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Material Safety Data Sheet (MSDS) for Β-Nicotinamide Adenine Dinucleotide Phosphate Monosodium Salt

Identification

Product Name: β-Nicotinamide Adenine Dinucleotide Phosphate Monosodium Salt
Synonyms: NADP Monosodium Salt, Nicotinamide adenine dinucleotide phosphate sodium salt
Chemical Formula: C21H27N7NaO17P3
CAS Number: 24292-60-2
Recommended Use: Biochemical research, laboratory reagent
Supplier: Contact local distributor or manufacturer
Emergency Telephone: Refer to local emergency contact numbers or established institutional response protocols

Hazard Identification

GHS Classification: Not classified as hazardous under GHS criteria for laboratory chemicals
Pictograms: None required for this substance
Signal Word: No signal word assigned
Hazard Statements: May cause mild irritation to eyes or skin upon prolonged exposure; inhalation of dust may irritate respiratory tract
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use only in a well-ventilated area, do not eat or drink during handling
Potential Effects: Prolonged contact may cause dry skin, eye redness; ingestion or inhalation unlikely to cause acute toxicity at laboratory exposure levels

Composition / Information on Ingredients

Chemical Name: β-Nicotinamide Adenine Dinucleotide Phosphate Monosodium Salt
CAS Number: 24292-60-2
Concentration: Greater than 98% by weight
Impurities: Residual moisture and trace by-products, less than 2%
Molecular Weight: 765.4 g/mol
EC Number: 246-115-7

First Aid Measures

Eye Contact: Rinse eyes with plenty of clean, lukewarm water for several minutes; remove contact lenses if present; seek medical advice if irritation persists
Skin Contact: Wash affected area with soap and copious amounts of water; remove contaminated clothing if necessary
Inhalation: Move person to fresh air; provide artificial respiration if not breathing; consult physician if symptoms develop
Ingestion: Rinse mouth thoroughly with water; drink several glasses of water; do not induce vomiting; seek medical attention for large accidental ingestion
Important Symptoms: Redness, itching, mild discomfort; high exposure by ingestion unlikely to cause severe effects
Advice for Medical Personnel: Treat symptomatically, no known specific antidote

Fire-Fighting Measures

Suitable Extinguishing Media: Use water spray, dry chemical powder, foam, or carbon dioxide
Unsuitable Media: Direct water jets may spread spilled material
Special Hazards: Decomposition may produce nitrogen oxides, carbon oxides, phosphorous oxides
Protective Equipment: Use self-contained breathing apparatus, full protective gear
Advice for Firefighters: Approach from upwind; avoid breathing decomposition products; cool containers exposed to fire with water
Explosion Sensitivity: No significant risk of explosion at standard laboratory scale

Accidental Release Measures

Personal Precautions: Wear disposable gloves, eye protection, laboratory coat; avoid dust formation
Environmental Precautions: Prevent spillage from entering drains, waterways, or soils
Cleaning Up: Scoop up solid and transfer to closed container for waste disposal; wash area with water and mild detergent
Disposal of Spills: Collect residues and contaminated absorbent for proper disposal as laboratory waste; ventilate area after clean up

Handling and Storage

Handling Precautions: Handle using standard laboratory safety protocols; avoid creating or inhaling dust; practice proper hygiene after handling
Storage Conditions: Store in tight, light-resistant containers; keep container tightly closed in a cool, dry, well-ventilated location; protect from strong oxidizers, moisture
Incompatible Materials: Strong acids, strong bases, oxidizing agents may cause degradation
Specific Requirements: Label containers appropriately; maintain inventory for traceability; restrict access to qualified personnel

Exposure Controls and Personal Protection

Occupational Exposure Limits: No established limits by OSHA, NIOSH, or ACGIH
Engineering Controls: Use local exhaust ventilation, laboratory fume hood where dust formation possible
Personal Protection Equipment: Safety glasses with side shields, chemical-resistant gloves (nitrile or latex), disposable laboratory coat
Hygiene Measures: Wash hands thoroughly after use; do not eat, drink, or smoke in laboratory; keep contaminated clothing out of common areas

