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Product Name: Vitamin B2, Vb2, Riboflavin Pharmaceutical Grade
Chemical Name: 7,8-Dimethyl-10-ribityl-isoalloxazine
Molecular Formula: C17H20N4O6
Molecular Weight: 376.36 g/mol
Synonyms: Riboflavin, Vitamin B2
Recommended Use: Nutritional supplement, food additive, pharmaceutical ingredient
Supplier Name: [Supplier Information Omitted]
Contact Details: [Supplier Contact Omitted]
Emergency Phone: [Supplier Emergency Phone Omitted]
Classification: Not classified as hazardous according to GHS.
Signal Word: None
Hazard Statements: Inhalation or direct eye contact could irritate.
Precautionary Statements: Avoid breathing dust, contact with eyes or prolonged skin exposure.
Potential Health Effects: May dry out skin or cause temporary eye discomfort.
Environmental Hazards: Low environmental hazard; not known to bioaccumulate or harm aquatic life in typical concentrations.
Chemical Name: Riboflavin
CAS Number: 83-88-5
Content: 97–100% pure
Impurities: Trace organics below reportable limits for food and pharma use only
Inhalation: Move person to fresh air. Seek medical advice if breathing becomes difficult.
Skin Contact: Wash skin with plenty of soap and water. Remove contaminated clothing.
Eye Contact: Rinse cautiously with water for several minutes. If irritation persists, consult a healthcare professional.
Ingestion: Rinse mouth with water. Drink water if conscious. On discomfort or persistent symptoms, call for medical assistance.
Most Important Symptoms: Mild eye or skin irritation. No delayed symptoms known from standard exposure levels.
Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide.
Unsuitable Media: Avoid high-pressure water jets.
Fire Hazards: Powder can form explosive mixtures with air at high concentrations.
Hazardous Combustion Products: Carbon oxides, nitrogen oxides may form above 300°C.
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear in a chemical fire involving powders.
Special Procedures: Move containers from fire area, cool exposed containers with water spray.
Personal Precautions: Avoid powder contact with skin, eyes, clothing. Wear respiratory protection in case of dust.
Environmental Precautions: Keep out of drains and soil. Sweep up, bag, and seal for disposal.
Methods for Clean-Up: Collect spillage by sweeping or vacuuming, minimize dust production. Ventilate area.
Handling: Handle powders in ventilated spaces. Wash hands after use. Do not eat or drink in handling area.
Protection: Wear gloves, lab coat, safety glasses.
Storage: Store tightly closed in cool, dry, well-ventilated area. Keep away from direct sunlight and sources of heat. Store at 2–8°C for pharmaceutical quality.
Exposure Limits: Not established for riboflavin. Respect general dust thresholds (e.g., 10 mg/m³ total dust).
Engineering Controls: Use local exhaust, dust extraction and containment methods. Regularly clean workplace surfaces.
PPE: Wear dust mask, protective gloves, safety goggles, protective clothing. Emergency showers and eye-wash stations recommended.
Appearance: Bright yellow to orange-yellow crystalline powder
Odor: Odorless
pH (1% Water Solution): 6–7
Melting Point: > 280°C (decomposition)
Boiling Point: Not applicable (decomposes on heating)
Solubility: Slightly soluble in water, insoluble in ether, freely soluble in dilute mineral acids
Density: 1.7 g/cm3
Vapor Pressure: Not measurable
Partition Coefficient: logP = -1.46
Flash Point: No data; not flammable under normal conditions
Chemical Stability: Stable at ambient temperatures, especially in absence of light and moisture.
Conditions to Avoid: Heat, light, moisture, strong oxidizers and reducing agents.
Hazardous Decomposition: Carbon monoxide, carbon dioxide, nitrogen oxides under severe decomposing conditions.
Polymerization: No hazardous polymerization expected.
Acute Toxicity: Low toxicity, oral LD50 (rat): > 10,000 mg/kg
Skin Contact: Not a known skin sensitizer.
Eye Contact: Mild irritant, temporary effects.
Chronic Effects: No evidence of carcinogenicity, mutagenicity, or reproductive toxicity in standard risk assessments.
Inhalation: Dust may irritate respiratory tract if in high concentrations, but no systemic toxicity from inhalation typical.
Ecotoxicity: Practically non-toxic to aquatic organisms.
Persistence: Biodegradable in the environment, breaks down over weeks to months.
Bioaccumulation: Not expected due to high solubility and metabolism.
Mobility: Limited mobility expected due to poor water solubility.
Other Effects: Not classified as hazardous to the environment at expected levels of release.
Waste Disposal Methods: Dispose of waste powder or solutions in accordance with local regulations for pharmaceuticals or laboratory chemicals.
Container Disposal: Rinse and recycle or dispose of containers in approved waste facilities.
Special Precautions: Prevent spillage from entering watercourses or municipal sewage.
UN Number: Not classified as hazardous cargo.
UN Proper Shipping Name: Not regulated
Transport Hazard Class: None
Packing Group: Not applicable
Special Provisions: Protect against physical damage and moisture during transit. No transport restrictions for air, sea, or road at standard quantities.
Labeling: No hazard symbol or signal word required for pharmaceutical grade Riboflavin under GHS.
Regulations: Approved as safe food additive and vitamin supplement by FDA (21 CFR 182.8201), listed in European Pharmacopoeia, complies with REACH inventory for chemical substances.
Other Requirements: Meets monograph requirements for compendial identity and purity under USP, BP, JP. No restrictions for import or export under normal intended use.
