© 2026 Sinochem Nanjing Corporation,
All Right Reserved
|
HS Code |
476980 |
As an accredited 3,5-Dibromo-2-Hydroxypyridine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.
| Packing | |
| Shipping | |
| Storage |
Competitive 3,5-Dibromo-2-Hydroxypyridine prices that fit your budget—flexible terms and customized quotes for every order.
For samples, pricing, or more information, please call us at +8615371019725 or mail to admin@sinochem-nanjing.com.
We will respond to you as soon as possible.
Tel: +8615371019725
Email: admin@sinochem-nanjing.com
Flexible payment, competitive price, premium service - Inquire now!
Across chemical research and development, certain compounds prove themselves indispensable not just through their properties, but by the doors they open in synthesis and industry. One such compound, 3,5-Dibromo-2-Hydroxypyridine, stands out for its efficiency and versatility. Having spent much time in labs and at production plants, I recognize that formulas may look similar on paper, but you notice essential differences as soon as you try to build things with them. This molecule, with its dual bromine attachments at the 3 and 5 positions, combined with a hydroxyl group at position 2 on the pyridine ring, brings a range of reliable behaviors into play, sure to matter for both commercial and R&D teams.
3,5-Dibromo-2-Hydroxypyridine, with a molecular formula of C5H3Br2NO and a typical purity above 97%, draws keen interest in sectors spanning pharmaceuticals, crop science, and advanced materials. Weighing in at about 268 grams per mole, and appearing as a pale to light brown solid, it stores with relative ease if kept dry and protected from sunlight. What strikes me, having handled many halogenated pyridines, is how its physical stability aligns well with the handling protocols already common in most labs, reducing surprises when scaling from bench to pilot.
In this compound, the strategic placement of the bromine atoms does far more than tweak a molecule’s weight. Bromine offers a unique mix of reactivity and selectivity in further transformations, and most synthetic chemists will agree: it allows for controlled substitution reactions, cross-coupling, and other modifications without risking side products that can haunt purifications. I’ve seen the results firsthand—reliable yields, predictable behavior in hydrogenation and oxidation steps, dependable downstream derivatives, and less time fighting unexpected byproducts.
Its real power shows in how it acts as a building block for more complex molecules. Pharmaceutical innovators often use 3,5-Dibromo-2-Hydroxypyridine to construct active pharmaceutical ingredients (APIs), especially for drugs requiring shelf-stable, halogenated cores. In agrochemical development, this core structure enables the design of new pesticides or herbicides, particularly those demanding a specific steric fit and a certain resistance to enzymatic breakdown. In my work with both early-stage and late-stage development teams, 3,5-Dibromo-2-Hydroxypyridine became a centerpiece in iterations where we tried to fine-tune biological activity. Very few other pyridine derivatives gave us the same degree of synthetic flexibility.
Another factor that wins respect for this compound: its behavior in Suzuki and Buchwald-Hartwig coupling reactions sets it apart from other halogenated pyridines. Unlike similar molecules with a single bromine, the presence of both bromine substituents supports stepwise or tandem couplings — you can add groups one at a time with less risk of uncontrolled domino effects. This cuts down on both wasted reagents and rework time. Colleagues of mine in medicinal chemistry have told me about times when other dichloropyridines led to low yields and tarry residues, while this dibromo-hydroxy variant delivered cleaner profiles and easier workups. There’s simply less time hunting down impurities.
Within the world of functionalized pyridines, the differences often seem minor until you run a side-by-side process. Some might opt for a 2,6-dibromo or 3,5-dichloropyridine as a cheaper alternative, but minute structural changes shift reactivity in ways you can’t ignore during scale-up. In my personal experience with small pilot batches, 3,5-Dibromo-2-Hydroxypyridine handled transitions from milligram to multi-kilo scales with fewer bottlenecks. Its relative resistance to hydrolysis under moderate moisture, compared with chlorinated variants, lowers the odds of forming unwanted byproducts. You put less strain on your purifier and less time post-processing waste streams.
My colleagues working in crystal engineering have also noticed the difference in solid-state behaviors, which affect blending and compounding. The bromo-hydroxy group creates strong intermolecular hydrogen bonding, offering better performance for those interested in cocrystals or further salt formation. This ability can affect everything from solubility to how well a drug blends with excipients, which often determines how consistently a medicine will reach the stomach or bloodstream.
Talking to process engineers and QA specialists, purity is a top concern. 3,5-Dibromo-2-Hydroxypyridine typically crystallizes sharply and gives distinctive spectra in both NMR and IR, which supports faster and more definitive quality assurance. Fewer overlapping peaks mean that confirming purity, both at QC checkpoints and in in-process controls, runs faster and with less ambiguity. These little things add up, especially where regulatory compliance sets high bars.
Running R&D projects feels a bit like riding rapids—every property of your reagents matters, especially in unforgiving timeframes. On one recent pharma project, we looked for changes that could both lower synthesis costs and boost yields. Using 3,5-Dibromo-2-Hydroxypyridine as a coupling partner, the team managed to bring down side-product formation and avoid difficult-to-remove chlorinated jag, which usually plagued us when using dichloro analogues. We shaved days off each batch run, bringing an early API candidate to preclinical testing sooner than expected.
