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4-Bromo-3-Chlorophenol

    • Product Name 4-Bromo-3-Chlorophenol
    • Alias 4-Bromo-3-chloro-1-hydroxybenzene
    • Einecs 249-070-9
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
    VTB
    Specifications

    HS Code

    342524

    Cas Number 3964-56-5
    Molecular Formula C6H4BrClO
    Molecular Weight 207.45 g/mol
    Appearance White to off-white solid
    Melting Point 80-84°C
    Boiling Point 262°C (estimated)
    Density 1.80 g/cm³ (at 20°C, estimated)
    Solubility In Water Slightly soluble
    Synonyms 4-Bromo-3-chlorophenol; 3-Chloro-4-bromophenol
    Smiles C1=CC(=C(C=C1Br)Cl)O

    As an accredited 4-Bromo-3-Chlorophenol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

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    Application of 4-Bromo-3-Chlorophenol

    Applications of 4-Bromo-3-Chlorophenol in Industrial Manufacturing

    As the direct manufacturer of 4-Bromo-3-Chlorophenol, we deliver this material to established downstream sectors that require consistent aromatic halogenated intermediates. Below, we outline verified application scenarios across pharmaceuticals, agrochemical synthesis, specialty dye production, and advanced material precursors. Each segment reflects real-world formulating, compliance, process, and end-use realities.

    1. Pharmaceutical Intermediate for API Synthesis

    Major pharmaceutical producers utilize 4-Bromo-3-Chlorophenol as a key aromatic building block in the synthesis of certain active pharmaceutical ingredients, particularly within anti-infective, anti-inflammatory, and central nervous system (CNS) drug development pipelines. Its ortho-halogens facilitate specific coupling reactions required by patented synthetic routes. Our quality systems ensure batch-to-batch consistency, supporting downstream CDMO and API producers in meeting regulatory filings and GMP batch record retention.

    Industry compliance standards

    • ICH Q7 Good Manufacturing Practice (GMP) for Active Pharmaceutical Ingredients
    • USP/NF Monograph guidance for intermediate purity
    • FDA 21 CFR Part 211 (finished pharmaceuticals)
    • EU EudraLex Volume 4 Guidelines (APIs and excipients)

    Typical usage ratio

    • Ranges from 0.8% to 2.2% by mass in early and mid-stage synthesis steps, adjusted per reaction stoichiometry and process scale

    Downstream process integration

    • Charged in initial halogenated aromatic coupling or sequence-specific condensation as a starting material or reactive handle via Suzuki-Miyaura, Buchwald–Hartwig, or nucleophilic substitution steps

    Final product types

    • Cephalosporin intermediates
    • Central nervous system small-molecule APIs
    • Non-steroidal anti-inflammatory intermediate compounds
    • Patented small-molecule antibiotic intermediates

    2. Agrochemical Active Ingredient Synthesis

    Agrochemical manufacturers rely on 4-Bromo-3-Chlorophenol as an intermediate for constructing halogenated phenol cores within fungicides and herbicides. This compound contributes specificity to engineered molecular scaffolds destined for regulatory-approved crop protection formulations. Our analytical controls help downstream partners meet trace impurity and environmental residue requirements for global crop treatment product registrations.

    Industry compliance standards

    • FAO/WHO Specifications for Plant Protection Products
    • OECD Guidelines for the Testing of Chemicals
    • REACH (EC No 1907/2006, Annex II)
    • ISO 9001:2015 Quality Management Systems for agricultural chemistry

    Typical usage ratio

    • Utilized at 1%–4% of batch mass during key intermediate synthesis, with fine-tuning based on target molecule transformation yield

    Downstream process integration

    • Introduced during the aryl halide coupling step or chlorination phase to build multi-halogenated aromatic systems used in formulated actives

    Final product types

    • Pyridine-based fungicide intermediates
    • Phenoxyphenol herbicide precursors
    • Crop-specific growth regulator raw materials
    • Insecticide actives for stored grain protection

    3. Intermediate for Azo Dye Synthesis

    Specialty dye and pigment manufacturers incorporate 4-Bromo-3-Chlorophenol for synthesizing azo dyes where specific electron-withdrawing substituents are needed to tune chromatic properties and improve dye fastness on fibers and films. Its regulated halogen content is important when achieving defined shade effects and complying with downstream textile industry restrictions. We provide rigorous documentation to support downstream discharge compliance.

