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Chemical Name: Tiopronin
Synonyms: N-(2-Mercaptopropionyl)glycine, N-2-MPG
CAS Number: 1953-02-2
Recommended Use: Pharmaceutical ingredient, chelating agent
Supplier Information: Manufacturer details, emergency contact number provided on label
Emergency Contact for Spills: As listed by supplier, usually a 24-hour agency hotline
Hazard Classification: Acute toxicity – Oral Category 4, Eye irritation Category 2A, Skin sensitization Category 1
GHS Label Elements: Signal word "Warning", pictograms for exclamation mark, health hazard
Hazard Statements: Harmful if swallowed, causes serious eye irritation, may cause an allergic skin reaction
Precautionary Statements: Avoid breathing dust, wash skin thoroughly after handling, wear protective gloves and eye protection, IF INHALED remove person to fresh air, call poison center if unwell
Chemical Name: Tiopronin
Concentration: >=99% pure
Impurities: Trace amounts, typically not hazardous in supplied concentration
Molecular Formula: C5H9NO3S
Molecular Weight: 163.2 g/mol
Inhalation: Move to fresh air immediately. Seek medical attention if breathing is difficult.
Skin Contact: Remove contaminated clothing, rinse skin with plenty of water and mild soap. Medical help for persistent irritation.
Eye Contact: Rinse cautiously with clean water for several minutes, remove contact lenses. Immediate medical attention for redness or pain.
Ingestion: Rinse mouth, do not induce vomiting. Drink water if conscious. Seek medical support right away.
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide
Specific Hazards: May emit toxic fumes such as nitrogen oxides, sulfur oxides under combustion.
Special Protective Equipment: Firefighters need self-contained breathing apparatus, full protective gear.
Advice for Firefighters: Isolate area, cool containers with water spray even after fire is out.
Personal Precautions: Ventilate area, avoid dust formation, use appropriate PPE including gloves, lab coat, and safety goggles
Spill Cleanup: Sweep up and place in a suitable, labeled container. Avoid creating dust clouds.
Environmental Precautions: Prevent entry into sewers, groundwater, or waterways. Notify authorities if large spills occur.
Methods for Cleaning Up: Clean contaminated area with water and detergent, ensure surfaces are rinsed thoroughly.
Safe Handling: Wear suitable protective clothing, handle inside well-ventilated space, avoid contact with skin, eyes, or clothing, do not eat or drink while handling
Storage Conditions: Store refrigerated between 2–8℃ in original tightly-sealed container, away from strong oxidizing agents, acids, and light
Incompatibilities: Keep away from alkalis, oxidizing substances
Other Protective Measures: Regular inspection of storage and packaging integrity, use designated chemical storage refrigerators
Occupational Exposure Limits: No established value from OSHA, ACGIH, or NIOSH
Engineering Controls: Use local exhaust or general laboratory ventilation to control airborne levels
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), protective lab coat, tightly sealed safety goggles, face mask in case of dust formation
Hygiene Measures: Wash hands thoroughly after handling, change contaminated clothing, avoid ingestion and inhalation of dust particles
Appearance: White to off-white crystalline powder
Odor: Faint mercaptan-like odor
Odor Threshold: Not determined
pH: 2.5–3.5; solution in water
Melting Point: 165–170℃
Boiling Point: Decomposes before boiling
Flash Point: Not applicable
Evaporation Rate: Not available
Solubility: Freely soluble in water; slightly soluble in ethanol
Partition Coefficient (log Kow): -2.5 (estimated)
Vapor Density: Not available
Decomposition Temperature: Above 170℃
Chemical Stability: Stable under recommended conditions (2–8℃, dry, sealed packaging)
Conditions to Avoid: Excess heat, direct sunlight, moisture, air exposure
Incompatible Materials: Strong acids, bases, oxidizers, metal salts
Hazardous Decomposition Products: Sulfur oxides, nitrogen oxides, toxic fumes
Polymerization: Will not occur under normal conditions
Routes of Exposure: Inhalation, ingestion, skin and eye contact
Acute Toxicity: Oral LD50 in rats: 400 mg/kg
Skin Corrosion/Irritation: Possible irritant, may cause dryness or cracking
Serious Eye Damage/Irritation: Causes moderate to severe irritation
Respiratory Sensitization: Possible with prolonged exposure
Skin Sensitization: Repeated or prolonged contact may cause sensitization
Germ Cell Mutagenicity: No data available
Carcinogenicity: Not classified as cancer-causing based on available data
Reproductive Toxicity: Insufficient data for classification
Other Effects: Can aggravate medical conditions involving the skin, eyes, or respiratory system
Ecotoxicity: Limited data, not expected to cause widespread ecological harm under normal laboratory or pharmacy handling
Persistence and Degradability: Expected to be biodegradable
Bioaccumulative Potential: Low based on molecular structure and partition coefficient
Mobility in Soil: Expected moderate mobility, soluble in water
Other Adverse Effects: Prevent product or rinse waters from entering natural waterways, municipal sewers, or storm drains as a best practice
Disposal Methods: Place in tightly closed, labeled containers; dispose as hazardous pharmaceutical waste through licensed chemical disposal contractor
Contaminated Packaging: Triple rinse and manage as hazardous waste
Precautions for Disposal: Do not dispose alongside household trash; avoid discharges to the environment
UN Number: Not classified as a dangerous good under UN regulations
Transport Hazard Class: Not regulated for ground, air, or sea transport in supplied form
Packing Group: Not assigned
Special Precautions for User: Keep refrigerated (2–8℃) during transit, use insulated secondary packaging
Environmental Hazards: Not expected to pose risks in transport; package securely to avoid leaks or spills
OSHA Status: Not specifically listed
TSCA Status: Listed on US Toxic Substances Control Act Inventory
REACH Status: Registered as pharmaceutical ingredient in EU
Other Local/International Regulations: Not subject to major restrictions as a non-bulk hazardous material in most jurisdictions
Labeling Requirements: Follow national, state, and local chemical safety regulations for workplace labeling, storage, and reporting