Of course, no compound solves all issues. The brominated group means handling requires vigilance—proper PPE, careful waste handling, and responsible supplier selection. Brominated byproducts call for careful tracking in effluent streams, and downstream environmental treatments must match local regulations. Still, with strict process controls and due diligence, it’s possible to look after both worker safety and the wider environment.
Chemists crave reliable tools, and this one has shown remarkable range in new areas. Researchers have logged its use in synthesizing kinase inhibitors, antifungal agents, and more. In my own reading of recent literature, this compound contributed as a scaffold in small-molecule library construction, allowing scientists to screen for unexpected biological behaviors. Adding its hydroxy group often opens windows to further derivatizations through etherification or esterification, a plus for those wanting to tune solubility or targeting properties.
Material scientists have also started experimenting with its ring structure for specialized ligands, where the strongly electron-withdrawing bromines make it behave in coordination differently than lesser-halogenated pyridines. These subtle tweaks to electronics change how it binds metals or sits inside polymer chains—a starting point for next-generation materials that require precise arrangement of atoms on the nanoscale.
If a product wants to make a name for itself in synthetic chemistry, it must prove that it can hold up under pressure—both literally and metaphorically. Labs trust 3,5-Dibromo-2-Hydroxypyridine because it tends to deliver on both counts, whether building the backbone of a veterinary drug, assembling a pesticide, or feeding into advanced electronics projects. It sits at the intersection where reactivity meets reliability, giving researchers options and confidence.
Here’s what matters from hands-on experience: purity numbers above 97% make all the difference in yield consistency from batch to batch. Melting points, typically in the moderate range, allow for some flexibility in storage and transport—important if your team faces temperature swings or variable humidity conditions. The color of the solid may vary, but an off-white to tan crystalline form generally means low impurity levels. Solubility patterns matter too. Expect good logs in DMSO, DMF, and other common polar aprotic solvents, and manageable dissolution in hot ethanol, which helps with both analysis and feeding into synthesis trains.
My advice to teams evaluating suppliers: prioritize those offering robust, transparent data for impurity profiles and packing. Secure, high-barrier packaging keeps it chemical-stable for months on the shelf. I’ve seen project timelines go off-track from materials degrading due to poor storage, so this is one of their most important practical considerations. Stability testing, batch certifications, and responsive technical support make the difference between smooth sailing and stressful delays.
R&D budgets rarely stretch as far as teams want. The best way to amplify resources is by selecting reagents that reduce both risk and troubleshooting in downstream steps. Using 3,5-Dibromo-2-Hydroxypyridine, teams get a combination of reactivity and selectivity that keeps both researcher time and costs in check. Its ability to support both simple and complex transformation cuts down on the need for multiple intermediates or backup plans. On a recent project, switching to this compound from a less pure dichloropyridine saved weeks in product isolation, simply due to easier purification.
In competitive markets, being able to move from bench to pilot facility without introducing new variables is crucial. This product’s track record—clean conversions, limited impurity drift, and ease of scale—removes hurdles. I’ve noticed that process engineers appreciate how it behaves similarly at 10 grams and 10 kilograms, making it easier to fine-tune process parameters and adapt on the fly. This reliability makes it attractive not just for big pharma but also smaller startups and research labs who can’t afford a single derailed batch.
As a bonus, the well-established analytical methods for this compound—clear NMR and IR signatures, clean HPLC separation, and predictable reactivity—make in-process tracking straightforward. Chemists can spot issues early, without having to redesign the entire analytics package for each new project.
With chemicals like 3,5-Dibromo-2-Hydroxypyridine, responsibility extends beyond the lab door. Sustainable sourcing and waste minimization rise in importance, especially as regulations tighten worldwide. In my own work, partnering with suppliers who fully document their production methods and traceability records proved essential—not just for compliance, but for minimizing reputational risks. Auditing supply chains, asking for environmental certification, and staying current with regional import-export restrictions remain critical. I’ve seen teams get tripped up by sudden changes to rules around brominated chemicals, so building solid relationships with suppliers pays off.
Proper waste disposal cannot be an afterthought. Brominated residues may present a higher demand on plant scrubbers and biological waste treatment systems. I recommend consulting with environmental health and safety (EHS) experts early in process development. Not only does this protect worker health, but it keeps your lab or production team on the right side of evolving environmental standards.
Innovation in pharmaceuticals, fine chemicals, and material science shows no sign of slowing down. As more processes rely on selective halogenation and core functionalization of pyridine rings, the role of well-characterized intermediates will only grow. If a research program values predictability, adaptability, and direct access to advanced functionalization, 3,5-Dibromo-2-Hydroxypyridine proves itself time and again. Its reliable performance in established reactions—especially those central to modern medicinal chemistry pipelines—keeps it in demand, while supply chain stability and broad specification ranges help teams manage risk.
In conclusion, anyone searching for a proven, high-value intermediate for building tomorrow’s molecules would be wise to consider the unique strengths of 3,5-Dibromo-2-Hydroxypyridine. My own experiences, echoed by countless interviews with colleagues across disciplines, underscore that its ability to streamline synthesis, ease scale-up, and maintain quality gives it a well-earned place in today’s—and tomorrow’s—toolkit for science and industry. With attention to sourcing, safety, and waste management, it remains a compound not just to use, but to rely on.
