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Chemical Name: Tetra-N-Propyl Titanate
Synonyms: Tetrapropoxytitanium, Titanium(IV) propoxide, TPT
CAS Number: 546-68-9
Molecular Formula: C12H28O4Ti
Recommended Use: Catalyst, precursor for titania films, chemical synthesis in industry
Manufacturer Details: Supplier’s information with address and emergency contact number
Emergency Phone: Provided by chemical supplier
Product Code: TPT-54668
GHS Classification: Flammable Liquid (Category 3), Skin Corrosive (Category 1B), Eye Damage (Category 1), Specific Target Organ Toxicity - Single Exposure (Category 3; respiratory tract), Acute Toxicity, Oral (Category 4)
Signal Word: Danger
Hazard Statements: Causes severe skin burns and eye damage, flammable liquid and vapor, causes respiratory irritation, harmful if swallowed
Pictograms: Flame, Corrosion, Exclamation mark
Precautionary Statements: Keep away from heat, sparks, open flames; avoid breathing vapor or mist; wear protective gloves, eye protection, and face protection; wash hands thoroughly after handling; use only outdoors or in a well-ventilated area
Potential Health Effects: Eye contact can cause severe irritation, potential blindness; skin contact may lead to burns and blistering; inhalation causes respiratory tract irritation and may lead to coughing or difficulty breathing; ingestion may damage gastrointestinal tract
Environmental Hazards: May be toxic to aquatic organisms due to hydrolysis reaction in water producing titanium dioxide and propanol
Chemical: Tetra-N-Propyl Titanate
Concentration: Pure substance (≥ 98%)
Impurities: Minor amounts of propanol, titanium dioxide (hydrolysis byproduct), unspecified organotitanium residues
Other Ingredients: None significant for classification
Inhalation: Move person to fresh air immediately; if breathing is difficult, give oxygen; seek medical attention if symptoms persist
Skin Contact: Immediately flush skin with copious amounts of water for at least 15 minutes; remove contaminated clothing and wash before reuse; seek urgent medical attention if burns or irritation develop
Eye Contact: Rinse cautiously with water for several minutes; remove contact lenses if present and easy to do; continue rinsing and get immediate medical help
Ingestion: Do not induce vomiting; rinse mouth with water if person is conscious; seek immediate advice from a poison center or a physician
Most Important Symptoms: Chemical burns, severe irritation, possible delayed effects on mucous membranes or lung function
Note for Physicians: Treat symptomatically and monitor for delayed respiratory complications
Suitable Extinguishing Media: Alcohol-resistant foam, dry chemical powder, carbon dioxide—do not use water jet, as hazardous hydrolysis may occur
Specific Hazards: Vapors may form explosive mixtures with air; combustion may produce toxic fumes including titanium oxides, carbon oxides, and propanol
Special Protective Equipment for Firefighters: Self-contained breathing apparatus and full protective gear
Firefighting Procedures: Evacuate area and use water spray to cool containers; prevent run-off to sewers or waterways as product hydrolyzes and forms slippery, hazardous surfaces
Unusual Fire Hazards: Sealed containers may rupture under intense heat
Personal Precautions: Evacuate unnecessary personnel, use appropriate personal protection including chemical-resistant gloves, safety goggles, and respiratory protection
Environmental Precautions: Prevent contamination of soil and waterways, avoid entry into drains, notify authorities if significant spill threatens the environment
Methods for Clean-up: Absorb spillages with inert, dry material such as sand or vermiculite; do not use materials that react with water; collect residues in suitable containers for proper disposal; ventilate area; decontaminate with alcohol only after main cleanup
Precautions for Handling Leaks: Treat touched areas with alcohol to hydrolyze residues safely, ventilate, avoid contact with humidity or water
Safe Handling Recommendations: Use only in well-ventilated environments; avoid inhalation, ingestion, and contact with skin or eyes; keep away from sources of ignition and incompatible materials (strong oxidizers, acids, moisture); ground and bond container and receiving equipment
Storage Requirements: Store in tightly closed, original containers under inert atmosphere or dry nitrogen, in a cool, dry place; keep away from direct sunlight, moisture, and incompatible chemicals; keep away from heat sources and open flames
Packaging Materials: Use containers made of glass, stainless steel, or compatible plastics; avoid containers with unlined metal that might react with product; label clearly with hazard information
Exposure Limits: No occupational exposure limit established; general recommendation to minimize exposure as much as possible
Engineering Controls: Use local exhaust ventilation or chemical fume hood; maintain proper workplace air flow to prevent vapor accumulation
