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Looking back at the history of modern medicine, it’s hard to overstate the role anti-inflammatory drugs play. Sulindac didn’t exist in isolation—it came on the scene in the 1970s, about a decade after indomethacin set the stage for nonsteroidal anti-inflammatory drugs (NSAIDs). Before that, aspirin dominated for nearly a century, but issues with gastrointestinal bleeding pushed researchers to look for alternatives. Scientists working for Merck synthesized Sulindac through a process of iterative chemical tweaks, drawing inspiration from indomethacin’s scaffold but aiming for longer action and a safer profile. Folks dealing with chronic pain and arthritis soon found another option on the pharmacy shelf, and rheumatologists gained a new tool that promised fewer gastric side effects than its predecessors. The journey of Sulindac reflects the cycle of chemical creativity; it’s a testament to researchers who tested thousands of analogs before pinpointing a structure that managed inflammation without wiping out patient comfort.
Most people who take Sulindac know it from the pharmacy counter: an oval tablet, often yellow, with a bitter tin. It’s more than just a pill, though. Sulindac belongs to the arylalkanoic acid class, which means it blocks cyclooxygenase (COX) enzymes, stifling prostaglandin synthesis and with it, pain and swelling. What puts it in a unique spot among NSAIDs is its prodrug status. You swallow Sulindac, but it doesn’t do much until your liver converts it into its active sulfide metabolite—a clever workaround to mitigate some of the stomach trouble caused by other NSAIDs. This property alone set it apart for physicians treating persistent pain, especially in patients who’d soured on older options. While generics now dominate pharmacy shelves, that design principle persists and tells a story of medicinal chemistry aimed at better tolerability.
Those who remember college chemistry might appreciate how Sulindac quietly blends structure with function. Its molecular formula—C20H17FO3S—houses a sulfoxide group alongside a fluorinated indene ring, which packs a punch in terms of lipophilicity. This arrangement lets Sulindac dissolve best in organic solvents but just barely in water, which adds a hurdle for formulation scientists. At room temperature, it stays solid, with a melting point over 180°C that keeps it shelf-stable through long storage and distribution. Its bitterness makes formulating palatable tablets an art in itself, with excipients chosen carefully to mask taste without disturbing absorption. These physical quirks, shaped by the molecule’s architecture, dictate how drugmakers process, coat, and release Sulindac tablets to patients around the world.
Labels aren’t just regulatory obligations—they’re the main line of defense for patient safety. The Sulindac label spells out dosing by condition, whether a person wrestles with osteoarthritis, ankylosing spondylitis, or acute gouty arthritis. The recommended maximum daily dose—usually capped at 400mg—offers some margin but pushes clinicians to stress caution, especially in people with thin stomach linings or tricky kidneys. The label highlights potential drug interactions, like problems when paired with blood thinners, lithium, or ACE inhibitors. The “black box” warning reminds users about the risk of cardiovascular events and gastrointestinal bleeding. Patients see warnings about combining Sulindac with alcohol, aspirin, or high doses of vitamin K antagonists, which could tip the scales toward dangerous side effects. By clearly listing inactive ingredients, manufacturers help those with allergies or intolerances steer clear of trouble. As someone who reads these labels closely, I see them as a road map—sometimes daunting, always necessary—designed to shepherd safe use through real-world uncertainties.
The story of how Sulindac comes together still impresses me. Synthetic chemists designed a route that starts with the assembly of the indene core, attaching a fluorine atom and building out the arylalkanoic acid side chain. Conditions for each step—solvent choice, temperature control, order of reagent addition—carry the weight of decades of organic synthesis know-how. Critical to the final product: oxidation to the sulfoxide, which gives Sulindac its prodrug character. Modern drug plants crank out hundreds of kilograms per batch, but scale-up brings its own snares, from unwanted byproducts to environmental controls. Each tablet passes multiple rounds of quality control, from purity testing to dissolution rate measurement, sometimes using techniques like high-performance liquid chromatography and infrared spectroscopy. All this work comes together so a patient gets reliable pain relief, batch after batch, season after season.
Scientists never stop tweaking molecules to sharpen their benefits or soften side effects. With Sulindac, researchers have tinkered with both the indene ring and side chain to optimize its pharmacological profile. The sulfoxide group—unusual among oral NSAIDs—requires careful control of oxidation, as over-oxidation can dramatically change the molecule’s activity. Chemists investigated analogs where substituents at the fluorinated position influenced both potency and metabolic rate, while tweaks to the carboxylic acid aim to adjust binding to COX enzymes. Metabolism studies flagged key steps in bioactivation: reduction to the active sulfide in the liver and further breakdown to inactive sulfone or carboxylated metabolites. Teams working in medicinal chemistry labs continue to look for ways to cut down on kidney burden or boost selectivity for COX-2, hoping to extend Sulindac’s legacy or even launch the next generation of NSAIDs.
