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4-Bromophenylthiourea

    • Product Name 4-Bromophenylthiourea
    • Alias 4-Bromophenylthiocarbamide
    • Einecs 219-361-5
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    950564

    Cas Number 103-53-7
    Molecular Formula C7H7BrN2S
    Molecular Weight 231.12 g/mol
    Iupac Name 1-(4-bromophenyl)thiourea
    Appearance White to off-white crystalline powder
    Melting Point 151-154 °C
    Boiling Point Decomposes before boiling
    Solubility In Water Slightly soluble
    Density 1.64 g/cm³
    Smiles C1=CC(=CC=C1NC(=S)N)Br
    Storage Temperature Store at 2-8°C
    Purity Typically ≥98%

    As an accredited 4-Bromophenylthiourea factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

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    Application of 4-Bromophenylthiourea

    Applications of 4-Bromophenylthiourea in Industrial Manufacturing

    4-Bromophenylthiourea serves as a crucial intermediate across several specialized chemical manufacturing routes. Our facility maintains disciplined production and validated quality systems to support its integration in advanced downstream sectors. Below we outline the primary real-world application areas where this compound fits into modern industrial practices.

    1. Agrochemical Synthesis: Intermediate for Herbicide Production

    Major agrochemical manufacturers use 4-Bromophenylthiourea as a building block in sulfonylurea herbicide synthesis. Our material enters at the condensation stage, where it participates in nucleophilic substitution steps forming key heterocyclic structures. Strict trace control ensures minimal impurities impacting downstream activity and crop safety. Leading companies request our analytical support to meet documentation needs for global crop protection registration.

    Industry compliance standards

    • ISO 9001:2015 Quality Management System
    • REACH registered (EC 1907/2006, Annex VII/VIII)
    • CropLife regulatory guidelines (EPA, EU PPP, GB/T 39305-2020 for technical active substances)
    • FAO/WHO Specifications for Plant Protection Products

    Typical usage ratio

    • Ranges from 7%–18% of total formulation weight in the herbicidal active ingredient pathway. Adjusted based on desired heterocyclic ring substitution and reaction scale.

    Downstream process integration

    • Introduced during the nucleophilic substitution/Urea condensation step. Reaction temperature commonly controlled at 70–110°C. Purification by crystallization or solvent extraction.

    Final product types

    • Sulfonylurea herbicides (e.g., metsulfuron-methyl synthesis)
    • Selective pre-emergence weed control agents
    • Biologically active crop protection actives
    • Intermediates for further crop-specific formulations

    2. Pharmaceutical Intermediate in Thiohydantoin Synthesis

    Pharmaceutical clients employ 4-Bromophenylthiourea within chemical routes to targeted thiohydantoin scaffolds. These are key steps in prototype anticancer and antidiabetic agent R&D. Our material’s purity supports reproducibility in multi-step syntheses. We regularly ship GMP-supporting documentation and analytical data along with each batch. Manufacturing chemists depend on our consistent supply for route validation and scaling studies.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice for Active Pharmaceutical Ingredients
    • USP/EP Residual Solvents Guidelines
    • 21 CFR Part 210/211 (cGMP for Drug Products, USFDA)
    • ISO 9001:2015 for supplier quality audits

    Typical usage ratio

    • Generally introduced at 10–22% of starting reagent mix, tailored according to target thiohydantoin yield and parallel reactions in the synthetic sequence.

    Downstream process integration

    • Enters post-alkylation as a key nitrogen/sulfur donor. Critical in heterocycle ring closure (cyclization) steps. Purification through re-crystallization or preparative HPLC.

    Final product types

    • Thiohydantoin-based pharmaceutical intermediates
    • Synthetic lead compounds for oncology discovery
    • Reference materials for process development teams
    • Quality-controlled APIs pending regulatory submission

    3. Dye and Pigment Synthesis: Precursor for Azo and Reactive Dyes

    Textile and specialty dye manufacturers use 4-Bromophenylthiourea as a functional intermediate to introduce both bromine and sulfur functionalities during the design of advanced colorants. This compound supports diazo coupling and offers tunable reactivity for producing intense, wash-fast dyes favored in high-performance fabrics. Our material enables high conversion yields with tight impurity profiles suited for regulated textile markets.

    Industry compliance standards

    • OEKO-TEX Standard 100 (textile chemicals)
    • ZDHC MRSL for input chemical compliance
    • EU REACH Annex XVII (restricted aromatic amines under dye regulations)
    • ISO 17025-accredited analytical certification

    Typical usage ratio

    • Introduced at 5–15% of combined raw material basis in diazo dye pathways. Variation reflects desired chromophore intensity and bromination degree.

