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1-(4-Bromophenyl)-Naphthlene

    • Product Name 1-(4-Bromophenyl)-Naphthlene
    • Alias 4-Bromophenyl-1-naphthyl
    • Einecs 629-877-6
    • Mininmum Order 1 g
    • Factory Site Tengfei Creation Center,55 Jiangjun Avenue, Jiangning District,Nanjing
    • Price Inquiry admin@sinochem-nanjing.com
    • Manufacturer Sinochem Nanjing Corporation
    • CONTACT NOW
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    Specifications

    HS Code

    759095

    Name 1-(4-Bromophenyl)-Naphthalene
    Molecular Formula C16H11Br
    Molecular Weight 283.17 g/mol
    Cas Number 22482-18-8
    Appearance White to off-white powder
    Melting Point 113-117 °C
    Boiling Point 444.9 °C at 760 mmHg
    Density 1.44 g/cm³
    Purity ≥98%
    Solubility Insoluble in water; soluble in organic solvents

    As an accredited 1-(4-Bromophenyl)-Naphthlene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

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    Application of 1-(4-Bromophenyl)-Naphthlene

    Applications of 1-(4-Bromophenyl)-Naphthlene in Industrial Manufacturing

    As a specialized manufacturer of 1-(4-Bromophenyl)-Naphthlene, we supply this intermediate-grade raw material for several core downstream industrial sectors. Below, we outline key application scenarios where our product integrates into advanced manufacturing workflows, alongside specific compliance requirements, recommended formulation ratios, process entry points, and ultimate product categories. Each section reflects actual client applications and process demands.

    1. Electronic Chemicals: Liquid Crystal Intermediate

    The electronic chemicals sector employs 1-(4-Bromophenyl)-Naphthlene as a precursor in synthesizing advanced biphenyl compounds essential for high-performance liquid crystal materials. Material purity, brightness, and strict halogenation control all form process prerequisites in LC panel manufacturing. The raw material’s specific configuration and substituent group directly impact mesogenic properties and temperature ranges in final LC mixtures.

    Industry compliance standards

    • RoHS Directive (2011/65/EU, EU REACH 1907/2006)
    • IEC 62474 declarable substances for electronics
    • IECQ QC 080000:2017 (Hazardous Substance Process Management)
    • GB/T 2423 (Environmental testing for electronics, China)

    Typical usage ratio

    • Added at 2–7% weight in pre-polymer or pre-blend stages of liquid crystal formulation, subject to target transition temperature and viscosity requirements

    Downstream process integration

    • Introduced in the early synthesis of biphenyl derivatives via Suzuki coupling; finalized within LC mesogen formulation blends during isotropic-nematic phase calibration

    Final product types

    • TFT-LCD substrates
    • OLED alignment layers
    • Display panel liquid crystal fillers
    • Specialty polymer-dispersed LC films

    2. Organic Synthesis: Pharmaceutical Intermediate

    Pharmaceutical API manufacturers incorporate this compound as a building block in selective arylation and halogenation pathways, where naphthalene moieties improve molecular rigidity or receptor binding. Its consistent reactivity enables high-purity intermediate output, critical in both patent and off-patent synthesis routes for specialty drugs targeting neurological and oncological indications.

    Industry compliance standards

    • ICH Q7 (Good Manufacturing Practice for Active Pharmaceutical Ingredients)
    • USP-NF, Ph. Eur. monographs as applicable to downstream APIs
    • 21 CFR Part 211 (US FDA GMPs)
    • Chinese Pharmacopoeia (when for local finished dosage forms)

    Typical usage ratio

    • Stepwise conversion: stoichiometric to 1.2-fold molar excess in aryl coupling stages; actual input adjusted based on API yield optimization and impurity profile control

    Downstream process integration

    • Charged in the arylation or halogenation reactor after base naphthalene core preparation, often pre-cleared for trace metal impurities prior to subsequent condensation and purification steps

    Final product types

    • Neurological agent API intermediates
    • Selective kinase inhibitor intermediates
    • Oncology-targeted small molecules (finished APIs after further steps)
    • Development-stage research compounds for innovative therapy portfolios

    3. Functional Dyes and Pigments Manufacturing

    Producers of high-stability organic pigments use this compound in advanced pigment synthesis, as the aryl-brominated naphthalene structure serves as a chromophore enhancer. Its controlled halogen content provides increased color fastness and solvent resistance, supporting demanding application environments in plastics, coatings, and specialty inks.