Most patients know medications by the brand names their doctors prescribe. Sulindac entered the market under the name Clinoril, but today’s shelves display generics without much fuss. Its chemical name spells out the structure piece by piece: (Z)-5-fluoro-2-methyl-1-[(4-methyl-2-p-tolylsulfinyl)benzylidene]indene-3-acetic acid. Pharmacy reference books often list synonyms that pop up in scientific literature—like NSC 657298 and MSD 8383—though only researchers tend to remember these. While branding rarely shapes a patient’s daily routine, clear labeling helps keep confusion down, especially for older adults juggling multiple prescriptions. For providers, a firm grasp of both generic and trade names means fewer mistakes and safer care.
Pharmaceutical safety comes from layers of vigilance, not just from rules on paper. Every step, from sourcing raw chemicals to final packaging, runs through a gauntlet of good manufacturing practices. Workers in the plant wear protective gear and adhere to handling rules because direct contact or inhalation of bulk powder poses health risks. Tablet presses and packaging lines run under strict inspection, with routine sampling to spot contamination. Tablets and powders head to shelves in tamper-resistant bottles, labeled with lot numbers and expiration dates. Pharmacists double-check storage conditions, since humidity or high temperature can erode shelf life. Health authorities like the FDA keep an eye on reports of adverse events, triggering recalls or label changes when problems surface. I’ve watched pharmacists educate patients about signs of liver or kidney stress and track patterns in pharmacy software to catch early warning signs of trouble. Patient safety continues to ride not only on tight regulations but also on the daily vigilance of people who handle Sulindac from factory floor to pharmacy counter.
Doctors reach for Sulindac mainly in the trenches of rheumatology, where chronic pain, inflammation, and swelling threaten quality of life. For many years, Sulindac’s twice-daily dosing and stomach-sparing properties made it the prescription for arthritis, bursitis, and acute gout attacks. In hospital settings, Sulindac sometimes steps in when patients can’t tolerate naproxen or ibuprofen. It fits into protocols for short-term pain after minor surgery, easing strains without pumping up opioid risk. Over the past decade, researchers also flagged Sulindac for its possible cancer-fighting properties. Epidemiological studies linked regular NSAID use with decreased polyp formation in certain genetic cancer syndromes; in this role, Sulindac attained orphan drug status for familial adenomatous polyposis, a rare precancerous condition. Although newer COX-2 inhibitors and alternative painkillers have crowded the NSAID field, Sulindac held on by carving a niche among patients needing effective pain relief without reaching straight for steroids.
Innovation keeps the story of Sulindac from ending on a pharmacy shelf. Basic research continues to map its effects on inflammation, pain, and even tumorigenesis. In the lab, Sulindac’s mechanism—blocking both COX-1 and COX-2—remains a benchmark against which other drugs are measured. Long-term epidemiological studies watch for decreased rates of colon cancers among users, and teams test combinations with other chemopreventive agents in high-risk populations. Research also looks at modifying dosing strategies to cut down on gastrointestinal and cardiovascular risk, including the use of gastroprotective agents or alternate-day dosing in certain patient groups. In medical literature and conference halls, doctors debate where Sulindac fits amid modern biologics, aiming for targeted relief with fewer side effects. Collaboration between academic labs, regulatory bodies, and pharmaceutical companies helps keep patient safety at the forefront while pushing the boundaries of anti-inflammatory therapy.
Every drug that fights pain has a flip side, and Sulindac’s drawbacks have shaped its reputation. Decades of clinical experience revealed patterns in adverse effect reporting—no drug skates by forever. Patients with preexisting kidney disease, heart risk, or stomach ulcers run into trouble fastest, while high doses or long-term use can tip healthy users into problems. Liver injury, although rare, surfaces more often with Sulindac than with some cousins, likely due to the way the body activates the drug through the liver. Studies in both animals and humans mapped out metabolic byproducts, feeding data back into regulatory frameworks. Clinicians wade through these data when deciding how to balance pain control against possible harm. Warnings on the bottle grew bolder over time, shaped by real-world cases and adverse event tracking. Periodic lab monitoring—liver function, kidney tests, and blood counts—act as sentinels to catch damage before it escalates. As people live longer with chronic disease, these lessons remind us that relief always comes with responsibility and oversight.
