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Product Name: Α-Lipoic Acid
CAS Number: 1077-28-7
Synonyms: Thioctic Acid, 1,2-Dithiolane-3-pentanoic acid
Chemical Formula: C8H14O2S2
Intended Use: Antioxidant in dietary supplements, laboratory chemical
Manufacturer Details: Available from multiple international suppliers, distributed in research, food, and supplement industries
GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Acute toxicity oral (Category 4)
Signal Word: Warning
Hazard Statements: Causes serious eye irritation, may cause skin irritation, harmful if swallowed
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, do not eat/drink/smoke while using, wear protective gear
Potential Health Effects: May lead to gastrointestinal distress, headache, allergic skin reactions on direct contact, eye irritation with direct splashes
Chemical Name: Α-Lipoic Acid
Concentration: ≥98% purity in pure form
Other Components: Trace impurities may include water, residual solvents (usually very low concentrations), no significant hazardous impurities identified in analytical-grade batches
Inhalation: Move person to fresh air, keep comfortable for breathing, seek medical help if symptoms persist
Skin Contact: Wash off with soap and plenty of water, remove contaminated clothing, consult a physician for irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, seek medical attention for persistent discomfort
Ingestion: Rinse mouth with water, never give anything orally to an unconscious person, seek immediate medical advice if large amounts consumed
Most Important Symptoms: Redness, swelling, irritation, nausea, headache in sensitive individuals
Medical Attention: Treat symptomatically, supportive care may be required for severe exposure
Suitable Extinguishing Media: Use dry chemical, carbon dioxide, foam, or water spray
Specific Hazards: May produce irritating or toxic gases such as sulfur oxides during combustion
Special Protective Equipment: Firefighters should wear full protective clothing and self-contained breathing apparatus
Firefighting Procedures: Isolate fire area, avoid breathing combustion gases, use water to cool containers, move containers if safe to do so
Personal Precautions: Avoid dust formation, ventilate area, use respirator if dust levels are high, prevent skin and eye contact
Spill Cleanup Methods: Sweep up and place in suitable container for disposal, avoid generating dust, wash affected areas with water
Environmental Precautions: Prevent runoff into drains, surface water, or soil; inform authorities if significant spill threatens environment
Containment: Use appropriate barriers to contain powder, use damp cloths to minimize spreading
Handling: Wear gloves, goggles, and lab coat, avoid inhaling dust, wash thoroughly after handling, use in well-ventilated area
Storage: Keep container tightly closed, store in a dry, cool, well-ventilated place away from sunlight, heat sources, and incompatible materials
Incompatibilities: Strong oxidizing agents, strong bases, reducing agents, avoid storing with food or beverages
Hygiene Measures: Do not eat, drink, or smoke in the working area, keep work clothes separate, maintain clean working conditions
Engineering Controls: Use local exhaust ventilation, maintain eye wash stations and safety showers
Exposure Limits: No established occupational exposure limits for Α-Lipoic Acid as of 2024
Personal Protective Equipment: Protective gloves (nitrile or latex), safety goggles, lab coat, dust mask or respirator if generating dust
Environmental Protection: Contain work area, use protective covering on benches, dispose of waste according to regional guidelines
Appearance: Pale yellow to yellow crystalline powder
Odor: Faint, unpleasant, sulfur-like
Odor Threshold: Not established
pH: Not applicable (insoluble in water), slightly soluble in ethanol and methanol
Melting Point: 60–62°C
Boiling Point: Decomposes before boiling
Flash Point: 164°C (closed cup)
Evaporation Rate: Not applicable
Vapor Pressure: Negligible at 25°C
Vapor Density: Not applicable
Relative Density: Approx. 1.23 g/cm³
Solubility: Poorly soluble in water, soluble in organic solvents like ethanol, methanol, DMSO
Partition Coefficient: Log Kow ~ -2.2
Autoignition Temperature: Not determined
Decomposition Temperature: Above 110°C (releases toxic fumes)
Viscosity: Not applicable (solid)
Chemical Stability: Stable under normal storage and handling conditions
Conditions to Avoid: Excessive heat, moisture, open flame, sunlight
Incompatible Materials: Strong oxidizers, reductive metals, alkali metals
Hazardous Reactions: Avoid mixing with oxidizers; decomposition releases toxic fumes (SOx)
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, sulfur oxides
Acute Toxicity: LD50 (oral, rat) ~ 400–500 mg/kg (moderate toxicity); potential for nausea, vomiting, dizziness
Irritation/Corrosion: Skin and eye irritant at higher concentrations
Respiratory Sensitization: May trigger coughing and sneezing with dust inhalation
Chronic Exposure: Rarely reported, some people may show mild allergic responses with long-term skin contact
Carcinogenicity/Mutagenicity: No evidence of carcinogenicity or mutagenicity reported for Α-Lipoic Acid
Reproductive Toxicity: No documented evidence in standard toxicological references
Symptomology: Headache, dizziness, nausea, contact dermatitis, conjunctival redness
Aquatic Toxicity: Low toxicity towards aquatic organisms under laboratory conditions
Persistence/Degradability: Readily biodegradable under aerobic conditions
Bioaccumulative Potential: Negligible, low log Kow value which limits accumulation in living organisms
Mobility: Not mobile in soil, tends to bind to organic matter
Other Hazards: No evidence for long-term ecological effects, rare potential for minor localized impact if large quantities enter waterways
Waste Treatment Methods: Collect residue and dispose in accordance with local, regional, and national regulations as non-hazardous chemical waste
Container Disposal: Rinse containers before recycling or disposal, do not discharge to sewage or surface water
Special Precautions: Avoid generating dust during disposal, use personal protective equipment, do not mix with incompatible materials
UN Number: Not regulated for transport
Proper Shipping Name: Not hazardous for transport purposes
Transport Hazard Class: Not classified
Packing Group: Not applicable
Marine Pollutant: Not a marine pollutant
Special Precautions for Users: Ensure containers are sealed, protected from moisture, labeled properly according to applicable laws
US TSCA: Listed
EU REACH: Registered/List status varies by supplier
Canada DSL/NDSL: Listed
Other Regulatory Status: No specific restrictions under FDA, EFSA, or EPA for intended use; consult regional regulations for dietary supplement or food additive status
Workplace Labelling: Use appropriate precautionary and hazard labels in occupational contexts, maintain accessible safety documentation as required by law
