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Product Name: Trifluralin
Chemical Name: 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)aniline
CAS Number: 1582-09-8
Recommended Use: Selective pre-emergence herbicide for weed control in agriculture
Supplier Details: Various agrochemical manufacturers and importers
Emergency Contact Number: Local poison control center or chemical incident line
Synonyms: Treflan, Gowan Trifluralin, Trific, Agriflan, Trilin, Trifurex
Form: Liquid, granule, or coated granule, depending on manufacturer
UN Number: 3077 (Environmentally hazardous substance, solid, n.o.s.)
Classification: Hazardous according to GHS and US OSHA
Label Elements: Pictogram (Exclamation mark, Health hazard, Environment)
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation; Harmful if swallowed; Suspected of causing cancer; Very toxic to aquatic life with long lasting effects
Precautionary Statements: Avoid contact with skin, eyes, clothing; Do not breathe dust or vapors; Wash skin thoroughly after handling; Use personal protective equipment as required; Avoid release to environment
Routes of Exposure: Inhalation, dermal absorption, ingestion, eye contact
Acute Health Hazards: Irritation of eyes, skin, respiratory tract
Chronic Health Hazards: Potential carcinogenicity with prolonged or repeated exposure
Environmental Hazards: Highly toxic to fish and aquatic invertebrates; may persist in water, sediments, and soil
Active Ingredient: Trifluralin 85%–98% by weight
Other Ingredients: Inert carriers, surfactants, solvents (varies by product)
Impurities of Concern: Dinitroaniline derivatives (trace)
Formulating Solvent: Aromatic hydrocarbons or light paraffinic oils, when present
Known Sensitizers: Not identified under typical use concentrations
Common Additives: Emulsifiers, anti-caking agents, dispersants (typically non-hazardous at applied concentrations)
If in Eyes: Rinse cautiously with water for 15 minutes, lifting eyelids. Remove contact lenses if present. Seek medical attention if irritation occurs or persists.
If on Skin: Remove contaminated clothing. Wash thoroughly with soap and water. Get medical attention if irritation develops or symptoms persist.
If Inhaled: Move person to fresh air, keep at rest in a comfortable position. Get medical attention for persistent symptoms such as coughing, shortness of breath, or dizziness.
If Swallowed: Rinse mouth. Never give anything by mouth to an unconscious person. Do not induce vomiting unless directed by a health professional. Seek immediate medical attention.
Advice to Physicians: Provide symptomatic and supportive treatment. Monitor for delayed effects. Product contains hydrocarbons and nitroanilines with potential for methemoglobinemia.
Protection of First Responders: Use protective gloves, goggles, mask or respirator if needed, and avoid direct contact
Suitable Extinguishing Media: Foam, dry chemical, carbon dioxide, water spray (avoid direct stream on burning product).
Unsuitable Extinguishing Media: High-pressure water jet, which may spread contamination.
Specific Hazards: Burning releases toxic fumes including nitrogen oxides, hydrogen fluoride, carbon oxides, and haloacetic compounds.
Protective Equipment: Full bunker gear and self-contained breathing apparatus needed for fire in area containing trifluralin.
Special Procedures: Evacuate area; use water spray to cool containers. Prevent contaminated runoff from entering drains or watercourses.
Explosion Hazard: Product is not classified as explosive; sealed container rupture may occur under fire conditions
Hazardous Combustion Products: Nitrogen dioxide, carbon monoxide, hydrogen fluoride, fluoride gases
Additional Information: Keep people away from upwind. Fight fire from safe distance
Personal Precautions: Use suitable protective equipment, including gloves, goggles, coveralls, and respiratory protection if dust or vapor present.
Environmental Precautions: Prevent spillage from entering drains, surface waters, or soil. Notify authorities in case of large spill or entry to waterways.
Cleanup Methods: Cover spilled material with absorbent (earth, sand, vermiculite), collect into suitable container for disposal. Decontaminate spill site with detergent and water. Dispose of residues in accordance with local regulations.
Methods for Containment: Stop leak if safe to do so; dike area to prevent spreading
Decontamination: Wash tools and equipment after cleanup to remove residues. Avoid contamination of water sources or soil by rinsate.
Special Instructions: Do not touch or walk through spilled material. Avoid raising dust or creating aerosols.
Reference to Other Sections: See sections on personal protection and disposal
Precautions for Safe Handling: Wear appropriate personal protective equipment, avoid breathing dust/fumes, and avoid contact with eyes, skin, or clothing.
Conditions for Safe Storage: Store in tightly closed original container, in a cool, dry, well-ventilated area, away from direct sunlight and food/animal feedstuffs.
Incompatible Materials: Strong acids, strong oxidizing agents, alkalies; avoid prolonged contact with metals.
Storage Temperature: Between 0°C and 40°C; protect from freezing.
Packing Materials: Use approved chemical-resistant containers only.
Additional Advice: Keep away from children, unauthorized persons, pets. Avoid storage near heat sources, open flames, or in areas susceptible to flooding. Regularly check containers for leaks or damage.
Hygiene Practices: Wash hands and face with soap and water before eating, drinking, smoking, or using toilet. Clean up any small spills immediately.
Control Parameters – OELs: ACGIH TLV: Not established for trifluralin; general nuisance dust PEL: 10 mg/m3 for particulates.
Engineering Controls: Use adequate local exhaust and general ventilation to keep airborne concentrations below recommended exposure limits, especially during mixing/loading.
Personal Protective Equipment: Chemical resistant gloves (nitrile, neoprene), long-sleeved shirts, pants, waterproof boots, chemical splash goggles, face shield if risk of splash.
Respiratory Protection: NIOSH-approved respirator if risk of inhaling dust, mist, or vapor above recommended levels.
