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Product Name: Voriconazole Intermediate
Chemical Name: Specific intermediate designation, used in the synthesis of voriconazole
CAS Number: Available upon request or from supplier documentation
Synonyms: Varies according to production batch; examples include key intermediates in triazole ring formation
Recommended Use: For laboratory, research, and pharmaceutical manufacturing applications
Supplier Details: Manufacturer or distributor’s address, emergency contact numbers, available during working hours
Emergency Overview: Solid compound, variable odor, pale color, formulated for industrial scale chemical synthesis
Classification: Potential irritant to eyes, skin, and respiratory tract; not intended for direct human or animal consumption
Signal Word: Warning
Hazard Statements: May cause respiratory irritation, skin sensitization observed in sensitive individuals, some intermediates show slight toxicity in animal models; target organs include liver or kidneys in rare cases
Pictograms: GHS07 (Exclamation mark)
Precautionary Statements: Avoid inhalation of dust, wash thoroughly after handling, wear protective gloves and goggles, operate under fume hood
Physical Hazards: Dust buildup may present low-level fire risk in poorly ventilated areas
Environmental Hazards: Moderate toxicity to aquatic life, persistence depends on chemical structure, runoff should be strictly controlled
Main Component: Voriconazole synthetic intermediate, purity usually exceeds 95%
Impurities: Synthesis byproducts include minor percentages of related triazole or chlorinated compounds
Ingredient Percentages: Ranges depend on process stage; most batches have trace amounts of unreacted starting materials
Additives: None, unless specified for stability reasons
CAS Numbers for Related Components: Supplier’s document or product label provides full list
Molecular Formula: Designation varies, typical for azole-derived intermediates (C13H10ClN3O2 or other, depending on intermediate)
Inhalation: Move exposed person to fresh air immediately; seek medical attention if symptoms like coughing or shortness of breath develop; keep victim warm and immobilized until breathing improves
Skin Contact: Remove contaminated clothing; wash affected skin with plenty of water and mild soap; keep rinsing for at least 15 minutes; if irritation appears, call a physician
Eye Contact: Rinse cautiously with clean, flowing water for 10 to 20 minutes; remove contact lenses if present and easy to do; continue rinsing, seek medical help if discomfort persists
Ingestion: Do not induce vomiting; if conscious, rinse mouth and drink a small amount of water; consult a physician or Poison Control Center promptly
Acute Effect Notes: Most symptoms involve mild mucous membrane irritation; rare cases show nausea or mild dizziness
Suitable Extinguishing Media: Dry chemical, CO2, foam are effective on most fires involving organic materials
Unsuitable Media: Avoid direct water jets, as these may spread product powder or contaminate runoff
Special Hazards: Combustion produces CO, CO2, and potentially hazardous fumes such as nitrogen oxides or noxious organic vapors
Protective Equipment: Firefighters require full protective gear, including self-contained breathing apparatus
Precautions for Surrounding Areas: Move containers from hazard area if possible; control contaminated runoff
Personal Precautions: Evacuate unprotected personnel; restrict dust generation; ensure proper ventilation
Protective Equipment: Use particulate respirator, gloves, goggles; wear lab coat or disposable coveralls
Cleanup Methods: Collect spilled material with non-sparking tools; gather solid into suitable container, avoid dry sweeping to prevent dust clouds; wash the spill site with water after material pickup
Environmental Protection: Prevent release into drains, surface water, or soil; use absorbent material for large releases
Disposal: Place all contaminated material in sealed waste disposal container, label as hazardous chemical waste and follow local legislation
Handling: Work in well-ventilated area; avoid breathing dust, avoid skin or eye contact; use PPE at all times, keep containers tightly closed to minimize leak risk
Storage Conditions: Store in cool, dry, well-ventilated location; lock up chemicals out of unauthorized reach; avoid exposure to direct sunlight and incompatible materials
Storage Temperature: Maintain at room temperature or as specified in product documentation, most intermediates stay stable at 20-25°C
Storage Security: Use secure shelving; prevent stacking to avoid container rupture
