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Product Name: Tolnaftate
Chemical Name: O-(2-naphthyl)methyl-3-methylthiocarbamate
Synonyms: NP-27, Tinactin, Aftate, Desenex, Absorbine Jr.
CAS Number: 2398-96-1
Recommended Use: Antifungal agent used in topical medications
Manufacturer Contact: Emergency contact phone numbers, address, and relevant safety contact details provided by the supplier or manufacturer
Emergency Contact: National Poison Control Center: 1-800-222-1222, or local emergency services
GHS Classification: Not classified as dangerous under GHS for most end-user concentrations
Primary Dangers: Can irritate eyes, skin, and respiratory tract; ingestion may cause gastrointestinal discomfort
Label Elements: Avoid close or prolonged exposure. Wear suitable protective gear
Signal Word: Caution
Pictograms: Exclamation mark
Other Hazards: May aggravate conditions in individuals with existing skin or respiratory disorders
Chemical Name: Tolnaftate
CAS Number: 2398-96-1
Concentration: Pure substance; topical formulas typically use 1% tolnaftate
Impurities/Additives: May contain excipients or carriers in formulated products (ethyl alcohol, propylene glycol, talc in powders)
Inhalation: Move to fresh air if breathed in. Seek medical attention if discomfort persists
Skin Contact: Wash gently and thoroughly with soap and water. Remove contaminated clothing
Eye Contact: Flush thoroughly with lukewarm running water for several minutes. Seek medical help if irritation continues
Ingestion: Rinse mouth with water. Do not induce vomiting. Call Poison Control or a physician right away; show container or label
Suitable Extinguishing Media: Use alcohol-resistant foam, dry powder, carbon dioxide or water spray
Unsuitable Extinguishing Media: Do not use direct water jet, which may spread powder formulations
Hazards from Combustion: Toxic fumes (including oxides of sulfur, nitrogen, carbon) can form
Protective Equipment: Firefighters need self-contained breathing apparatus and protective clothing
Advice for Firefighters: Remain upwind and avoid breathing vapors
Personal Precautions: Wear gloves, goggles, and dust mask; avoid skin and eye contact
Environmental Precautions: Prevent runoff to soil, sewers, and waterways; avoid contaminating the environment
Cleanup Methods: Use absorbent material for liquids. Sweep up powders without raising dust. Place in secure, labeled containers for proper disposal
Decontamination: Wash area with water and detergent after cleanup
Precautions for Safe Handling: Handle in a well-ventilated area. Avoid breathing dust and direct contact with skin or eyes. Do not eat, drink, or smoke while using
Safe Storage Conditions: Store tightly sealed in a cool, dry place away from direct sunlight, heat, and incompatible materials. Keep out of reach of children
Storage Materials: Store in original or chemically resistant containers
Incompatibles: Strong oxidizing agents
Occupational Exposure Limits: No established exposure limits for tolnaftate
Ventilation: Use local exhaust or general room ventilation
Personal Protective Equipment: Wear chemical splash goggles, gloves, and protective lab coat or apron
Respiratory Protection: Use NIOSH-approved dust mask in case of dust formation
Hygiene Measures: Wash hands before breaks and after work. Remove contaminated clothing
Appearance: White to pale yellow crystalline powder
Odor: Odorless or mild odor
Solubility: Practically insoluble in water; slightly soluble in alcohol, chloroform, and ether
Molecular Weight: 307.40 g/mol
Boiling Point/Melting Point: Melts at about 110°C
Density: 1.25 g/cm³
pH: Not applicable for solid
Vapor Pressure: Negligible
Partition Coefficient (Log Pow): 3.65
Chemical Stability: Stable at room temperature under normal conditions
Conditions to Avoid: Excessive heat, light, moisture
Materials to Avoid: Strong oxidizers, strong acids
Hazardous Decomposition Products: May release carbon oxides, sulfur oxides, nitrogen oxides during thermal decomposition
Polymerization: Does not polymerize
Potential Acute Effects: Can cause mild skin irritation, eye irritation, or gastrointestinal upset if ingested
Long-term Effects: Not expected to cause significant chronic health effects; no evidence of carcinogenicity or reproductive toxicity in available data
Exposure Routes: Inhalation, skin contact, eye contact, ingestion
Sensitization: Rare case reports of allergic reactions after repeated topical use
LD50 (Oral, Rat): Greater than 5000 mg/kg (low acute oral toxicity)
Mutagenicity: No evidence from available studies that tolnaftate is mutagenic
Aquatic Toxicity: Not expected to cause significant hazard to aquatic organisms at levels encountered in pharmaceutical products
Persistence and Degradability: Tolnaftate is not highly persistent and may biodegrade slowly
Bioaccumulation: Potential for low to moderate bioaccumulation due to low water solubility
Soil Mobility: Low, due to insolubility in water
Other Adverse Effects: No known significant adverse effects on the environment at therapeutic doses
Waste Disposal Method: Dispose in accordance with local, regional, and national regulations. Incinerate or send to approved landfill
Contaminated Containers: Rinse thoroughly before recycling or disposal as hazardous waste
Precautions: Do not dispose of in natural waterways, drains, or household waste
Special Guidance: Seek professional waste management provider for bulk quantities
UN Number: Not regulated for transportation
Class: Not classified as a dangerous good under ADR, IMDG, IATA regulations
Packing Group: Not applicable
Labeling Requirements: No special hazard labeling required for transport
Special Precautions: Keep package well sealed; avoid excessive heat during transit
US Regulations: Tolnaftate is listed by the US FDA for over-the-counter topical antifungal use; not listed as hazardous under SARA Title III or CERCLA
International Status: Approved for use as antifungal in many countries; not included in EU hazardous substances list
Workplace Safety: OSHA hazard communication standard applies, though tolnaftate is not classified as hazardous
Chemical Inventory: Listed in US TSCA Inventory, European EINECS/ELINCS, Canadian DSL
