2, this compound has carved out its own niche due to both its physical properties and performance in demanding environments.

    What Sets Ethyl 2,4-Dibromobutyrate Apart?

    Most folks who work with organobromine compounds know that purity levels and reactivity profiles make a huge difference in laboratory outcomes. Ethyl 2,4-Dibromobutyrate draws attention for its consistency. Produced as a colorless to pale yellow liquid, this compound stays stable under the correct storage conditions and delivers dependable results—a big plus for anyone running multi-step syntheses or scaling up production. With a molecular weight of 273.96 g/mol, it's easy enough to handle in both bench-scale and pilot plant setups. The purity often exceeds 98%, helping chemists avoid surprises due to side reactions or unpredictable impurities.

    Usage That Reaches Beyond the Basics

    Through my years in organic synthesis research, I’ve come to appreciate the impact a single intermediate can have on the entire development chain. Ethyl 2,4-Dibromobutyrate isn’t some dusty relic of specialty chemistry—it actively fuels progress. Its primary role lies as a building block for pharmaceuticals, agrochemicals, and advanced materials. Across different labs and factories, folks lean on it to introduce both ethyl and dibromide groups in the midst of synthesizing larger, more complex molecules. The double bromination of the butyrate backbone gives it a reactivity profile that’s hard to match with alternatives.

    Working with this compound, you notice the difference right away compared to single-brominated or non-brominated analogues. The dibrominated nature makes downstream substitutions possible at two distinct positions. Chemists recognize this advantage in multi-step syntheses, where skipping tricky intermediate steps often saves both time and money. For example, producing certain pyrrole and furan derivatives can be simplified by using Ethyl 2,4-Dibromobutyrate as the starting point. In crop protection chemistry and medicinal discovery work, this flexibility means researchers can pursue new molecules without worrying about hitting a dead end due to lack of suitable intermediates.

    Comparison with Similar Compounds

    Take a closer look at brominated butyrates in the market, and you’ll spot a clear difference: most are mono-substituted or carry bromines on adjacent carbons. Ethyl 2,4-Dibromobutyrate has bromines at the second and fourth positions, providing a strategic arrangement that broadens its utility. Mono-brominated versions lack the symmetry and tend to be less reactive for certain substitutions. Other options with closely positioned bromines might not allow selective reactions at both positions without causing over-reaction or side degradation.

    Chemists value time-tested results; that means the trusted performance provided by this dibrominated compound often gets the nod over competitors. Fewer side products mean purer final goods, making downstream purification easier. In an era where regulatory environments grow tougher and environmental concerns force companies to cut waste, clean reactions bring both regulatory and financial wins. From my own experience running gram- to kilogram-scale syntheses, the switch to this compound trimmed hours off workups and reduced solvent waste, helping both the bottom line and the planet.

    Why Quality Control Matters

    If you’ve tried sourcing intermediates from inconsistent suppliers, you’ll know why folks pay attention to product grade and reporting. Ethyl 2,4-Dibromobutyrate typically lands on a chemist’s bench from a batch that’s passed rigorous identity, purity, and safety tests. Analytical methods like HPLC and NMR back up what’s on the label. Most suppliers deliver technical data sheets detailing spectral characteristics and recommended handing—a vital resource. It’s not just about having a chemical; it’s about knowing you can rely on proper behavior through every step of a project. From working in academia and industry, I’ve seen entire projects delayed due to variable intermediate quality; one can’t overstate the value of a solid pedigree.

    Working Safely with Ethyl 2,4-Dibromobutyrate

    People entering the world of brominated compounds quickly learn the ropes of safe handling. Ethyl 2,4-Dibromobutyrate volatilizes slowly, and though its boiling point sits comfortably above room temperature, good ventilation remains a must. Contact with skin or eyes brings irritation risks, common for reactive organobromines. I remember once accidentally brushing a gloved hand against a spill; even heavy-duty gloves don’t offer infinite protection, so quick washing and careful storage can’t be overlooked. Reliable chemical labeling and ventilation—alongside a sturdy fume hood for weighing and mixing—should stay standard practice.