    Downstream process integration

    • Feeds into diazotization and subsequent coupling reactions. Process operated at acidic pH, 0–5°C in batch mode. Final isolation via salting-out and filtration.

    Final product types

    • High-purity azo dyes for wool, silk and nylon
    • Reactive dyes compatible with cotton and cellulosics
    • Special-effect pigments for printing inks
    • Color masterbatches for technical textiles

    4. Specialty Rubber Accelerator Manufacturing

    Synthetic rubber producers incorporate 4-Bromophenylthiourea as a precursor in the formulation of tailored thiourea-based accelerators. These substances enhance vulcanization efficiency and improve aging properties of finished elastomers, especially for automotive and footwear applications. Our facility supplies this intermediate with full traceability and batch records required for quality audits in the rubber sector.

    Industry compliance standards

    • ISO 9001:2015 Certified Management System
    • ASTM D4678 (Rubber—Standard Classification for Accelerators)
    • EU Regulation 1907/2006 (REACH, Annex XVII for rubber chemicals)
    • FDA 21 CFR 177.2600 (Rubber articles intended for repeated use – where applicable)

    Typical usage ratio

    • Usually applied at 2–6% in composite blends for accelerator synthesis, adjusted according to the grade of rubber and targeted cure profile.

    Downstream process integration

    • Integrated during primary mixing of accelerator components. Further processed through controlled heating and compounding. Cross-linking characteristics monitored in QC lab.

    Final product types

    • Thiourea-based accelerators for NR, SBR, and EPDM
    • Rubber vulcanization aids
    • Automotive tire components
    • Technical grade elastic goods for industrial use

    5. Analytical Reagents for Metal Ion Detection

    Analytical laboratory supply firms utilize 4-Bromophenylthiourea as a chelating reagent in metal ion detection processes. The compound forms complexes with particular metal cations, increasing detection sensitivity in spectrophotometric assays. Our controlled synthesis ensures low background interference, supporting research, environmental monitoring, and quality control in regulated laboratories worldwide.

    Industry compliance standards

    • ISO 17034 (Reference Material Producers)
    • EPA Method 7196A (Hexavalent Chromium by Colorimetry)
    • EN ISO/IEC 17025 (Testing and Calibration Laboratories)
    • USP General Chapters <851> (Spectrophotometry)

    Typical usage ratio

    • Applied at 0.05–0.5% final solution volume in standard protocols. Adjusted based on metal ion concentration and assay sensitivity requirements.

    Downstream process integration

    • Dissolved into buffer or solvent prior to sample introduction. Used as a specific color-forming agent in batch or continuous flow analysis.

    Final product types

    • Analytical reagent kits for spectrophotometry
    • In-house laboratory testing standards
    • Certified reference solutions for environmental testing
    • Custom assay additives for OEM laboratory equipment
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    More Introduction

    Introducing 4-Bromophenylthiourea: A Closer Look at Purpose and Performance

    Exploring 4-Bromophenylthiourea: An Everyday Perspective

    Chemistry shapes daily life more than most people realize. Every so often, a compound like 4-Bromophenylthiourea comes along that draws the attention of both researchers and industries for what it can do—and sometimes, for what sets it apart from the rest. This compound, known by its molecular formula C7H7BrN2S, brings a specific set of properties to the table—enough to create real advantages in select fields. Understanding what makes this particular molecule useful isn’t just about reciting data; it’s about seeing how its unique blend of elements can change the way labs, manufacturers, or educators approach chemical tasks.

    The Structure That Matters and How It Shows Up in Use

    4-Bromophenylthiourea’s backbone includes a brominated phenyl ring joined to a thiourea group. That combination isn’t just theoretical—it influences everything from solubility to reactivity. People who have spent time in a chemistry lab will recognize the subtle unpredictability these little tweaks in molecular makeup can introduce. Bromine doesn’t just tag along; it changes the way the molecule interacts with others, adjusting both its stability and its chemical handshake with partners in a reaction.

    Typical physical appearances vary depending on the batch and processing, but you often see it as a crystalline powder, sometimes off-white or faintly colored. This matters when practical applications call for a reliable, consistent physical form, whether you’re measuring out quantities for synthesis or preparing teaching samples for a classroom demonstration. Tackling a real-life chemical project demands more than just knowing what’s on paper—you need a substance that handles the way you expect every time you open the bottle. In my own experience, surprises with handling or solubility can stop progress dead in its tracks, so consistency in the lab counts for more than some folks might admit.