Physical and Chemical Properties

Appearance: White to off-white powder or crystalline solid
Odor: Odorless
Odor Threshold: Not determined
pH: 2.5 – 3.5 (1% solution)
Melting Point: No data available (decomposes before melting)
Boiling Point: Not applicable (solid decomposition)
Flash Point: Not applicable
Evaporation Rate: Not applicable
Flammability: Not classified as flammable
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Solubility in Water: Soluble (typically up to 10 mg/mL at room temperature)
Partition Coefficient (n-octanol/water): Data not available
Decomposition Temperature: Decomposes above 200°C
Viscosity: Not applicable for solids
Refractive Index: Not established

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Reactivity: No dangerous reactions reported under normal laboratory use
Hazardous Reactions: Exposure to strong acids or oxidizers could yield hazardous degradation products
Conditions to Avoid: Excessive heat, light, moisture, contact with incompatible chemicals
Incompatibilities: Strong oxidizing agents, strong acids, alkalis
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, sodium compounds, phosphorous oxides

Toxicological Information

Acute Toxicity: Expected to pose little acute toxicity to humans under normal use; not classified as toxic
Oral LD50: No specific data for this compound; structurally related nucleotides show low toxicity in mammals
Inhalation: Dust may irritate respiratory system
Skin Contact: May cause slight irritation on prolonged exposure
Eye Contact: May produce mild, transient irritation
Chronic Effects: No data indicating significant long-term health risks
Sensitization: Insufficient data; not suspected to be a sensitizer
Carcinogenicity: Not listed by IARC, NTP, OSHA
Mutagenicity: No mutagenic effects reported
Reproductive Toxicity: Not expected to produce reproductive harms at standard laboratory levels
Medical Conditions Aggravated by Exposure: Existing respiratory or skin conditions could worsen upon repeated exposure

Ecological Information

Ecotoxicity: No specific information on environmental toxicity available; similar compounds rapidly biodegrade
Aquatic Toxicity: Not expected to be toxic to aquatic organisms at typical laboratory discharge levels
Persistence and Degradability: Likely to break down through natural biological processes; no indication of persistent environmental risk
Bioaccumulation Potential: Not expected to bioaccumulate in the food chain
Mobility in Soil: Highly soluble in water, expected to migrate readily in aqueous environments
Other Adverse Effects: Avoid large, uncontrolled releases; adhere to responsible laboratory waste disposal

Disposal Considerations

Waste Disposal Methods: Collect material in sealed containers; hand over to authorized chemical waste handler
Contaminated Packaging: Dispose of containers and contaminated items as chemical waste
Special Precautions: Observe all local, state, and federal regulations for disposal; avoid disposal through general sewage
Recycling Information: No practical recycling methods for laboratory quantities
EPA Waste Numbers: Not listed under RCRA hazardous waste codes

Transport Information

UN Number: Not regulated for transport by road, air, or sea
Proper Shipping Name: Not subject to ADR, IATA, or IMDG transport regulations
Transport Hazard Class: None assigned
Packing Group: Not assigned
Environmental Hazards: Not considered environmentally hazardous in transport
Special Precautions for User: Package securely to prevent spillage; handle with appropriate personal protection during transfer

Regulatory Information

OSHA Status: Not considered hazardous under OSHA Hazard Communication Standard
TSCA Status: Component listed in the TSCA inventory
SARA Title III: Not subject to emergency planning or hazardous release notification
California Proposition 65: Not listed
WHMIS Classification (Canada): Non-controlled
EU Regulations: Not classified as hazardous under EU Regulation (EC) No 1272/2008
Other International Regulations: Consult local and national requirements for laboratory chemicals
Labeling Requirements: Identification and precautionary information should comply with institutional and local standards