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7-Bromo-5-Chloro-8-Hydroxyquinoline

    • Product Name 7-Bromo-5-Chloro-8-Hydroxyquinoline
    • Alias Bromo-Resochin
    • Einecs 221-481-7
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    434653

    Product Name 7-Bromo-5-Chloro-8-Hydroxyquinoline
    Molecular Formula C9H5BrClNO
    Molecular Weight 258.50 g/mol
    Cas Number 86143-99-3
    Appearance Light yellow to beige powder
    Melting Point 231-235°C
    Solubility Slightly soluble in water, soluble in organic solvents
    Purity Typically ≥98%
    Storage Conditions Store at 2-8°C, protect from light
    Chemical Class Quinoline derivative

    As an accredited 7-Bromo-5-Chloro-8-Hydroxyquinoline factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing Amber glass bottle containing 25 grams of 7-Bromo-5-Chloro-8-Hydroxyquinoline, sealed with tamper-evident cap and labeled for laboratory use.
    Shipping 7-Bromo-5-Chloro-8-Hydroxyquinoline is shipped in secure, airtight containers to prevent moisture and contamination. Packaging complies with chemical safety regulations. It is transported as a non-hazardous, stable solid, with clear labeling and handling instructions. Shipping includes documentation for traceability and is typically sent via ground or air freight following all regulatory guidelines.
    Storage Store **7-Bromo-5-Chloro-8-Hydroxyquinoline** in a tightly sealed container in a cool, dry, well-ventilated area, protected from light and moisture. Keep away from incompatible substances such as strong oxidizing agents. Ensure appropriate chemical labeling and restrict access to trained personnel. Use secondary containment to prevent spills and store at room temperature unless otherwise specified by the manufacturer.
    Application of 7-Bromo-5-Chloro-8-Hydroxyquinoline

    Applications of 7-Bromo-5-Chloro-8-Hydroxyquinoline in Industrial Manufacturing

    As a specialized manufacturer of 7-Bromo-5-Chloro-8-Hydroxyquinoline, we supply to a range of sectors reliant on precision synthesis, high product purity, and strict quality assurance. Here we detail the primary downstream industrial applications, including specific compliance frameworks, formulation data, process workflow, and finished goods achieved in real manufacturing environments.

    1. Active Pharmaceutical Ingredient (API) Synthesis for Antimicrobial Agents

    Pharmaceutical producers value this raw material as a key intermediate in the preparation of novel antimicrobial drugs. Its unique halogenated quinoline structure enables targeted molecular modification, allowing process chemists to construct active moieties for proprietary API projects. Production uses closed systems and digitally tracked lots in cGMP environments, prioritizing impurity control and batch consistency. Final APIs undergo registration and stringent batch-release testing before formulation into oral and topical antimicrobials.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for APIs
    • European Pharmacopoeia reference standards
    • US FDA 21 CFR Part 210/211 cGMP for Finished Pharmaceuticals
    • WHO GMP Guidelines

    Typical usage ratio

    • Intermediate use: typically 0.15–0.45 molar equivalents relative to main substrate, adjusted by process yield data and impurity thresholds

    Downstream process integration

    • Stagewise introduction during condensation or substitution reactions in medicinal chemistry labs
    • Inline analytical monitoring for reaction progress and endpoint verification

    Final product types

    • Small-molecule antimicrobial APIs
    • Finished antimicrobial formulations (oral tablets, topical creams)
    • Licensed generic and proprietary drugs
    • Clinical trial investigational compounds

    2. Intermediate for Agrochemical Synthesis

    Major crop protection manufacturers incorporate this compound in the development of advanced fungicide and bactericide actives. Its molecular framework facilitates the synthesis of heterocyclic building blocks integral to active pesticide scaffolds. Companies use closed batch synthesis and high-throughput purification tailored to downstream bioassay validation. Handling procedures focus on rigorous trace impurity removal and consistent scale-up for regulatory approvals.