Modern medicine seldom stands still, and Sulindac’s story keeps evolving. Some experts wonder if the future lies in finding ways to personalize NSAID therapy, using genetic testing or metabolic profiling to pick the safest option for each patient. Researchers eye opportunities to repurpose old drugs for new indications, especially where inflammation, cancer risk, or pain overlap with other health issues. Advances in formulation science, like extended-release tablets or targeted delivery systems, might help reintroduce Sulindac to new patient groups who could benefit from tailored therapy. As regulatory standards grow tighter and knowledge of drug interactions deepens, Sulindac’s profile in the medical community stays dynamic—never static. No medicine stays relevant forever without adaptation, and the lessons drawn from Sulindac’s journey—tinkering in the lab, close watching in the clinic, and honest tracking of harm—guide how we approach the next chapter in pain relief.
Sulindac doesn’t come up in everyday conversation. You won’t hear it in TV drug ads or see it in the newer, flashier pill boxes at the pharmacy. Still, in many doctor’s offices, especially among those who treat arthritis and long-term pain, the name stands for relief, even when other medicines fall short.
Doctors reach for sulindac mostly to help with swelling, pain, and stiffness that come with arthritis. This includes osteoarthritis—the kind linked to wear and tear over time. It also covers rheumatoid arthritis, a more aggressive, immune-driven sort of joint trouble. Gout can bring people to their knees in pain, and sulindac has a long track record helping folks weather those attacks.
The drug belongs to a group called NSAIDs (non-steroidal anti-inflammatory drugs). People often try newer ones first, like ibuprofen and naproxen. These work for most garden-variety strains and aches. Sulindac often steps in when people don’t get enough relief or have stomach trouble on other medications. In some circles, it’s known for going easier on the stomach, though every person’s experience runs differently.
Not every use for sulindac stays in the pain aisle. Decades ago, doctors noticed something odd—patients with certain genetic conditions, especially familial adenomatous polyposis (FAP), developed far fewer colon polyps when they used the drug. Polyps in FAP can turn cancerous at a frightening pace, so any step to slow things down matters. Sulindac helps shrink these growths, sometimes giving families precious time before surgery or additional treatment.
I learned about this use from a friend’s family—her younger brother started sulindac in his teens to manage FAP. They ended up talking more with specialists about this drug than any other. Reading more, I found that major medical guidelines still mention sulindac as an option for this rare but serious condition. That made me think about how some medications carve out a special role outside the usual pain-and-arthritis territory.
Anyone who has taken NSAIDs for more than a quick muscle ache knows there’s a trade-off. Gut problems can creep in, from heartburn to dangerous ulcers. Sulindac can raise blood pressure, put a strain on kidneys, and bring on allergic reactions in some people. Older adults, people with heart conditions, and those already managing lots of medications need to check with their doctor about risks.
Some safer routines can help. Always take sulindac with food. Keep up with regular check-ins—lab work helps spot problems before they turn serious. Sharing every medication and supplement with the prescriber may seem tedious, but those tiny details often steer people toward the safest care.
If someone finds themselves stacking pills for joint pain, it may be time for a different plan. Physical therapy, weight management, and local therapies such as joint injections sometimes work better or sidestep medication side effects. For those needing long-term anti-inflammatory help, regular re-evaluation by a doctor helps spot new or safer options as they come to market.
Sulindac still has its champions for more stubborn or unusual cases. The real story comes down to knowing what’s in your pill bottle, asking questions, and working out what lets you feel and function best.
Doctors often choose sulindac for people who have ongoing pain from arthritis or similar problems. It’s part of a group of medicines called NSAIDs, drugs that tackle inflammation and help with pain. I’ve seen many folks relieved after starting medication like sulindac, but nobody likes the road bumps that can come with it. Side effects happen, and they matter.
Sulindac isn’t a gentle visitor to the stomach. Nausea, heartburn, and belly pain are regular guests for some. In my own family, a cousin started sulindac for her aching joints, then spent days dealing with stomach aches and a sense of queasiness that kept her up at night. More than half of the folks using it might feel some discomfort in their gut. Less often, ulcers or bleeding rise up, and those are nothing to take lightly.
Doctors warn about taking sulindac on an empty stomach, and meals can help coat things, but that’s not always enough. I’ve seen patients who fix their diet, skip alcohol, and still feel the burn. If black stools show up, or a sharp pain hits, it’s time to call a doctor—no waiting and hoping it’ll pass.
