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Chemical Name: Tetraethyl Pyrophosphate
Common Names: TEPP, O,O,O',O'-Tetraethyl pyrophosphate
CAS Number: 107-49-3
Molecular Formula: C8H20O7P2
Recommended Use: Insecticide, chemical synthesis intermediate
Supplier Details: Manufacturer and distributor information, including emergency contact numbers
Emergency Telephone: Local Poison Control Center, National Chemical Emergency hotline
GHS Classification: Acute toxicity (oral, dermal, inhalation); specific target organ toxicity; aquatic toxicity
Signal Word: Danger
Hazard Statements: Fatal if inhaled or swallowed; causes skin irritation; suspected of damaging fertility or the unborn child; highly toxic to aquatic life
Pictograms: Skull and crossbones; exclamation mark; health hazard; environmental hazard
Precautionary Statements: Avoid breathing dust, fumes, gas, mist, vapors, or spray; use protective equipment; do not eat, drink, or smoke during use; wash thoroughly after handling; in case of exposure seek medical attention immediately
Substance: Tetraethyl Pyrophosphate (TEPP)
Concentration: Pure compound, typically greater than 95%
Impurities: Possible trace solvents, degradation products
Synonyms: O,O,O′,O′-Tetraethyl pyrophosphate
UN Number: 1704
EC Number: 203-501-3
Inhalation: Move person to fresh air; keep at rest; call poison center or physician immediately; if breathing stops, give artificial respiration
Skin Contact: Rapidly remove contaminated clothing; wash skin with plenty of water and mild soap; seek urgent medical attention for signs of poisoning
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing; seek medical care
Ingestion: Rinse mouth; do not induce vomiting; get medical help urgently; administer activated charcoal only if advised by a medical professional
Symptoms and Effects: Reduced cholinesterase activity, muscle twitching, headache, respiratory difficulty, convulsions, risk of death without treatment
Immediate Medical Attention: Required for all routes of exposure, as onset can be rapid and fatal
Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide, do not use water jet directly
Specific Hazards: Releases toxic and irritating phosphorus oxides under fire conditions; container may explode if heated
Protective Equipment for Firefighters: Self-contained breathing apparatus, full protective gear, chemical splash suit
Special Procedures: Shut off source of fuel if safe; fight fire from upwind; avoid runoff to water sources or sewers
Fire Decomposition Products: Combustion releases phosphorus oxides, carbon oxides, ethylene, other atropine-reactive gases
Personal Precautions: Ventilate area; evacuate non-essential personnel; wear chemical-resistant suit, gloves, and respirator
Environmental Precautions: Prevent entry into waterways, sewers, or soil; alert local authorities if large amounts escape
Methods for Cleanup: Absorb with inert dry material (sand, earth); scoop into sealable container; decontaminate spill site with alkaline detergent solution
Decontamination: Wash area with soapy water, neutralize with sodium hydroxide solution if available
Special Instructions: Dispose of contaminated clean-up materials as hazardous chemical waste
Safe Handling: Work in well-ventilated or fume-hood areas; keep away from heat, sparks, open flames, or hot surfaces; avoid any contact with skin, eyes, and clothing; do not inhale vapors; wash hands and face before eating or drinking
Storage Conditions: Store tightly sealed in original chemically resistant container, in a cool, dry, well-ventilated, locked chemical storage facility; segregate from acids, alkalis, oxidizers, food products, feed, and animal housing
Incompatibilities: Strong acids and bases, strong oxidizers, water; incompatible with many metals
Special Requirements: Limit access to trained personnel; maintain emergency washing facilities and spill clean-up materials nearby
Occupational Exposure Limits: No established OSHA or ACGIH limits; handle as extremely toxic material
Engineering Controls: Local exhaust ventilation, chemical fume hood, closed systems
