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Material Safety Data Sheet (MSDS): Valnemulin Hydrochloride

Identification

Product Name: Valnemulin Hydrochloride
Chemical Formula: C31H53N3O5S.HCl
CAS Number: 33996-33-7
Manufacturer: Contact details provided by supplier
Recommended Use: Veterinary antibiotic for swine
Synonyms: (E)-[2-[(2-amino-1,3-thiazol-4-yl)methylsulfanyl]ethyl](dihydroxy-methylpropyl)methylpropenamide hydrochloride

Hazard Identification

GHS Classification: Eye irritation (Category 2A), Skin irritation (Category 2), Specific target organ toxicity (Category 3)
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation. May cause respiratory irritation. Harmful if swallowed.
Pictograms: Exclamation mark
Precautionary Statements: Avoid breathing dust. Wash hands thoroughly after handling. Use only outdoors or in a well-ventilated area. Wear protective gloves, eye protection, face protection.

Composition / Information on Ingredients

Substance: Valnemulin Hydrochloride
Concentration: >98% active ingredient
Impurities: Minor process contaminants <2% (specifics from manufacturer)
Molecular Weight: 599.28 g/mol

First Aid Measures

Inhalation: Move individual to fresh air. Seek medical attention if symptoms develop. Keep at rest.
Skin Contact: Remove contaminated clothing immediately. Wash affected area with plenty of water and mild soap. If irritation persists, contact physician.
Eye Contact: Rinse cautiously with water for several minutes. Remove contact lenses if present and easy to do. Continue rinsing. Obtain medical aid.
Ingestion: Rinse mouth with water if conscious. Do not induce vomiting. Seek prompt medical advice.

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam.
Specific Hazards: Thermal decomposition may form toxic fumes: carbon monoxide, nitrogen oxides, sulfur oxides, hydrogen chloride gas.
Advice for Firefighters: Wear self-contained breathing apparatus and protective gear. Prevent runoff from entering drains.
Protective Actions: Cool exposed containers with water spray. Remove personnel to safe area.

Accidental Release Measures

Personal Precautions: Avoid dust generation. Ventilate area. Wear protective equipment: gloves, mask, goggles.
Environmental Precautions: Prevent entry into drains, waterways, or soil.
Containment and Cleanup: Sweep up without generating dust. Collect in a properly labelled container. Wipe residue with damp cloth. Dispose of in accordance with regulations.

Handling and Storage

Safe Handling: Avoid contact with skin, eyes, and clothing. Do not breathe dust or powder. Wash thoroughly after use.
Storage Conditions: Store in cool, dry, well-ventilated area in tightly closed original container. Keep away from heat sources and incompatible materials.
Incompatibilities: Avoid oxidizers, strong acids and bases. Protect from moisture.

Exposure Controls and Personal Protection

Engineering Controls: Use local exhaust ventilation in processing areas. Eye wash and safety shower available.
Personal Protective Equipment (PPE): Protective gloves (nitrile recommended), chemical splash goggles, long-sleeved lab coat, dust mask or respirator (approved for nuisance dust).
Work Hygiene: No eating, drinking, or smoking while handling. Wash hands and exposed skin before breaks and after work.

Physical and Chemical Properties

Appearance: White to off-white crystalline powder
Odor: Slight pharmaceutical odor
Odor Threshold: Not determined
pH (1% Solution): 3.0-6.0
Melting Point: 135-145°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not applicable
Solubility: Soluble in water
Vapor Pressure: Not available
Partition Coefficient: Not available
Stability: Stable under recommended storage
Density: Not established

Stability and Reactivity

Chemical Stability: Stable under standard temperature and pressure.
Conditions to Avoid: Moisture, high temperatures, open flames, incompatible materials.
Incompatible Materials: Strong oxidizers, strong acids or bases.
Hazardous Decomposition Products: Carbon dioxide, carbon monoxide, nitrogen oxides, sulfur oxides, hydrogen chloride.
Possibility of Hazardous Reactions: No hazardous polymerization reported.

Toxicological Information

Acute Toxicity: Oral LD50 (rat): >2,000 mg/kg, not acutely toxic.
Skin Corrosion/Irritation: Mild skin irritant, may cause redness on contact.
Serious Eye Damage/Irritation: May provoke irritation and watering.
Respiratory Sensitization: Dust may cause mild respiratory irritation.
Germ Cell Mutagenicity: No evidence found in standard tests.
Carcinogenicity: Not listed as a carcinogen.
Reproductive Toxicity: No reproductive effects seen at low exposure.
Chronic Effects: Repeated exposure may cause minor skin and respiratory irritation.

Ecological Information

Ecotoxicity: Harmful to aquatic life with long lasting effects. Limited data on long-term environmental impact.
Persistence and Degradability: Not readily biodegradable in the environment.
Bioaccumulative Potential: Low based on structure and water solubility.
Mobility in Soil: Mobile, risk of leaching to groundwater if released in bulk.
Other Adverse Effects: Large spills may impact microbial populations in wastewater treatment.
Avoid discharge to surface waters or sewers unless properly treated.

Disposal Considerations

Waste Treatment: Dispose of contents and container in accordance with national and local regulations.
Incineration: Incinerate in approved facility if permitted.
Alternative Disposal: Landfill in compliance with environmental authorities.
Contaminated Packaging: Dispose of in the same manner as product. Decontaminate if possible.
Avoid unregulated release to environment.

Transport Information

UN Number: Not classified as hazardous for transport.
Proper Shipping Name: Not regulated unless transported with other hazardous materials.
Transport Hazard Class: Not applicable
Packing Group: Not classified
Special Precautions: Protect from moisture and direct sunlight during transit.
Follow all local and international transport regulations.

Regulatory Information

TSCA: Not listed
EINECS: Not listed
REACH Registration: Check supplier for status
OSHA: Not specifically regulated
SARA Title III: Not listed
Other Local Regulations: Handle as pharmaceutical bulk chemical; observe specific national rules for veterinary drugs.
Worker Protection: Follow all national special substance regulations for health and environmental protection, including packaging and labelling rules relevant to the workplace.