Some people feel lightheaded or get headaches, especially when starting sulindac. I remember seeing a friend, a teacher, who felt cloudy and couldn’t focus in class after starting the drug. Fatigue sometimes tags along, and workdays feel twice as long. These side effects can drain everyday life, making simple tasks less simple.
Most get through it, and the mind clears up after the body adjusts. Still, not everyone shakes it off. Talking with a doctor can help sort out if it’s worth pushing through or switching to something milder.
NSAIDs, including sulindac, bring side effects that show up on the skin. Rashes sometimes pop up, or a person suddenly feels itchy. Hives or swelling around the eyes and mouth demand fast action—these aren’t the kind of problems to watch and wait. Rashes might seem a small price for pain relief, but any unexpected reaction should always get attention.
For folks with kidney problems or heart conditions, sulindac can make things worse. Over time, kidneys don’t filter as well, which means fluid builds up. That can lead to swelling in the ankles or even high blood pressure. Some patients have told me they noticed swelling in their hands or feet, wondering if it’s the medication or just the heat outside. Careful lab checks and doctor visits are the best safety net.
Another thing people forget is how sulindac might affect liver numbers in tests. Routine blood tests become important, even if there’s no pain or visible signs. A small number of users see changes in their liver readings, and early spotting matters.
Managing pain shouldn’t mean living with side effects, so it’s smart to check in with the prescribing doctor pretty often. Taking the lowest dose that still brings relief often means fewer problems. Many doctors suggest getting bloodwork done every few months, sticking to a routine, and reporting any changes, no matter how small. Hydration, eating regular meals, and avoiding taking other over-the-counter NSAIDs all help.
Sulindac offers relief to people who don’t want to lean on stronger drugs, but there’s always a trade-off. The important thing is knowing what to watch for and acting quickly when something seems off. The side effects are real, and so are the ways to lower their risks.
Dealing with pain or inflammation puts a hold on daily life fast. Doctors turn to medicines like Sulindac for relief from arthritis, gout, and aches that linger. My uncle, a retired mechanic, tried just about every pain pill out there before Sulindac showed up on his prescription list. The big question for folks like him isn’t what Sulindac does — it’s how to take it the right way and steer clear of trouble.
Let’s not kid ourselves—most folks miss a pill or two. Forgetting a dose ruins more than just a pharmacy’s profit chart. Skipping Sulindac or taking double “to make up for it” can come with risk. The best way is to take Sulindac with food or a full glass of water. My uncle started having heartburn, so his doctor told him to skip empty-stomach doses. Because Sulindac can be tough on the stomach lining, food helps soften the blow.
Doctors tend to give clear instructions: same dose every day, same time. People try to wing it, but drugs like Sulindac work best with routine. Pills don’t respect wishful thinking; they act on what you do, not what you hope. I’ve seen friends start strong with a sharp new medicine schedule and, by week three, slip back to chaos. Phone reminders or pill organizers cut down on mistakes.
NSAIDs like Sulindac have real risks. Long-term use messes with blood pressure, can lead to ulcers, and sometimes causes kidney problems. I learned this the hard way: a bad bout of stomach pain after two weeks of steady pills had me on the phone to my doc. We switched to a lower dose. If you notice black tarry stools, sudden stomach pain, swelling in the legs, or struggle to breathe, it’s time to call for help—waiting it out rarely goes well.
Drinking less alcohol, quitting cigarettes, and eating softer foods can help keep side effects away. People think herbal “detoxes” patch everything. They don’t. Sulindac’s risks rise with other drugs; mixing with blood thinners like warfarin or even over-the-counter ibuprofen ramps up danger. Keeping the doctor in the loop about every vitamin or painkiller matters.
Health feels personal, but Sulindac’s side effects and benefits have been studied by real scientists, not just folks trading stories in online groups. Meta-analyses published by medical journals say kidney injuries and gastrointestinal bleeding rise with unchecked NSAID use. Serious talk with a healthcare provider beats late-night searching or guesswork.
Staying on top of refills, checking in before stopping or stacking drugs, or reporting anything new helps everyone. Doctors see the big picture—arthritis takes years, not weeks, to deal with. Alternative strategies like stretching, physical therapy, and steady follow-ups help keep you moving and keep medicines like Sulindac working without nasty surprises.
From my uncle’s toolbox to my own medicine cabinet, instructions matter more than brand names or clever shortcuts. People remember to lock the door at night, but forget to take their pill with water. One small shift—habit, honesty with the doctor, skipping the shortcuts—keeps Sulindac from causing more harm than good.
