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Product Name: Tetraisopropyl Titanate
Chemical Formula: Ti[OCH(CH3)2]4
SYNONYMS: Titanium tetraisopropoxide, TTIP
CAS Number: 546-68-9
Manufacturer: Refer to supplier information
Recommended Use: Used in material science labs, sol-gel processing, and surface coatings
Contact Information: Emergency telephone numbers typically available from supplier or local poison control center
Classification: Flammable liquids, Category 3; Acute toxicity (inhalation), Category 4; Skin corrosion/irritation, Category 2; Eye damage/irritation, Category 2
Signal Word: Danger
Hazard Statements: Causes skin irritation; causes serious eye irritation; harmful if inhaled; highly flammable liquid and vapor
Precautionary Statements: Avoid breathing vapor or mist. Keep away from heat, sparks, open flames. Wear protective gloves, clothing, and eye/face protection. Use only in well-ventilated areas. Wash skin thoroughly after handling.
Symptoms of Exposure: Contact causes eye, skin, and respiratory irritation. Inhalation can cause headaches, dizziness, and respiratory distress.
Label Elements: Pictograms illustrating flammable, exclamation mark, and health hazard for acute toxicity and irritation.
Chemical Identity: Tetraisopropyl Titanate
CAS Number: 546-68-9
Concentration: 98-100%
Impurities / Stabilizing Additives: Typically present in negligible quantities but specification sheets from the supplier or manufacturer will note trace residues or specific inhibitors.
Molecular Weight: 284.22 g/mol
Eye Contact: Quickly flush eyes gently with water for at least 15 minutes, lifting eyelids. Seek medical attention promptly.
Skin Contact: Remove contaminated clothing. Rinse skin immediately with plenty of water for at least 15 minutes. Seek medical attention if irritation persists.
Inhalation: Remove victim to fresh air. Ensure they are breathing comfortably. If symptoms such as coughing, wheezing, or shortness of breath develop, seek immediate medical advice.
Ingestion: Rinse mouth thoroughly with water; do not induce vomiting. Seek immediate medical attention.
Medical Attention: Show physician this safety data sheet. Treat symptomatically based on the individual's response to exposure.
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide.
Unsuitable Extinguishing Media: Water may cause violent reaction with product; avoid use where practical.
Specific Hazards: Vapors may form explosive mixtures with air. Containers exposed to fire may burst violently.
Thermal Decomposition Products: Titanium oxides, carbon oxides, irritating organic compounds.
Protective Equipment for Firefighters: Full chemical protective clothing with self-contained breathing apparatus.
Fire-Fighting Tactics: Evacuate area, use water spray to cool containers, avoid inhalation of toxic fumes.
Personal Precautions: Wear chemical-resistant gloves, eye protection, and suitable protective clothing. Evacuate non-essential personnel.
Environmental Precautions: Prevent entry into sewers and waterways; contain spill with sand or non-combustible absorbent.
Cleanup Methods: Cover with inert absorbent such as vermiculite; transfer to sealable chemical waste containers using non-sparking tools. Ensure adequate ventilation. Do not wash away with water.
Decontamination: Wash spill area thoroughly with detergent solution.
Safe Handling: Work in a well-ventilated space. Avoid inhalation of vapors and any skin/eye contact. Do not eat, drink, or smoke in work areas.
Hygiene Measures: Wash hands and exposed surfaces after every use. Remove contaminated clothing and equipment before leaving work area.
Storage Conditions: Store in cool, dry, well-ventilated, flammable storage area. Keep tightly closed in containers designed for flammable liquids. Protect from moisture and incompatible materials.
Incompatible Materials: Strong oxidizing or reducing agents, water, acids, ammonia, mineral acids.
Special Storage Instructions: Ensure containers are properly labeled.
Exposure Limits: No specific occupational exposure limits for tetraisopropyl titanate; use general limits for organic vapors and titanium compounds where available.
Engineering Controls: Use fume hood or local exhaust ventilation. Maintain eye wash stations and safety showers in work areas.
Personal Protection: Chemical splash goggles, face shield, nitrile or neoprene gloves, flame-resistant lab coat.