    Industry compliance standards

    • EN 71-3 (Safety of toys—migration of certain elements, for pigments in decorative applications)
    • OEKO-TEX Standard 100 (Textile dye safety, where applicable)
    • ASTM D5538 (Limitations on heavy metal content in pigments)
    • ECHA SVHC (for pigment export to the EU)

    Typical usage ratio

    • Commonly introduced at 5–12% by weight in the initial diazotization or coupling step; precise level depends on the color index and end-use exposure scenarios

    Downstream process integration

    • Incorporated into the synthesis kettle prior to heterocyclic condensation; undergoes oxidative coupling, forming key classes of naphtho-based pigments during filtration and calcination

    Final product types

    • High-performance textile dyes
    • Organic pigment concentrates for plastics compounding
    • UV-stable printing inks
    • Industrial coating colorants used in automotive and electronic casing

    4. Advanced Polymer Additives: Specialty Engineering Plastics

    High-end engineering plastics manufacturers integrate 1-(4-Bromophenyl)-Naphthlene as a functional aromatic unit in the step-growth polymerization of custom polyarylene copolymers. Its use improves both mechanical rigidity and flame resistance in critical molding applications, notably within high-voltage insulation and precision connectors where brominated aromatic groups impart self-extinguishing characteristics.

    Industry compliance standards

    • UL 94 (Flammability Standard for Plastic Materials)
    • ISO 1043 (Nomenclature for plastics—basis for halogenated structure disclosure)
    • REACH Annex XVII (Restricted halogenated substances)
    • IEC 60695-2-11 (Glow-wire test for end-use resin safety in electrical applications)

    Typical usage ratio

    • Typically employed at 3–10% (weight basis) within the monomer mix for polyarylene synthesis; ratios optimized based on the required heat distortion temperature and flame retardancy index

    Downstream process integration

    • Blended in the melting reactor at the pre-polymerization stage, often co-polymerized with other di-aryl or di-halogen monomers to achieve tailored molecular weight and brittleness thresholds

    Final product types

    • Flame-retardant electrical housings
    • Precision electronics connectors
    • Insulation parts for automotive wiring
    • Specialty high-strength polymer films

    5. Specialty Agrochemical Synthesis

    Agrochemical formulators utilize this compound in advanced active ingredient synthesis, where the brominated naphthyl unit introduces high selectivity for enzyme inhibition in targeted herbicide and fungicide molecules. Its entry point within the synthetic stage determines both spectrum activity and subsequent derivatization into patent-protected crop protection agents.

    Industry compliance standards

    • FAO/WHO Joint Meeting on Pesticide Specifications (JMPS)
    • ISO 9001:2015 (Quality Management Systems, required for active ingredient synthesis)
    • EPA 40 CFR Part 180 (Tolerances and exemptions for pesticide chemicals, US)
    • Regulation (EC) No 1107/2009 (Marketing of Plant Protection Products, EU)

    Typical usage ratio

    • Loaded at 1.5–4% equivalent in precursor reaction step, adjusted by downstream conversion rate and anticipated impurity load

    Downstream process integration

    • Processed in the aryl halide coupling reactor during the early-stage active ingredient core assembly, prior to formulation of wettable powders or suspension concentrates

    Final product types

    • Selective herbicide technical concentrate
    • Broad-spectrum fungicide intermediates
    • Agrochemical-combination pre-mixes for field application
    • Registered crop protection product actives
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    More Introduction

    Introducing 1-(4-Bromophenyl)-Naphthlene: Redefining Advanced Chemical Research

    A Fresh Arrival in the Chemical Toolkit

    Chemistry finds its breakthroughs in small details. One such innovation comes in the form of 1-(4-Bromophenyl)-Naphthlene, a compound that's started catching the eye of researchers in fields like pharmaceuticals, organic electronics, and advanced materials. This molecule stands out thanks to a structure that bridges a classic naphthalene backbone with a bromophenyl group, giving it both versatility and reliability for those working at the leading edge of synthesis.

