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Substance Name: Tolterodine Tartrate
Chemical Formula: C22H31NO·C4H6O6
Molecular Weight: 475.58 g/mol
Synonyms: Tolterodine L-tartrate, Detrol Tartrate
Product Use: Pharmaceutical agent for urinary incontinence
Manufacturer Information: Contact details available on request from supplier
Emergency Contact: Go to local emergency services or call Poison Control
CAS Number: 124937-52-6 (Tolterodine Base: 124937-51-5, Tartrate: 868-14-4)
Hazard Classification: Not classified as hazardous under GHS for normal laboratory quantities, but can be dangerous in large exposures
Route of Exposure: Inhalation, Ingestion, Skin, Eye
Acute Effects: May cause respiratory tract irritation, stomach upset, dizziness, or dry mouth
Chronic Effects: Prolonged exposure can lead to antimuscarinic symptoms, urinary retention, increased heart rate
Target Organs: Urinary bladder, central nervous system
Label Elements: Use gloves and eye protection; avoid dust formation
Signal Word: Warning
Pictograms: Exclamation mark (irritant)
Main Ingredient: Tolterodine Tartrate
Concentration: ≥ 98% pure
Impurities: Related substances may be present but account for < 1%
Additives: None present in pure chemical
Inhalation: Move individual to fresh air, seek medical attention for symptoms like difficulty breathing
Skin Contact: Remove contaminated clothing, wash skin with soap and plenty of water for at least 15 minutes, consult medical professional
Eye Contact: Rinse thoroughly with water for at least 15 minutes, lift upper and lower eyelids occasionally, consult ophthalmologist
Ingestion: Rinse mouth, drink water if conscious, avoid vomiting unless instructed by medical personnel, seek immediate medical assistance
Recommended Assistance: Carry medication label/container during medical visit
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Unsuitable Media: Avoid high-pressure water jets
Special Hazards: Toxic fumes of nitrogen oxides, carbon oxides, and tartrate decomposition can form under combustion
Protective Equipment for Firefighters: Full protective gear including NIOSH-approved self-contained breathing apparatus, avoid inhaling gases
Precautions for Fire Response: Control runoff to prevent environmental contamination
Personal Precautions: Use personal protective equipment such as gloves, lab coat, goggles, and ventilation
Environmental Precautions: Prevent spillage from entering drains or surface waterways
Clean-Up Methods: Sweep up without creating dust, collect in suitable waste container, wash contaminated surfaces with soap and water
Disposal: See Disposal Considerations for further instruction
Handling: Minimize dust production, avoid inhalation and contact with skin or eyes, use in well-ventilated areas or under fume hood, maintain good hygiene
Storage: Store in tightly closed original container, keep in cool, dry place protected from light and incompatible substances such as strong oxidizers
Incompatibilities: Avoid acids and strong oxidizing agents
Exposure Limits: No occupational exposure limits set; minimize exposure as per good laboratory practices
Engineering Controls: Use local exhaust or general laboratory ventilation; closed operational systems reduce dust and vapors
Personal Protective Equipment: Wear lab coat, chemical-resistant gloves (e.g., nitrile), safety goggles, face shield if handling large amounts
Respiratory Protection: NIOSH-approved respirator if dust or aerosols are likely
Hygiene Measures: Wash hands before breaks, at end of work, remove contaminated clothing
Environmental Controls: Prevent uncontrolled releases to environment, install spill containment if storing large volumes
Physical State: Solid (powder or crystalline material)
Color: White to off-white
Odor: Odorless or faint
pH (in water): Slightly acidic (tartrate salt) when dissolved
Melting Point: 218–224 °C (decomposes)
Boiling Point: Not applicable (decomposes before boiling)
Flash Point: Not determined
Solubility: Soluble in water, methanol, and slightly in ethanol
Partition Coefficient (log Pow): 1.83 (for tolterodine base)
Vapor Pressure: Negligible at room temperature
Relative Density: Not measured
Evaporation Rate: Not applicable
Auto-ignition Temperature: Not determined
Chemical Stability: Stable under normal laboratory and storage conditions
Conditions to Avoid: Excessive heat, open flame, high humidity, light exposure
Hazardous Reactions: Reacts with strong oxidizers, risk of toxic decomposition products under fire
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, decomposition products from tartrate
Polymerization: No known risk of hazardous polymerization
Acute Toxicity: LD50 oral (rat): > 2000 mg/kg; moderate toxicity
Likely Symptoms: Drowsiness, dry mouth, blurred vision, tachycardia, gastrointestinal upset
Potential Health Effects: Irritation to skin, eyes, respiratory and digestive systems; overdose can cause central nervous system and cardiac symptoms
Carcinogenicity: No evidence found in animal studies or human epidemiology
Mutagenicity: Tests on bacterial and mammalian cells: negative
Reproductive Toxicity: Studies in rats and rabbits: no teratogenic effects at therapeutic doses
Sensitization: May cause allergic reactions in sensitive individuals
Other Data: Chronic oral studies up to six months in animals showed typical antimuscarinic side effects without severe organ-specific toxicity
Ecotoxicity: Moderately hazardous to aquatic organisms in the event of large spills
Persistence and Degradability: Complex degradation process, not considered readily biodegradable
Bioaccumulation: Low potential for significant bioaccumulation, but residues may persist in sediment
Mobility in Soil: Moderate; likely to partition to water
Other Adverse Effects: Pharmaceuticals pose long-term environmental risk when not disposed properly
Waste Treatment Methods: Incinerate in controlled facility or return to pharmaceutical supplier for approved hazardous waste disposal
Waste Classification: Considered hazardous pharmaceutical waste, not for landfill
Contaminated Packaging: Decontaminate containers or dispose as hazardous waste
Do Not Release: Product or rinsate should not enter drains, watercourses, or soil
UN Number: Not regulated as dangerous goods under current international transport regulations
Proper Shipping Name: Tolterodine Tartrate (non-regulated for transport)
Transport Hazard Class: Not applicable
Packing Group: Not assigned
Transport Precautions: Protect from excessive heat, moisture, rough handling; keep packaging sealed and properly labelled
Inventory Status: Listed in US TSCA, EU EINECS, and select national inventories for research purposes
SARA Title III (Hazard Categories): Not classified as a hazardous substance
OSHA Status: Not specifically regulated, follow good laboratory safety standards
California Proposition 65: Not listed
REACH Status (EU): Compliant for laboratory/research use
WHMIS (Canada): Not a controlled product
Labelling: Chemical products require clear labelling in all jurisdictions
Other Information: Consult overarching chemical safety laws and institutional procedures before working with this pharmaceutical