    Waste disposal marks another critical area. Organic bromides can pose both environmental and health hazards if dumped recklessly. Industry best practice means collecting all liquid and solid waste in proper containers and making use of licensed disposal providers. Over years of collaboration with waste handlers, I learned that proper communication—chemical name, hazard class, physical state—prevents mishaps downstream. Forward-thinking companies now track and report hazardous intermediates to regulators as a matter of course, and stricter policies mean everyone benefits from a safer workplace and cleaner world.

    The Market Impact of High-Purity Intermediates

    The need for reliable specialty chemicals has only grown as pharmaceutical pipelines expand and crop protection agents require new solutions. Ethyl 2,4-Dibromobutyrate, with its well-documented reactivity and high batch consistency, becomes more appealing as intellectual property lifts certain formulations above the competition. My former colleagues in fine chemicals always kept an eye out for intermediates that meet evolving compliance standards. Lately, global regulatory shifts highlight the need for traceability in sourcing and production, making clean, auditable chemical histories as important as purity values.

    Companies who invest in cleaner, better-controlled intermediates cut down on rejected batches and late-stage regulatory headaches. This compound, thanks to its double bromination and clean route to further functionalization, means scientists spend less time troubleshooting and more time developing useful products. Longevity in this industry often tracks innovation, but also hinges on the little details—where and how building blocks come together, and which ones prove themselves through reliability and clear value.

    Potential Environmental and Health Concerns

    It’s no secret that brominated organics draw extra scrutiny from both an environmental and human safety angle. Ethyl 2,4-Dibromobutyrate is no exception. Accidental releases or poor storage can produce problems, as brominated volatiles don’t play nicely with waterways or sensitive air environments. In several jurisdictions, regulators keep a sharp eye on releases of such compounds, requiring clear documentation and accident reporting. Within labs and plants, safety data sheets guide chemical hygiene and spill protocols. From my own work with hazardous materials, the strongest lesson is not just knowing the data, but translating it into real routines—sealed containers, monitored storage, and ongoing training for everyone involved.

    Some research has flagged organobromine compounds for potential long-term toxic effects or issues with bioaccumulation. Responsible users of Ethyl 2,4-Dibromobutyrate regularly update safe handling procedures and disposal strategies in line with the freshest research and guidelines. A culture that supports transparent discussion of minor incidents—without blame—encourages the kind of improvements that protect both human health and the environment. Newer analytical tools, including advanced mass spectrometry and environmental monitoring systems, offer real-time feedback should a release or exposure occur. Fact-based, responsive adjustments can mean the difference between a close call and a costly accident.

    How Sourcing Drives Progress in R&D

    No one in chemical research likes to get held up by a missing or unreliable intermediate. Ethyl 2,4-Dibromobutyrate, sourced from reputable suppliers, keeps research teams on schedule and backs up data integrity. Contracts among pharmaceutical and agrochemical firms sometimes specify not only strict purity but clear origins and quality documentation. My colleagues working on patent filings stress the importance of traceable intermediates; a clear, continuous record of sourcing and quality compliance can tip the scales if intellectual property faces challenges downstream.

    Even as smaller startups and academic labs push boundaries with new molecules, the need for reliable building blocks stays core to the creative process. This compound shows up in grant lists and lab order forms not just because it fills a structural need, but because those who order it know the headache of substitutions or substitutes that fail quality checks. Consistency from batch to batch adds momentum to the development cycle, trimming delays and supporting the creative energy that drives discovery.

    Strategies to Minimize Drawbacks and Maximize Value

    Some challenges always come with handling reactive organobromine compounds. With good protocols, these issues shrink to manageable scale. Closed transfer systems, active local exhaust, and high-visibility safety training mark the path forward for responsible handling of Ethyl 2,4-Dibromobutyrate. In one project, I helped implement a triple-check system for inventory, which cut usage errors and improved reporting to our regulatory office. Team meetings, hands-on demonstrations, and updates from chemical safety officers turn standard operating procedures from paperwork into real habits.

