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Product Name: Tetramisole Hydrochloride
Chemical Formula: C11H12N2S·HCl
Synonyms: (±)-Tetramisole Hydrochloride, Levamisole Racemic Hydrochloride, Tetramisole HCl
CAS Number: 5086-74-8
Recommended Use: Anthelmintic, pharmaceutical intermediate
Manufacturer Details: Contact information of supplier or manufacturer, including address and emergency phone number
Other Identifiers: UN number for shipping, unique batch numbers, and emergency contact protocols for response teams
Classification: Toxic if swallowed, irritating to skin and eyes, harmful by inhalation, suspected of causing genetic defects
GHS Label Elements: Skull and crossbones pictogram, exclamation mark, health hazard
Signal Word: Danger
Hazard Statements: Causes acute irritation to respiratory tract, may affect central nervous system, causes damage to liver and kidneys with prolonged exposure, risk of serious damage to eyes, may be harmful to aquatic organisms
Precautionary Statements: Avoid contact with skin and eyes, avoid breathing dust or vapor, use only in well-ventilated areas, do not eat, drink, or smoke during use, wash hands thoroughly after handling, wear protective gloves/eye protection
Chemical Name: Tetramisole Hydrochloride
Concentration: 99% or greater (technical grade)
Impurities and Stabilizing Additives: Less than 1% water and related byproducts from manufacturing
CAS Number: 5086-74-8
EC Number: 225-799-5
Molecular Weight: 240.75 g/mol
Relevant Exposure Limits: Occupational exposure limits not well established; good practice keeps levels as low as possible
Inhalation: Remove person to fresh air, seek medical attention if breathing difficulties or coughing arise, keep comfortable for breathing
Skin Contact: Immediately wash skin thoroughly with soap and water, remove contaminated clothing and shoes, consult a physician if irritation or rash develops
Eye Contact: Rinse eyes cautiously with water for at least 15 minutes, remove contact lenses, seek immediate medical help if irritation persists
Ingestion: Rinse mouth with water, do not induce vomiting, seek urgent medical attention, provide information on substance to health professionals
General Advice: Observe for symptoms such as persistent headache, nausea, or muscle tremors after exposure, medical monitoring for occupational exposure is recommended
Suitable Extinguishing Media: Use water spray, foam, dry chemical, or carbon dioxide for small fires, large fires may require deluge with water
Specific Hazards: May produce toxic fumes of nitrogen oxides, sulfur oxides, hydrogen chloride upon combustion, risk of accumulation of hazardous vapors
Protective Equipment: Firefighters wear self-contained breathing apparatus and full turnout gear, prevent runoff from entering water supplies or drains
Explosion Sensitivity: Not classified as an explosive, but dust may form explosive mixtures with air under certain conditions
Special Procedures: Remove containers from fire zone if possible, avoid breathing combustion products, cool adjacent surfaces with water spray
Personal Precautions: Wear chemical-resistant gloves, goggles, and protective clothing, ensure adequate ventilation, prevent dust formation
Environmental Precautions: Prevent spillage from entering drains, surface water, and soil, report significant releases to authorities as required
Methods for Cleaning Up: Collect spilled material mechanically into suitable, labeled containers for disposal, vacuum residues using equipment with HEPA filters, wash spill area with water and detergent with proper collection for disposal, decontaminate tools and equipment after use
Handling: Keep containers tightly closed, handle in a well-ventilated workspace, avoid dust generation, use personal protective equipment for all operational steps, maintain clean working conditions
Storage Requirements: Store in cool, dry, and well-ventilated facility, protect from direct sunlight and moisture, avoid temperature extremes, segregate from incompatible substances such as oxidizing agents, acids, and bases
Packaging Materials: Store in original containers or chemically resistant secondary containers with clear labeling; ensure storage areas are alarmed for spills
Storage Class: Toxic solid, non-combustible; follow site-specific protocols for hazardous chemicals
Engineering Controls: Local exhaust ventilation at points of dust or vapor generation, fume hoods for laboratory handling, process enclosures in industrial settings
Personal Protective Equipment: Chemically resistant gloves, tight-fitting safety goggles, face shields, laboratory coats or chemical-resistant suits, NIOSH-approved respirators if dust or aerosols cannot be controlled