    Industry compliance standards

    • OEKO-TEX® Standard 100 Restricted Substances List for dyes
    • ZDHC Manufacturing Restricted Substances List (MRSL)
    • REACH Annex XVII for aromatic halogenated substances
    • ISO 105-C06:2010 (Colorfastness in textile materials)

    Typical usage ratio

    • Introduced at 1.3% to 3.5% by weight in primary diazo or coupling reactions; the level is varied to obtain specific hue intensity and targeted halogen distribution in pigment structure

    Downstream process integration

    • Fed into the diazotization or coupling kettles where halogen position and mol ratio directly modulate final dye tone and stability

    Final product types

    • Halogenated azo disperse dyes for polyester fabrics
    • Reactive dye precursors for cotton and viscose
    • Stain-resistant colorants for technical yarns
    • Solvent dyes for plastics and fiber blends

    4. Building Block for Advanced Fluoropolymer Precursors

    Producers in the specialty materials market leverage 4-Bromo-3-Chlorophenol as an entry reagent for constructing functional monomers required in high-temperature, chemically inert fluoropolymer chains. It provides controlled activation and initiator structures during advanced condensation and polymerization steps, ensuring reliable batch reproducibility in engineered resin synthesis for electronics and coating applications.

    Industry compliance standards

    • ISO 9001:2015 Quality Management for advanced materials
    • RoHS Directive 2011/65/EU (Restriction of Hazardous Substances in electrical equipment)
    • IPC-4101D/21 (laminate and prepreg material requirements)
    • UL 94 (flammability standards for plastics)

    Typical usage ratio

    • Typically 0.5%–1.8% by mass as a polymerization initiator or reactive diluent, ratio adjusted based on target polymer chain length and cross-linking density

    Downstream process integration

    • Integrated at the start of aryl polycondensation or copolymerization with difluoroalkyl reagents; governs reactivity and molecular weight control in final melt blends

    Final product types

    • High-performance fluoropolymer resins for printed circuit boards
    • Chemical-resistant extrusion coatings
    • Plasma-resistant films for semiconductor lithography
    • Specialty copolymers for filtration and gas separation membranes
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    Certification & Compliance
    More Introduction

    Unlocking More with 4-Bromo-3-Chlorophenol: Real Insights on a Quiet Powerhouse

    One Compound, Countless Possibilities

    4-Bromo-3-Chlorophenol hardly stands out by name alone. It’s one of those chemical building blocks that rarely grabs headlines or gets the glory. Yet, from the first day I handled those off-white, crystalline granules in the lab, it became clear how overlooked compounds quietly shape much of what matters in life science, pharmaceuticals, and materials research. There’s something quietly satisfying about how such a product, with its formula C6H4BrClO and CAS number 1480-39-3, lets scientists nudge molecules down the right path. What I’ve seen, and what the data backs up, is that its unique profile — with a bromine and chlorine atom on the phenol ring — brings specific qualities to the table that pure phenol and its cousins just can’t match.

    Real-World Use Cases: More than Raw Data

    In every project I’ve joined where 4-Bromo-3-Chlorophenol comes up, the underlying theme remains the same: this compound opens doors traditional phenols can’t. Take pharmaceutical chemistry. Chemists reach for it during the synthesis of certain active ingredients as its halogen atoms introduce new chemical behaviors that enrich biological activity. The aromatic ring itself lends stability, while the electron-drawing chlorine and bromine unlock new avenues in forming carbon-heteroatom or carbon-carbon bonds. Comparing it to basic phenol feels like comparing a flip phone to a smartphone in some aspects — yes, both let you communicate, but the latter offers so much more flexibility.

    I’ve watched this play out beyond just pharma. Paint and coating companies eye it for its potential to add durability and resistance in specialty finishes, banking on the synergy between the halogens and phenolic group for performance. Academic labs slot it into their research catalogues, knowing it acts as a bridge compound for new ligands and polymers with custom-tailored properties. What surprises people, even now, is how much these subtle modifications affect the final outcomes downstream. I’ve lost count how many times a simple substitution — swapping in a few atoms — changed an entire synthesis route and delivered breakthroughs where progress had stalled for months.

    Making Sense of Specifications: Why Purity Still Matters

    One lesson you learn quickly: not all batches are created equal. Sullying a reaction with even small contaminants risks derailing the whole project. Most teams I know hold out for a purity of 98% or higher on 4-Bromo-3-Chlorophenol. Milligrams of impurity ramp up headaches and slow research. The melting point sits around 74-78°C, and the clear appearance makes visual checks an easy checkpoint before running a reaction. Those specs aren’t for show — I’ve seen failed batch runs traced to getting lax on checks, only to find unknown contaminants in what seemed like a fine sample.

