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Product Name: Sulfapyridine
Chemical Name: 4-Aminophenylsulfonylpyridine
CAS Number: 144-83-2
Synonyms: Amidopyridine, Sulfanilylpyridine
Molecular Formula: C11H11N3O2S
Molecular Weight: 249.29 g/mol
Recommended Use: Pharmaceutical intermediate, analytical agent
Supplier Details: Pharmaceutical and chemical laboratories, academic research facilities
Emergency Contact: Local poison control, medical professionals
Classification: Acute toxicity (oral, dermal, inhalation, category 4), Eye irritation category 2A, Skin sensitization category 1
Signal Word: Warning
Hazard Statements: Harmful if swallowed or inhaled. Causes skin irritation. Causes serious eye irritation. May cause allergic skin reactions. Prolonged or repeated exposure may cause organ damage to blood, liver, or kidneys.
Precautionary Statements: Avoid breathing dust or fumes. Use protective gloves and eye protection. Wash hands thoroughly after handling. Do not eat, drink, or smoke when handling this product.
Chemical Identity: 4-Aminophenylsulfonylpyridine
CAS Registry Number: 144-83-2
EC Number: 205-668-2
Concentration: Pure substance; impurities less than 1% by weight
Other Components: None considered hazardous under applicable safety regulations
Inhalation: Move person to fresh air immediately. Remove contaminated clothing. Seek medical attention if breathing problems occur.
Skin Contact: Rinse skin thoroughly with water for at least 15 minutes. Remove contaminated clothing and wash before reuse. Medical attention is recommended if irritation or symptoms develop.
Eye Contact: Flush eyes with running water for 15 minutes, lifting eyelids regularly. Remove contact lenses if present. Get medical advice immediately.
Ingestion: Rinse mouth with water. Seek immediate medical assistance. Do not attempt to induce vomiting unless directed by a healthcare professional.
General Notes: Medical personnel should observe supportive therapy based on individual response and exposure.
Suitable Extinguishing Media: Foam, dry chemical powder, carbon dioxide, or water spray
Fire Hazards: May emit toxic fumes including nitrogen oxides and sulfur oxides on combustion
Special Protective Equipment: Firefighters require self-contained breathing apparatus and full protective gear
Specific Hazards: Dust can form explosive mixtures with air. Runoff from firefighting water may pose environmental risks.
Advice: Move containers away from affected area if safe to do so. Avoid raising dust or inhaling smoke.
Personal Precautions: Wear protective equipment for eyes, skin, and respiratory system. Remove ignition sources from the area.
Spill Cleanup Methods: Use damp absorbent materials (sand, earth, inert materials) to contain and collect spills. Place collected waste in sealed, labeled containers for disposal.
Environmental Precautions: Prevent material from entering soil, drains, surface water, or groundwater. Report releases as required by local regulations.
Decontamination: Clean spill area using water and detergent. Dispose of cleaning materials as hazardous waste.
Handling: Use in well-ventilated areas away from dust, heat, sparks, open flames, and static discharge. Minimize dust generation. Avoid direct contact with skin and eyes. Do not breathe dust.
Storage: Keep containers tightly closed, labeled, and stored in a cool, dry, well-ventilated place. Protect from humidity and sunlight. Store away from strong oxidizers and incompatible chemicals.
Incompatible Materials: Strong acids, bases, and oxidizers.
Special Instructions: Use explosion-proof electrical equipment. Ground all equipment containing material. Keep separate from food and drinks.
Exposure Limits: No established OSHA PEL or ACGIH TLV. Observe good industrial hygiene practices.
Engineering Controls: Use chemical fume hoods or local exhaust ventilation to control airborne amounts. Facilities must have eye wash stations and safety showers.
Personal Protective Equipment: Safety goggles, chemical-resistant gloves, lab coat or apron, respiratory protection if airborne dust is generated.
Hygiene Measures: Wash hands and exposed skin after use, before eating, and before leaving work area. Remove contaminated clothing before entering dining areas.
Appearance: Pale yellow, odorless crystalline powder.
Melting Point: 191–193 °C
Boiling Point: Decomposes before boiling
Solubility: Slightly soluble in water, soluble in acetone and ethanol
pH: Not available (slightly acidic in solution)
Vapor Pressure: Negligible at room temperature
Flash Point: Not applicable (non-volatile solid)
Autoignition Temperature: Data not available
Density: 1.49 g/cm³
Odor Threshold: Odorless
Partition Coefficient (octanol/water): 0.2 (estimated)
Chemical Stability: Stable under recommended storage conditions, unaffected by air when dry.
Reactive Conditions: Strong oxidizers, strong acids, and bases may cause hazardous reactions.
Hazardous Decomposition: Produces nitrogen oxides, sulfur oxides, and carbon monoxide when decomposed by fire or heat.
Polymerization: Not known to polymerize.
Incompatible Materials: Avoid compounds that strongly oxidize or reduce, as well as strong acids and bases.
Acute Toxicity: LD50 for rats (oral): 2700 mg/kg. Harmful by ingestion, inhalation, or skin contact.
Chronic Toxicity: Prolonged exposure may affect liver, blood, kidneys. Risk of methemoglobinemia, hemolytic anemia.
Skin and Eye Contact: Causes moderate irritation. Sensitization in predisposed individuals reported.
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, or OSHA.
Mutagenicity: Not classified as mutagenic in recognized assays.
Reproductive Effects: No known effects in reproductive studies at controlled exposure levels.
Ecotoxicity: Harmful to aquatic organisms. Limited data shows EC50/LC50 in aquatic species (daphnia, algae) range: 5–50 mg/L.
Persistence and Degradability: Moderately persistent in the environment. Partial decomposition by microbial action in soil and water.
Bioaccumulation Potential: Low, based on estimated partition coefficient.
Mobility in Soil: Slight to moderate, may leach in sandy or loose soils.
Other Adverse Effects: Avoid uncontrolled release to aquatic and terrestrial environments.
Disposal Methods: Treat as hazardous chemical waste. Incinerate or deliver to licensed chemical disposal contractor. Comply with local, regional, national regulations.
Container Disposal: Rinse empty containers three times with adequate solvent. Render vessels unusable before disposal.
Precautions: Do not pour down the drain. Do not recycle contaminated packaging. Prevent chemical from entering the water course.
UN Number: Not regulated under ADR/RID/IMDG/IATA for typical quantities
Proper Shipping Name: Not applicable for routine laboratory use
Hazard Class: Not classified as a dangerous good
Packing Group: Not assigned
Special Transport Precautions: Avoid generating dust in transit. Keep containers upright, tightly sealed, and away from food and feedstuffs.
Marine Pollutant: Not classified as marine pollutant, but avoid bulk releases.
US Federal Regulations: Not listed under TSCA; not on SARA Title III Sections 302, 311, 312, or 313. Meets regulatory reporting thresholds for hazardous substances if released in significant amounts.
EU Regulations: Not subject to REACH registration at low tonnage. Classified as hazardous under CLP Regulation (EC 1272/2008). Observe local chemical safety legislation and workplace hazard communication requirements.
Other Country Regulations: Regulated in Canada under WHMIS, classified as D2B (toxic). Local guidelines may further restrict use or require notification. Always check local chemical safety databases and inventories.
