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Product Name: Triamterene
Chemical Formula: C12H11N7
CAS Number: 396-01-0
Synonyms: Dyrenium, 2,4,7-Triamino-6-phenylpteridine
Intended Use: Pharmaceutical, diuretic agent
Manufacturer: Refer to supplier details on packaging
Emergency Contact: Refer to local, regional, or national emergency numbers
Classification: Harmful if swallowed, irritant to eyes and skin, possible respiratory irritant
Signal Word: Warning
Hazard Statements: May cause skin and eye irritation, possible risk of allergic reactions, toxic if ingested in large amounts
Precautionary Statements: Avoid contact with skin, eyes, and clothing; handle in well-ventilated areas; wash hands after handling
Symptoms of Exposure: Nausea, rash, dizziness, headache, eye redness
Chemical Name: Triamterene
Concentration: ≥98% (active pharmaceutical ingredient)
Impurities: May contain trace amounts of residual solvents or synthesis intermediates depending on the manufacturer
Other Ingredients: None noted for pure Triamterene powder
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, continue rinsing and seek medical attention
Skin Contact: Wash off immediately with plenty of soap and water, remove contaminated clothing, seek medical advice if irritation develops or persists
Inhalation: Remove person to fresh air, keep at rest, get medical attention if symptoms occur
Ingestion: Rinse mouth with water, do not induce vomiting, seek immediate medical attention if accidentally swallowed
Advice for Doctors: Symptomatic treatment as required, monitor electrolytes, consider gastric lavage if large ingestion noted
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam as needed
Specific Hazards: May emit hazardous fumes of nitrogen oxides or carbon oxides during combustion
Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Special Procedures: Move containers from fire area if it can be done safely without risk, cool exposed containers with water spray
Personal Precautions: Use personal protective equipment, avoid dust formation, ensure proper ventilation
Environmental Precautions: Prevent further leakage or spillage if safe to do so, do not let product enter drains
Cleanup Methods: Pick up and arrange disposal without creating dust, sweep up and shovel, keep in suitable closed containers for disposal, ventilate the area and wash spill site thoroughly after material pickup
Handling: Avoid creating dust or aerosol, wear protective clothing, maintain clean work environment, wash hands and exposed skin after use
Storage: Store in tightly closed containers in a cool, dry, well-ventilated area, keep away from humidity, heat sources, and incompatible materials (oxidizers), restrict access to authorized personnel
Engineering Controls: Use appropriate exhaust ventilation at processing areas, maintain eyewash stations and safety showers nearby
Personal Protective Equipment (PPE): Protective gloves, chemical safety glasses or goggles, lab coat or apron, approved respirator if dust or aerosol generation likely
Hygiene Measures: Do not eat, drink, or smoke while using, wash thoroughly after handling, avoid hand-to-mouth or hand-to-eye contact
Appearance: Green-yellow crystalline powder
Odor: No distinct odor
pH: Not applicable (insoluble in water)
Melting Point: 316–317°C
Boiling Point: Not applicable (decomposes)
Solubility: Practically insoluble in water, soluble in dilute acids and alkalis
Vapor Pressure: Not available
Density: Approximately 1.55 g/cm³
Flash Point: Not flammable
Partition Coefficient (log Pow): 2.45
Chemical Stability: Stable under recommended storage conditions, decomposes at high temperatures
Reactivity: No significant reactivity under ordinary conditions
Incompatible Materials: Strong oxidizers, acids, and bases
Hazardous Decomposition Products: May release nitrogen oxides, carbon monoxide, carbon dioxide during thermal decomposition
Polymerization: Does not occur
Acute Toxicity: Oral LD50 (rat): ~1700 mg/kg
Chronic Toxicity: Long-term exposure may affect kidney function, hemopoietic system
Irritation: Expected to cause mild skin and eye irritation
Carcinogenicity: No evidence in humans, not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity/Teratogenicity: Not found mutagenic or teratogenic in standard animal studies
Sensitization: Anaphylactic reactions are rare, hypersensitivity reactions have occurred
Target Organs: Kidneys, possibly liver
Aquatic Toxicity: Harmful to aquatic life with long-lasting effects, low solubility limits direct hazard
Persistence and Degradability: Expected to degrade slowly in the environment
Bioaccumulation Potential: Predicted to have moderate bioconcentration in aquatic organisms
Mobility in Soil: Low, due to low water solubility
Other Adverse Effects: No known significant effects on ozone, endocrine disruption not established
Disposal Methods: Dispose of in accordance with official regulations, incinerate in an approved facility if possible
Contaminated Packaging: Empty containers should be thoroughly rinsed and offered for recycling or disposal in accordance with local requirements
Precautions: Do not dispose of with household waste, do not discharge into waterways or sewers
UN Number: Not regulated as a hazardous material
Proper Shipping Name: Triamterene
Hazard Class: Not applicable
Packing Group: Not applicable
Environmental Hazards: Not considered environmentally hazardous for ground and air transport
Transport Precautions: Protect from physical damage, keep container tightly closed and upright during transport
OSHA Status: Not classified as hazardous under OSHA Hazard Communication Standard (29 CFR 1910.1200)
TSCA Status: Listed on the US Toxic Substances Control Act (TSCA) Inventory
SARA Title III: Not subject to SARA Title III reporting requirements
DSL/NDSL (Canada): Listed/Not listed as applicable
Other Regulatory Info: Complies with relevant EU regulations for pharmaceuticals, not restricted by major global chemical control laws
