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Product Name: Triamcinolone Acetonide
Chemical Name: 9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 16,17-acetonide
Other Names: Kenalog, Aristocort
CAS Number: 76-25-5
Molecular Formula: C24H31FO6
Molecular Weight: 434.5 g/mol
Recommended Use: Pharmaceutical corticosteroid for reduction of inflammation
Manufacturer Information: Available through pharmaceutical suppliers
Emergency Contact: Local poison control or regulatory agency
Hazard Classification: Not categorized as hazardous under GHS for regular handling in solid or formulated state. Dust may cause mild irritation.
Main Hazards: Dust inhalation could trigger respiratory discomfort. Direct eye contact can bring about irritation. Repeated exposure may lead to skin dryness or dermatitis.
Routes of Exposure: Inhalation, skin contact, eye contact, ingestion
Target Organs: Skin, respiratory tract, eyes, liver (with chronic exposure and improper handling)
Health Effects: Potential for hypersensitivity reactions in exposed individuals
Signs of Overexposure: Coughing, redness or rash on skin, eye redness
Precautionary Statements: Avoid dust formation, keep away from children, apply with adequate ventilation
Active Ingredient: Triamcinolone Acetonide (CAS 76-25-5) 98%-100%
Impurities: May contain trace solvents, water content below 1%, carrier or excipient (in formulated products only)
Formulation Additives: See finished product MSDS for excipient list
Inhalation: Move to fresh air, monitor for any signs of allergic response or respiratory distress, provide oxygen if breathing is difficult, seek medical attention for persistent effects
Skin Contact: Wash thoroughly with soap and plenty of water, remove contaminated clothing, monitor for irritation, seek attention if rash or symptoms persist
Eye Contact: Flush with plenty of water for at least fifteen minutes, keep eyelids open, seek medical help if irritation continues
Ingestion: Rinse mouth with water, never provide anything orally to an unconscious person, seek immediate medical advice, monitor for nausea or dizziness
Acute Symptoms: Irritation, allergy, discomfort; monitor and treat symptomatically
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: No data suggesting special complications with common fire suppression materials
Special Hazards: Combustion may emit toxic fumes, including carbon oxides and hydrogen fluoride
Protective Equipment: Full protective gear and self-contained breathing apparatus for large fires
Firefighting Guidance: Minimize dust, control smoke, move containers from fire area if safe, use water to cool exposed surfaces, avoid inhalation of byproducts
Personal Precautions: Wear protective gloves, dust mask, and goggles to limit exposure
Environmental Precautions: Prevent entry of bulk quantities into sewers or waterways, contain spill if possible
Clean-Up Procedures: Sweep or vacuum gently to avoid dust, place into labeled, closed containers for proper disposal
Decontamination: Clean area with soap and water, dispose of cleaning solutions in suitable containers
Disposal: Dispose of collected material in accordance with federal, state, and local regulations
Safe Handling: Limit dust generation, avoid inhaling particles, wash hands after use, handle in a well-ventilated area
Storage Requirements: Store below 25°C (77°F), keep container tightly closed in dry conditions, protect from light and moisture
Incompatibilities: Strong oxidizing agents, strong acids or bases, prevent contact with reactive chemicals
Specific Use Considerations: Only authorized and trained personnel should access bulk material
Containers: Use original container, seal tightly after each use to minimize moisture absorption
Control Parameters: Occupational exposure limit not established for Triamcinolone Acetonide
Engineering Controls: Use local exhaust ventilation where dust is generated, keep storage area cool and well-ventilated
Protective Equipment: Safety goggles, chemically-resistant gloves, dust mask or N95 respirator for powder handling, lab coat or apron
Hygiene Measures: Wash hands after handling, do not eat or drink while using this substance, remove and clean contaminated clothing
Environmental Exposure: Control releases to environment, prevent bulk release into water systems
Appearance: White to off-white crystalline powder
Odor: Odorless
pH: Not applicable—insoluble in water
Melting Point: Approx. 266°C (511°F) (decomposes)
Boiling Point: Not measurable (decomposes before boiling)
Solubility: Insoluble in water; soluble in methanol, ethanol, chloroform, acetone
Specific Gravity: 1.3 (approximate)
Vapor Pressure: Negligible at ambient conditions
Other Properties: Stable under normal temperature and storage conditions
Stability: Chemically stable in normal storage and handling conditions, avoid exposure to excessive heat or light
Reactivity: Not reactive with most materials; avoid strong oxidizers and acids
Decomposition Products: Carbon oxides, hydrogen fluoride, other unknown toxic compounds when burned
Polymerization: Hazardous polymerization will not occur
Conditions to Avoid: High humidity, strong sunlight, extreme temperatures, incompatible chemicals
Acute Toxicity: Low acute toxicity by oral, dermal, and inhalation routes (LD50: Not established for humans; rat oral LD50 > 3000 mg/kg)
Potential Health Effects: May cause skin and eye irritation, prolonged inhalation may affect respiratory tract, rare allergic reactions possible
Chronic Effects: Long-term misuse may trigger adrenal suppression, immune function alteration, skin thinning, or hormone-related side effects
Carcinogenicity: Not classified as carcinogen by IARC, NTP, OSHA
Mutagenicity / Teratogenicity: Some studies on animals indicate risk at high doses, relevance to workers not established
Other Data: Contact with physicians recommended for suspected overexposure
Aquatic Toxicity: Data limited, not expected to be acutely toxic to aquatic life in small releases
Persistence and Degradability: Compound is not readily biodegradable, may persist in the environment if not properly contained
Bioaccumulation Potential: Moderate potential, environmental accumulation possible with large, repeated releases
Mobility in Soil: Low mobility, tends to adhere to soil and sediment
Additional Information: Hazard to environment increases with improper disposal of large quantities; respect regulations on chemical waste management to prevent ecosystem impact
Disposal Methods: Collect excess material and deliver to authorized chemical waste facilities
Container Disposal: Rinse and render empty containers unserviceable, follow local requirements for chemical waste
Do Not: Flush significant quantities into sewage, water courses, or drains
Regulatory Compliance: Dispose in accordance with regulation—EPA, national, state, and municipal rules
UN Number: Not regulated as a dangerous good
Proper Shipping Name: Triamcinolone Acetonide
Hazard Class: Does not meet criteria for hazardous chemicals for ground, air, or sea
Packing Group: Not assigned
Special Precautions: Protect from moisture and breakage during transport, avoid transport with corrosives or strong oxidizers
International Inventory Status: Listed on relevant inventories (e.g., TSCA, EINECS/ELINCS for research/industrial use)
Labeling Requirements: Requires standard pharmaceutical and chemical labeling, hazard communication as per OSHA, CLP, WHMIS where applicable
Other Regulations: Subject to controls and restrictions as per local, federal, and international pharmaceutical and workplace safety standards
Worker Health and Safety: Requires adherence to exposure prevention, personal protection, training in handling pharmaceutical substances
Specific Provisions: Ensure updated safety documentation and staff training
