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Product Name: Tranexamic Acid
Chemical Formula: C8H15NO2
Synonyms: AMCA, trans-4-(Aminomethyl) cyclohexanecarboxylic acid
CAS Number: 1197-18-8
Manufacturer: Pharmaceutical manufacturers and chemical suppliers handle specifics.
Recommended Uses: Control of unwanted bleeding, medical laboratory, research and hospital pharmacy.
Contact Information: Emergency number and manufacturer address should be included by supplier.
Classification: Non-flammable solid, may cause mild to moderate eye irritation, can provoke respiratory or skin discomfort by prolonged exposure. Rare risk of allergic reactions.
Signal Word: Warning
Hazard Statements: Causes mild eye and skin irritation, not considered acutely toxic. Chronic exposure: medical supervision for hematological effects.
Pictograms: Exclamation mark (irritant).
Precautionary Statements: Avoid inhalation, wear gloves and eye protection, wash hands after handling, use only in well-ventilated settings.
Routes of Exposure: Inhalation, eye and skin contact, accidental ingestion.
Chemical Name: Tranexamic Acid
Concentration: 100% (for pure API); may vary in formulated products
Impurities: Supplier specification required for minor contaminants
Molecular Weight: 157.21 g/mol
Eye Contact: Rinse immediately with plenty of clean water for several minutes, hold eyelids open, seek medical advice for persistent irritation.
Skin Contact: Remove contaminated clothing, wash affected area with soap and water, get medical help if symptoms continue.
Inhalation: Move to fresh air promptly, seek medical attention if symptoms such as dizziness, coughing, or irritation persist.
Ingestion: Rinse mouth with water, consult a physician immediately, show product label if available.
Medical Attention: Treat symptomatically, monitor for allergic or hematological responses.
Suitable Extinguishing Media: Water spray, dry powder, carbon dioxide, foam.
Unsuitable Extinguishing Media: High-pressure water streams may spread product.
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide, traces of toxic fumes.
Protective Equipment: Wear self-contained breathing apparatus and full protective clothing.
Special Procedures: Cool nearby containers with water spray, prevent runoff to sewers or waterways.
Personal Precautions: Wear gloves, goggles, dust mask or respirator.
Environmental Precautions: Avoid release to environment, contain spill with absorbent material, prevent from entering drains or water bodies.
Methods for Cleaning Up: Sweep up, avoid dust formation, transfer to suitable closed container for proper disposal, ventilate area.
Safe Handling: Use in a well-ventilated area, wear appropriate protective equipment, do not eat, drink, or smoke while handling, keep container tightly closed.
Storage Conditions: Store in original container, cool and dry place, avoid exposure to moisture and direct sunlight, temperature between 15°C and 30°C recommended.
Incompatibilities: Strong oxidizers, acidic and basic substances that may degrade product.
Packaging Materials: Polyethylene or glass containers preferred to avoid chemical interaction.
Exposure Limits: No established occupational exposure limits; minimize dust and airborne particles.
Engineering Controls: Use fume hood or local exhaust, avoid confined, unventilated spaces
Personal Protective Equipment: Gloves (nitrile, latex, or suitable material), lab coat, safety goggles, face protection for bulk handling, dust mask or respirator if risk of inhalation.
Hygiene Measures: Wash hands thoroughly after use, remove contaminated clothing, do not bring contaminated clothing home.
Appearance: White crystalline powder
Odor: Odorless
pH: Approximately 7.0 for 1% w/v aqueous solution
Melting Point: 300°C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Solubility: Readily soluble in water, slightly soluble in ethanol, insoluble in ether
Density: About 1.31 g/cm3
Vapor Pressure: Negligible
Partition Coefficient (log Kow): –1.6
Flammability: Non-flammable solid
Explosive Properties: Not considered explosive.
Chemical Stability: Stable in dry air and under recommended storage conditions
Reactivity: Inert to most chemicals under ambient conditions
Conditions to Avoid: Heat, moisture, direct sunlight, strong oxidizing agents
Hazardous Decomposition Products: Nitrogen oxides, carbon monoxide and carbon dioxide if heated to decomposition
Polymerization: Will not occur.
Routes of Entry: Oral, inhalation, skin and eye contact
Acute Toxicity: Oral rat LD50 >10 g/kg, low toxicity by single dose
Chronic Toxicity: High, repeated doses affect blood clotting system and may cause rare seizures
Inhalation: May cause mild respiratory irritation at high concentrations
Skin Contact: Mild irritation possible with prolonged exposure
Eye Contact: May irritate eyes
Carcinogenicity: Not listed as carcinogen by IARC, NTP, or OSHA
Mutagenicity: No evidence from current literature
Reproductive Toxicity: No conclusive evidence in humans
Sensitization: Uncommon allergic reactions possible in some individuals.
Ecotoxicity: Expected to be of low ecological toxicity, rapid breakdown in the environment
Aquatic Toxicity: No known significant toxicity for aquatic life forms under standard exposure, but best practice advises against direct release to water bodies.
Biodegradability: Readily biodegradable
Bioaccumulation Potential: Low, due to water solubility and rapid metabolism
Mobility in Soil: High, substance can leach into groundwater if extensively spilled.
Persistence: Unlikely to persist in most environmental compartments.
Product Waste: Incinerate in controlled facility, follow national and local regulations
Contaminated Packaging: Dispose of in accordance with local laws; triple rinse and offer containers for recycling if practical
Precautions: Avoid landfill where possible, do not flush to sewer.
UN Number: Not classified as hazardous for transport
Transport Hazard Class: Not regulated
Proper Shipping Name: Tranexamic Acid
Packing Group: Not assigned
Environmental Hazards: None known, product is not a marine pollutant
Special Precautions: Keep containers tightly sealed, avoid moisture exposure
TSCA (USA): Listed
DSL/NDSL (Canada): Listed
EU Regulations: Not classified as hazardous, no REACH registration needed for pure substance below threshold
OSHA Hazard Communication: Not hazardous under normal laboratory and medical conditions
WHMIS (Canada): Not classified as controlled product
Safety Assessment: Follows GHS guidelines for labeling and standard handling precautions.
