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Product Name: Topotecan Hydrochloride
Synonyms: Hycamtin, NSC 609699, SK&F 104864-A
CAS Number: 119413-54-6
Recommended Use: Antineoplastic agent, pharmaceutical intermediate
Manufacturer: Pharmaceutical suppliers and research laboratories
Emergency Contacts: Poison Control Center at 1-800-222-1222, Local emergency services
Formula: C23H23N3O5·HCl
UN Number: Not assigned
Intended Users: Healthcare professionals, laboratory personnel
GHS Classification: Acute toxicity (oral, dermal, inhalation); Eye and skin irritant; Reproductive toxicity; Carcinogenicity (suspected); Specific target organ toxicity
Signal Word: Danger
Hazard Statements: Harmful if swallowed, inhaled, or in contact with skin; May cause genetic defects; May cause cancer; Causes serious eye irritation; Toxic to aquatic life
Pictograms: Skull and crossbones, exclamation mark, health hazard, environment
Precautionary Statements: Avoid all unnecessary contact; Wear protective equipment; Use only in fume hood or well-ventilated area; Wash exposed areas after handling
Other Hazards: Dust may produce respiratory and skin sensitization; Repeated exposure increases health risk
Chemical Name: Topotecan Hydrochloride
CAS Number: 119413-54-6
EC Number: Not available
Concentration: 98% - 100% (pure substance)
Impurities: Minor process-related organic compounds, moisture, possible residual solvents in trace amounts
Molecular Weight: 457.9 g/mol
Inhalation: Move individual to fresh air, keep at rest, seek medical attention if symptoms like coughing or difficulty breathing develop
Skin Contact: Immediately remove contaminated clothing, rinse skin with soap and plenty of water for at least 15 minutes, seek medical help if irritation persists
Eye Contact: Flush eyes continuously with running water for at least 20 minutes, lift eyelids occasionally, seek prompt medical attention
Ingestion: Do not induce vomiting, rinse mouth thoroughly with water, seek immediate medical attention
Notes for Medical Practitioners: Treat symptomatically and monitor for cytotoxic effects, provide supportive care for low blood counts or gastrointestinal distress
Suitable Extinguishing Media: Water spray, dry chemical, foam, carbon dioxide
Unsuitable Extinguishing Media: Strong water jets that may spread powder
Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen chloride gas, possible toxic fume generation
Protective Gear for Firefighters: Full protective gear, self-contained breathing apparatus
Fire Hazards: Dust may form explosive mixture in air under specific conditions, containers may burst in case of fire
Additional Information: Use water sprays to cool unopened containers nearby, avoid inhaling smoke or vapors
Personal Precautions: Evacuate area, wear certified respiratory protection, avoid contact with skin and eyes, prevent dust generation
Environmental Precautions: Prevent entry into drains, sewers, or waterways, contain and control runoff
Cleanup Methods: Use inert absorbents (earth, sand), sweep up without raising dust, place in sealed, labeled containers for disposal, ventilate area thoroughly
Decontamination: Clean spill site with detergents and water, avoid using solvents, dispose of all cleaning materials as hazardous waste
Handling: Operate in certified chemical fume hood or ventilated enclosure, avoid inhalation and direct contact, do not eat, drink, or smoke near this compound, use closed systems where possible and avoid activities that generate dust
Storage: Store locked up in tightly closed container, shielded from direct sunlight, incompatible substances, and moisture, maintain temperature between 2°C and 8°C (refrigerated), keep separate from food and animal feed, label storage clearly with hazard information
Incompatible Substances: Strong oxidizers, strong acids and bases
Exposure Limits: No occupational exposure limits established, minimize exposure as much as possible
Engineering Controls: Local exhaust ventilation, closed process equipment, glove boxes for weighing and handling
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile, latex), fully enclosed goggles or face shield, impermeable lab coat or coveralls, suitable respiratory protection (N95 or better), use of single-use PPE preferred
Hygiene Measures: Wash hands and face thoroughly after handling, do not reuse contaminated clothing, launder everything before reuse
Appearance: Pale yellow to yellow-green powder
Odor: Odorless
Odor Threshold: Not determined
pH: Approximately 3.0 - 5.0 (1% solution, water)
Melting Point/Range: 213°C - 215°C (decomposition)
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Flammability: Combustible as organic powder, but not highly flammable
Vapor Pressure: Negligible at room temperature
Water Solubility: Soluble in water, sparingly soluble in methanol, practically insoluble in ethyl acetate
Partition Coefficient (log Kow): < 0
Auto-ignition Temperature: Not available
Decomposition Temperature: Above melting point
Viscosity: Not applicable (solid)
Chemical Stability: Stable under recommended storage conditions, may slowly degrade if exposed to air, light, or moisture
Conditions to Avoid: Prolonged exposure to elevated temperatures, direct sunlight, humidity, and open air
Incompatible Materials: Strong oxidizing agents, strong bases, reducing agents
Hazardous Decomposition Products: Carbon oxides, nitrogen oxides, hydrogen chloride, possibly other toxic gases
Polymerization: Will not occur
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity Data: LD50 (oral, rat): 7.6 mg/kg
Chronic Toxicity: May cause mutagenicity, carcinogenicity, reproductive toxicity based on animal studies
Inhalation Effects: May cause respiratory irritation, difficulty breathing, throat inflammation
Ingestion Effects: Nausea, vomiting, severe gastrointestinal injury, cytopenia, myelosuppression
Dermal Effects: Skin irritation, burns, possible delayed toxic effects
Eye Effects: Irritation, possible corneal injury
Sensitization: Prolonged contact can cause allergic reactions
Other Information: Classified by IARC as Group 2A, probable human carcinogen; reproductive risk at high exposures
Ecotoxicity: Highly toxic to aquatic life with long-lasting effects, LC50 (fish, 96 hrs): < 1 mg/L
Persistence and Degradability: Not readily biodegradable, remains active in environment for extended periods
Bioaccumulation Potential: Low expected bioaccumulation (log Kow < 0), yet persistent in aquatic system
Mobility in Soil: Likely to remain in upper soil layers, moderate to high mobility
Additional Information: Avoid environmental release, harmful to microorganisms and plants in low concentrations
Waste Disposal: Incinerate in approved facility, follow all federal, state, and local guidelines
Container Disposal: Triple rinse with appropriate solvent, destroy and dispose in chemical landfill or incinerator
Precautions: Do not release into environment or public sewage systems, keep waste separate from regular trash
Special Instructions: Use hazardous drug protocols for disposal, include handling of cleaning materials and contaminated PPE
UN Number: Not regulated under standard UN hazardous materials codes
Proper Shipping Name: Not classed as dangerous goods for transport
Transport Hazard Class: None assigned
Packing Group: None
Environmental Hazards: Mark "Marine Pollutant" if shipped in bulk or near water
Transport Precautions: Ship in sealed, labeled secondary containers, protect from physical damage and extreme temperatures
OSHA Status: Not specifically regulated as hazardous, treat as cytotoxic drug
TSCA: Not listed for commercial use
SARA 313: Not listed
California Prop 65: Not listed, but cytostatics often flagged by health departments
REACH Status: Research pharmaceutical, not registered for bulk industrial use
Labeling Requirements: Chemical name, health hazard, cytotoxic, handling precautions, use only by trained personnel
Additional Regulations: Institutional exposure limit policies, hazardous drug lists for hospital or lab use