    Industry compliance standards

    • FAO/WHO Specifications for plant protection products
    • REACH Regulation (EC) No 1907/2006
    • ISO 9001:2015 Quality Management
    • OECD Guidelines for chemical testing

    Typical usage ratio

    • Input: 10–20% by weight relative to other core precursors in heterocycle-formulation steps for pilot or production batches

    Downstream process integration

    • Direct addition to reaction vessels during halogen exchange and ring closure steps
    • Purification of resulting intermediates prior to formulation of end-use active ingredient

    Final product types

    • Technical-grade agrochemical intermediates
    • Active ingredients for broad-spectrum fungicides
    • Bactericidal agents for seed treatment products
    • Soil amendment active blend concentrates

    3. Specialty Dye and Pigment Manufacturing

    Colorant manufacturers employ this compound as a tailored synthon for high-performance pigment production. Its halogen and hydroxy substituents allow precise tuning of shade, photostability, and functional group compatibility. Downstream processes involve high-temperature coupling and purification steps, with quality assurance focused on color consistency and non-volatile residue controls vital for industrial-grade pigments.

    Industry compliance standards

    • EN 71-3 Safety of Toys (migration of chemical elements)
    • ISO 1248:2012 Inorganic pigments—General specifications and methods of test
    • REACH Authorization and Restriction List
    • RoHS Directive 2011/65/EU (where applicable)

    Typical usage ratio

    • Functional additive level: 1–7% by total pigment mass, optimized for targeted color properties in lab-scale and industrial-scale syntheses

    Downstream process integration

    • Charge into pigment synthesis reactors during nucleation phase
    • Processed post-synthesis by vacuum drying, calcination, and micronization

    Final product types

    • Solvent-stable dyes for plastics
    • Weather-resistant industrial pigments for inks
    • Specialty colorant dispersions
    • Coatings-grade pigment preparations

    4. Analytical Grade Reference Standard in Chemical Testing

    Accredited testing laboratories utilize this material as an analytical reference for validating chromatographic methods. The compound’s high purity profile and defined impurity composition provide robust calibration points in pharmaceutical and agrochemical residue testing. Laboratories perform in-house qualification and storage under controlled conditions, using documented chains of custody for regulated projects.

    Industry compliance standards

    • ISO/IEC 17025 Testing and Calibration Laboratories
    • GLP (Good Laboratory Practice) Principles
    • USP General Chapter <621> Chromatography
    • European Pharmacopoeia, Section 2.2.46 Chromatographic separation techniques

    Typical usage ratio

    • Calibration standard: Typically 50–100 micrograms per analytical run; solution strength based on sensitivity and detection limits of target method

    Downstream process integration

    • Dissolved in certified solvents for preparation of validation standards
    • Direct injection into HPLC or GC-MS systems for system suitability and recovery studies

    Final product types

    • Certified reference solutions
    • Analytical quality control kits
    • Chromatography system suitability samples
    • Residue and impurity validation reports for regulatory submissions

    5. Synthesis of Metal Coordination Complexes for Electronic Applications

    Electronic material manufacturers regard this compound as an essential ligand precursor for the synthesis of custom metal complexes. The presence of bromo, chloro, and hydroxy groups allows fine-tuned coordination with transition metals used in optoelectronic and sensor devices. Downstream processes require controlled atmosphere synthesis and ultra-trace metal impurity screening to meet functional requirements for device integration.

    Industry compliance standards

    • IPC-1752A Material Declaration Management
    • ISO 14001 Environmental Management Systems
    • RoHS (Restriction of Hazardous Substances) Compliance, where applicable
    • IEC 62474 Material Data Exchange Standard

    Typical usage ratio

    • Trial coordination studies: 0.9–1.2 molar equivalents relative to targeted metal ion

    Downstream process integration

    • Initial dissolution into chelating cocktails under inert gas
    • Gradual addition of metal salts with real-time monitoring of ligand-metal complexation reactions

    Final product types

    • Functionalized metal chelates for OLED display fabrication
    • Sensor-grade quinoline metal complexes
    • Electronic device coating precursors
    • Specialty chelating agents for semiconductor processes
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    Certification & Compliance
    More Introduction

    Introducing 7-Bromo-5-Chloro-8-Hydroxyquinoline: Innovation for Modern Research and Industry

    Understanding the Role of 7-Bromo-5-Chloro-8-Hydroxyquinoline

    Stepping into the world of chemical research, you notice that progress rarely relies on single advances, but rather on a careful build-up of tried and tested building blocks. Among these, 7-Bromo-5-Chloro-8-Hydroxyquinoline stands out as one of those reliable compounds that researchers keep in their toolkit, especially when precise targeting of biological or industrial concerns matters. The chemical’s structure, involving both bromine and chlorine substitutions on the hydroxyquinoline backbone, makes it more than just another niche product. Specific substitution patterns, like those seen here, aren’t always easy to develop, which reflects the ongoing demand for compounds that offer selectivity, efficiency, and the ability to advance work rather than simply fill a slot on a shelf.