Personal Protective Equipment: Splash-resistant safety goggles, face shield, chemical-resistant gloves (nitrile, neoprene or butyl rubber), flame-retardant lab coat, closed-toed shoes, respiratory protection if ventilation is insufficient
Hygiene Measures: Wash hands thoroughly after handling, remove contaminated clothing, ensure eyewash stations and safety showers are accessible
Appearance: Clear, colorless to pale yellow liquid
Odor: Faint, characteristic organic odor
Odor Threshold: Not established
pH: Not applicable
Melting Point/Freezing Point: -35°C
Boiling Point/Range: 143–145°C at 14 mmHg (decomposes before boiling at atmospheric pressure)
Flash Point: 42°C (closed cup)
Evaporation Rate: Not available
Flammability: Flammable liquid and vapor
Upper/Lower Flammability or Explosive Limits: Not established
Vapor Pressure: 2.4 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: About 0.98–1.02 g/cm³ at 20°C
Solubility: Reacts with water; soluble in many organic solvents
Partition Coefficient: Not determined
Autoignition Temperature: 245°C
Decomposition Temperature: Decomposes upon heating
Viscosity: 6–9 mPa·s at 20°C
Molecular Weight: 284.23 g/mol
Chemical Stability: Stable under recommended storage conditions, sensitive to moisture and air
Reactivity: Reacts readily with water, alcohols, and acids releasing heat, forming titanium dioxide, and organic byproducts
Possibility of Hazardous Reactions: Violent hydrolysis in contact with water; formation of flammable propanol; may produce flammable gases with strong reducing agents
Incompatible Materials: Moisture, water, acids, strong oxidizers, reducing agents
Hazardous Decomposition Products: Titanium dioxide, propanol, carbon oxides, possibly irritating vapors or gases
Acute Toxicity: LD50 (oral, rat): estimated at 3,900 mg/kg; harmful if swallowed
Skin Corrosion/Irritation: Causes severe skin burns; animal studies show significant irritation and potential to cause necrosis
Serious Eye Damage/Irritation: Causes serious eye damage and potential for blindness
Respiratory Sensitization: Irritating to respiratory tract
Chronic Toxicity: No conclusive data for long-term carcinogenicity, mutagenicity, or reproductive toxicity in humans
Ingestion Effects: Burns to mouth, throat, esophagus; abdominal pain, vomiting
Inhalation Effects: Coughing, choking, dizziness, shortness of breath due to hydrolysis products
Additional Information: Unintentional hydrolysis may exacerbate toxicity risk due to exotherm and byproducts
Ecotoxicity: Freshly released Tetra-N-Propyl Titanate may not have direct measured aquatic toxicity data, but hydrolysis forms titanium dioxide and propanol, which can affect water quality and aquatic life
Persistence and Degradability: Decomposes rapidly in water to titanium dioxide and propanol; titanium dioxide remains as persistent solid in soil or sediment
Bioaccumulation Potential: Not likely to bioaccumulate due to rapid decomposition
Mobility in Soil: Product hydrolyzes quickly, so titanium dioxide remains with limited mobility; propanol may leach in soil
Other Adverse Effects: Accidental releases to waterways may result in clouding from suspended solids, affecting aquatic photosynthesis and food chains
Waste Treatment Methods: Dispose of contents/container in accordance with local, regional, national, and international regulations; do not pour into drains or natural water bodies
Disposal of Contaminated Packaging: Containers which have held the substance should be emptied as completely as possible; rinse with an appropriate solvent; incinerate or send to hazardous waste processor
Special Considerations: Hydrolyze unused product under controlled conditions to form less hazardous components before disposal; seek advice from certified waste management company
Regulatory Recommendation: Classified as hazardous waste in most jurisdictions
UN Number: UN 1993
UN Proper Shipping Name: Flammable liquid, n.o.s. (Tetra-N-Propyl Titanate)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: II
Environmental Hazards: Not classed as a marine pollutant by IMDG, though accidental releases can pose risk
Special Precautions: Handle as flammable liquid; ensure containers remain sealed, upright, and away from moisture during transit; emergency response information must accompany shipment
Transport Regulations: Comply with ADR/RID (Europe), IMDG (Sea), ICAO/IATA (Air), DOT (USA) as applicable
Safety, Health and Environmental Regulations: Subject to chemical safety reporting and workplace exposure controls under OSHA (USA), REACH (EU), WHMIS (Canada), and similar regulatory frameworks
Hazard Symbols: F (Highly flammable), C (Corrosive)
Risk Phrases: R10, R21/22, R34, R37
Safety Phrases: S23, S26, S28, S36/37/39, S45
Restrictions: Industrial use only; not approved for food, drug, or cosmetic preparations
Compliance: Users must follow all federal, national, and local laws regarding handling and disposal
