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Product Name: Verapamil Hydrochloride
Synonyms: Isoptin HCl, Calan HCl, Verelan HCl
Chemical Formula: C27H38N2O4·HCl
Molecular Weight: 491.08 g/mol
Manufacturer: Refer to packaging or supplier
Product Use: Pharmaceutical ingredient, prescription medication for cardiac issues
Emergency Phone: Refer to regional emergency numbers on label
Recommended Restrictions: For research, laboratory, or prescription use only; not for food or household use
GHS Classification: Acute toxicity (oral, Category 4), Skin sensitization (Category 1)
Label Elements: Hazard symbol (exclamation mark), signal word: Warning
Hazard Statements: May be harmful if swallowed, may cause allergic skin reaction
Precautionary Statements: Avoid breathing dust, wash hands thoroughly after handling, avoid release to environment
Health Effects: Nausea, vomiting, dizziness, hypotension, bradycardia, skin irritation
Environmental Risks: Harmful to aquatic life with long lasting effects
Routes of Exposure: Inhalation, skin, ingestion, accidental eye contact
Chemical: Verapamil Hydrochloride
CAS Number: 152-11-4
Concentration: ≥98% (depending on manufacturer)
Impurities: Levels of related compounds and residual solvents under guideline thresholds
Additives: No additives present in pure substance, excipients present in formulated products
Inhalation: Move person to fresh air immediately, monitor breathing, provide oxygen as needed, seek medical advice if symptoms persist
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with soap and water for at least 15 minutes, seek medical attention with persistent irritation
Eye Contact: Rinse with plenty of water for at least 15 minutes holding eyelids apart, get medical help with irritation
Ingestion: Rinse mouth with water, seek medical attention, do not induce vomiting except on medical advice
Note for Physicians: Treat symptomatically; consider hypotension and arrhythmias
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide (CO2), alcohol-resistant foam
Unsuitable Media: High-pressure water streams may spread powder
Special Hazards: Toxic or irritating fumes of carbon monoxide, carbon dioxide, nitrogen oxides, hydrochloric acid released during combustion
Protective Equipment: Wear self-contained breathing apparatus, full protective gear
Firefighting Advice: Move containers away from fire area if safe; stay upwind of fire
Personal Precautions: Use proper protective equipment, prevent breathing dust, avoid contact with skin and eyes, evacuate area if necessary
Environmental Precautions: Do not discharge into drains, soil, or water bodies
Cleanup Methods: Sweep up spilled material avoiding dust formation, transfer to suitable containers for disposal, ventilate area, clean with water after collection
Disposal: Collect in sealed, labeled containers for appropriate waste disposal as per local regulations
Handling: Handle in a well-ventilated place, avoid generation of dust, use PPE like gloves and goggles, avoid ingestion or inhalation during dispensing or processing
Storage Conditions: Store in tightly closed container, cool and dry place, away from heat, light, and incompatible substances, label storage clearly
Incompatible Materials: Strong oxidizers, strong acids or bases, moisture
Hygiene Practices: Wash thoroughly after handling, do not eat, drink, or smoke around chemicals
Exposure Limits: No established occupational exposure limits, handle as potentially hazardous
Engineering Controls: Use local exhaust ventilation, fume hood in case of powder manipulation
Personal Protection: Nitrile gloves for hands, safety goggles or face shield, laboratory coat or chemical-resistant suit, particulate respirator for dust
Hygiene Measures: Avoid contact with skin, eyes, and clothing, remove contaminated clothing before leaving lab or work area
Monitoring: Periodic environmental and personal exposure monitoring in manufacturing settings
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not available
pH: ~4.0-6.0 (1% aqueous solution)
Melting Point/Range: 145-150°C (decomposition)
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Evaporation Rate: Not available
Flammability: Not known to be flammable under normal conditions
Explosive Properties: Not classified as explosive
Vapor Pressure: Not applicable
Solubility: Freely soluble in water, sparingly soluble in ethanol, insoluble in ether
Partition Coefficient (log Pow): 3.8 (octanol/water, base)
Density: Not determined
Viscosity: Not applicable
Decomposition Temperature: Above 150°C
Molecular Structure: Refer to chemical reference for detailed structure
Chemical Stability: Stable under recommended storage and handling conditions
Reactive Risks: Reacts with strong oxidizers
Conditions to Avoid: Excessive heat, exposure to moisture, prolonged exposure to light
Incompatible Materials: Strong acids, bases, oxidizing agents
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, nitrogen oxides, hydrochloric acid
Polymerization: Does not polymerize under normal conditions
Acute Toxicity: Oral LD50 (rat) ~40 mg/kg
Chronic Effects: Prolonged or repeated exposure may lead to liver, kidney, or cardiovascular issues
Irritation: May cause mild skin or eye irritation
Sensitization: Can induce allergic reactions in sensitive individuals
Mutagenicity: No mutagenic effects reported in standard tests
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Reproductive Toxicity: Animal studies show possible effects on embryo development at high doses
Target Organs: Heart, blood vessels, liver, kidneys
Ecotoxicity: Toxic to aquatic organisms at low concentrations, potential for bioaccumulation
Environmental Fate: Poorly biodegradable, may persist in water and soil
Mobility in Soil: Moderate, depends on soil characteristics
Aquatic Toxicity: LC50 (fish) ~21 mg/L (96h), EC50 (Daphnia) ~12 mg/L (48h)
PBT/vPvB Assessment: Not identified as persistent, bioaccumulative, and toxic or very persistent/very bioaccumulative by available data
Further Information: Avoid uncontrolled release into waterways and drains
Waste Disposal Methods: Treat as hazardous pharmaceutical waste, incinerate in approved facility wherever possible, avoid landfill disposal
Container Disposal: Triple rinse empty containers, puncture and dispose in line with local, state, or national regulations
Environmental Caution: Prevent entry to sewers, surface waters, groundwaters
Regulatory Requirements: Comply with regional, national, and local regulations for disposal of pharmaceutical and chemical waste, and documentation
UN Number: Not regulated for transport by ADR/RID, IMDG, IATA
Proper Shipping Name: Verapamil Hydrochloride
Hazard Class: Not classified as dangerous for transport
Packing Group: Not applicable
Marine Pollutant: Not listed
Special Precautions: Ship in sealed, labeled containers, protect from moisture and direct sunlight
Emergency Response Guide: N/A for non-hazardous in transport settings
US Regulations (TSCA): Not listed, drug substances regulated under FDA
OSHA: Hazardous by definition, refer to Hazard Communication Standard
EU Regulation (REACH): Exempt as active pharmaceutical ingredient
WHMIS (Canada): Prescription Drug Exemption
California Proposition 65: Not listed as causing cancer, birth defects, or other reproductive harm
Other National Inventories: Not required to be listed, subject to drug and health product regulations
Labeling Requirements: Clearly labeled as prescription substance, include handling and hazard warnings on shipping and storage containers
