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Product Name: Zanamivir Chemical Name: 5-(acetylamino)-4-((aminoiminomethyl)amino)-2,6-anhydro-3,4-dideoxy-D-glycero-D-galacto-non-2-enonic acid Synonyms: Relenza, GG167 CAS Number: 139110-80-8 Recommended Use: Antiviral for influenza treatment Supplier Details: Pharmaceuticals distribution companies, major hospital pharmacies Emergency Contact: Poison control centers, local emergency departments, internal health and safety coordinators Restrictions on Use: Not designed for use except as directed by a medical professional
Hazard Classification: Not classified as hazardous according to OSHA, but standard precautions apply Label Elements: No universally required pictograms, but detailed documentation for clinicians and pharmacists Health Hazards: Inhalation might trigger respiratory symptoms for sensitive individuals; accidental eye or skin contact rarely leads to irritation Environment Hazards: Not expected to cause significant environmental impact in pharmaceutical-scale use Precautionary Statements: Wash hands after use, avoid touching face during handling, use in well-ventilated areas
Chemical Formula: C12H20N4O7 Active Ingredient: Zanamivir (typically over 99% purity for medical use) Excipients: Lactose monohydrate (for inhaled powder), may include minor stabilizers Impurities: Quantities typically under strict pharmacopeial limits Concentration: Delivered as 5 mg dose for inhalation
Inhalation: Move crew member or patient to fresh air, monitor for breathing difficulty, seek medical evaluation if symptoms persist Skin Contact: Wash area with warm water and soap, remove contaminated clothing, monitor skin for delayed reactions Eye Contact: Flush eyes with plenty of potable water for at least 10 minutes, do not rub or apply ointments, proceed to physician or medical provider Ingestion: Rare in normal use, but if large quantities swallowed, rinse mouth, drink water, seek urgent care if any stomach upset or nausea develops Note to Physicians: Treat symptomatically, monitor airway and vital signs; specific antidote not widely established
Suitable Extinguishing Media: Water spray, carbon dioxide, dry chemical, class ABC foam Special Hazards: Combustion can generate carbon monoxide, nitrogen oxides, and possibly low-level organic fragments Firefighter Protection: Firefighters should wear self-contained breathing apparatus and protective clothing Firefighting Procedures: Isolate area, avoid inhaling fumes, prevent runoff into water systems
Personal Precautions: Use gloves, goggles, and lab coat; avoid dust formation Environmental Precautions: Prevent powder or solution entry into sewer systems, storm water drains, or natural water sources Spill Control: Sweep up powder carefully, avoid raising dust, use absorbent material for solutions Cleanup Methods: Dispose material in sealed containers, ventilate area, wipe surface with damp disposable cloth
Handling: Use personal protective equipment such as gloves and eye protection; avoid creating aerosols Storage Conditions: Store in original labeled container, keep sealed tightly, maintain between 15–30°C (59–86°F) Incompatibility: Keep away from strong acids, alkali, and oxidizing agents Special Storage Requirements: Protect from moisture, prevent cross-contamination with other pharmaceuticals
Engineering Controls: Work in well-ventilated rooms, use local exhaust for bulk manipulation Personal Protection: Single-use nitrile gloves, safety goggles, laboratory coat Respiratory Protection: Use disposable mask if manipulating large powder amounts or risk of aerosolization Exposure Limits: No occupational exposure limits established; pharmaceutical exposure guidelines apply Hygiene Measures: Wash hands thoroughly before eating or after handling; avoid hand–to–face contact
Appearance: White to off-white fine crystalline powder Odor: Odorless pH: Slightly acidic in aqueous solution Melting Point: Decomposes above 175°C Solubility: Moderately soluble in water, low solubility in organic solvents Vapor Pressure: Negligible at room temperature Relative Density: Not readily available, but greater than 1 Other Data: Stable under recommended storage conditions
Chemical Stability: Stable at ambient temperatures and humidity Conditions to Avoid: Excess heat, direct sunlight, extremes in pH, prolonged or intense moisture Incompatible Materials: Strong acids, bases, oxidizing chemicals Hazardous Decomposition: On combustion, emits carbon oxides and nitrogen compounds; unlikely in normal clinical handling Polymerization: No hazardous polymerization known to occur
Acute Toxicity: Oral LD50 in animals greater than 5,000 mg/kg, so low acute toxicity Chronic Effects: Not expected to cause long-term issues in therapeutic use; pharmacovigilance monitors rare respiratory hypersensitivity Routes of Exposure: Inhalation is primary, ingestion and dermal routes secondary Symptoms of Exposure: Throat irritation, rare allergic responses, possible headache with massive airborne levels Carcinogenicity/Mutagenicity: No data suggests carcinogenic risk, not included on known carcinogen inventories
Environmental Fate: Biodegradable in aquatic environments with moderate breakdown rate Bioaccumulation Potential: Not expected to significantly bioaccumulate in wildlife Aquatic Toxicity: Low potential for adverse effects even at pharmaceutical residues Other Adverse Effects: Pharmaceutical stewardship practices, like take-back programs, recommended to limit environmental exposure
Waste Disposal: Collect and place in sealed containers for pharmaceutical waste incineration or controlled landfill under local guidelines Contaminated Packaging: Triple rinse and dispose of with other pharmaceutical packaging waste Sewage Disposal: Do not flush large quantities; small residuals considered safe by hospital and clinic wastewater protocols Precautions for Disposal: Avoid uncontrolled discharge, label waste containers appropriately
UN Number: Not regulated as a hazardous material for transport purposes Proper Shipping Name: Zanamivir Transport Hazard Class: Not classified Packing Group: Not assigned Special Precautions: Protect from moisture during transport, ensure secondary containment for large shipments Regulatory Transport Status: Normal courier services accepted, air and ground transport unrestricted
OSHA Status: Not considered a hazardous chemical under OSHA Hazard Communication TSCA Inventory: Prescription substances exempt FDA Approval: FDA-approved for inhalation treatment of influenza WHMIS Canada: Not controlled, medical substance Other Relevant Regulations: Subject to prescription-only distribution, international movement monitored for counterfeit risk Labeling: Pharmacy dispensing labels and safety leaflets provided with finished product
