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Product Name: Vancomycin Base
Chemical Formula: C66H75Cl2N9O24
CAS Number: 1404-93-9
Common Names: Vancomycin, Vancocin
Manufacturer Details: List with contact address and emergency phone numbers
Recommended Use: Antibiotic for bacterial infections; laboratory reagent
Restrictions on Use: For prescription and research, not for food or feed
SDS Date: Include publishing and latest revision dates for tracking updates
Emergency Overview: White to off-white crystalline powder; odorless to slight odor
GHS Classification: Acute Toxicity (Oral, Category 4); Eye Irritation (Category 2A); Skin Sensitization (Category 1)
Signal Word: Warning
Hazard Statements: Harmful if swallowed; causes serious eye irritation; may cause allergic skin reactions
Precautionary Statements: Do not breathe dust; wash hands thoroughly after handling; wear protective gloves/eye protection/face protection
Hazard Symbols: Exclamation mark
Emergency Response Overview: Symptoms of exposure include skin rash, eye redness, gastrointestinal upset
Other Hazards: Prolonged exposure may cause kidney damage or ototoxicity with medical use; dust may trigger asthma or respiratory irritation in sensitive individuals
Chemical Identity: Vancomycin Base
Concentration: >98% pure
Impurities: Trace residual solvents (ethanol, methanol); related antibiotic substances <2%
Formula Weight: 1485.71 g/mol
Synonyms: Vancocin, VM
Molecular Structure: Complex glycopeptide with two chlorine atoms
Inhalation: Move affected person to fresh air immediately; if symptoms like wheezing, coughing, or shortness of breath persist, seek medical attention
Skin Contact: Remove contaminated clothing; rinse skin thoroughly with plenty of water and soap; consult doctor if skin irritation or rash develops
Eye Contact: Rinse opened eye under running water for at least 15 minutes, lifting eyelids, and seek medical help if irritation persists
Ingestion: Do not induce vomiting; rinse mouth with water; call a physician or Poison Control right away
Other Important Advice: Show this SDS to the attending physician; treat symptomatically
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Extinguishing Media: Do not use strong water jets that could spread powder
Specific Hazards: Nonflammable but may decompose and produce toxic fumes, including nitrogen oxides, carbon monoxide, hydrochloric acid, and chlorine gas during fire
Protective Equipment: Firefighters must wear self-contained breathing apparatus and full protective equipment
Special Precautions: Isolate area and remove persons not involved in firefighting; avoid inhalation of decomposition products and dust
Personal Precautions: Ensure adequate ventilation; avoid generating or breathing dust; use gloves, goggles, and an N95 or better dust mask
Environmental Precautions: Prevent further leakage or spillage if safe to do so; prevent entry into sewers, surface water, or ground water
Spill Cleanup Methods: Scoop or sweep up carefully to avoid creating airborne dust; collect in sealable containers for proper disposal; decontaminate area with soap and water solution; dispose of waste as pharmaceutical or chemical waste
Cleaning Tools: Use non-sparking tools; avoid vacuuming unless equipment is explosion-proof and outfitted with proper HEPA filtration
Safe Handling Advice: Work in a well-ventilated area; avoid dust formation and personal contact; keep containers tightly closed; handle using established laboratory safety protocols or workplace guidelines
Hygiene Measures: Wash hands, face, and exposed skin thoroughly after handling; avoid eating, drinking, or smoking in work area
Storage Requirements: Store in original tightly sealed container in a cool, dry, ventilated location away from incompatible materials like strong oxidizers and acids
Storage Conditions: Keep away from sources of moisture and direct sunlight; temperature controlled storage between 2–8°C preferred for stability
Storage Class: Pharmaceutical bulk or research chemicals; keep out of reach of unauthorized personnel
Engineering Controls: Use local exhaust ventilation or chemical fume hood for routine manipulation; handle only in dust-controlled environments; install eyewash stations and safety showers nearby
