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Material Safety Data Sheet (MSDS) – Thidiazuron

Identification

Product Name: Thidiazuron
Chemical Name: N-phenyl-N′-1,2,3-thiadiazol-5-ylurea
CAS Number: 51707-55-2
Formula: C9H8N4OS
Recommended Use: Plant growth regulator, defoliant for cotton
Supplier: Information available upon request from manufacturer
Emergency Phone: Local poison control center or nearest hospital

Hazard Identification

Classification: Acute Toxicity (Oral, Dermal, Inhalation), Eye and Skin Irritant
Label Elements: Caution, hazardous dust, potential allergen
Routes of Exposure: Eye, skin, ingestion, inhalation
Symptoms: Eye and skin irritation, headache, nausea, respiratory distress with overexposure
NFPA Ratings: Health: 2, Flammability: 1, Reactivity: 0
Environmental Hazard: Possible aquatic toxicity in concentrated form

Composition / Information on Ingredients

Main Ingredient: Thidiazuron (purity typically 95% or greater)
Other Ingredients: Formulation carriers, wetting agents, inert fillers
Impurities: Degradation products and naturally occurring contaminants within agricultural synthesis
Concentration Range: Depends on formulation, technical grade up to 99%

First Aid Measures

Eye Contact: Flush gently with water for at least 15 minutes, seek medical attention if irritation persists
Skin Contact: Remove contaminated clothing, wash skin with soap and water
Ingestion: Rinse mouth, never give anything by mouth to unconscious person, seek immediate medical assistance
Inhalation: Move to fresh air, support breathing as needed, call poison center or doctor
Notes for Doctors: Treat symptomatically, monitor for allergic or respiratory reactions

Fire-Fighting Measures

Suitable Extinguishing Media: Water spray, foam, dry chemical, carbon dioxide
Hazardous Combustion Products: Oxides of nitrogen, sulfur oxides, carbon monoxide, irritating fumes
Special Equipment: Wear self-contained breathing apparatus, protective clothing
Fire Hazards: May release hazardous gases under high heat, dust may form explosive mixture with air
Precautions: Cool fire-exposed containers with water spray

Accidental Release Measures

Personal Precautions: Evacuate non-essential personnel, avoid creating dust
Protective Equipment: Chemical goggles, gloves, NIOSH-approved respirator
Spill Cleanup: Sweep up carefully, avoid generating dust, collect in labeled containers for disposal
Decontamination: Wash spill area with water and detergent after removal
Environmental Precautions: Prevent runoff into waterways, contain large spills with barriers

Handling and Storage

Handling: Use with adequate ventilation, avoid contact with eyes and skin, wear protective gear
Storage: Store in cool, dry, well-ventilated area, away from food and feed
Incompatible Materials: Strong oxidizers, concentrated acids, bases
Hygiene Measures: Wash hands before breaks and at end of work, keep out of reach of children

Exposure Controls and Personal Protection

Exposure Limits: No OSHA PEL, keep concentrations in air below nuisance dust levels
Engineering Controls: Local exhaust ventilation, dust collection systems
Personal Protective Equipment: Chemical-resistant gloves, long sleeves, goggles or face shield, NIOSH-certified respirator during high exposure risk
Hygiene Practices: Remove contaminated clothing, wash thoroughly after handling, do not eat or smoke during use

Physical and Chemical Properties

Appearance: Off-white to pale yellow powder
Odor: Characteristic, mild
Melting Point: 210–213°C
Boiling Point: Not available (decomposes before boiling)
Density: About 1.5 g/cm³
Solubility: Moderately soluble in water, more soluble in organic solvents
Vapor Pressure: Extremely low at ambient temperature
pH: Slightly acidic to neutral in 1% solution
Stability: Stable under recommended storage, decomposes with intense heating or strong acids

Stability and Reactivity

Chemical Stability: Stable under normal use and recommended storage
Conditions to Avoid: Excessive heat, moisture, direct sunlight
Incompatibility: Strong oxidizers, acids, bases
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide
Hazardous Reactions: Polymerization and runaway reactions not expected under normal conditions

Toxicological Information

Routes of Entry: Skin, inhalation, ingestion, eye contact
Acute Toxicity: LD50 (oral, rat): 2500-3500 mg/kg; LD50 (dermal, rabbit): >2000 mg/kg
Chronic Effects: Prolonged skin contact may cause irritation; repeated inhalation may affect respiratory system
Allergic Sensitization: Skin or respiratory sensitization possible in susceptible individuals
Carcinogenicity: Not listed as carcinogen by NTP, IARC, OSHA
Other Information: Reproductive and developmental toxicity data not clear; use with care

Ecological Information

Aquatic Toxicity: Harmful to aquatic organisms at high concentrations
Biodegradability: Moderately persistent, breaks down eventually in soil and water
Bioaccumulation Potential: Low for most wildlife species
Mobility in Soil: Limited leaching, bonds to soil particles
Additional Information: Follow best practices to prevent contamination of natural water sources

Disposal Considerations

Waste Disposal Methods: Treat as hazardous waste under local regulations, incinerate or dispose in approved chemical landfill
Container Disposal: Triple rinse, puncture and submit to recycling or landfill facility where approved
Precautions: Do not contaminate lakes, streams, or sewers
Disposal Guidance: Consult regional environmental authorities for specific disposal rules

Transport Information

UN Number: Not classified as dangerous under UN transport regulations
Transport Hazard Class: Not regulated for ground, sea, or air
Packing Group: Not applicable
Labeling Requirements: Standard agricultural chemical labeling
Special Precautions: Keep containers upright, dry and secure during transport

Regulatory Information

TSCA Inventory: Listed
FIFRA Status: Registered as a plant growth regulator in several countries
RCRA Status: May meet criteria for hazardous waste if discarded
SARA Title III: Not listed as extremely hazardous substance
Workplace Labeling: Use GHS-compliant labeling where mandated, safety training required for handlers
Other Requirements: Observe pesticide use permits, EPA registration, worker protection standards