    Model and Core Specifications

    Today’s research programs often demand materials that handle high performance and exhibit unique reactivity. 1-(4-Bromophenyl)-Naphthlene steps up, offering purity levels suited for advanced lab work. It brings together two well-known fragments, naphthalene and 4-bromophenyl, in a configuration that keeps its physical properties stable during bench chemistry operations. Labs working on organic synthesis will notice its solid, off-white crystalline appearance, with a melting point that supports safe transport and storage. It enters reaction vessels clean and free of excess impurities, which means less worry about side products muddying up reactions.

    What makes this molecule click isn’t just in how it’s built—it’s how researchers can harness its chemistry. With the bromine substituent, 1-(4-Bromophenyl)-Naphthlene opens doors for further functionalization by cross-coupling, especially with Suzuki and Heck protocols proving popular in medicinal and materials research. I’ve seen this compound dropped into a Suzuki-Miyaura reaction, transforming the direction of a project by letting a chemist quickly expand a library of fused aromatic scaffolds.

    Standing Out in a Crowded Landscape

    Working in the lab, I’ve run into compounds that promise a lot but fall short on reliability or ease of handling. The market is full of halogenated aromatics that can be stubborn or feel too generic. 1-(4-Bromophenyl)-Naphthlene offers something different: it combines structural complexity with real practical handling. Standard bromonaphthalenes or simple aryl bromides won’t always match the electronic properties or reactivity that this compound can deliver. When you compare it to widely used biphenyl derivatives, for instance, the naphthyl ring system adds a degree of rigidity and π-system extension that changes how it interacts with catalysts and reagents.

    What I appreciate is how this molecule gets out of the way and lets researchers focus on what matters—the chemistry. It allows for predictable electrophilic aromatic substitution, handles strong bases without decomposing prematurely, and doesn’t generate troublesome byproducts under organometallic conditions. The aromatic backbone brings physical robustness, which helps during purification or chromatography steps. In practical terms, this means fewer worries about losing product on silica or fighting to remove unexpected spots on a TLC plate.

    Why This Molecule Matters Right Now

    We’re in an age where new organic semiconductors and pharmaceutical precursors need special building blocks. I’ve watched teams lose momentum because an intermediate falls apart during synthesis, or reacts too unpredictably to be useful on scale. 1-(4-Bromophenyl)-Naphthlene cuts through that uncertainty. Its structural stability, even at high temperatures, invites use in multi-step syntheses and late-stage diversification.

    In pharmaceutical research, where even small tweaks to a molecule can make the difference between a hit and a miss, being able to attach or modify aromatic rings quickly counts for a lot. For scientists exploring new ligands or biaryl scaffolds, this compound plays nicely with the latest advances in palladium-catalyzed cross-coupling, giving rise to molecules that simply weren’t easy to make a decade ago. I’ve handled plenty of brominated aromatics over the years, and I don’t take for granted the clean reactivity that 1-(4-Bromophenyl)-Naphthlene offers.

    Beyond the bench, innovation matters most when it’s accessible. There’s no benefit to a game-changing molecule if it’s too costly or inconvenient for a typical research group to buy and store. This compound arrives in stable batches, ships well under ambient conditions, and endures reasonably long storage times without significant degradation. For those sourcing chemicals for high-stakes projects or small startup labs, reliable supply and shelf stability make planning a lot less stressful.