    Finding Its Role: Where 4-Bromophenylthiourea Provides Value

    Actual usage depends on the context. Laboratories see value in 4-Bromophenylthiourea for synthesis research and evaluation as a building block in organic chemistry. Some teams use it when developing new reagents or exploring structure-activity relationships that could spark advances in pharmaceuticals or agrochemicals. The compound’s brominated aromatic core often becomes a stepping stone for more complex derivatives, offering an anchor point that’s both stable and versatile.

    Function doesn’t stop at academic experiments. In some industries, researchers harness the distinct properties of 4-Bromophenylthiourea to explore new catalysts or intermediates. The sulfur-containing thiourea moiety makes it suitable for experiments where sulfur’s reactivity is needed, while the bromine adds an element of tunability that changes how the compound interacts with other chemicals under certain reaction conditions. Real success in chemical development only comes with the right blend of predictability and responsiveness in a molecule—qualities that this product can offer if you match its strengths to your application.

    Comparing to Alternatives: Why This Compound Stands Out

    Experience in the lab teaches that not all thiourea derivatives behave—or perform—the same way. 4-Bromophenylthiourea distinguishes itself because of the bromine atom on the aromatic ring. Many similar compounds will swap this atom for chlorine, iodine, or even a hydrogen. Every change brings a shift in electronic effects, size, and reactivity.

    If you use plain phenylthiourea in a reaction, you get a certain baseline set of properties. Add a bromine to the fourth position on the ring, and suddenly, you’ve got a molecule with new electron-withdrawing power and altered steric effects. Often, this means faster or more selective reactions in organic syntheses. The result: chemists gain a tool for reactions demanding a particular kind of control or for plugging into pathways not open to other analogues. Choices in research aren’t made lightly—most people only switch to a compound like this if the edge in reactivity, yield, or selectivity makes the cost and effort worthwhile.

    From Researcher’s Eyes: Handling, Storage, and Real-World Application

    Anyone who has spent real time with sensitive, potent chemicals knows the importance of handling practices. 4-Bromophenylthiourea is stable when stored away from heat and direct sunlight. Most labs keep it sealed in airtight containers at room temperature, where it maintains integrity long enough for long-term projects.

    For daily use, weighing and transferring aren’t fussy when compared to more volatile or reactive substances. People working directly with the material usually find that accidental exposure risk is manageable—gloves, eye protection, and ventilation prevent most safety concerns. But respect for the unknowns in toxicity means you don’t cut corners. There’s a certain comfort in knowing the product doesn’t break down too quickly, doesn’t outgas strong odors, and doesn’t present the kinds of acute hazards seen with less stable chemicals.

    What you learn in the lab stays with you—the process of verifying material purity is a critical habit. Most suppliers offer material above 98% purity, validated by NMR or HPLC. If you’ve ever had a reaction fail due to impurities in a starting reagent, you remember it for a long time. Reliable purity allows for reproducibility and helps teams trust their results. In certain academic settings, students use compounds like this to illustrate reaction principles or to practice analytical techniques, so knowing the strength and composition is crucial for fair learning.

    Recognizing Risks and Acting Responsibly

    No chemical comes without its risks, and 4-Bromophenylthiourea is no exception. Exposure limits or toxicological data may not be widely available, which makes erring on the side of caution the default setting. Safety data often indicate possible skin and respiratory irritation. Veteran chemists take these warnings seriously—familiarity breeds care, not complacency. PPE has little glamour, but experience shows that a small investment in gloves, goggles, or proper ventilation saves time, discomfort, and maybe even health.

    Waste management matters too. Responsible labs follow local disposal requirements, sending unused or spent material through proper channels. Others might try to minimize leftover quantities by prepping only needed amounts each session, saving money and reducing potential environmental impact. Someone not familiar with chemical waste might look at these steps as overkill, but seasoned hands know accidents or regulatory headaches rarely make the news until it’s too late.

    Diving Deeper: Synthesis and Research Insights

    There’s something compelling about building a molecule from scratch, and 4-Bromophenylthiourea demonstrates how organic synthesis isn’t just about theory. Its preparation frequently involves reacting 4-bromoaniline with isothiocyanates under appropriate conditions. Each step on the path depends on care, patience, and an eye for detail—temperatures, reaction times, and solvent choices can mean the difference between a solid yield and a frustrating cleanup. Anyone who’s logged long hours on a synthetic bench can recall the feeling of turning a routine process into a learning experience when a minor parameter throws the outcome for a loop.

