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Product Name: Warfarin Sodium
Chemical Formula: C19H15NaO4
Synonyms: Coumadin, Panwarfin, Athrombin-K, Warfarin Sodium Salt
CAS Number: 129-06-6
Recommended Use: Pharmaceutical anticoagulant, rodenticide
Manufacturer: Refer to package insert or supplier information for detailed company data.
Contact Information: Emergency medical line listed on label; Poison Control Centers can be reached for first aid.
GHS Classification: Acute Toxicity (Oral) Category 2; Acute Toxicity (Dermal) Category 3; Acute Toxicity (Inhalation) Category 3; Specific organ toxicity (repeated exposure) Category 2; Reproductive Toxicity Category 2.
Signal Word: Danger
Hazard Statements: Fatal if swallowed, Toxic in contact with skin or if inhaled, May cause damage to organs through prolonged or repeated exposure, Suspected of damaging the unborn child.
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, use personal protective equipment, keep away from food and drink, store locked up.
Chemical Name: Warfarin Sodium
Concentration: 100% in pure form or as indicated on product packaging
CAS Number: 129-06-6
Impurities and Stabilizing Additives: Not expected in pharmaceutical-grade forms; technical-grade may carry trace stabilizers; detailed spectral analysis available on request from supplier.
Inhalation: Move person to fresh air, support breathing, contact emergency personnel immediately.
Skin Contact: Remove contaminated clothing, rinse skin under running water for 15 minutes, seek immediate medical advice.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, continue rinsing, call for medical help.
Ingestion: Rinse mouth, do not induce vomiting, immediate medical attention required, transport patient to health facility as rapidly as possible; Vitamin K1 is an antidote in case of poisoning but only under direct medical supervision.
Most Important Symptoms: Hemorrhage, nosebleeds, bruising, blood in urine or stool, general malaise, possible shock in severe cases.
Advice to Physician: Intensive symptomatic and supportive treatment. Monitor blood parameters and coagulation profile, start Vitamin K and, if necessary, prothrombin complex transfusions.
Suitable Extinguishing Media: Water spray, dry chemical, foam, or carbon dioxide; avoid high-pressure water, which may spread the material.
Special Hazards: Formation of toxic fumes under fire conditions, including oxides of carbon and sodium compounds; flash point information typically lower due to organic structure.
Protective Equipment: Self-contained breathing apparatus and full protective gear; personnel should avoid dust inhalation.
Specific Methods: Move containers from fire area if safe, prevent runoff from entering drains, cool fire-exposed containers with water spray.
Thermal Decomposition Products: Carbon monoxide, carbon dioxide, sodium oxides, gaseous organics.
Personal Precautions: Evacuate non-essential personnel, wear protective clothing including gloves, goggles, and particulate respirators.
Environmental Precautions: Prevent entry to sewers or waterways, isolate spill, contain dust formation.
Cleanup Methods: Scoop up dry spills with non-sparking tools, wipe area with damp disposable cloths, place material in properly labeled hazardous waste containers, ventilate area well afterwards.
Decontamination: Wash spill area with detergent and water, dispose of cleaning materials as hazardous waste.
Precautions for Safe Handling: Use only in well-ventilated areas, avoid contact with skin and eyes, do not eat, drink, or smoke during use, wash hands before eating or using restroom, avoid formation of dust.
Conditions for Safe Storage: Store in cool, dry, well-ventilated place, away from incompatible substances such as strong acids and oxidizers, keep containers tightly closed, store locked up, label all storage containers with proper hazard warnings.
Technical Measures: Use spill trays, secondary containment for storage; keep materials off the floor and avoid stacking heavy containers.
Control Parameters: Occupational exposure limits not established generally, but minimize all exposures with best industrial hygiene practice.
Engineering Controls: Use local exhaust ventilation, enclose operations, maintain negative pressure in workroom, monitor airborne concentrations with appropriate detection equipment.