    Bench Experience: Where This Compound Proves Its Worth

    The biggest measure for any reagent on my bench is consistency. I value a compound that dissolves cleanly in common lab solvents, doesn’t clog up columns, and keeps side reactions to a minimum. In hands-on applications, 1-(4-Bromophenyl)-Naphthlene answers these needs. Its low solubility in cold polar solvents pairs nicely with workup processes, aiding precipitation and crystallization when isolating end products.

    Labs working in material science, especially those chasing novel OLED or thin-film transistor materials, get a bump from the planar naphthalene core. This attribute can impact packing and stacking in solid-state materials, translating into improvements in charge mobility and film uniformity. Synthetic access to more rigid, π-conjugated systems like this compound often streamlines late-stage tuning, without demanding major overhauls to upstream synthetic routes.

    I’ve seen colleagues use this molecule in the creation of new ligands for transition metal catalysis, extending into asymmetric synthesis projects. The ability to use cross-coupling techniques reliably supports efforts to optimize biological activity in drug candidates, or to create new prototype devices in optoelectronic labs. Time spent battling impurities drops, letting research groups move forward instead of troubleshooting basic issues.

    How It Compares to Traditional Alternatives

    Lots of classic aromatic bromides line the shelves in every organic lab. Many have been essential workhorses, but some fail to meet the selectivity or stability tests forced by modern synthesis. Compared to monobromonaphthalenes or conventional aryl bromides, 1-(4-Bromophenyl)-Naphthlene stands out in a few key ways. Its bifunctional structure brings both an extended aromatic system and a reactive handle suited to modern coupling protocols.

    Other brominated aromatics sometimes suffer from issues like overreaction or poor solubility. I’ve disposed of plenty of batches that yellowed over time or gave unreliable yields after sitting on a shelf for a year. Stable batches of 1-(4-Bromophenyl)-Naphthlene, tested by NMR and chromatography, display a shelf life that makes stocking up for longer-term projects less risky.

    Its reactivity profile blends the best of both worlds. The bromine is reactive enough for cross-coupling while the naphthyl moiety brings a level of stiffness and electronic tuning that changes the behavior of the resulting molecules. This means medicinal chemists and material scientists can fine-tune properties like solubility, absorption, or packing in ways that simpler halides don’t easily allow.

    Building Future Solutions: Opportunities for Progress

    One of the biggest issues for organic researchers comes from sourcing starting materials that don’t introduce unwanted variables. Suppliers often mix batches or push less stable alternatives to save costs, which introduces risks during scaling or when running precision reactions. Developing robust, well-characterized intermediates like 1-(4-Bromophenyl)-Naphthlene helps address concerns around reproducibility and process control.

    Moving forward, improvements could arrive by broadening green chemistry initiatives in manufacturing this compound. Current routes rely on halogenation and functional group exchange, which generate some hazardous waste streams. Shifting towards milder bromination technologies or using renewable feedstocks may reduce the environmental footprint without sacrificing product quality. Companies could benefit from providing clear batch data, more transparent safety documentation, and certifying supply chain sustainability.

    I’d like to see further integration with automated synthesis platforms. Digital chemistry is gaining ground in scale-up labs, where automation slashes waste and improves repeatability. Consistent, well-defined aromatic bromides like this one allow researchers to build automated reaction libraries, screen new coupling partners, and accelerate drug or device discovery. This could make a big impact in both academic and commercial settings, where every hour of saved analysis turns into another compound reaching the test bench.

    Product Handling and Everyday Utility

    For all its high-tech applications, 1-(4-Bromophenyl)-Naphthlene is a manageable material on the bench. It resists caking, pours easily from standard bottles, and doesn’t emit strong odors or dust excessively. I find this makes it less of a hassle during routine inventory checks or when measuring out multi-gram batches for a longer synthesis protocol. Standard safety practices—good ventilation, gloves, and eye protection—are all that’s needed for routine handling.