    Model and Specifications: Quality Begins at the Source

    From my time working hands-on in synthetic labs, you really get to know which materials you can count on for their consistency and which ones might slow your work with batch-to-batch variations. The most reliable suppliers of 7-Bromo-5-Chloro-8-Hydroxyquinoline push for standards that safeguard integrity, focusing on retaining a high degree of purity—most typically above 98%, though the finest grades edge even closer to the theoretical maximum. Physical form matters, too. For this compound, you’ll encounter it as a solid, often presenting as a fine, off-white to pale yellow powder, which handles well inside most laboratory setups. Chemical stability frequently gets tested, and this product has shown itself to be robust under ordinary storage conditions: keep it closed tight, protect it from direct light and moisture, and you’re set for a solid shelf life.

    Some might think these kinds of details are trivial, but as someone who’s watched entire experiments collapse because of poorly-characterized products, I appreciate suppliers who confirm purity using methods like NMR or HPLC, and who actively check for residual solvents and related compounds. Sure, these technical details aren’t flashy, but they add up to increased confidence—whether your team runs analytical chemistry, pharmaceutical development, or advanced manufacturing.

    Where 7-Bromo-5-Chloro-8-Hydroxyquinoline Fits: Real-World Applications

    A lot of molecules get their reputation from the company they keep, and this one is no exception. Based on both literature and my own experience, I’ve seen 7-Bromo-5-Chloro-8-Hydroxyquinoline primarily play a role in complex synthesis routines. Its unique substitution pattern gives it utility as an intermediate for crafting new pharmaceuticals or agrochemicals. Rather than being locked into one use case, the compound’s structure opens doors to a range of modifications. Medicinal chemistry often relies on hydroxyquinolines as starting points for exploring antibacterial, anticancer, or antiviral properties, thanks to their ability to interfere with biological targets at a molecular level.

    For example, in the early stages of drug discovery, researchers use derivatives like this one to fine-tune properties such as solubility, metabolic stability, and interaction with specific enzymes. The bromine and chlorine atoms both influence the electron density and reactivity of the molecule, making for new options in coupling reactions or further functional group modifications. Based on published studies and the pattern I’ve observed in academic and industrial circles, the compound shows promise in pathways where traditional hydroxyquinolines were too reactive or not selective enough.

    How This Compound Stands Apart: A Look Beyond the Label

    Plenty of hydroxyquinoline derivatives crowd the market, but most are simpler versions without dual halogenation or are substituted differently. 7-Bromo-5-Chloro-8-Hydroxyquinoline has a sweet spot in reactivity; it doesn’t lean towards the instability seen in more heavily halogenated quinolines, nor does it lack the punch needed for cross-coupling reactions. Being able to count on this kind of performance saves time and increases the chances that your next experiment won’t be a shot in the dark.

    One of the consistent surprises for newcomers is the compound’s solubility profile. You’ll get moderate solubility in most organic solvents, especially those with some polar character—think DMSO or DMF. Traditional hydroxyquinolines might disappoint here, dissolving poorly and making it hard to run smooth reactions. With this product, you get more reliable results across a series of commonly used solvents, reducing the sort of frustrating rework that often plagues synthesis campaigns. These practical differences in solubility and reactivity aren't often apparent until you run side-by-side trials, but the improvements are real.

    Meeting Evolving Industry Demands

    In regulated industries like pharmaceutical development and environmental testing, you can’t afford to take shortcuts on material quality. This is where the product’s strict quality checks and certificates of analysis come into play. Drawing a line from my own experience, there’s a peace of mind that comes from knowing your starting materials have full traceability and that every lot has been scrutinized to weed out contamination and ensure compliance with both regulatory expectations and internal protocols.

    For industries scaling up from bench to pilot plant or even to full commercial production, reproducibility counts. Each variable, from particle size to impurity profile, influences yield and process efficiency. 7-Bromo-5-Chloro-8-Hydroxyquinoline, produced under these tight controls, can help teams avoid setbacks that waste critical time. Streamlined documentation and batch records go beyond bureaucratic boxes to check; they become assurances that let you focus on developing the next big application, rather than retracing steps to troubleshoot unexpected setbacks.

