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Substance Name: Sulfamonomethoxine Sodium
Chemical Formula: C11H11N4NaO3S
CAS Number: 1220-83-3
Synonyms: Sulfadimezine sodium salt, Sodium Sulfamonomethoxine
Recommended Use: Veterinary antibiotic, pharmaceutical ingredient
Supplier: Details available on request based on purchase
Emergency Contact: Refer to product label or supplier safety hotline
Classification: Eye Irritant (Category 2A), Skin Sensitizer (Category 1), Acute Toxicity (Oral, Category 4)
Signal Word: Warning
Hazard Statements: May cause an allergic skin reaction, Harmful if swallowed, Causes serious eye irritation
Pictograms: Exclamation mark
Precautionary Statements: Avoid contact with skin and eyes, Wear appropriate personal protective equipment, Do not eat, drink, or smoke when handling
Potential Health Effects: Irritation to respiratory tract, eyes, and skin; may trigger hypersensitivity in susceptible individuals; ingestion may cause gastrointestinal symptoms including vomiting and diarrhea
Chemical Name: Sulfamonomethoxine Sodium
Concentration: >98% (by weight), depending on batch
Impurities: Typically less than 2%, trace inorganic salts as byproducts from manufacturing
Molecular Weight: 302.3 g/mol
EINECS Number: 214-916-4
General: Move exposed person to fresh air, remove contaminated clothing
Inhalation: If breathing becomes difficult, get into the open and seek medical attention
Skin Contact: Wash thoroughly with soap and water, remove affected clothing, seek medical advice if irritation persists
Eye Contact: Rinse with plenty of water for at least 15 minutes, contact a physician if irritation continues
Ingestion: Rinse mouth, seek immediate medical attention, do not induce vomiting unless directed by medical personnel
Suitable Extinguishing Media: Use water spray, dry chemical, foam, or carbon dioxide
Hazardous Combustion Products: May emit toxic fumes such as sulfur oxides, nitrogen oxides, and sodium compounds when burning
Special Protective Equipment: Firefighters should wear self-contained breathing apparatus and full protective gear
Fire & Explosion Hazards: Powder may form explosive mixtures with air in certain conditions; avoid dust accumulation
Advice for Firefighters: Approach fire from upwind, prevent runoff from entering drains or water sources
Personal Precautions: Evacuate area, avoid dust generation, use appropriate personal protective equipment to prevent exposure
Environmental Precautions: Prevent further leakage or spillage, do not let product enter drains or waterways
Methods for Cleaning Up: Sweep up and place in a suitable container for disposal, ventilate area, clean residual with damp cloth
Small Spill: Use absorbent material for residue
Large Spill: Dike spillage, collect mechanically for disposal
Safe Handling: Work in a well-ventilated area, avoid inhaling dust, practice good industrial hygiene, use protective equipment
Storage Conditions: Store in original tightly closed container, keep in a cool, dry, well-ventilated area away from incompatible substances like strong acids and oxidizers
Incompatibilities: Avoid contact with moisture, acids, strong bases, oxidizing agents
Specific End Uses: Approved for non-human pharmaceutical and research uses only
Occupational Exposure Limits: Not established for this ingredient; general dust limits apply
Engineering Controls: Local exhaust ventilation or general room ventilation to control airborne dust
Personal Protective Equipment (PPE): Safety goggles with side protection, chemical-resistant gloves (nitrile or rubber), lab coat, dust respirator if exposure limits might be exceeded
Hygiene Measures: Wash hands thoroughly after handling, do not eat, drink, or smoke near product, launder clothing regularly
Appearance: White to off-white crystalline powder
Odor: Odorless
Odor Threshold: Not applicable
pH: 9.0 – 10.5 (10% aqueous solution)
Melting Point: 185–190°C (decomposition)
Boiling Point: Not available
Flash Point: Not flammable under normal conditions
Evaporation Rate: Not applicable
Solubility: Freely soluble in water, practically insoluble in alcohol, slightly soluble in chloroform
Vapor Pressure: Negligible at ambient temperatures
Vapor Density: Not applicable
Relative Density: About 1.6 (water = 1)
Partition Coefficient (log Kow): No data
Decomposition Temperature: >185°C
Viscosity: Not applicable
Particle Characteristics: Fine powder, tendency to become airborne if mishandled
Chemical Stability: Remains stable under recommended storage conditions
Reactivity: Stable under normal processing, not reactive with most materials
Hazardous Decomposition Products: Decomposes at high temperature releasing toxic gases such as sulfur oxides, nitrogen oxides, and sodium fumes
Polymerization: Product will not undergo hazardous polymerization
Conditions to Avoid: Extended exposure to heat, humidity, open flames; dust formation
Incompatible Materials: Strong oxidizing agents, strong acids, moisture
Routes of Exposure: Inhalation, skin, eye contact, ingestion
Acute Toxicity: LD50 (oral/rat): approximately 2750 mg/kg
Chronic Effects: Prolonged contact may cause sensitization or allergic reactions; long-term exposure may affect liver or blood systems based on animal studies
Irritant Effects: Can cause significant eye and mucous membrane irritation
Mutagenicity/Reproductive Toxicity: No conclusive evidence of mutagenic or reproductive hazards based on available studies, further research ongoing
Carcinogenicity: Not classified as a carcinogen by IARC, NTP, or OSHA
Symptoms of Overexposure: Nausea, vomiting, headache, allergic dermatitis, rhinitis
Aquatic Toxicity: Product can harm aquatic organisms at elevated concentrations; EC50/LC50 values not fully established but caution recommended
Persistence and Degradability: Moderately persistent in soil and water, undergoes slow biodegradation
Bioaccumulation Potential: Data limited, presumed low due to water solubility
Mobility in Soil: High mobility possible due to solubility in water, risk for leaching
Other Adverse Effects: Risk of developing antibiotic resistance in environmental microbial communities if released in significant quantities; avoid uncontrolled discharge
Precautionary Environmental Measures: Handle waste responsibly, avoid spills near water bodies or sewage systems
Waste Disposal Methods: Follow local, regional, and national regulations for pharmaceutical or hazardous waste
Incineration: Suitable for large quantities using high-temperature chemical incineration
Landfill: Only as per regulatory allowance, with proper containment
Contaminated Packaging: Triple rinse, then puncture or crush before disposal to prevent reuse, comply with all governing regulations
Special Precautions: Avoid release to environment, consult licensed waste disposal contractor
Regulatory Compliance: Adhere to hazardous waste codes specific for antimicrobial agents
UN Number: Not regulated under current UN hazardous goods transport listings
Proper Shipping Name: Not classified as dangerous for transport
Transport Hazard Class: Not assigned
Packing Group: Not assigned
Label Requirements: No special labeling required for transport under most conditions
Additional Transport Measures: Keep dry, away from incompatible materials, secure containers to prevent damage or leakage
EU Regulations: Registered under REACH; SDS fulfills requirements of Regulation (EC) No 1907/2006
US TSCA: Not listed for commercial chemical inventory
OSHA Status: Not classified as hazardous chemical under US hazard communication standard, handle as potential irritant
WHMIS Classification (Canada): D2B (Toxic Material Causing Other Toxic Effects)
Labeling: All containers require clear hazard and safety labeling in compliance with national and local laws
Other Regulations: Subject to residue limits and veterinary drug approvals, varies by country
Workplace Safety: Employers required to inform and train workers under hazard communication standards, update safety protocols annually