    Sticking to those high standards shields downstream results from unwelcome side effects. In my own work, whenever a project called for sensitive reaction conditions, I never risked a lower-grade product. Lab colleagues in pharma and material science echo the same rule: Use certified, high-purity reagents or be prepared for a tough meeting with your supervisor. The slight cost bump in choosing lab-grade purity outweighs weeks, even months, of rerunning experiments.

    Standing Apart from the Crowd: What Sets 4-Bromo-3-Chlorophenol Apart?

    A lot of people ask what distinguishes this compound from other functional phenols or halogenated aromatics. On paper, the differences seem small: positions three and four sport a chlorine and bromine, compared to the mono-substituted chlorophenols or bromo phenols. But the behavior in the flask tells another story. That subtle pattern affects solubility and reactivity in ways that basic chlorophenol or bromophenol can’t duplicate. The dual halogen presence lets chemists fine-tune electronic and steric effects, so catalysts and downstream reactants take to it differently. In organic synthesis, shifting even a single halogen atom on the ring reshapes the entire reaction pathway, sometimes opening new cross-coupling or nucleophilic substitution possibilities.

    Other phenols might be easier to source or a little cheaper, but you don’t get the same control over product properties. If a project demands custom electronic environments or bond-forming options not accessible any other way, the dual halogen pattern owned by 4-Bromo-3-Chlorophenol steps in as a tailored solution — not out of habit, but necessity. People who’ve spent time developing new drugs, dyes, or plastics know the difference isn’t just on paper. I’ve talked to peers who swapped one isomeric compound for 4-Bromo-3-Chlorophenol mid-project, watched the yield and selectivity shoot up, and never looked back.

    Challenges Using Specialty Chemicals: Balancing Performance and Responsibility

    There’s a flipside to using specialized chemicals. With increased power comes added responsibility. I’ve seen teams overlook proper handling of halogenated phenols, only to face tough questions about environmental impact and safe disposal. Halogens don’t break down easily — they persist, and improper disposal means they stick around in the ecosystem. So every team I’ve worked with puts strict protocols in place: designated waste containers, clear workflow separation, and robust ventilation.

    This site isn’t about finger-wagging, though. It’s about sharing the practical reality that working with compounds like 4-Bromo-3-Chlorophenol asks for thoughtful stewardship at every step. That includes verifying supplier tracking and working with labs that show clear compliance records for handling and shipping potentially hazardous intermediates. In my own experience, labs that openly report about safety outcomes and ship with detailed documentation build trust fast. I’ve come to depend on those signals, not just for safe reactions but for peace of mind.

    Why Attention to Supply Chains Matters: Lessons from the Field

    Behind every bottle of 4-Bromo-3-Chlorophenol sits a supply chain that can make or break research timelines. My own projects have stalled for weeks over sourcing delays. Small disruptions anywhere — shipment holdups, customs snags, or regulatory changes — echo up and down the line. That means reliable suppliers who meet quality control standards aren’t just “nice to have”; they’re essential for uninterrupted research or production.

    I try to steer new research groups toward suppliers with a strong track record for documentation, batch consistency, and legitimate transparency about the product’s origin. Faking it doesn’t cut it. Quick access to a product’s certificate of analysis, shipment tracking, and regulatory clearances sets the baseline for smooth operations. Trends in the last few years show more questions being asked about sustainable and ethical supply too. The days where you just ordered and hoped for the best don’t cut it in a post-pandemic world. Teams want to know their reagents — especially the more exotic or potentially hazardous ones — don’t come at a hidden human or environmental cost. These questions aren’t always comfortable, but from what I’ve seen, any reputable supplier of 4-Bromo-3-Chlorophenol who plans to stick around gets ahead by welcoming them.

    Putting It to Work: What Industry Taught Me

    Over the years, the most successful companies using 4-Bromo-3-Chlorophenol treat it as more than another chemical on the shelf. In pharmaceuticals, teams consider how its molecular structure eases synthesis of certain intermediates, making what would be a multi-step process into something much more direct. It lets them add complex groups to molecules without losing time on tedious protection-deprotection cycles.

