© 2026 Sinochem Nanjing Corporation,
All Right Reserved
Substance Name: Tylosin Base
Chemical Family: Macrolide antibiotic
Recommended Uses: Used in veterinary medicine to treat respiratory and gastrointestinal infections in livestock
Form: Off-white or yellowish powder, often with a mild characteristic odor
Solubility: Sparingly soluble in water, readily soluble in alcohol and methanol
Health Risks: Prolonged or repeated contact may lead to skin irritation or allergic reactions, especially with sensitive individuals; dust inhalation can cause respiratory irritation
Primary Exposure Routes: Inhalation, skin contact, eye contact
Acute Effects: Sneezing, coughing, skin rash, eye irritation
Long-Term Effects: May develop sensitivity with routine handling; some reports suggest antibiotics like tylosin may contribute to resistant bacterial strains if handled carelessly
Environmental Concerns: Potent antibiotic, even minute residues often impact aquatic environments, so accidental spills outside proper facilities raise red flags
Active Ingredient: Tylosin Base (major constituent, typically >80%)
Impurities: Trace residues of fermentation by-products; non-active fillers may accompany commercial formulations
Physical Appearance: Fine, light-appearing powder, often clings to surfaces and clothing
Inhalation: Move to fresh air, breathe normally; if symptoms persist, seek medical help
Skin Contact: Wash with mild soap and plenty of water; persistent rash or irritation requires a doctor’s attention
Eye Contact: Rinse repeatedly with clean water; protect uninjured eye; get medical care for ongoing redness or discomfort
Ingestion: Avoid inducing vomiting; rinse mouth, get professional help if unwell or after swallowing large amounts
Precaution: Allergy-prone individuals, including those with a penicillin history, should keep away from dust and direct contact
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide; water spray only around periphery to avoid dust clouds
Hazards: Powder may form combustive dust-air mixtures in confined spaces; avoid open flames and sparks
Protection: Firefighters need full protective gear and breathing apparatus, as burning generates irritating fumes
Storage Cautions: Keep large stocks away from ignition sources; clean up any spilled powder promptly
Spill Handling: Avoid dry sweeping, dampen spilled powder with water or use HEPA vacuum; ventilate area well
Protective Equipment: Gloves, dust masks, protective goggles vital for cleaning crews
Disposal: Gathered material must go in sealed containers marked as antibiotic waste; keep out of drains
Avoid: Any means that generate airborne dust; inform facility management after larger spills
Handling: Wear gloves and eye protection before opening containers; never eat or drink in work areas
Ventilation: Use in well-ventilated locations; local exhaust systems cut down inhalable dust
Hygiene: Wash hands religiously after each session; change work clothes to avoid bringing residues home
Storage: Keep in dry, cool, labeled containers; lock storerooms to prevent unauthorized access; avoid sunlight
Segregation: Store separately from food, animal feed, acids, oxidizing agents; keep containers closed
Engineering Controls: Laboratories and mixing rooms need effective air extraction; scales and mixers covered or enclosed
Personal Protective Equipment (PPE): Lab workers and handlers use disposable gloves, certified dust masks, and safety goggles every time
Exposure Limits: No official government exposure limit exists, but following pharmaceutical dust control standards proves wise
Workplace Practices: Change gloves after each shift; never reuse contaminated ones; launder overalls separately from regular laundry
Appearance: Light yellow or beige powder, sometimes clumps if damp
Odor: Distinct musty or earthy smell reminiscent of similar antibiotics
Melting Point: Over 150°C; thermal decomposition before melting
Solubility: Low in cold water; dissolves better in ethanol and other common lab solvents
Stability: Stable under normal temperatures; breaks down at high moisture and heat
Chemical Stability: Strong in cool, dry storage; hydrolyzes slowly if exposed to humidity
Hazardous Reactions: Flares up with strong oxidizers; keep away from acids or bases that might alter structure
Breakdown Products: Heat or strong light over time creates irritating smoke, hazardous in unventilated spaces
Hazardous Polymerization: Not expected under normal conditions
Acute Toxicity: Large doses make lab animals sick, mostly due to gut effects; no evidence of carcinogenicity in humans
Allergic Reactions: Skin contact often causes rash or dermatitis in sensitive handlers
Respiratory Effects: Breathing dust causes sore throat, skin, or eye irritation; not known for major systemic poisoning through skin
Chronic Effects: Continual exposure raises risk of antibiotic resistance bacteria on the skin and in the living environment
Aquatic Toxicity: Sensitive to life in ponds and streams; even trace runoff harms beneficial bacteria and plankton
Persistence: Stays undegraded in soil, builds up in farm run-off sites, especially around dosing points
Bioaccumulation: Veterinary antibiotics may concentrate in organisms at the bottom of the food chain over time
Mobility: Easily moves through loose soils, especially if spilled outside animal facilities
Waste Disposal: Unused powder, expired stocks, and contaminated packaging head to licensed hazardous waste contractors
Incineration: Burn waste in high-temperature incinerators to destroy antibiotic residues
Avoid: Spreading dust near water sources, landfills not licensed for pharmaceuticals
Personal Responsibility: Everyone handling tylosin must enforce strict containment right through the disposal chain
Shipping Description: Non-bulk, solid powder; container integrity and labeling trump all during transit
Packing: Triple packaging often for long distances; outer drums lock out moisture
Regulatory Guidance: Carriers usually check for “pharmaceutical product” stickers and documentation
Precautions: Never combine with food, beverages, or incompatible chemicals on the same pallet or transport crate
Veterinary Oversight: Tylosin belongs under veterinary prescription in most countries; tight controls on farm and commercial use
Environmental Restrictions: Discharge of residues into water or fields often banned; proper record-keeping required
Worker Safety: Laws stipulate personal protective gear and training for handlers
Food Safety: Withdrawal periods for animals treated with tylosin enforced to keep residues out of consumer meat and milk
Continuous Oversight: Regular inspections demanded by agriculture and health authorities to track handling, storage, and disposal