Respiratory Protection: If ventilation inadequate, use organic vapor respirator approved by national standards.
Other Precautions: Prevent spills and minimize exposure duration.
Physical State: Liquid
Appearance: Colorless to pale yellow, clear liquid
Odor: Faint alcohol-like odor
Boiling Point: 232 °C
Melting Point: -25 °C
Flash Point: 40 °C (closed cup)
Evaporation Rate: Not established
Solubility: Reacts with water
Vapor Pressure: 0.62 mmHg at 20 °C
Vapor Density: >1 (air = 1)
Density: 0.96 g/cm³
Autoignition Temperature: 335 °C
Viscosity: 1.3 mPa·s at 25 °C
Chemical Stability: Stable under recommended storage conditions; highly sensitive to moisture and hydrolysis.
Reactivity: Can react strongly with water, releasing heat and forming corrosive products.
Conditions to Avoid: Heat, flames, sparks, contact with moisture, incompatible chemicals.
Hazardous Decomposition: Burning creates titanium oxides, carbon oxides, and possibly irritating organic fumes.
Hazardous Polymerization: Not expected under normal storage and usage.
Incompatible Materials: Water, strong acids, bases, oxidizers, reducing agents.
Acute Toxicity: LC50 (rat, inhalation): Approximate value 4.3 mg/L/4h; Oral LD50 (rat): >2000 mg/kg
Skin Corrosion/Irritation: Causes moderate skin irritation
Serious Eye Damage/Irritation: Produces severe irritation and possible lasting effects with direct contact
Respiratory Effects: Vapor or mist may cause irritation to mucous membranes, respiratory tract symptoms, and drowsiness
Repeated Exposure: Prolonged or repeated contact may dry and crack skin, possible allergic reactions rare
Carcinogenicity/Mutagenicity: Data lacking for the substance; not listed by IARC, NTP, or OSHA as a carcinogen
Other Features: Inhalation at high levels may cause headaches, dizziness, nausea; substantial ingestion may result in systemic effects
Aquatic Toxicity: Limited data available; hydrolyzed product (titanium dioxide) generally of low toxicity to aquatic life
Persistence/Degradability: Reacts rapidly with moisture to form isopropanol and titanium hydroxide, both generally expected to degrade in the environment
Bioaccumulation Potential: Not expected to bioaccumulate, titanium compounds typically exhibit low mobility in soil
Mobility in Soil: Hydrolyzed product likely to remain close to the point of discharge
Other Harmful Effects: Large uncontrolled releases may damage aquatic habitats due to pH shifts or titanium compound precipitation
Waste Disposal Methods: Collect and segregate chemical waste in containers approved for flammable substances; do not pour down drains or release into the environment.
Container Disposal: Empty containers should be triple-rinsed and offered for recycling or incineration in accordance with local, regional, and national regulations.
Regulatory Compliance: Dispose of in cooperation with local environmental authorities to ensure compliance with applicable regulations.
Special Considerations: Do not attempt to neutralize on-site without appropriate chemical training and safety gear.
UN Number: 2924
Proper Shipping Name: Flammable liquid, corrosive, n.o.s. (tetraisopropyl titanate)
Transport Hazard Class: 3 (Flammable Liquid), 8 (Corrosive)
Packing Group: II
Hazard Labels Required: Flammable Liquid, Corrosive
Environmental Hazards: Not classed as a marine pollutant
Special Precautions: Use sealed containers, label in compliance with UN/IMDG/IATA rules, avoid moisture ingress
OSHA Status: Considered hazardous based on flammability and skin/eye irritation
TSCA Status: Listed in TSCA inventory
DSL/NDSL Status: Listed in Canadian DSL
EPA SARA Title III: Not subject to stringent reporting under SARA 302, 304, or 313
REACH Status: Registered under EU REACH where applicable; confirm status for region of use
WHMIS Classification: B2 (Flammable Liquid), D2B (Toxic Material causing other toxic effects)
Other Local Requirements: Follow all national, state, and local environmental and workplace regulations pertaining to storage, use, and disposal
