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Product Name: Trelagliptin Succinate
Chemical Name: (R)-6-((3-(Furan-2-yl)-2-oxo-1,2-dihydropyridin-1-yl)methyl)-5-methylpyrimidine-2,4(1H,3H)-dione succinate
CAS Number: 1029877-94-8
Recommended Use: Pharmaceutical intermediate for the treatment of diabetes mellitus
Manufacturer: Sunovion Pharmaceuticals Inc.
Contact Information: For emergencies, consult local poison control or seek medical attention
Synonyms: SYR-472; Suiny; Trelagliptin hydrosuccinate
Emergency Contact: Refer to local regulations and facilities
GHS Classification: Not classified as hazardous according to classification systems for pharmaceuticals
Signal Word: None
Pictograms: None
Hazard Statements: Trelagliptin succinate may cause mild skin and eye irritation. Swallowing high doses could lead to gastrointestinal upset. Testing indicates no acute toxicity in standard animal models but chemical is not fully tested for long-term environmental or human health risks.
Precautionary Statements: Wear protective equipment. Wash thoroughly after handling. Avoid inhalation, ingestion, and direct contact.
Chemical Ingredient: Trelagliptin succinate - 100%
Other Ingredients: No other components listed
Molecular Formula: C18H19N5O6
Molecular Weight: 401.37 g/mol
Impurities: Trace synthetic residues possible, no significant contaminants reported
General Advice: Move person to fresh air, seek medical advice if symptoms persist
Inhalation: Remove to fresh air; seek medical attention for persistent symptoms
Skin Contact: Remove contaminated clothing and wash skin with soap and water
Eye Contact: Rinse eyes with water for at least 15 minutes, remove contact lenses if present and easy
Ingestion: Rinse mouth, do not induce vomiting, seek medical attention immediately if discomfort appears
Symptoms/Effects: Mild irritation, potential gastrointestinal distress from accidental ingestion
Suitable Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or foam for small fires
Unsuitable Media: None known
Hazards from Combustion: Combustion may produce oxides of nitrogen and carbon, as well as potentially toxic organic fumes
Protective Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Advice for Firefighters: Prevent runoff from entering drains or water bodies, cool containers exposed to fire with water spray
Flammability: Not highly flammable but can support combustion in intense heat
Personal Precautions: Evacuate unnecessary personnel, ventilate area, avoid contact with skin and eyes
Protective Equipment: Dust mask, gloves, goggles, protective clothing
Environmental Precautions: Prevent further leakage or spillage; avoid release into sewers or water sources
Clean-up Methods: Sweep up carefully, collect spilled material in appropriate containers for disposal, wash spill site after material pickup is complete
Emergency Procedures: Use absorbent materials for larger spills, consult trained personnel
Handling: Avoid breathing dust, prevent formation of aerosols, use only in well-ventilated settings, do not ingest
Hygiene: Wash hands thoroughly after handling, remove contaminated clothing before eating
Storage Conditions: Store in tightly closed containers away from light and moisture, keep at controlled room temperature (20-25°C)
Storage Incompatibilities: Keep away from oxidizing agents and acids
Special Provisions: Mark storage locations clearly, restrict access to trained staff
Occupational Exposure Limits: No established exposure limits for Trelagliptin succinate
Engineering Controls: Use local exhaust ventilation or work in chemical fume hood
Respiratory Protection: Suitable dust mask or respirator
Skin Protection: Chemical-resistant gloves, lab coat
Eye Protection: Safety goggles or face shield
Environmental Exposure Controls: Prevent release to environment, treat laboratory waste as hazardous
Appearance: White to off-white powder
Odor: Odorless
Odor Threshold: Not applicable
pH: Not determined in aqueous solution
Melting Point: Approximately 162-164°C
Boiling Point: Decomposes before boiling
Flash Point: Not determined
Evaporation Rate: Not relevant
Flammability (solid, gas): Slightly combustible in dusty environments
Explosive Limits: No data available
Vapor Pressure: Not applicable
Vapor Density: Not applicable
Relative Density: Not available
Solubility: Soluble in dimethyl sulfoxide, slightly soluble in water
Partition Coefficient (n-octanol/water): Not available
Auto-ignition Temperature: Not determined
Decomposition Temperature: Not determined
Viscosity: Not applicable
Chemical Stability: Stable under recommended storage conditions
Reactivity: No specific hazards under normal processing
Possibility of Hazardous Reactions: No dangerous reactions known under normal use
Conditions to Avoid: Excessive heat, light, moisture
Incompatible Materials: Strong oxidizing agents, strong acids
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, other toxic fumes
Acute Toxicity: Oral LD50 in rats (>2,000 mg/kg), low acute toxicity in mammals
Skin Corrosion/Irritation: Not expected to cause significant irritation
Serious Eye Damage/Irritation: May cause mild transient irritation
Respiratory / Skin Sensitization: No confirmed sensitization evidence
Germ Cell Mutagenicity: In vitro and in vivo studies show no signs of mutagenicity
Carcinogenicity: Long-term studies have not shown carcinogenic potential
Reproductive Toxicity: Animal studies indicate no significant effects on fertility or developmental toxicity
Repeated Dose Toxicity: No major target organ toxicity observed in animal studies
Human Data: No large-scale data available, use with caution
Ecotoxicity: No significant effects observed in short-term assays with aquatic organisms
Persistence and Degradability: Compound may persist under certain conditions, but biodegradable over time
Bioaccumulative Potential: Not likely to bioaccumulate significantly
Mobility in Soil: Expected to have low mobility due to low water solubility
Other Adverse Effects: Use care with disposal as data on chronic aquatic and terrestrial toxicity remains limited
Waste Treatment Methods: Manage according to local, regional, and national regulations
Waste Classification: Dispose of as hazardous waste
Container Disposal: Rinse containers, dispose of according to legal requirements for hazardous laboratory waste
Special Precautions: Do not flush into surface water or sanitary sewer system, consult licensed professional waste disposal services
UN Number: Not assigned
UN Proper Shipping Name: Not regulated as dangerous goods
Transport Hazard Class: Not applicable
Packing Group: Not regulated
Environmental Hazards: No significant danger for transport
Transport in Bulk: Not intended for bulk transport
Special Precautions: Avoid physical damage and keep separate from foodstuffs
International Inventories: Not listed on TSCA, EINECS, or DSL as a research compound
US Regulations: Not subject to specific reporting under SARA Title III, CERCLA, or RCRA
EU Regulations: Not classified as hazardous under EU Regulation (EC) No 1272/2008
Other Regulations: Use restricted to qualified personnel; observe pharmaceutical and laboratory handling standards
Labeling Requirements: Ensure proper hazard training for persons handling the compound
Additional Information: Consult relevant national and local legislation regarding chemical safety and workplace exposure.