    Innovators keep searching for greener alternatives and waste minimization strategies. Chemists work to reclaim and recycle solvents wherever feasible, and some projects now report on organobromine consumption as part of environmental impact statements. Green chemistry principles push back against historical shortcuts, placing higher bars for intermediates like this one—if you can safely work with less toxic analogues, or find ways to neutralize waste before disposal, both process and people benefit.

    Companies exploring continuous flow chemistry or microreactor processes may unlock further potential by minimizing human exposure even further. While traditional batch production dominates today, the shift toward miniaturized, closed-system approaches has shown real promise. Less spillage, tighter control, and easier waste capture all align with regulatory expectations and internal risk management goals. As industry trends keep evolving, so too will the use of compounds like Ethyl 2,4-Dibromobutyrate, tailoring their roles to fit emerging processes and safety norms.

    The Bigger Picture: Sustainable Growth and Innovation

    Careful selection and deployment of a building block like Ethyl 2,4-Dibromobutyrate speaks to larger shifts in chemical practice. Both researchers and manufacturers now chase not just new molecules, but pathways that reduce risks and environmental impacts. Market demand keeps shifting, with government agencies and public watchgroups asking for more info on everything in the supply chain. Every lab switch to higher quality or greener intermediates sends ripples through the ecosystem, making waves that reach suppliers, partners, and end-users. During my time managing R&D teams, the push to improve sourcing practices and support safer processes paid major dividends—speeding up commercialization and trimming costs caused by preventable setbacks.

    Transparency remains fundamental. Shared experiences, peer-reviewed studies, and reliable product documentation anchor decisions made at the lab bench and in corporate boardrooms alike. As more folks document both successes and setbacks in handling organobromine compounds, best practices evolve. Whether tackling a major production run or running a new synthetic route on the side, learning from both the data and each other cements sustainable improvements.

    A Product Aligned with Today’s Demands

    Demand for robust, predictable chemical intermediates only rises as industries stretch to meet both business targets and societal expectations. Ethyl 2,4-Dibromobutyrate, with its double bromination and practical usability, reflects the lessons learned by chemists who’ve gone through countless batches and process tweaks. This compound eases stress across development cycles, from academic labs to commercial benchwork.

    New generations of scientists face regulatory and ethical scrutiny that sometimes outpaces the availability of textbooks or precedents. Open dialogue with suppliers, continuous training, and a sharp focus on best-practice handling ensure today’s users stay ahead of tomorrow’s challenges. During site visits and industry roundtables, the most common refrain I heard was the need for predictable, cleanly sourced intermediates that won’t blow up budgets or project timelines. The compounds that stay in favor do more than “check the box”—they unlock discovery, speed up process improvement, and underline a business’s commitment to safe, responsible progress.

    Moving Forward: Ethyl 2,4-Dibromobutyrate as a Trusted Partner

    If you spend enough years in chemistry, you realize the most critical steps often hide in the details. Ethyl 2,4-Dibromobutyrate may not be the flashiest compound, but its footprint runs large across advanced synthesis, crop protection research, and custom manufacturing. By offering high selectivity, manageable safety profiles, and proven reliability, it does more than form a piece of the puzzle—it helps raise the standard for what chemists and industries can achieve.

    Chemical supply and usage never move in a vacuum. Tightening rules, better science, and higher expectations converge on the choice of intermediates. Companies and teams who stay vigilant, keep asking questions, and improve both sourcing and handling create environments where accidents fade and progress accelerates. In my own projects, those willing to invest in the right tools, training, and supplier relationships see payoffs in both safety and output. That’s what sets the great operations apart and why attention to compounds like Ethyl 2,4-Dibromobutyrate goes beyond a product name—it’s a catalyst for responsible innovation, secure in its proven place in the working chemist’s toolkit.