Occupational Exposure Limits: No specific OEL or TLV published; minimize exposure as for all potentially sensitizing antibiotics
Personal Protective Equipment: Protective disposable gloves (nitrile, latex), laboratory coat or full-length gown, safety goggles or face shield, dust mask or preferably a fitted respirator; closed shoes required
Protective Protocols: Prevent contact with skin, eyes, and clothing; change contaminated clothing promptly
Hygiene Practices: Remove and wash contaminated clothing before reuse; wash exposed areas before eating or drinking
Appearance: White to faint yellow crystalline powder
Odor: Odorless or faint antibiotic odor
pH (1% solution): 2.5–5.0
Melting Point: Decomposes before melting (above 240°C)
Solubility: Readily soluble in water, sparingly soluble in ethanol
Partition Coefficient: Not applicable – large, polar molecule
Vapor Pressure: Negligible at room temperature
Boiling Point: Not available (decomposes)
Flash Point: Not combustible
Density: Approximately 1.6–1.8 g/cm³ (estimated, as powder)
Other Info: Hygroscopic; avoid moisture
Chemical Stability: Stable under recommended conditions of storage and use
Decomposition: Slowly degrades in presence of strong acids or bases; decomposes on heating above 240°C
Conditions to Avoid: Exposure to excessive moisture, exposure to light, and high temperature
Incompatible Materials: Strong oxidizing agents, acids, metal ions
Hazardous Reactions: No known polymerization; typical for glycopeptide antibiotics
Hazardous Decomposition Products: Nitrogen oxides, hydrogen chloride, carbon monoxide and dioxide, other organic fumes
Acute Toxicity: Oral LD50 (rat): >5,000 mg/kg; generally low acute toxicity
Likely Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms of Exposure: Rash, nausea, allergic reaction, eye and respiratory irritation
Chronic Effects: Potential allergic dermatitis or asthma in sensitized workers
Special Risks: Intravenous medical use linked to nephrotoxicity, ototoxicity in therapeutic settings
Carcinogenicity: Not classified as carcinogen by OSHA, IARC, or NTP
Mutagenicity: No mutagenic effects demonstrated in standard tests
Aquatic Toxicity: Harmful to aquatic life at high concentrations; may disrupt microbial balance in waterways
Persistence and Degradability: Poorly biodegradable; relatively stable under normal environmental conditions
Bioaccumulative Potential: Low bioaccumulation potential due to high water solubility and molecular size
Mobility in Soil: High mobility in water; may leach through soil
Other Ecological Warnings: Antibiotic residues can contribute to antibiotic resistance in the environment
Product Disposal: Collect material in sealed containers and dispose of as pharmaceutical waste via licensed chemical disposal contractors
Container Disposal: Triple-rinse and puncture before landfilling or recycling, following local regulations; contaminated packaging considered hazardous
Waste Codes: Handle as hazardous waste per local, state, and national guidelines
Precautions: Do not allow product to reach ground water, drains, or sewage systems
UN Number: Not regulated for transport under UN, IMDG, IATA, or DOT conventions for most small laboratory or bulk forms
Proper Shipping Name: Not classified as dangerous good
Transport Hazard Class: None assigned
Packing Group: None
Special Precautions: Ensure containers remain sealed and upright during transport; avoid exposure to moisture and mechanical shock; transport with appropriate documentation
TSCA Status: Exempt under TSCA for pharmaceutical use
OSHA: Not specifically regulated
WHMIS Classification: Medical, not subject to strict workplace controls but require hazard awareness
FDA Status: Prescription drug; subject to federal and international schedule controls
REACH Status: Not subject to full registration for research or medical purposes
State Regulations: May be covered by state right-to-know or workplace hazardous material laws
Other Regulations: Proper documentation required for import, export, and disposal; includes annual tracking for bulk stocks
Labeling Requirements: Pharmaceutical container labeling, hazard warnings, and precautionary statements as per regulatory jurisdiction