Exposure Limits: No standardized occupational exposure limit for most intermediates, but minimize all exposure through engineering controls
Engineering Controls: Use chemical fume hood, local exhaust ventilation plus closed transfer systems for transfers
Personal Protection: Use nitrile or rubber gloves, standard safety glasses with side-shields, laboratory overalls or chemical resistant suit; use P2/P3 dust respirator if airborne contamination exceeds background level
Hygiene Measures: Wash hands after handling, remove contaminated clothing immediately; do not eat or drink in working areas
Appearance: Solid powder or crystalline form, color typically ranges from white to light yellow
Odor: Slight, not easily detectable under normal conditions
pH: Not applicable to solids, solutions generally mildly acidic or neutral
Melting Point/Range: Most intermediates melt above 100°C, depends on exact structure
Boiling Point/Range: Decomposition often occurs before boiling
Vapor Pressure: Negligible at room temperature
Solubility: Variable; some dissolve in acetone, methanol, DMSO, poorly soluble in water
Flash Point: Not easily flammable, test results vary depending on organic substituents
Density: Generally 1.2 to 1.5 g/cm³
Partition Coefficient: Range depends on substitution pattern, most intermediates moderately lipophilic
Auto-Ignition Temperature: No reliable data for most intermediates; treat conservatively as organic combustibles
Chemical Stability: Stable under recommended storage and usage conditions; sensitive to strong acids, alkalis, and oxidizers
Reactivity: May react with highly reactive halogenating agents or strong reducing agents
Hazardous Decomposition Products: Generates CO, CO2, nitrogen oxides, and potentially hazardous fumes if heated or burned
Polymerization: Not expected under normal industrial handling
Incompatible Materials: Avoid storage with oxidizing reagents, strong acids, or alkali metals
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Limited data shows low-level acute toxicity; respiratory or skin irritation reports exist in lab settings
Chronic Effects: No long-term human data; repeated contact may lead to mild dermatitis or sensitization
Carcinogenicity: No classification from major agencies for most intermediates
Mutagenicity: No positive findings in standard in vitro tests; handle with suitable precautions
Symptoms: Temporary discomfort in eyes, skin, throat after direct contact, resolved with proper care
Target Organs: Sustained exposure could affect liver or kidney function in rare animal studies
Ecotoxicity: Moderate hazard to aquatic organisms; chemical structure influences environmental impact; certain triazoles may cause bioaccumulation
Persistence and Degradability: Slowly biodegradable in soil or water; breakdown products have lower mobility
Bioaccumulative Potential: Low to moderate, based on partition coefficients
Mobility in Soil: Remains near point of release, avoid uncontrolled dumping
Other adverse effects: Minimal ozone depletion or greenhouse gas impact; principal concern is water contamination
Waste Treatment Methods: Dispose through licensed hazardous waste handler; chemical incineration recommended where regulations require
Container Disposal: Rinse empty container three times; any residual material treated as hazardous waste
Disposal Regulation: Control in accordance with regional, national, and local environment disposal regulations; do not dispose by household garbage or drains
Reuse/Recycle: Not recommended due to toxic impurities remaining post-use
UN Number: Assigned according to transport regulations and hazard class
Proper Shipping Name: Organic solid, not otherwise specified, or use chemical name
Transport Hazard Class: Non-dangerous for most intermediates, but labeling as toxic or irritant may be required
Packing Group: III, unless specific risk factors identified
Special Precautions: Prevent container damage, accidental release, or exposure during transit; keep documentation and emergency contacts readily available
OSHA Status: Not listed as hazardous by OSHA but handle using standard chemical safety rules
TSCA Status: Check if substance or precursor appears on US Toxic Substances Control Act inventory
REACH Compliance: Most intermediates imported into the EU must follow REACH registration, safety guidelines may require full disclosure for quantities above 1 tonne/year
Labeling: GHS hazard, precautionary, and first aid pictograms, plus supplier’s trade name, recommended PPE
Other Regulations: Country or state-level rules on handling, emission, and reporting requirements; monitor for local workplace and environmental health regulations to cover all accidental releases and employee exposure