Medication management brings its own set of challenges — especially with prescription drugs like sulindac. This anti-inflammatory medicine sits in many medicine cabinets to help ease conditions like arthritis. My mom has used sulindac to deal with joint pain, and I've seen firsthand how these pills can cut through discomfort. Still, something that every patient and their family wrestles with is what happens when you take sulindac alongside other medications. Not everything goes smoothly: some combinations can bring more harm than help.
Doctors and pharmacists spend a lot of time warning folks about combining medicines, and for good reason. Nonsteroidal anti-inflammatory drugs (NSAIDs) like sulindac change how the body handles other drugs. Blood pressure pills, blood thinners, and certain antidepressants can react with sulindac in ways that put real strain on the body’s organs. My uncle had a scare combining sulindac with his blood thinner — he ended up with a nosebleed that wouldn’t stop for hours, prompting a late-night trip to the ER. Turns out, sulindac can make blood thinners far more potent by raising the risk of bleeding throughout the body. Even over-the-counter medicines like aspirin increase this danger.
People with heart problems often end up using blood pressure medications called ACE inhibitors or diuretics. Sulindac can make these pills less effective, meaning blood pressure goes up and puts extra work on the kidneys. Long-term use can even damage the kidneys, especially in older adults or anyone with existing kidney issues. I’ve seen seniors need to switch blood pressure meds after NSAIDs nudged their numbers too high. Those with mood disorders who rely on selective serotonin reuptake inhibitors (SSRIs) or lithium also need to keep a close eye because sulindac can raise lithium to unsafe levels or raise bleeding risk when combined with SSRIs.
Steroids like prednisone, used for all sorts of inflammatory diseases, also don’t mix with sulindac. This combo can increase the odds of developing stomach ulcers or gastrointestinal bleeding. Folks taking diabetes medicine should know that sulindac can alter blood sugar levels, complicating the daily routine of anyone monitoring glucose. There’s also the risk with methotrexate, used for arthritis and cancer: sulindac can slow methotrexate’s removal from the body, causing dangerous buildup. Cough and cold season brings another layer, since many people use NSAIDs like ibuprofen — mixing these with sulindac piles on the risk for kidney issues and bleeding.
Doctors and pharmacists have one goal: helping people feel better. Still, with complex medicine regimens, patients slip through the cracks. The best step before starting sulindac: go through your current prescriptions, vitamins, and herbal supplements with your healthcare team. Use one pharmacy, and ask the pharmacist to keep an eye out for dangerous splits. Digital health records have made it easier to catch conflicts, but the responsibility still rests with the patient to speak up and double-check. In my own life, getting everyone on the same page — doctors, pharmacists, and family — has helped my relatives avoid bad interactions and hospital stays.
Medication safety isn’t just a healthcare provider’s role; patients play an equal part. Keep an updated list of all medications, ask about possible side effects or interactions every time something new gets prescribed, and don’t start or stop a medicine on your own. Adverse drug reactions take a real toll on families — I’ve seen firsthand how one missed warning led to a week in the hospital for a loved one. With honest conversations and vigilance, those taking sulindac can find relief without needless risks. Stay informed, ask questions, and keep communication open for safer treatment and peace of mind.
Sulindac, a nonsteroidal anti-inflammatory drug, often gets the nod for relief from pain and swelling due to arthritis, gout, or certain joint disorders. Plenty of folks put their trust in these kinds of meds to help them keep moving. I have seen family members do just that for their stubborn knee pain. On doctor’s orders, they felt better but read about the precautions and warnings closely. Not everyone can reach for this bottle without risks latching on.
Anyone with a past issue after taking aspirin or similar painkillers needs to steer clear. Swelling, hives, or even severe breathing issues come on quick for some people after a dose. The science shows allergies often run true across this whole class of drugs, including Sulindac. One bad reaction can lead to a much worse crisis if someone ignores the warning.
Stomach problems and Sulindac just don’t mix. These drugs can open old wounds or trigger fresh bleeding. Data from both large studies and emergency rooms warns doctors about new or worsening ulcers, GI bleeding, or holes in the stomach lining. Blood in the stool or black tarry stools can appear after regular doses. Sulindac does not wait long to cause trouble in someone already on thin ice from a history of ulcers.
The body relies on the liver and kidneys to process out drugs like Sulindac. Trouble surfaces when those organs already fight to keep up because of chronic conditions. Toxicity sneaks up fast—waste backs up, blood numbers go out of whack, and patients feel much worse instead of better. Doctors check bloodwork regularly when someone absolutely needs this drug, but most look for safer pain control for these patients.
