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Product Name: Trilostane
Chemical Name: 4α,5-Epoxy-17β-hydroxy-3-oxoandrostan-2-yl cyanide
Synonyms: Modrenal, Vetoryl
CAS Number: 13647-35-3
Recommended Use: Veterinary medicine, Cushing’s syndrome agent
Supplier Information: Pharmaceutical provider or licensed distributor
Emergency Contact: National poison center or facility safety officer
GHS Classification: Acute Toxicity (Oral Category 3), Reproductive toxicity (Category 2), Specific target organ toxicity - repeated exposure (Category 2)
Signal Word: Danger
Hazard Statements: Toxic if swallowed; suspected of damaging fertility or the unborn child; may cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, health hazard
Precautionary Statements: Avoid breathing dust; wash hands thoroughly after handling; do not eat or drink when using; use only outdoors or in a well-ventilated area; wear protective gloves/protective clothing/eye protection
Chemical Component: Trilostane
Purity: ≥98%
Impurities: Proprietary minimal levels (pharmaceutical grade)
Molecular Formula: C20H27NO3
Molecular Weight: 329.43 g/mol
Inhalation: Remove to fresh air immediately, keep victim at rest, administer oxygen if breathing becomes difficult, seek medical attention without delay
Skin Contact: Remove contaminated clothing, wash thoroughly with soap and water, seek medical attention if irritation occurs or persists
Eye Contact: Rinse cautiously with water for at least 15 minutes while holding eyelids open, remove contact lenses if present and easy to do, seek medical advice
Ingestion: Rinse mouth with water, do not induce vomiting, call poison control center or physician immediately
Suitable Extinguishing Media: Dry chemical, carbon dioxide, water spray, foam
Unsuitable Media: Direct water jet on burning bulk material
Specific Hazards: Emits toxic fumes of carbon monoxide, nitrogen oxides, and unidentified organic compounds in fire
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Firefighting Instructions: Move containers from fire area if safe; cool surrounding containers with water spray; avoid inhalation of combustion products
Personal Precautions: Use personal protective equipment including gloves, safety glasses, and dust respirator; evacuate area if necessary
Spill Cleanup: Do not touch or walk through spilled material, ventilate area, avoid dust formation, scoop or shovel loose material into labeled waste container for disposal
Environmental Precautions: Prevent entry into sewers, drains, soil, or waterways; inform environmental authorities
Decontamination: Clean area with water and detergent, ventilate the area
Safe Handling: Handle in a chemical fume hood, minimize dust and powder formation, avoid exposure to skin, eyes, and respiratory tract, wash hands after handling
Storage Conditions: Store in tightly closed original container, in a cool, dry, and well-ventilated place, away from direct sunlight and incompatible substances (alkalis, oxidizers)
Incompatibility: Strong oxidizers, strong acids, alkalis
Special Precautions: Use dedicated equipment for handling; label clearly
Occupational Exposure Limits: No specific OSHA or ACGIH limit; treat as hazardous
Engineering Controls: Process enclosure, local exhaust ventilation, and mechanical ventilation as required
Personal Protective Equipment: Chemical-resistant gloves, lab coat, safety goggles, and approved dust respirator
Hygiene Measures: Avoid ingestion, inhalation, and skin contact; wash thoroughly after handling and before eating or drinking
Appearance: White crystalline powder
Odor: Odorless
pH: Not applicable (insoluble in water)
Melting Point: 261-263°C
Boiling Point: Decomposes before boiling
Solubility: Sparingly soluble in water, soluble in methanol and ethanol
Vapor Pressure: Not determined
Density: 1.24 g/cm³
Flash Point: Not determined
Stability in Storage: Stable under recommended storage conditions
Reactivity: Stable under normal conditions
Chemical Stability: Stable if kept away from incompatible materials
Hazardous Reactions: None expected under recommended conditions
Incompatible Materials: Strong acids, oxidizing agents, strong bases
Decomposition Products: Releases carbon monoxide, carbon dioxide, nitrogen oxides under extreme heat or fire
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: LD50 (oral, rat): 212 mg/kg; may be fatal if swallowed
Chronic Toxicity: Possible reproductive and developmental effects based on animal studies; long-term organ effects documented
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA
Other Effects: May cause skin or eye irritation, headache, nausea, fatigue, hormonal disruption
Ecotoxicity: Toxic to aquatic organisms; may cause long-term adverse effects in the aquatic environment
Persistence and Degradability: Limited biodegradability; potential for bioaccumulation
Mobility in Soil: Low mobility, binds strongly to organic matter
Other Adverse Effects: Potential for environmental harm if released in high quantities; avoid unintentional release
Disposal Methods: Dispose through licensed chemical waste contractor, incineration recommended
Unused Product: Must not be disposed into the environment, sewer, or household waste
Contaminated Packaging: Dispose of as hazardous waste in accordance with local, regional, and national regulations
Additional Information: Consult local environmental authorities for detailed guidance
UN Number: Not assigned
Proper Shipping Name: Trilostane
Transport Hazard Class: Not regulated for ground, air, or sea transport in small quantities, but treat as toxic material under spill or emergency conditions
Packing Group: Not assigned
Special Precautions: Secure packaging, accurate labeling, complete documentation
U.S. TSCA Status: Registered or exempt
Hazard Symbol: T (Toxic)
EU Regulation: Classification and labelling per Regulation (EC) No. 1272/2008 (CLP/GHS)
Other Regulatory Info: Listed in relevant inventories (EINECS, DSL, etc.); controlled substance for medicinal use; subject to veterinary prescription only
Labelling Requirements: Hazard warnings, manufacturer details, handling, and disposal instructions
