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Product Name: Trimethyl Orthoacetate
Synonyms: Methyl orthoacetate
Chemical Formula: C5H12O3
CAS Number: 1445-45-0
Recommended Use: Industrial chemical, synthesis of pharmaceuticals and fine chemicals
Manufacturer: Refer to supplier or importer records for sourcing details
Contact Information: Emergency telephone and physical address provided at purchase
GHS Classification: Flammable liquids (Category 2), Acute Toxicity (Category 4), Eye Irritation (Category 2A)
Label Elements: Flame, Exclamation Mark
Signal Word: Danger
Hazard Statements: Highly flammable liquid and vapor, Harmful if inhaled or swallowed, Causes serious eye irritation
Precautionary Statements: Keep away from heat, sparks, open flames, and hot surfaces. Wear protective gloves and eye protection. Wash hands thoroughly after handling. Use explosion-proof electrical and ventilation equipment.
Other Dangers: Vapor may cause drowsiness and dizziness; can form explosive mixtures with air.
Chemical Name: Trimethyl Orthoacetate
Chemical Formula: C5H12O3
Concentration: ≥ 98% by weight
Impurities: Trace amounts of methanol and acetic acid may be present
Additives: No stabilizers or additives included in commercial product
Inhalation: Move to fresh air, rest in a position comfortable for breathing; get medical attention if symptoms persist.
Skin Contact: Remove contaminated clothing immediately, rinse affected area thoroughly with water; seek medical care for irritation or persistent discomfort.
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do; continue rinsing, seek urgent medical attention for irritation.
Ingestion: Rinse mouth with water, do not induce vomiting, consult a doctor or poison center immediately.
Most Important Symptoms: Burning in eyes or throat, coughing, headache, nausea, dizziness
Notes to Physician: Provide symptomatic treatment, monitor respiratory function and treat as per specific clinical symptoms.
Suitable Extinguishing Media: Alcohol-resistant foam, carbon dioxide, dry chemical, water spray in large quantities
Unsuitable Media: Direct water jet, as risk of spreading fire may rise
Special Hazards: Vapors may travel long distances and ignite at remote sources, container rupture possible under fire conditions
Protective Equipment for Firefighters: Full protective clothing and self-contained breathing apparatus recommended
Advice for Firefighters: Cool exposed drums or tanks with water spray, keep upwind to avoid hazardous vapors, prevent runoff from entering waterways
Personal Precautions: Evacuate personnel to safe areas, remove all sources of ignition, wear chemical-resistant gloves, goggles, and suitable respirator
Environmental Precautions: Prevent leaks from entering sewers, drains, soil, or waterways; notify authorities if large quantities spill
Methods for Containment: Stop source of leakage safely, contain with inert absorbent materials like vermiculite or sand
Cleanup Procedures: Collect waste in properly labeled, closed containers for disposal, ventilate area, rinse spill site post-cleanup
Handling: Use only in well-ventilated areas, avoid inhalation or contact with skin and eyes, do not eat, drink, or smoke while using product, ground and bond containers during transfer
Storage: Store in tightly sealed, clearly labeled containers, keep in a cool, dry, well-ventilated space away from direct sunlight and sources of ignition
Storage Incompatibilities: Keep separate from oxidizing agents, acids, and water; methanol released on hydrolysis
Specific Storage Design: Use explosion-proof electrical fixtures, avoid static accumulation, maintain temperature below 25°C for maximum shelf life
Exposure Limits: Occupational exposure limit not established for Trimethyl Orthoacetate, refer to general guidance for organic vapors and methanol
Engineering Controls: Local exhaust ventilation or fume hood, explosion-proof ventilation system, maintain good industrial hygiene
Personal Protective Equipment: Chemical-resistant nitrile gloves, splash-proof safety goggles, flame-resistant lab coat, approved respiratory protection for high vapor concentrations
Environmental Exposure Controls: Handle with care to prevent leaks, use containment dikes for storage tanks
Physical State: Colorless liquid
Odor: Characteristic, sharp ether-like
pH: Not applicable
Boiling Point: 106-108°C
Melting Point: -64°C
Flash Point: 15°C (closed cup method)
Evaporation Rate: Fast
Vapor Pressure: 40 mmHg at 25°C
Solubility: Decomposes in water, miscible with most organic solvents
Specific Gravity: 0.99 g/cm³ at 20°C
Viscosity: Low
Partition Coefficient (log Kow): No data available
Auto-Ignition Temperature: 370°C
Chemical Stability: Stable under inert, dry atmospheres; decomposes on exposure to water, moisture or acids
Reactivity: Reacts with water or moisture to produce methanol and acetic acid; can form flammable mixtures
Conditions to Avoid: Heat, flames, sparks, moisture, incompatible chemicals
Incompatible Materials: Acids, alkalis, oxidizing agents, water, strong bases
Hazardous Decomposition Products: Methanol vapors, acetic acid, carbon monoxide, carbon dioxide; thermal decomposition increases risk
Acute Toxicity: Harmful by inhalation, ingestion, or skin absorption; causes respiratory irritation, central nervous system depression
Chronic Effects: Frequent or prolonged exposure may damage liver, kidney; chronic respiratory symptoms can develop after repeated vapor inhalation
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Symptoms: Dizziness, nausea, vomiting, headache, drowsiness, irritation, blurred vision from methanol exposure
Carcinogenicity: Not classified as carcinogenic
Reproductive Toxicity: Not established, but methanol byproduct is classified for developmental toxicity
Aquatic Toxicity: Not expected to be highly toxic to aquatic life, but methanol byproduct hazardous to fish and invertebrates
Persistence and Degradability: Readily hydrolyzes to biodegradable products, persistence in moist environments short
Bioaccumulation Potential: Low likelihood based on solubility and volatility
Mobility in Soil: Rapid migration possible in presence of water due to decomposition
Other Environmental Hazards: Large spills can disrupt aquatic environments, release of methanol into sewers or surface waters can lead to oxygen depletion; avoid uncontrolled releases
Waste Treatment Methods: Collect liquid and contaminated materials in suitable, labeled chemical waste containers; incineration preferred under controlled conditions
Disposal of Product: Follow local, regional, and national hazardous waste regulations, consult approved waste disposal contractors
Contaminated Packaging: Triple-rinse before recycling or disposal; puncture and dispose of in compliance with local ordinances
Precautions: Do not discharge to surface water, sewers or soil; never attempt to neutralize spills with acids or bases, as violent reaction may occur
UN Number: UN 3272
Proper Shipping Name: Esters, n.o.s. (contains Trimethyl Orthoacetate)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: II
Labels Required: Flammable liquid symbol
Special Transport Precautions: Securely seal all containers, keep upright, avoid heat and direct sunlight during transit
Marine Pollutant: No data suggests significant marine toxicity but avoid waterway release
TSCA Inventory Status: Listed
REACH Registration: May be subject to registration or notification in Europe
OSHA Classification: Hazardous chemical under OSHA Hazard Communication Standard
SARA Title III: Methanol byproduct is a listed hazardous substance; reportable quantity applicable after decomposition
WHMIS (Canada): Class B2 (Flammable Liquid)
Other Regulations: Complies with major international and national chemical safety, labeling, and transportation regulations; consult local authorities for additional requirements