    Tools like thin layer chromatography, recrystallization, or mass spectrometry become old friends in these scenarios. 4-Bromophenylthiourea’s profile on a TLC plate doesn’t get lost in the mix; usually, its brominated core provides enough UV absorption for easy spot detection. Even for advanced students or early career researchers, hands-on work with real compounds like this draws connections between textbook knowledge and lab reality. Building those links forms a foundation for future innovation in science and industry.

    The Learning Journey: Education, Practice, and Real Science

    In teaching settings, 4-Bromophenylthiourea has a way of sparking engagement. Instead of asking students to imagine theoretical molecules, instructors bring out real substances. Picking up a vial, weighing out a sample, students see how even tiny changes in molecular structure carry outsized consequences in reaction outcome.

    Using 4-Bromophenylthiourea in undergraduate laboratories offers practical lessons difficult to capture in virtual scenarios. Instructors watch as students practice melting point measurement or study its solubility in various solvents. Feedback comes fast and often surprisingly—the powder dissolves slightly in one solvent but not another, giving a concrete example of polarity and chemical compatibility. Such demonstrations anchor concepts in the minds of beginners, giving them a realistic grasp of organic chemistry’s challenges and rewards.

    Even beyond classroom use, the compound sometimes takes part in research projects or outreach events where young scientists work side-by-side with mentors. They watch firsthand as purification techniques separate out the compound, and see why proper analytical verification makes a difference. It isn’t about memorizing values or tables; the real lesson comes in appreciating the persistent, incremental nature of chemical science.

    Room for Improvement: Transparency, Availability, and Next Steps

    Reliable access makes all the difference between a handy laboratory staple and a frustrating bottleneck. Availability of 4-Bromophenylthiourea, including variations in particle size or packaging, continues to be shaped by producer scale, stock practices, and regional regulation. Some researchers find that small lot purchases—through research chemical suppliers—give a way to test new hypotheses on a modest budget.

    The question of transparency comes up every so often, too. Scientists and educators would benefit from more published data on long-term stability, comprehensive toxicology, and standardized handling practices. While core safety information gets shared, it sometimes takes a little extra networking in the research community to collect thorough, application-specific advice. That’s an area ripe for improvement: suppliers, universities, and industry consortia might do more to pool open-source information. A good start would be regular updates to online resource databases, clearer labeling practices, or the sharing of application notes covering both routine use and edge cases.

    Experience suggests that simple fixes can boost reliability—sealed, resealable packaging helps prevent moisture ingress; batch certificates of analysis give peace of mind for high-stakes applications. On several occasions, colleagues have shared how even modest improvements in batch tracking or documentation can reduce troubleshooting headaches downstream. New researchers stepping into the lab for the first time benefit as much from these ground-level improvements as seasoned chemists, fostering a culture of care and responsibility.

    Building on the Foundation: Practical Suggestions for Users

    Practical wisdom carries serious weight in research environments. Teams looking to adopt 4-Bromophenylthiourea in routine synthesis tend to benefit by piloting reactions on a small scale first. Evaluating yield, ease of purification, and reactivity before moving to larger-scale preparations avoids costly missteps. Routine double-checks—melting point, NMR, or even IR spectroscopy—help catch purity slips or unexpected byproducts. From long hours running reactions and watching for outliers, it’s clear that up-front diligence pays off later in cleaner data and fewer postmortems.

    It can be tempting to focus exclusively on novel reactions or product innovation, but the backbone of responsible science always returns to repeatable protocols, documented methods, and incremental learning. Feedback from frequent users suggests that periodic review of storage, handling, and disposal practices saves not just money in lost inventory but also guards against compliance violations as regulatory standards shift over time. Such groundwork brings stability to projects and keeps science moving forward.

    Conclusion — Charting the Future for Chemical Innovation

    Reflecting on the journey with 4-Bromophenylthiourea, it’s plain that small molecules often play outsize roles in both research and development. Whether facilitating new discoveries, serving as training tools, or offering unique reactivity in synthesis, this compound carves out a space for itself by combining reliability, adaptability, and a touch of creative risk-taking. The story doesn’t end here—continued dialogue between chemists, educators, manufacturers, and safety experts holds the key to unlocking greater value and better outcomes.

    Every day in the laboratory offers more lessons, but the consistent thread is care—care in handling, in documentation, in choosing which tool to apply to which challenge. 4-Bromophenylthiourea isn’t just another entry in a catalog. It stands as an invitation to experiment thoughtfully, to learn from cautious innovation, and to build on the diverse insights of the research community. By remaining grounded in both practice and shared knowledge, today’s scientists and tomorrow’s students can find new possibilities in even the most unassuming vials on the shelf.