Environmental Controls: Use measures to prevent runoff or leaching into ground or waterways.
Recommended Monitoring: Routine workplace air monitoring during large-scale or repeated exposures
Special Instructions: Do not eat, drink, or smoke during handling. Wash thoroughly after use. Launder contaminated clothing before reuse.
Appearance: Orange-yellow crystalline solid, free-flowing granule, or yellow liquid emulsion (formulation-dependent)
Odor: Mild aromatic
Odor Threshold: Not established
pH: 5 - 7 (1% aqueous suspension)
Melting Point: 48°C–49°C (pure substance)
Boiling Point: Decomposes before boiling
Flash Point: >107°C (closed cup, for technical material)
Evaporation Rate: Not available
Flammability: Not flammable (solid); lower risk for explosions
Upper/Lower Flammability or Explosion Limits: Data not established
Vapor Pressure: 1.53 x 10-4 mm Hg @ 25°C
Vapor Density: Not available
Relative Density: 1.36 – 1.38 @ 20°C
Solubility: Practically insoluble in water (<0.5 mg/L @ 20°C), highly soluble in organic solvents
Partition Coefficient/octanol-water (Log Kow): 5.3 – 5.5
Auto-ignition Temperature: >400°C
Decomposition Temperature: >180°C
Viscosity: Not applicable for the solid
Other Data: Stable under normal environmental conditions; not volatile at ambient temperatures
Chemical Stability: Stable under normal processing and storage conditions
Reactivity: No hazardous reactions observed in proper use
Hazardous Reactions: Avoid strong acids, strong bases, oxidizing agents. Product may react with light and moisture over time, causing minor breakdown.
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide, hydrogen fluoride, and other hazardous analogs during combustion or thermal breakdown
Conditions to Avoid: Extreme heat, sunlight, contact with oxidizing agents or strong acids
Polymerization: Will not occur
Corrosivity: Non-corrosive to metals under normal conditions
Other Information: Store away from incompatible materials to avoid accidental chemical reaction
Acute Toxicity (Oral): LD50 (rat) >2,000 mg/kg (low acute toxicity)
Acute Toxicity (Dermal): LD50 (rabbit) >2,000 mg/kg
Acute Toxicity (Inhalation): LC50 (rat, 4h) >3 mg/L
Irritation: Mild skin and moderate eye irritation possible in experimental animals
Sensitization: Not a skin sensitizer based on available tests
Chronic Effects: Liver enzyme changes, increased organ weights in animal studies at high and repeated doses; possible thyroid and hepatic effects
Carcinogenicity: IARC: Group 3 (not classifiable as to carcinogenicity for humans); US EPA: Possible human carcinogen (evidence in animal studies)
Mutagenicity: No significant evidence in standard in vitro and in vivo tests
Reproductive/Developmental Effects: No conclusive evidence of teratogenicity or developmental toxicity in animals
Other Health Effects: Inhalation can cause dizziness, nausea, and headache with high exposures
Aquatic Toxicity: Very high toxicity to fish (LC50 < 1 mg/L for several species), daphnia, and algae
Bird Toxicity: Low toxicity to birds (oral LD50 >2,000 mg/kg)
Bee Toxicity: Not highly toxic to bees under field conditions
Persistence and Degradability: Persistent in soil and sediment; slow degradation (soil half-life: 45–140 days, influenced by organic matter content and climate)
Bioaccumulation Potential: High (log Kow 5.3–5.5)
Mobility: Slight mobility in soil; binds strongly to organic matter
Other Data: Potential for groundwater contamination exists in areas with permeable soils and shallow water tables. Environmental monitoring demonstrates persistence in agricultural runoff and water bodies
Waste Generation: Collect all waste material, leftovers, and residues as hazardous waste
Product Disposal: Incinerate at licensed hazardous waste facility; avoid landfilling untreated material
Container Disposal: Triple rinse, puncture, and dispose through authorized hazardous waste contractor. Never reuse empty containers for other purposes.
Special Precautions: Do not discharge waste or rinsate into surface water, storm drains, or sewage systems
Regulatory Considerations: Dispose according to federal, state, and local regulations; product classified as hazardous for disposal
Non-recyclable Packaging: Treat as hazardous waste. Follow specific national requirements for agrochemical disposal.
UN Number: 3077
Proper Shipping Name: Environmentally hazardous substance, solid, n.o.s. (Trifluralin)
Transport Hazard Class: 9 (Miscellaneous dangerous substances and articles)
Packing Group: III
Labels Required: Environmentally hazardous, Miscellaneous
Special Provisions: Avoid exposure to excessive heat, moisture, open flame during transport
Marine Pollutant: Yes (environmentally hazardous)
ADR/RID/IMDG/IATA: Regulations apply; confirm with carrier on packaging and labeling before consignment
Other Advice: Keep containers upright and secure; transport in compliance with all local and international regulations.
US EPA Registration: Registered as a restricted use pesticide; subject to use and reporting controls
OSHA Status: Hazardous chemical under hazard communication standard
SARA Title III: Reportable under Sections 311/312 and 313 (toxic chemical requirements)
TSCA Inventory: Listed
European Union: Approved active substance under Regulation (EC) No 1107/2009 with conditions—subject to national authorization and application limits
REACH Status: Substance of very high concern review; subject to authorization in some member states
FIFRA: Restricted use; commercial applicators must be specially trained and certified
WHMIS Classification (Canada): D2B (Toxic, skin/eye irritant); subject to workplace labeling
Other National and International Regulations: Covered under Rotterdam Convention for prior informed consent; international maritime and air transport restrictions apply
Product Label Requirements: Complete hazard, handling, storage, and emergency response information required on all commercial packaging.
