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Product Name: Tocopheryl Polyethylene Glycol Succinate
Chemical Family: Vitamin E derivatives, Polyethylene Glycol Esters
Synonyms: Vitamin E TPGS, Tocopherol PEG 1000 Succinate
CAS Number: 9002-96-4
Recommended Use: Used as an excipient, solubilizer, and antioxidant in pharmaceutical and food industries
Manufacturer Contact: Details available on manufacturer’s technical documentation or website; 24-hour emergency contact listed by supplier
Formula: C33H54O5 (core structure combined with PEG units of varying chain length)
GHS Classification: Not classified as hazardous under GHS criteria for most uses
Potential Hazards: May cause mild eye irritation; repeated or prolonged skin contact could lead to slight dryness or irritation; swallow large quantities may upset stomach
Pictograms: None required under current standards
Signal Word: None
Precautionary Statements: Avoid contact with eyes; wash hands after handling; use in well-ventilated areas if heated
Hazard Statements: Causes slight eye irritation; no evidence of carcinogenicity or mutagenicity in available studies
Main Component: D-alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (Content: ≥98%)
Synonymous Components: Polyethylene glycol esterified with succinic acid and tocopherol
Impurities: Typical levels of free tocopherol, unreacted PEG, and stabilizing antioxidants may be present at low concentrations, often below 2%
Inhalation: Move person to fresh air, seek medical attention if coughing or irritation develops
Skin Contact: Wash off with soap and water, remove contaminated clothing if persistent irritation occurs
Eye Contact: Rinse eyes with room temperature water for several minutes; if irritation persists, seek medical advice
Ingestion: Rinse mouth; drink water in small sips; do not induce vomiting; consult a healthcare provider for symptoms
Medical Note: No known chronic effects or delayed symptoms associated with exposure
Suitable Extinguishing Media: Foam, dry chemical, carbon dioxide, or water spray
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and trace organic gases
Firefighting Instructions: Wear self-contained breathing apparatus, full protective clothing; avoid inhaling combustion fumes
Flash Point: Typically above 200°C (392°F), non-volatile in ambient conditions
Explosion Hazard: Negligible for routine handling; dust in air may be combustible if allowed to accumulate
Special Protective Equipment: Positive pressure self-contained breathing apparatus
Personal Precautions: Avoid contact with eyes or excessive skin exposure; ventilate the area
Spill Response: Use absorbent materials such as sand or universal binders to collect spills
Cleanup Techniques: Sweep up and place in approved waste container; wash area with soap and water after removal
Environmental Precautions: Block entry of large amounts into drains or waterways; minimize dispersal
Disposal of Cleanup Materials: Follow all local/regional waste management regulations
Handling Practices: Handle with care to prevent contact with skin, eyes, or clothing; use in a well-ventilated space Hygiene Measures: Wash hands thoroughly after working with the material Storage Conditions: Store in tightly closed containers in cool, dry area; keep away from direct sunlight, heat sources, or strong oxidizers Incompatibilities: Strong oxidizers, acids, or alkali materials may degrade product over time Packaging: Use original, labeled containers; do not reuse packaging for food or drink
Occupational Exposure Limits: No established occupational exposure limits for Tocopheryl Polyethylene Glycol Succinate Engineering Controls: Use with adequate general or local exhaust ventilation as needed for operations that could create aerosols or dust Respiratory Protection: Not typically necessary for normal operations; use NIOSH-approved mask if dust is generated Hand Protection: Chemical-resistant gloves recommended for prolonged or repeated contact Eye Protection: Safety glasses or goggles where splashing may occur Skin Protection: Standard protective clothing for chemical handling Hygiene Measures: Wash hands and exposed skin after handling and before eating or drinking
Physical State: Waxy solid or viscous liquid, variable depending on PEG chain length and temperature
Color: Ranges from white to pale yellow
Odor: Mild, characteristic, sometimes faintly sweet
Solubility: Dispersible and soluble in water and oils
Melting Point: 37–41°C (98–106°F) depending on specific PEG
Boiling Point: Decomposes prior to boiling under normal pressure
Density: Approximately 1.1 g/cm³
pH (10% solution in water): 6.0–8.5
Viscosity: Thick, gel-like at room temperature
Partition Coefficient (log POW): Expected to be low due to PEG content
Decomposition Temperature: Above 250°C (482°F)
Chemical Stability: Stable when stored under recommended conditions Reactivity: Low; does not undergo hazardous polymerization Conditions to Avoid: Extended exposure to strong heat, open flames, oxidizers Incompatible Materials: Strong acids, alkalis, or oxidizing agents can degrade material Hazardous Decomposition Products: Produces carbon oxides and low molecular weight organics if overheated
Acute Toxicity: No acute toxicity expected in standard laboratory tests Skin Corrosion/Irritation: Mild irritation possible with repeated or prolonged exposure Eye Damage/Irritation: May cause minor, temporary eye irritation Respiratory or Skin Sensitization: Not expected to be a sensitizer based on available studies Chronic Toxicity: No evidence of mutagenic, carcinogenic, or reproductive toxicity from current data Other Effects: No known target organ toxicities or delayed systemic effects
Aquatic Toxicity: Low aquatic toxicity based on primary components; not expected to bioaccumulate Environmental Fate: Degrades under environmental conditions by hydrolysis and microbial action Persistence and Degradability: Biodegradable over time; does not persist significantly in the environment Bioaccumulative Potential: Low potential for accumulation due to polyethylene glycol’s water solubility Mobility in Soil: Moderate migration expected; soluble in water
Product Disposal: Dispose of product in accordance with local, regional, and national regulations; incineration or controlled landfill recommended where possible Contaminated Packaging: Rinse containers prior to recycling or disposal; avoid reuse for other chemicals or food products Special Precautions: Avoid release of large amounts into environment; consult local authorities for large-scale disposal
UN Number: Not regulated as dangerous goods for transportation Transport Hazard Class: Not classified under ADR/RID, IMDG, IATA, or DOT Packing Group: Not assigned Shipping Name: Tocopheryl Polyethylene Glycol Succinate, non-hazardous, non-regulated Special Precautions for Transport: Protect from moisture and physical damage during shipment; secure tightly closed containers
TSCA (USA): Listed
REACH (EU): Registered or exempted
EINECS/ELINCS: Included
RoHS and REACH Restrictions: Free from banned substances
FDA (USA): Permitted as food additive, pharmaceutical excipient
Occupational Safety: Not covered by specific OSHA PELs or ACGIH TLVs
Other Regulatory Status: No special hazard labeling required in most jurisdictions; always refer to local health and safety regulations