    Research and Collaboration: The Value of Shared Knowledge

    Research doesn’t happen in a vacuum. Effective collaboration relies on materials that perform the same way in every lab. I've traded notes with colleagues who ran into delays because two shipments of a similar quinoline derivative behaved differently due to uneven production standards, either from unfamiliar manufacturing processes or from suppliers that cut corners. In my own labs, projects sometimes came to a halt for weeks while we waited for reliable replacement materials. I’ve learned to value not just a compound’s listed specifications but also the follow-through on questions about stability, reporting, and responsiveness to custom requests.

    Feedback from partners working in biotech startups suggests that having access to high-purity hydroxyquinoline derivatives, with both bromine and chlorine substitutions, made certain lines of investigation possible that would otherwise be out of reach. It’s one thing to plan a series of SAR (structure-activity relationship) studies on paper, and entirely another to actually push forward without surprises in reagent behavior.

    What Matters Most: Safety and Handling

    In an ordinary research or production setting, questions about safety and handling don’t just sit in the fine print; they directly shape the day-to-day. 7-Bromo-5-Chloro-8-Hydroxyquinoline doesn’t fall into the most hazardous categories, but respecting its potency and the reactivity of halogenated aromatics pays off. Teams I’ve worked with take training seriously and use appropriate PPE. Good ventilation, working at the bench, and careful disposal protocols protect both people and environment. Reagents with multiple halogen atoms sometimes require disposal as hazardous chemical waste. Investing in clear communication and training builds confidence, which matters when research budgets and deadlines are both tight.

    Improving Accessibility Without Compromising Standards

    The science community makes progress only when vital resources become accessible to a wide range of researchers. In my early years, I remember how frustrating it was to track down unique starting materials—either you dealt with weeks-long delays waiting for imports, or you faced unexpected customs hurdles that could stall even the best-laid project plans. These days, seeing products like 7-Bromo-5-Chloro-8-Hydroxyquinoline carried by reputable distributors with global reach has lifted a weight off project timelines. Streamlined ordering, reliable lead times, and well-documented support mean scientists can spend more energy on developing solutions, not chasing down ingredients.

    Direct experience tells me that open dialogue between suppliers and customers fosters a cycle of improvement, especially when labs share insights from unexpected hurdles or new breakthroughs using the compound. Some suppliers, for example, now offer short technical webinars explaining optimal storage or giving troubleshooting tips for typical synthetic routes, which didn’t exist even a decade ago. Having this kind of proactive support makes a difference as complexity in synthetic targets grows.

    Environmental Considerations and Responsible Sourcing

    Any compound with both bromine and chlorine in its structure triggers justified questions about environmental footprint. While not on the same level as certain persistent pollutants, 7-Bromo-5-Chloro-8-Hydroxyquinoline demands care at every step, from sourcing to disposal. Modern producers increasingly rely on greener halogenation processes that limit toxic byproducts and support safer waste streams. There’s a growing movement around sustainable sourcing, with companies auditing suppliers for responsible stewardship—something I’ve seen grow out of both grassroots demands from scientists and top-down pressures from regulatory bodies. Teams who choose products with well-documented sourcing, who recycle packaging, and who take advantage of supplier-offered waste recycling programs do their part to shrink the footprint that specialty chemicals can create.

    Troubleshooting in the Real Lab: Lessons Learned

    It’s one thing to scan headlines about innovation, but another to sit through a tough day in the lab, puzzling over why a key intermediate won’t crystallize or reacts unpredictably. 7-Bromo-5-Chloro-8-Hydroxyquinoline has appeared in several projects where initial results stalled, only to break through once the team understood subtle differences between batches — sometimes as minor as a trace impurity or an overlooked difference in crystal form. One especially memorable experience involved a collaboration between four academic groups. We hit a wall because the samples we received showed minor, but crucial, variations. With careful screening and supplier engagement, we tracked the trouble back to differences in the final recrystallization solvent. From that hiccup, we learned to ask pointed questions before starting large-scale work—and to save time and money by demanding up-to-date certificates of analysis.

    Emerging researchers often underestimate just how many variables can affect project flow. Beyond purity and form, storage conditions—often an afterthought—can shift product characteristics subtly over time, especially in large-scale settings where stock sits in climate-controlled warehouses for months. Evidence points to the value of frequent in-house QC, supplemented by supplier transparency and joint troubleshooting. It brought home to me just how much smoother product development runs when the raw materials aren’t a question mark.