Hygiene Measures: Wash thoroughly after handling, do not eat, drink, or smoke in work areas, remove contaminated clothes and wash before reuse
Exposure Limits: Occupational exposure limits not specifically set, recommended to minimize all exposures as much as possible
Appearance: White or off-white crystalline powder
Odor: Characteristic, faint odor
pH (1% solution): Approx. 3.0-4.5
Melting Point: 180-185°C
Boiling Point: Not applicable (decomposes)
Flash Point: Not flammable
Relative Density: About 1.3 g/cm³
Solubility: Soluble in water, slightly soluble in ethanol, practically insoluble in most organic solvents
Partition Coefficient (n-octanol/water): Data limited, expected to be low
Vapor Pressure: Negligible at room temperature
Decomposition Temperature: Above 200°C, releases toxic gases such as nitrogen oxides, sulfur oxides, and hydrochloric acid
Chemical Stability: Stable under recommended storage conditions, no significant change in chemical structure at normal temperatures
Conditions to Avoid: Exposure to strong heat, light, acids, alkalis, incompatible chemicals, or moisture can degrade product
Incompatible Materials: Strong oxidizing agents, acids, bases, peroxides, heavy metals
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, hydrogen chloride, other toxic gases
Polymerization: Does not undergo hazardous polymerization by itself, avoid contamination
Routes of Exposure: Ingestion, inhalation, skin and eye contact
Acute Toxicity: Oral LD50 in rats: 250-300 mg/kg, toxic if swallowed, symptoms may include nausea, vomiting, abdominal pain, convulsions
Chronic Toxicity: Prolonged exposure can cause liver and kidney injuries, suspected to impact immune system, possible reproductive toxicity based on animal studies
Irritation: Causes skin and eye irritation, respiratory tract irritation on inhalation
Sensitization: Risk of allergic reactions from repeated exposure
Carcinogenicity/Mutagenicity: Not classified as carcinogenic, limited evidence for mutagenicity in animal models
Specific Target Organ Toxicity: Central nervous system, liver, kidneys; repeated exposure may cause organ damage
Ecotoxicity: Harmful to aquatic organisms, may cause long-term adverse effects in aquatic environments, toxicity to fish and Daphnia reported in literature
Persistence and Degradability: Expected to be partially biodegradable under environmental conditions, breakdown influenced by microbial action, persistence possible in sediments and soils
Bioaccumulative Potential: Low to moderate potential for bioaccumulation in aquatic species, risk depends on concentration and exposure frequency
Mobility in Soil: Moderate mobility, risk of leaching into water tables, especially with improper waste handling practices
Other Adverse Effects: Breakdown products can pose environmental hazards if released in large quantities over time
Waste Treatment Methods: Dispose of contents and containers through licensed hazardous waste disposal contractor, do not allow untreated product to enter sewer systems or water bodies
Contaminated Packaging: Handle as hazardous waste, triple rinse where permissible, then destroy by controlled incineration
Local Disposal Regulations: Follow local, regional, and national environmental regulations, documentation of proper disposal required for large quantities
Precautions: Proper labeling and segregation required in all handling, maintain waste logs for audit and compliance
UN Number: UN 2811
Proper Shipping Name: Toxic solid, organic, n.o.s. (Tetramisole Hydrochloride)
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Label Requirements: Toxic symbol for all transport containers, provide emergency response information
Special Precautions: Protect against physical damage and moisture during transport, handle containers with care, report any incident during transit as per international transport regulations
Transport Regulations: Subject to IMDG, ICAO/IATA, and ADR/RID standards
Workplace Classification: Regulated as hazardous material by OSHA and similar safety agencies worldwide
Inventory Status: Listed on major chemical inventories (TSCA, EINECS, DSL)
Country-Specific Regulations: Product use, disposal, and handling covered under U.S. EPA, European REACH, and other local frameworks
Hazard Symbols: Toxic (T), Irritant (Xi), Environmental hazard (N) as required by local GHS implementation
Other Information: Medical surveillance and training recommended for individuals with occupational exposure, SDS should be accessible at points of use, periodic review for regulatory updates suggested