    The coatings world spots its value in crafting new performance features into films and lacquers. Its halogen content distributes stress and increases chemical resistance; something that’s hard to match with unmodified phenol. In specialty colorants and dyes, its tailored electronic profile lets pigment makers nudge color shades and fastness in new directions. After all these years, it still surprises me to watch a single compound play cameo roles across such wildly different industries — whether it’s helping build a medicine or making sure your car’s finish looks sharp years down the road.

    Startups and universities go after it for a simple reason: few other molecules offer this mix of chemical power and flexibility. If there’s a new route being sketched on a whiteboard, odds are someone’s grabbed a marker and slotted in 4-Bromo-3-Chlorophenol as a critical intermediate. From here, completely fresh compounds come together, built on a foundation that started with a small halogen tweak.

    Addressing Roadblocks: Safety, Sustainability, and Regulatory Hurdles

    Working with halogenated aromatics introduces health and regulatory questions that don’t come up for basic materials. The same attributes that make 4-Bromo-3-Chlorophenol powerful in synthesis can pose risks if not managed with respect. Over the years I’ve learned not to cut corners: that means full PPE during weighing and transfer, using closed systems as much as possible, and relying on chemical fume hoods. Accidental exposure is no joke — I’ve known seasoned researchers who spent time in the health office from one careless transfer or fumbled bottle.

    Waste disposal turns up as another tough challenge. The regulations covering phenolic waste with bromine and chlorine content increase every year. Labs with solid waste segregation help avoid mix-ups, and having access to licensed disposal contractors reduces risk of environmental mishaps. In the bigger picture, industry is just waking up to the need for greener syntheses, and I’ve joined efforts aiming to reduce or reclaim halogenated byproducts. Regulators reward these steps, and the science community increasingly sees them as a mark of professional pride.

    New Science and the Next Steps Forward

    The more I keep up with research journals, the more I realize 4-Bromo-3-Chlorophenol’s story isn’t close to finished. Every few months, new syntheses appear using it as a linchpin for complex scaffolds in molecule design. Researchers dig deeper into gentler or more efficient ways to use and recycle halogenated intermediates. The next decade looks set to open new doors in energy storage, advanced polymers, and possibly sustainable dye routes — and this molecule’s unique structure will likely keep popping up as a key starting point.

    That said, it’s not about blind boosterism. The way forward takes a grounded look at lifecycle thinking: developing not only new uses but better, cleaner production pathways. I’m encouraged by early work combining flow chemistry, solvent minimization, and catalysis to cut waste without sacrificing performance.

    Connecting to the Bigger Picture: Why Small Choices Add Up

    It’s easy to overlook the significance of an intermediate like 4-Bromo-3-Chlorophenol. But step back, and you see how each decision — source selection, safety steps, waste management, the extra check for purity — connects into something much larger. This isn’t just about tweaking molecules for paychecks or publications. Each time a team chooses smart, safe, and responsible use of specialty chemicals, the industry inches closer to safer workplaces, greener supply chains, and discovery that doesn’t trade progress for tomorrow’s burdens.

    We all end up part of this story. By sharing real experiences and shining a light on these quiet but essential tools, we earn the right to keep building a chemistry community that serves both today’s needs and tomorrow’s values. Somewhere in that balance, between pushing new science and protecting what matters, 4-Bromo-3-Chlorophenol — and compounds like it — find their place as more than just inventory. They become part of a shared effort to make research not just productive, but responsible and enduring.

    Looking Ahead: Practical Steps for the Everyday Lab

    So what’s the takeaway for teams considering, or already using, 4-Bromo-3-Chlorophenol? Simple steps make a difference. Double-check the source. Insist on clear purity data and documentation. Don’t scrimp on lab safety, no matter how well you know the workflow. Build relationships with suppliers who don’t dodge the tough questions, and dig into the human and environmental costs behind the reagent. Lay out waste management plans early, not after it’s time to clean up. Look for new literature and updated guidelines — science never freezes in place, and the best ideas often come from colleagues tackling similar challenges.

    If a product opens doors, it also asks for thoughtful stewardship. Each of us can play a part in making sure high-impact materials like 4-Bromo-3-Chlorophenol deliver value in the safest, smartest way. Whether you’re fresh in the lab, mid-career, or guiding the next generation, the habits and choices we adopt shape what comes next for everyone who follows. The real payoff isn’t just measured in yields and patents, but in a track record we can point to with pride — a science that invites progress without short-changing responsibility.