Anyone carrying a diagnosis of heart failure, uncontrolled blood pressure, or prior heart attack faces real risk. Studies point to a higher chance of heart attack and stroke for people on NSAIDs, sometimes even after a few days of use. It also doesn’t take long for blood pressure to creep upward again on Sulindac. People in this group work hard to handle their heart risk, so adding another obstacle serves no one.
Pregnant women, especially in their third trimester, face warnings from every reputable source—this drug can cause heart problems in an unborn baby and is linked to severe kidney issues for the fetus. Kids under twelve rarely get prescribed Sulindac because safer options exist. In my own circle, doctors always looked elsewhere for pain relief in children.
Staying healthy means checking medicine facts that apply to you. Listen to doctors and pharmacists—they lean on science and years of experience. If someone already takes blood thinners, steroids, or certain antidepressants, the risk for stomach or bleeding problems jumps again. My relatives learned to take new prescriptions seriously after one ended up in the ER from a stomach bleed.
In chronic pain management, the best road involves clear talk with a trusted doctor and sometimes exploring different treatments. Physical therapy, targeted exercises, and other types of medication sometimes bring relief without the same risks seen with Sulindac. Better pain relief doesn't always fit into one pill—and for some, avoiding Sulindac avoids bigger health struggles down the road.
| Names | |
| Preferred IUPAC name | (Z)-2-[ (4-fluorobenzylidene)amino]-5-methyl-1-phenyl-1H-inden-3-yl]acetic acid |
| Other names |
Clinoril Sulindac Sodium |
| Pronunciation | /suːˈlɪn.dæk/ |
| Identifiers | |
| CAS Number | 42894-03-1 |
| Beilstein Reference | 2734361 |
| ChEBI | CHEBI:9354 |
| ChEMBL | CHEMBL153 |
| ChemSpider | 5210 |
| DrugBank | DB02144 |
| ECHA InfoCard | 13b8d9a3-ef41-4298-908a-2e4aa01c8f44 |
| EC Number | EC 3.2.1.65 |
| Gmelin Reference | 106265 |
| KEGG | D00424 |
| MeSH | D013213 |
| PubChem CID | 5350 |
| RTECS number | VN7525000 |
| UNII | 6RN4R6O2EZ |
| UN number | UN2811 |
| Properties | |
| Chemical formula | C16H14FO3S |
| Molar mass | 356.42 g/mol |
| Appearance | Yellow, round, tablets, debossed with product identification codes. |
| Odor | Odorless |
| Density | 1.3 g/cm³ |
| Solubility in water | slightly soluble |
| log P | 2.92 |
| Vapor pressure | 7.51E-10 mmHg |
| Acidity (pKa) | 4.5 |
| Basicity (pKb) | pKb = 11.51 |
| Magnetic susceptibility (χ) | -27.8×10⁻⁶ |
| Refractive index (nD) | 1.607 |
| Viscosity | Viscosity not reported |
| Dipole moment | 3.12 D |
| Thermochemistry | |
| Std molar entropy (S⦵298) | 354.6 J·mol⁻¹·K⁻¹ |
| Std enthalpy of formation (ΔfH⦵298) | -229.9 kJ/mol |
| Std enthalpy of combustion (ΔcH⦵298) | -7308 kJ/mol |
| Pharmacology | |
| ATC code | M01AB02 |
| Hazards | |
| Main hazards | May cause skin, eye, and respiratory irritation; harmful if swallowed; may cause allergic reactions. |
| GHS labelling | GHS labelling: Danger; H302, H315, H319, H335 |
| Pictograms | pregnancy-safe, prescription-only, liver-warning, kidney-warning, elderly-caution, gi-risk, nsaid |
| Signal word | Warning |
| Hazard statements | H302, H315, H319, H335 |
| Precautionary statements | Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. |
| NFPA 704 (fire diamond) | 1-2-0 |
| Flash point | 230°C |
| Autoignition temperature | 425°C |
| Lethal dose or concentration | LD50 (oral, rat): 450 mg/kg |
| LD50 (median dose) | LD50 (median dose) of Sulindac: "389 mg/kg (rat, oral) |
| NIOSH | MN1575000 |
| PEL (Permissible) | 10 mg/m3 |
| REL (Recommended) | 200 mg every 12 hours |
| Related compounds | |
| Related compounds |
Etodolac Indomethacin Zomepirac |