    Researchers often mention waste management as a growing concern in the lab. After reactions, I’ve found that this compound doesn’t complicate standard disposal, nor does it generate unexpected byproducts that demand special containment. This is a real advantage for smaller labs lacking advanced waste separation systems, and for organizations working on tighter budgets or under stricter regional regulations.

    Global Collaboration and Sharing Best Practice

    As science becomes more international, access to the same core building blocks enables real sharing and progress. My experience collaborating across borders shows how helpful it is to have uniformity in available reagents, with everyone starting from the same high-purity intermediates. 1-(4-Bromophenyl)-Naphthlene helps bridge that gap, arriving in standardized containers with batch-level quality data, letting teams share protocols, compare yields, and trouble-shoot across time zones.

    Broader access also means students and early-career scientists test their skills with advanced chemistry, previously reserved for major corporate or institutional labs. This boosts technical training and inspires new applications for well-designed molecules. It reminds me of early research days, where tracking down a reagent often meant months of waiting or unreliable mail orders. Availability of high-standard intermediates really changes the speed and impact of new discoveries.

    Catalyst for Innovation in Academics and Industry

    Chemical research doesn’t stand still. From optimizing reaction conditions to questioning long-held rules, every high-quality intermediate helps move the whole field forward. 1-(4-Bromophenyl)-Naphthlene answers a growing need for dependable, versatile reagents that offer control and flexibility at every stage. Academics leverage it to pursue basic research, testing new reaction types or mechanism-driven explorations. Industry puts it to work in developing next-generation products, boosting production efficiency, and pushing toward more sustainable manufacturing.

    My own projects have benefited from chemicals like this—where a single, well-chosen building block unlocked several routes and sped up structure-activity relationship studies. No scientist wants to spend weeks debugging their starting material, only to discover a supplier skimped on purity or batch characterization. The compound’s consistency means those headaches shrink, and the focus returns to the chemistry instead of troubleshooting.

    Refining the Standards for Advanced Aromatic Building Blocks

    Every field that leans on organic synthesis can benefit from thoughtfully designed, well-supplied reagents. The introduction of reliable options like 1-(4-Bromophenyl)-Naphthlene reflects broader changes in science—toward transparency, reproducibility, and efficiency. Product data and shelf labels mean less guesswork, making the transition from bench discovery to pilot scale-up less daunting.

    I’ve watched research shift from improvising with what’s on hand to carefully planning each step of a project, saving time, money, and, most importantly, avoiding waste. This compound fits well within newer strategies for modular synthesis, serving as a plug-and-play piece for rapid downstream exploration.

    Supporting Responsible Innovation

    Sustainability is now more than a buzzword; it’s a real standard for modern chemistry. Safe, predictable intermediates contribute by reducing failed reactions and minimizing unnecessary consumption of energy and solvents. 1-(4-Bromophenyl)-Naphthlene, particularly in carefully packaged forms and with robust analytical data, makes scaling and switching between projects more straightforward.

    Changing market dynamics, regulatory oversight, and customer expectations push suppliers to do more than just fill bottles. Top-tier intermediates come with clear certificates of analysis, traceability, and honest reporting of storage conditions and transport history. These changes, when coupled with steadily available products, support even the most ambitious targets for waste reduction and green chemistry compliance.

    Concluding Thoughts: Meeting Present and Future Research Demands

    The chemical landscape grows more complex every year, with discoveries from materials science overlapping with biotechnology and industrial process improvement. Amidst all this, reliable specialty reagents like 1-(4-Bromophenyl)-Naphthlene stand as unsung heroes. Their consistent performance, combined with practical physical and chemical properties, means the difference between a project’s success and yet another frustrating dead-end.

    Adopting new standards in intermediate supply, championing safer and greener synthesis, and investing in quality benchmarks help move research from idea to implementation. For those of us at the bench and in the planning meetings, the arrival of robust products like this symbolize a discipline that’s learned from its history—and is actively choosing a smarter, more collaborative future.