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Product Name: Tranilast
Chemical Name: N-(3',4'-dimethoxycinnamoyl) anthranilic acid
CAS Number: 53902-12-8
Synonyms: Rizaben, Tranilastum
Recommended Use: Pharmaceutical agent, research chemical
Manufacturer or Supplier: Manufacturer details and contact information local to your source
Emergency Phone Number: Supplier emergency line or chemist-on-call
Physical State: Solid, usually supplied as powder or crystalline substance
Hazard Classification: Not classified as hazardous under current GHS guidance; some irritation possible on direct exposure
Health Hazards: Potential irritant to eyes, skin, and mucous membranes if handled inappropriately
Environmental Hazards: Limited hazard data for aquatic organisms, prudent containment recommended
Label Elements: No mandatory pictograms; general caution advised
Chemical Structure: C18H17NO5
Purity: Typically 98% or greater when used in laboratory and pharmaceutical settings
Impurities: Minor process residuals during commercial synthesis, documentation available on request
Ingredient Percent: Tranilast as main component, trace inert excipients possible depending on formulation
Molecular Weight: 327.33 g/mol
Inhalation: Move affected individual to fresh air; seek medical advice if symptoms persist or breathing is difficult
Skin Contact: Remove contaminated clothing; wash affected area with soap and water
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; consult a physician efficiently
Ingestion: Rinse mouth, do not induce vomiting, seek professional medical evaluation promptly
Suitable Extinguishing Media: Use water spray, CO₂, dry chemical, or universal foam according to situation
Hazardous Combustion Products: May release carbon oxides, nitrogen oxides, other toxic vapors during decomposition
Protective Equipment: Full protective suit with self-contained breathing apparatus recommended for emergency responders
Special Procedures: Keep containers cool if exposed to fire, avoid inhaling combustion fumes
Personal Precautions: Wear gloves, face mask, laboratory coat; avoid dust generation
Environmental Precautions: Prevent material from entering drains, surface water, or soil
Methods for Containment: Collect using inert absorbent material, transfer to sealed waste container
Cleaning Techniques: Wet wipe or damp mop decreases dust; ventilate area thoroughly after clean-up
Safe Handling: Use in well-ventilated areas, avoid contact with skin and eyes, keep container tightly closed
Hygiene Practices: Standard laboratory hygiene, including regular handwashing
Storage Conditions: Store in cool, dry place at 2–8°C unless otherwise directed; keep away from strong oxidizers and direct sunlight
Incompatible Materials: Avoid prolonged or direct contact with oxidizing agents, strong acids, and strong bases
Exposure Limits: No occupational exposure limits specifically established
Engineering Controls: Use fume hood or local exhaust during operations producing dust or mist
Personal Protection: Appropriate chemical-resistant gloves, safety goggles, lab coat
Respiratory Protection: Certified particulate mask or respirator if airborne contamination likely
Other Measures: Eyewash station and safety shower in working area
Appearance: Off-white to pale yellow crystalline powder
Odor: Odorless or very faint odor
Melting Point: Around 157–161°C
Solubility: Slightly soluble in water; readily dissolves in organic solvents like ethanol and dimethyl sulfoxide
Boiling Point: Data limited, decomposes before boiling
pH: Weakly acidic when dissolved in water
Partition Coefficient: LogP: 2.8–3.0
Stability: Stable under recommended storage; sensitive to high temperature and strong light
Chemical Stability: Stable at room temperature under dry conditions
Reactivity: Does not present significant reactivity concerns when kept away from incompatible substances
Hazardous Reactions: No robust polymerization or violent reactions expected under normal uses
Decomposition Products: Oxides of carbon and nitrogen in case of fire or thermal decomposition
Conditions to Avoid: High temperatures, exposure to moisture, strong oxidizers
Acute Toxicity: Oral LD50 in rats reported at >2000 mg/kg, low acute toxicity profile established in animal studies
Chronic Effects: Some evidence for urinary tract toxicity at prolonged high doses in animal models
Potential Health Effects: Nonmutagenic in standard assay panels, no established carcinogenicity
Sensitization: Rare cases of skin sensitization described; not considered a common allergen
Target Organ Effects: High doses may affect liver and kidney function in rodents
Ecotoxicity: Limited aquatic toxicity data; unlikely to bioaccumulate significantly
Persistence and Degradability: Undergoes slow degradation in soil and water through environmental processes
Mobility: Low mobility expected in natural water due to hydrophobicity
Bioaccumulative Potential: Low potential anticipated; data still developing based on current usage patterns
Other Adverse Effects: Careful disposal protects aquatic and soil organisms, following current best practices
Product Disposal: Handle as hazardous waste when discarded; incineration in licensed facility preferred to minimize environmental release
Container Disposal: Rinse empty containers with suitable solvent, then dispose of according to local and national regulations
Sewage Disposal: Do not discharge into drains or natural waterways
Recycling Information: Recycling not commonly practiced; consult local waste management for options
Regulatory Requirements: Observe all environmental regulations specific to chemical waste
UN Number: Not classified as dangerous for transport; no UN number assigned
Transport Hazard Class: Not regulated under ADR, IMDG, IATA
Packing Group: Not listed
Marine Pollutant: Not considered a marine pollutant based on available data
Special Precautions for Transport: Protect from moisture, avoid package damage or spillage during shipment
Regulatory Status: Not a scheduled substance; subject to controls according to regional pharmaceutical or chemical use guidelines
TSCA Status: Not listed on US Toxic Substances Control Act inventory for routine industrial use
REACH Status: Used only for research, may not require full EU registration
Labeling Requirements: Consult regional regulations; general hazard and precautionary labeling advised
Other References: Safety standards evolve; always check current regulatory sources and up-to-date supplier certifications
