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Product Name: Tosufloxacin Tosylate
Chemical Name: (6R,7S,8S)-7-(3-Aminopyrrolidin-1-yl)-8-(cyclopropyl)-6-fluoro-1-oxo-4-quinolone tosylate
CAS Number: 115964-32-2
Molecular Formula: C19H17FNO3 · C7H8O3S
Recommended Use: Pharmaceutical intermediate, active ingredient for antibacterial drugs
Manufacturer Information: Supplier name, address, emergency phone, email contact
Emergency Number: Local emergency service information
Synonyms: Tosufloxacin mono-p-toluenesulfonate, Tosufloxacin mesylate
GHS Classification: Not classified as a hazardous chemical under GHS for typical laboratory handling
Main Hazards: Irritation to eyes, skin, respiratory tract; may cause allergic skin reactions; ingestion can affect gastrointestinal tract
Signal Word: Caution
Hazard Statements: H315: Causes skin irritation; H319: Causes serious eye irritation; H335: May cause respiratory irritation
Precautionary Statements: Use personal protective equipment, avoid inhalation of dust, use only with adequate ventilation
Environmental Hazards: Harmful to aquatic life with long lasting effects
Chemical Identity: Tosufloxacin Tosylate
CAS Number: 115964-32-2
Content: Pure (greater than 98% as active substance)
Impurities: Related fluoroquinolones, p-toluenesulfonic acid residue; trace manufacturing byproducts
Molecular Weight: 497.54 g/mol
Physical State: Crystalline powder
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; keep eyelids open and seek medical advice
Skin Contact: Gently wash affected area with soap and water; remove contaminated clothing; get medical attention if irritation continues
Inhalation: Move person to fresh air; provide oxygen if breathing becomes difficult; seek medical assistance if symptoms persist
Ingestion: Rinse mouth thoroughly; offer water; do not induce vomiting unless directed by a medical professional; seek immediate medical attention
Most Important Symptoms: Eye redness, skin rash, respiratory tract irritation, headache
Suitable Extinguishing Media: Dry chemical, carbon dioxide, foam, or water spray
Unsuitable Media: Direct water jet on the product
Hazards from Burning: Releases nitrogen oxides, sulfur oxides, hydrogen fluoride, carbon monoxide, carbon dioxide
Protective Equipment: Use self-contained breathing apparatus and full protective gear in fire zone
Firefighting Instructions: Evacuate personnel, cool containers with water spray from safe distance, prevent runoff to sewers or waterways
Personal Precautions: Evacuate unnecessary personnel, ventilate area, use appropriate protective clothing
Environmental Precautions: Prevent further leakage or spillage if safe; avoid discharge into drains, surface waters, or soil
Containment Methods: Sweep or vacuum up without raising dust; place in a suitable sealed container for disposal
Cleanup Procedures: Use wet methods to reduce dust formation; wash area thoroughly after material pickup; dispose of residue according to local regulation
Precautions for Safe Handling: Work with adequate ventilation, avoid dust generation, minimize contact with skin and eyes, use personal protection
Safe Storage Conditions: Store in tightly closed container in a cool, dry place, away from light, heat, and incompatible substances such as strong acids and oxidizers
Special Sensitivity: Protect from moisture, keep separated from food and drink
Incompatible Materials: Oxidizing agents, acids, bases; avoid contact with metal surfaces
Control Parameters: No occupational exposure limit established; minimize exposure as low as reasonably achievable
Engineering Controls: Use local exhaust ventilation, safety shower, and eye wash station in area
Personal Protection: Chemical-resistant gloves (nitrile or similar), lab coat or protective clothing, safety goggles, NIOSH-approved respirator in case of dust
Work Hygiene: Wash hands before breaks and after use, do not eat or drink in work area, clean contaminated clothing before reuse
Appearance: White to off-white crystalline powder
Odor: Nearly odorless
pH: 3.5 - 5.5 (1% aqueous solution)
Melting Point: About 210–220°C
Boiling Point: Decomposes before boiling
Solubility: Soluble in water, methanol, slightly soluble in ethanol
Vapor Pressure: Not applicable (solid at ambient conditions)
Density: Approximately 1.45 g/cm³
Partition Coefficient: Not readily available
Flash Point: Not flammable under standard conditions
Decomposition Temperature: Above 200°C
Other Properties: Stable under recommended conditions, avoids effects of light and moisture
Chemical Stability: Stable under typical storage and handling conditions
Possibility of Hazardous Reactions: May react with strong oxidizing agents or strong acids, releases harmful gases on decomposition
Incompatible Materials: Reactive with bases, oxidizers, acids
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, hydrogen fluoride, carbon oxides formed on burning or extreme heat
Conditions to Avoid: Prolonged exposure to moisture, direct sunlight, high temperatures
Acute Toxicity: Low acute oral toxicity in animal studies; no established lethal dose (LD50) for humans
Routes of Exposure: Skin, eye, inhalation, ingestion
Symptoms: Irritation to eyes, nose, throat, gastrointestinal discomfort if ingested, possible skin sensitization
Chronic Effects: Not known to cause chronic health issues in short-term exposure, but prolonged or repeated exposure may affect liver and kidneys
Carcinogenicity: Not listed as carcinogen by IARC, NTP, OSHA
Mutagenicity: Negative results in standard battery of in vitro and in vivo mutagenicity tests
Reproductive Effects: No adverse reproductive or developmental effects identified in animal studies
Acute Aquatic Toxicity: Harmful to aquatic organisms at high concentrations
Persistence and Degradability: Not readily biodegradable
Bioaccumulation: No significant bioaccumulation expected due to low octanol-water partition coefficient
Mobility in Soil: Moderate mobility in soil; may partition to water systems if released
Other Information: Avoid environmental releases; do not dispose in natural waterways
Disposal Methods: Collect and dispose of contents according to local, state, and national regulations; incineration preferred where permitted
Container Disposal: Triple rinse and puncture containers before disposal, do not reuse empty packaging
Special Instructions: Do not discharge into drains, surface water, or environment; label waste for hazardous pharmaceutical processing
Regulatory Guidance: Consult local hazardous waste agency for specific disposal recommendations
UN Number: Not classified as a dangerous good for transport
Proper Shipping Name: Tosufloxacin Tosylate
Transport Hazard Classes: Not regulated
Packing Group: Not applicable
Special Precautions: Protect from physical damage, keep container tightly closed; offer in original packaging with intact labeling
Environmental Hazards: Avoid release to surrounding environment during transport
Transport Label: Not required under standard transport guidelines
International Regulations: Not listed on major international chemical inventories as a hazardous substance
US Federal Regulations: Not subject to TSCA, SARA Title III Section 302, 313 reporting
EU Classification: Not classified as dangerous; REACH exempt for pharmaceutical intermediates
De minimis Concentration: Not applicable
Labeling Requirements: As per local regulations for laboratory and pharmaceutical chemicals
Other Regulatory Information: Observe all applicable local, regional, national, and international regulations