Personal Protective Equipment (PPE): Full face shield or goggles, chemical-resistant gloves (nitrile, butyl rubber), full-body suit, respiratory protection (supplied-air, positive pressure, or SCBA for emergency or high-concentration scenarios)
Hygiene Measures: Remove and launder contaminated clothing before reuse; do not eat, drink, or smoke in work areas; wash thoroughly after handling
Environmental Exposure Controls: Prevent release to environment; treat and capture all effluent and air emissions
Appearance: Colorless to light yellow liquid
Odor: Slightly fruity, unpleasant
Boiling Point: About 180°C at standard pressure
Melting Point: -42°C
Density: 1.16–1.18 g/cm³
Solubility: Slightly soluble in water; mixes with organic solvents
Vapor Pressure: 0.5 mmHg at 20°C
pH: No data; hydrolyzes in water
Flash Point: 130°C
Auto-Ignition Temperature: Data not available
Partition Coefficient (Log Kow): ~1 (estimate)
Viscosity: Mobile liquid
Chemical Stability: Unstable if exposed to light, heat, or moisture; hydrolyzes rapidly in the presence of water or alkaline media
Possibility of Hazardous Reactions: Violent reaction with strong oxidizers, bases, acids; decomposes under fire to produce toxic phosphorus oxides
Hazardous Decomposition: Ethylene, pyrophosphates, phosphorus oxides
Conditions to Avoid: Heat, sunlight, moisture, open flames, incompatible substances
Materials to Avoid: Water, alkalis, acids, oxidizers, some metals, reducing agents
Modes of Exposure: Inhalation, ingestion, skin, and eye contact
Acute Toxicity: Extremely toxic; estimated oral LD50 for humans less than 1 mg/kg
Chronic Effects: Potential inhibition of cholinesterase enzyme, leading to neurological damage
Symptoms: Nausea, vomiting, abdominal cramps, pinpoint pupils, muscle twitching, confusion, convulsions, respiratory failure
Delayed Effects: Symptoms may appear within minutes to hours; possible long-term neurologic damage
Carcinogenicity: Not classified as carcinogen by IARC or NTP
Other Health Effects: May impair fertility or harm the developing fetus
Target Organs: Central nervous system, respiratory system, kidneys, liver
Ecotoxicity: Highly toxic to aquatic invertebrates, fish, and birds; acute and chronic effects expected at very low concentrations
Persistence and Degradability: Degrades by hydrolysis in water but may persist in dry soils or organic-rich sediment
Bioaccumulation Potential: Unlikely due to rapid hydrolysis in moist environments, but acute toxicity persists
Mobility in Soil: Moderate, may migrate to ground water if dry and not hydrolyzed
Other Adverse Effects: Harmful to beneficial insects, can disrupt food chains and ecosystem balance
Waste Treatment Methods: Incinerate under controlled conditions at specialized hazardous waste facilities; must use high temperatures and scrubbing systems for gases
Product Disposal: Avoid direct release; contact licensed hazardous waste handler; do not dispose in drains, sewers, or ordinary waste streams
Contaminated Packaging: Triple rinse with compatible solvent and treat as hazardous waste; puncture and dispose of through certified chemical waste processor
Additional Notes: Comply with local, state, national, and international disposal regulations
UN Number: UN1704
Proper Shipping Name: Tetraethyl Pyrophosphate
Transport Hazard Class: 6.1 (Toxic substances)
Packing Group: I (high danger)
Marine Pollutant: Yes
Special Precautions: Keep upright in secure, well-labeled containers; transport with compatible chemical cargo only
Regulatory Transport Labels: Toxic, Marine Pollutant, Environmental Hazard
Relevant Regulations: Subject to regulation under OSHA, TSCA, FIFRA, CERCLA in the US; listed as extremely hazardous in multiple nations
Notification Requirements: Immediate reporting to local and national authorities for spills or workplace injuries
Worker Protection: Mandatory safety data sheet training, pre-employment and periodic medical exams, respiratory surveillance
Restricted Use: Banned/restricted in many countries due to acute toxicity and poisoning incidents
Other Regulatory Information: Strict import/export controls; compliance required with all chemical safety directives for manufacture, storage, transport, use, and disposal