Personal Protective Equipment: Wear chemical-resistant gloves (nitrile recommended), protective lab coat or coveralls, eye protection such as chemical splash goggles, particulate respirators (P2 or N95 class or better), use face shields where splash risk exists.
Hygiene Measures: Remove and wash contaminated clothing before reuse, avoid contaminating personal items, provide shower and eyewash stations near work areas.
Appearance: Fine or granular, odorless, white to off-white crystalline powder
pH (1% solution): 7 to 9
Boiling Point: Information not available, decomposes before boiling
Melting Point: Decomposes above 250°C
Vapor Pressure: Negligible at room temperature
Solubility in Water: Freely soluble
Density: 1.367 g/cm³ (as sodium salt)
Partition Coefficient (log Pow): Approx. 0.7 (warfarin base)
Other Data: Forms soluble complexes with certain metal ions, insoluble in most nonpolar organic solvents.
Chemical Stability: Stable under recommended storage conditions, sensitive to strong acids, light, and oxidizing agents.
Reactivity: May react with oxidizers, acids, reducing agents.
Incompatible Materials: Strong acids, alkalies, oxidizing materials, reducing agents.
Conditions to Avoid: Moisture, high humidity, direct sunlight, elevated temperatures.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, sodium oxides, smoke, unidentified toxic gases under fire conditions.
Routes of Exposure: Oral, inhalation, skin, and eye contact
Acute Toxicity: Oral LD50 (rat): 1–20 mg/kg; skin LD50 (rat): 20–100 mg/kg
Chronic Effects: Organ toxicity (blood, liver, kidneys); protracted exposure decreases blood clotting ability, leading to bleeding disorders.
Symptoms: Nosebleeds, bleeding gums, easy bruising, hematuria, gastrointestinal bleeding, lethargy.
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA.
Mutagenicity: Some studies suggest genotoxicity; more evidence necessary.
Reproductive Toxicity: Embryotoxic and teratogenic in laboratory animals; can harm developing fetus.
Aquatic Toxicity: Toxic to aquatic organisms, fish, and invertebrates (LC50: 0.0042 mg/L for Rainbow Trout)
Bird Toxicity: Lethal to some bird species.
Persistence and Degradability: Chemically persistent in soil and water, bioaccumulates in animal tissue.
Bioaccumulation Potential: Significant bioaccumulation in mammals, birds, fish through repeated exposure.
Mobility in Soil: Relatively low mobility, binds to soil organic matter but may leach in alkaline or sandy soils.
Other Adverse Effects: Secondary poisoning can occur in animals that ingest contaminated prey.
Waste Methods: Incinerate in controlled facility or dispose of in accordance with local, regional, and national regulatory requirements; do not allow material to reach watercourses, use hazardous waste landfill if approved.
Contaminated Packaging: Triple-rinse containers, puncture before disposal, label as hazardous, send for specialized incineration.
Handling Precautions: Reduce dust formation, avoid exposure to waste handlers, keep out of municipal landfills and normal sewers.
Special Instructions: Consult hazardous waste disposal company for legislative requirements and best practices.
UN Number: UN 2811
UN Proper Shipping Name: Toxic solid, organic, n.o.s. (contains Warfarin Sodium)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: II
Label Required: Skull and crossbones (toxic), Avoid release to environment.
Special Precautions: Secure shipment against shifting, prevent unauthorized access, transport in compliance with international, regional, and local regulations.
Environmental Hazards: Classified as marine pollutant for international shipment.
OSHA Status: Hazardous; subject to Hazard Communication Standard.
EPA Status: Listed under Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) as a restricted use pesticide; regulated maximum residue levels for food/agriculture.
TSCA Status: Not listed for non-pesticide uses.
WHMIS (Canada): Class D-1A (very toxic material); further restrictions may apply.
EU Directives: Subject to classification, labeling, and packaging regulation (CLP); labeled as toxic, R23/24/25, R48/21/22, R61.
Other International Regulations: Australia, Japan, and other regions list as a controlled hazardous substance.
Safety/SDS Requirements: Regular staff training, documented risk assessments, mandatory labeling for all containers.
