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Product Name: Trimethoprim Lactate
Chemical Family: Dihydrofolate Reductase Inhibitor
CAS Number: 23256-42-0
Trade Names: Antibacterial agent, used in combination with sulfonamides
Intended Use: Pharmaceutical raw material for bacterial infections
Supplier Information: Manufacturer or distributor contact noted on shipping documentation
Emergency Contact Number: Always access via local regulatory requirements
Classification: Eye and skin irritant; harmful if swallowed, inhaled, or absorbed through skin
Label Elements: Warning, Toxic; signal word noted on packaging
Hazard Statements: May cause allergic skin reaction, eye and respiratory irritation, reproductive toxicity suspected in laboratory animals
Precautionary Statements: Avoid breathing dust; wash skin thoroughly after handling; use only outdoors or in well-ventilated areas; wear protective gloves, protective clothing, and eye protection
Exposure Symptoms: Skin rash, eye watering, sneezing, breathing difficulty upon prolonged exposure
Other Hazards: Not classified as flammable, but fine dust may present explosion hazard in air
Chemical Identity: Trimethoprim Lactate
CAS Number: 23256-42-0
Concentration: Pure (greater than 98%)
Molecular Formula: C14H18N4O3.C3H6O3
Impurities: Trace process impurities; none known to increase hazard
Other Components: No hazardous solvents, fillers, or dyes present
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing; seek medical advice if irritation persists
Skin Contact: Immediately wash with soap and plenty of water for at least 15 minutes, remove contaminated clothing, seek medical attention for ongoing irritation
Inhalation: Move to fresh air promptly, keep at rest in a position comfortable for breathing, obtain medical help if breathing difficulties or allergic symptoms occur
Ingestion: Rinse mouth with water if conscious, never give liquids to unconscious person, seek urgent medical advice, do not induce vomiting unless directed by medical personnel
Suitable Extinguishing Media: Dry chemical powder, CO2, water spray, or foam
Unsuitable Media: Direct water jet may spread powder
Hazardous Products of Combustion: Nitrogen oxides, carbon oxides, possible toxic fumes
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Other Precautions: Remove containers from fire area if safe; cool unopened containers exposed to heat with water spray
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid dust formation, wear protective clothing, gloves, goggles, and NIOSH-approved mask
Environmental Precautions: Prevent further leakage or spillage, do not allow material to enter drains, soil, or natural waterways
Methods for Containment: Sweep without creating dust, collect in suitable containers for disposal, clean contaminated area thoroughly
Other Measures: Wash hands and remove protective equipment before leaving area after cleanup completed
Handling: Avoid ingestion, inhalation, and contact with skin and eyes, use only in well-ventilated location, handle with care to prevent spills, wash thoroughly after handling
Storage: Store in original container tightly closed, in cool, dry, and well-ventilated area away from moisture and incompatible substances, keep out of reach of children
Other Advice: Do not eat, drink, or smoke in work area; keep storage temperature room temp or lower for product integrity
Occupational Exposure Limits: None assigned specifically for this compound; use recommended good laboratory practices
Engineering Controls: Fume hood or effective general ventilation required
Respiratory Protection: Respirator mask for powder handling, NIOSH-approved for particulates
Eye Protection: Chemical safety goggles or safety glasses with side shields
Skin Protection: Gloves tested for chemical resistance, lab coat, clothing that covers exposed skin
Environmental Control: Avoid aerosol and dust formation, filter exhaust air to avoid release, regular monitoring advised
Appearance: Off-white to light yellow powder
Odor: Odorless
pH: Neutral to slightly acidic (aqueous solution)
Melting Point/Freezing Point: 199-208°C (decomposition)
Boiling Point: Not available; decomposes before boiling
Solubility: Soluble in water, ethanol; slightly soluble in organic solvents
Specific Gravity: Not determined
Vapor Pressure: Negligible
Partition Coefficient (log Pow): Not available
Viscosity: Not applicable
Explosive Properties: Dust may present explosion risk if dispersed in air
Molecular Weight: 378.4 g/mol (approximate)
Chemical Stability: Stable under recommended storage conditions
Conditions to Avoid: High temperatures, exposure to moisture, strong oxidizing agents
Incompatible Materials: Strong acids, strong bases, oxidizers
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides under fire or extreme heat
Polymerization: Does not occur under normal use
Acute Toxicity: Laboratory animal studies indicate moderate oral and dermal toxicity
Chronic Effects: Possible effects include blood disorders, allergic skin reactions, reproductive effects in test systems
Routes of Exposure: Inhalation, skin absorption, ingestion, contact with eyes
Symptoms of Exposure: Skin sensitization, rash, respiratory irritation, nausea, headache
Carcinogenicity: Not classified as carcinogen by IARC, NTP, ACGIH, or OSHA
Mutagenicity: No clear evidence; reproduce toxicity observed in some non-clinical studies
Other Data: Use care to control cumulative low-level exposures
Ecotoxicity: Harmful to aquatic organisms; may cause long-term adverse effects in aquatic environments
Persistence and Degradability: Substance may persist in natural environments, limited biodegradability
Bioaccumulative Potential: Expected to have some potential for accumulation in aquatic organisms
Mobility in Soil: Moderately mobile; can leach into groundwater if released in large amounts
Other Adverse Effects: Avoid release to environment; effective wastewater treatment reduces environmental risk
Waste Treatment Methods: Collect and place in approved labeled waste container, treat as hazardous waste
Disposal of Product: Dispose in accordance with local/regional/national regulations using licensed waste contractor
Disposal of Contaminated Packaging: Triple rinse containers before disposal, place in controlled waste stream
Other Cautions: Avoid contamination of sewage, waterways, and soil; incineration under controlled conditions preferred
UN Number: Not regulated for transport in most jurisdictions
Proper Shipping Name: Not classified as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not required
Environmental Hazards: Not a marine pollutant under standard classification
Special Precautions: Use secondary packaging to prevent dust escape during transport; label containers properly
Inventory Status: Confirm on regional databases, such as TSCA in the US, REACH in EU
SARA Title III: Not subject to reporting requirements under Sections 302, 304, 313
OSHA: Not regulated as hazardous chemical, but handle with standard safety policies for pharmaceuticals
IARC/NTP/OSHA Carcinogen List: Not listed
Other Regulations: Use consistent with pharmaceutical manufacturing and laboratory safety standards
Labeling Requirements: Use appropriate hazard pictograms and warning statements per GHS or local law
