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Product Name: Tinidazole
Chemical Name: 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitroimidazole
Synonyms: Fasigyn, Simplotan, Trimonase
CAS Number: 19387-91-8
Recommended Use: Antiprotozoal and antibacterial agent
Manufacturer Information: Pharmaceutical supply companies and health chemical providers
Contact Details: Emergency numbers and technical support linked to material producer or supplier
Hazard Class: Not defined under GHS categories, but hazardous by OSHA standards
Signal Word: Warning
Primary Hazards: Suspected carcinogen, possible reproductive hazard, reported to irritate skin, eyes, and respiratory tract
Acute Effects: Headaches, dizziness, nausea, allergic reactions
Chronic Effects: Liver toxicity, nerve damage, potential cancer risk with long-term use
Pictograms: Exclamation mark, health hazard
Routes of Entry: Inhalation, ingestion, skin and eye contact
Other Information: Reports link to mutagenic and teratogenic activity in experimental systems
Chemical Identity: Tinidazole
Purity: Typically over 98% purity in commercial supply
Relevant Impurities: Residual solvents from synthesis, trace intermediates
Ingredient List: Tinidazole as active, minor stabilizers and processing aids as per manufacturer specification
Physical Form: Powder or tablet form for pharmaceutical use
Concentration: Varies depending on form – pure or formulated in combination drugs
Inhalation: Move to fresh air, seek medical help for breathing difficulty or persistent coughing
Skin Contact: Wash affected area with plenty of water, remove contaminated clothing, seek medical advice for irritation
Eye Contact: Rinse immediately with running water, keep eyelids open, seek prompt ophthalmologic attention
Ingestion: Rinse mouth, do not induce vomiting, seek immediate medical evaluation
Most Important Symptoms: Nausea, dizziness, skin or eye redness, allergic reaction signs
Notes to Physician: Treat symptomatically and provide supportive care, attention to possible neurological symptoms
Suitable Extinguishing Media: Water spray, dry chemical, carbon dioxide, foam
Unsuitable Media: Avoid high pressure water jet
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, sulfur oxides
Special Firefighting Procedures: Wear self-contained breathing apparatus and chemical protective clothing
Fire and Explosion Hazards: Dusts could form explosive mixtures with air, avoid ignition sources
Advice for Firefighters: Do not enter fire area without proper gear, prevent run-off water from contaminating surface water
Personal Precautions: Use protective gloves, goggles, and a dust mask, restrict access to cleanup area
Environmental Precautions: Prevent release into drains, watercourses, and soil
Cleanup Methods: Collect spill with absorbent material, sweep up without raising dust, transfer to waste containers for disposal
Decontamination: Clean area thoroughly with water and detergent after removal of bulk material
Reporting: Notify supervisors and follow local incident reporting rules
Safe Handling: Use in well-ventilated spaces, avoid inhalation and contact with skin or eyes, do not eat, drink or smoke in handling areas
Storage Conditions: Store in cool, dry place away from heat, light, and incompatible materials, keep containers tightly closed
Incompatible Materials: Strong oxidizers, acids, and alkalis
Other Guidance: Keep away from food, feed and beverages; keep out of reach of children
Occupational Exposure Limits: Not established for tinidazole
Engineering Controls: Work in a chemical fume hood or use adequate ventilation
Personal Protection: Nitrile gloves, lab coat, safety glasses, and respiratory protection in case of dust
Hygiene Measures: Wash hands thoroughly after handling, do not touch face until hands are clean
Physical State: Crystalline powder or solid
Color: Off-white to pale yellow
Odor: Odorless or slight chemical smell
Melting Point: About 135-138°C
Boiling Point: Data not available; decomposes before boiling
Solubility: Very slightly soluble in water, soluble in alcohols
pH: Not applicable as a solid
Vapor Pressure: Negligible at ambient temperatures
Density: Approximately 1.49 g/cm³
Partition Coefficient: Log Kow about 0.1 (at pH 7)
Chemical Stability: Stable under usual conditions, decomposes with strong heat
Reactive Possibilities: Not reactive under normal handling
Hazardous Reactions: Contact with strong oxidizers may cause vigorous reactions
Decomposition Products: Emits toxic fumes under fire conditions
Conditions to Avoid: Excessive heat, direct sunlight, contact with incompatible substances
Acute Toxicity: Oral LD50 (rat): around 2000 mg/kg; low acute toxicity by dermal and inhalation routes
Potential Health Effects: Stomach upset, neurologic symptoms (such as seizures or peripheral neuropathy), allergic skin reactions
Carcinogenicity: Evidence of carcinogenicity seen in animal studies, not conclusively proven in humans
Reproductive/Developmental Effects: Animal studies point to potential for embryotoxicity and teratogenicity, contraindicated in first trimester of pregnancy
Mutagenicity: Positive in certain in vitro mutagenicity tests
Chronic Exposure: Prolonged high-level exposure might cause liver damage or nerve inflammation
Environmental Fate: Not readily biodegradable, may persist in aquatic environments
Water Toxicity: Harmful to aquatic life with long lasting effects
Bioaccumulation: Expected to be low due to moderate water solubility and limited lipophilicity
Mobility in Soil: Possible leaching potential, dependent on soil characteristics and environmental conditions
Other Effects: Possible negative impact on microbial communities in wastewater treatment settings
Waste Treatment: Dispose of as pharmaceutical or chemical waste, never in household drains
Container Disposal: Rinse empty containers thoroughly, dispose of through authorized facility
Regulations: Obey local rules for hazardous waste, consult national and regional legislation for pharmaceutical waste management
Special Precautions: Prevent spillage and release into the environment, document disposal actions
UN Number: Not regulated as a hazardous material for transport
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Labeling Requirements: No specific requirements under international road, sea, or air regulations
Special Precautions: Protect from damage and moisture in transit, store securely to prevent accidental release
TSCA: Not listed as a chemical substance subject to reporting
OSHA Hazard Communication: Recognized as hazardous
SARA: Not listed under SARA Title III Sections 302, 304, 313
California Proposition 65: Not directly listed as a known carcinogen or reproductive toxicant
WHMIS Classification: Pharmaceutical products typically exempt, but appropriate classification in laboratory settings
International Regulations: Monitored under pharmaceutical ingredient control for import, export and pharmacopeia standards