    Supporting Greater Diversity in Research

    Making sure researchers worldwide have access to materials like 7-Bromo-5-Chloro-8-Hydroxyquinoline boosts the breadth of scientific inquiry. There's a unique advantage to combining the perspectives of established labs with those at the startup or teaching lab level. Having predictable, high-quality compounds in every setting creates a baseline for innovation—it levels the playing field. Open-access publications and materials-sharing agreements are steps in the right direction; supporting these initiatives can widen the pool of scientists able to contribute, which in turn drives even faster, broader breakthroughs.

    Collaborative networks, like international chemical consortia, already exist to share best practices. My own role in such settings has often been as an intermediary—connecting junior researchers with technical support from suppliers, and ensuring everyone stays updated about hazards and best practices. These efforts pay off, not just in productivity, but in the safety and reliability of labs around the world.

    Challenges and Growing Pains: Room for Improvement

    No product, no matter how well-marketed or stringently produced, is perfect out of the gate. 7-Bromo-5-Chloro-8-Hydroxyquinoline faces hurdles common to specialty chemicals—price volatility tied to demand for halogenated starting materials, occasional supply chain disruptions, and shifts in regulatory policy. Past experiences have taught the value of building redundancy into procurement pipelines and maintaining open dialogue between research teams and suppliers. Collaborative buying arrangements and consortia-driven purchasing can sometimes help offset market swings, and regular forecasting of future needs lets teams avoid crunch periods.

    In times when synthetic innovation moves at top speed, having a trusted source of essential intermediates means fewer stops and starts in bringing novel ideas to life. On the flip side, shortfalls or inconsistencies push researchers either to compromise quality or to invest extra time in custom synthesis—a costly and unpredictable substitute. Balancing broad accessibility with the ethical manufacture of specialty products remains a work-in-progress, but it's an area ripe for shared leadership between suppliers and the research community.

    Comparing to Other Products: What's the Real Difference?

    It’s tempting to treat every hydroxyquinoline derivative as interchangeable, but experience reveals real, practical distinctions. Simpler hydroxyquinolines lack the dual reactivity pattern offered by the pairing of bromine and chlorine at the 7 and 5 positions. Using derivatives without both substitutions can limit how far you push downstream modifications. For example, bromine and chlorine can drive selective reactivity through classic coupling (Suzuki, Sonogashira, etc.) or regioselective halogen exchange, opening routes to novel analogs that show up in new drug candidates or material science prototypes.

    Some teams I’ve known tried sidestepping specialty compounds in favor of less expensive, more available derivatives. More often than not, they wound up paying more in both lost productivity and failed experiments than they ever saved up front. Real differentiation, then, comes not just from the compound’s structure, but the cumulative time saved, the breadth of options unlocked, and the stepwise predictability it brings to product pipelines.

    Hydroxyquinoline derivatives find their way into everything from analytical standards to pharmacophores in current lead compounds, but many lack the unique handling and performance offered by this dual-halogenated version. Substitutions on the quinoline ring can dramatically shift physical properties such as melting point, solubility, and electrochemical reactivity, and those aren't always predictable from structural diagrams alone. Each project, from synthesis of candidate molecules to diagnostic kit development, benefits from compounds optimized for both purity and stability. I’ve found that forward-thinking research programs don't settle—they search out building blocks that drive innovation, reliability, and a smoother transition from lab discovery to practical application.

    Looking Ahead: The Role of 7-Bromo-5-Chloro-8-Hydroxyquinoline in Future Progress

    As scientific discovery continues to accelerate, the need for better, more reliable intermediates and reagents grows. 7-Bromo-5-Chloro-8-Hydroxyquinoline lives up to its reputation as a versatile compound, one that actively contributes to new syntheses, speeds along pharma development, and supports cross-disciplinary research from materials to medicine. Adaptable and dependable, it outpaces simpler analogs while matching the safety, quality, and environmental expectations set by today’s global labs.

    Continued investment in education, supplier transparency, and responsible stewardship will help ensure this compound remains a trusted cornerstone in research and industry. From personal experience and feedback across the research spectrum, the feedback remains consistent: invest in the right starting materials, and the innovation follows. Whether handling gram-scale trials or prepping for a pilot plant run, knowing your key intermediates are as reliable as 7-Bromo-5-Chloro-8-Hydroxyquinoline can mean the difference between incremental steps and breakthrough discovery.