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Product Name: Sulfamethoxazole
Chemical Formula: C10H11N3O3S
Trade Names: Gantanol, SMZ
Synonyms: 4-amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
CAS Number: 723-46-6
Intended Use: Pharmaceutical, antibacterial agent
Manufacturer Contact: [specify local supplier]
Emergency Phone: [local/regional emergency info]
Classification: Harmful if swallowed, irritating to skin and eyes, possible sensitizer
GHS Label Elements: Warning; hazard pictograms for health hazard and exclamation mark
Potential Health Effects: Irritation to skin, eyes, or respiratory tract; possible nausea, vomiting, or headache if ingested
Route of Exposure: Inhalation, skin contact, eye contact, ingestion
Chronic Effects: Prolonged or repeated exposure may cause allergic skin or respiratory reactions
Environmental Risk: May pose a risk to aquatic life
Substance: Sulfamethoxazole
Purity: Typically >98% (may vary by batch)
Impurities: Contains trace synthetic byproducts
Hazardous Components: None present above reportable thresholds except for main compound
Molecular Weight: 253.28 g/mol
Inhalation: Move person to fresh air, provide rest and warmth, seek medical attention if respiratory irritation or discomfort develops
Skin Contact: Remove contaminated clothing, wash skin with soap and water, seek medical advice for irritation or allergic reactions
Eye Contact: Rinse cautiously for several minutes with water, remove contact lenses if present and easy to do, continue rinsing, obtain medical assistance
Ingestion: Rinse mouth, give water to drink if conscious, do not induce vomiting, consult a physician promptly, show label or MSDS if possible
Most Important Symptoms: May cause allergic reactions, rash, itching, irritation, gastrointestinal symptoms
Suitable Extinguishing Media: Use water spray, alcohol-resistant foam, dry chemical, or carbon dioxide
Specific Hazards: Decomposition can produce toxic gases such as nitrogen oxides and sulfur oxides; avoid inhaling smoke
Protective Equipment: Firefighters wear self-contained breathing apparatus and full protective clothing
Advice for Firefighters: Use water spray to cool unopened containers, beware of runoff water entering drains
Personal Precautions: Wear appropriate PPE (gloves, safety goggles, mask); avoid dust formation and breathing dust
Emergency Procedures: Evacuate area if lots of dust; ventilate enclosed spaces
Spill Cleanup Methods: Collect spillage with mechanical means (shovel, broom), transfer to a secure container for disposal; avoid creating airborne dust
Environmental Precautions: Prevent release into sewage systems or watercourses
Decontamination: Wash area with soap and water after bulk cleanup, assure good ventilation
Handling Guidelines: Operate in well-ventilated spaces; use gloves and eye protection to avoid contact; keep containers tightly closed; avoid dust creation
Hygiene Practices: Do not eat, drink, or smoke during use; wash hands thoroughly after handling
Storage Conditions: Store in a dry, cool, and well-ventilated area; keep away from incompatible substances such as oxidizers; protect from light and moisture
Packaging: Containers should remain sealed and labeled; avoid direct sunlight exposure
Occupational Exposure Limits: No established limits in many jurisdictions; minimize exposure nonetheless
Ventilation: Use local exhaust ventilation or general room ventilation to minimize airborne dust
Respiratory Protection: If dust levels are elevated, use a suitable particulate respirator
Skin Protection: Wear chemically resistant gloves, long sleeves, and lab coat
Eye Protection: Use safety goggles or face shield
Other Protective Measures: Wash work clothing regularly; eye wash stations and safety showers recommended in area
Appearance: White to off-white crystalline powder
Odor: Odorless
Solubility: Slightly soluble in water, soluble in organic solvents such as ethanol and acetone
Melting Point: 164-166 °C
Boiling Point: Decomposes
pH: 5.5–6.5 (1% solution in water)
Flash Point: Not available
Partition Coefficient (log Kow): 0.89
Vapor Pressure: Negligible at room temperature
Stability: Stable in standard storage, sensitive to prolonged heat or light exposure
Chemical Stability: Stable under normal conditions of handling and storage
Reactivity: Non-reactive under standard conditions
Conditions to Avoid: Elevated temperatures, direct sunlight, moisture
Incompatible Materials: Strong oxidizing agents, acids
Hazardous Decomposition Products: Nitrogen oxides, sulfur oxides, carbon monoxide may form under fire or intense heat
Polymerization: Not known to occur
Acute Toxicity: LD50 (oral, rat): around 6100 mg/kg
Skin Corrosion/Irritation: May cause mild irritation after prolonged contact
Serious Eye Damage/Irritation: Can cause irritation if dust gets in eyes
Respiratory or Skin Sensitization: Possible allergic reactions reported
Chronic Toxicity: Long-term exposure linked to effects on blood (anemia); some hypersensitivity reactions (Stevens-Johnson syndrome, though rare)
Symptoms of Overexposure: Digestive upset, skin rash, respiratory irritation, allergic reaction, rarely severe systemic effects
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Mutagenicity and Teratogenicity: No evidence in standard tests at therapeutic doses
Ecotoxicity: Sulfamethoxazole may be toxic to aquatic organisms, especially bacteria and algae; values for EC50 in algae and Daphnia range from microgram to low milligram per liter
Persistence and Degradability: Degrades in the environment but persists in water, detected in wastewater and natural bodies of water
Bioaccumulation Potential: Low, but repeated exposure may build up in sediments
Mobility in Soil: Moderately mobile, can leach to groundwater under some conditions
Other Adverse Effects: Potential contribution to drug-resistant bacteria in the environment reported by scientific studies
Disposal Methods: Incinerate or dispose as hazardous pharmaceutical waste in accordance with local, regional, and national regulations; do not release untreated into environment
Contaminated Packaging: Clean with water before recycling if possible; otherwise dispose as hazardous waste
Special Precautions: Avoid dust generation during handling for disposal; minimize environmental exposure at disposal site
UN Number: Not regulated as a hazardous material for transport in most countries
UN Proper Shipping Name: Not classified as dangerous goods
Packing Group: Not assigned
Transport Hazard Class: Not hazardous for ground, air, or sea transport under IATA, ICAO, IMDG, DOT guidelines
Special Transport Precautions: Product should travel in tightly sealed, labeled containers to avoid contamination; protect from moisture and sunlight during shipments
Labeling: Complies with GHS labeling for health hazards; country-specific requirements may apply
Inventory Status: Listed in US TSCA, EU EINECS, Canada DSL/NDSL, and others
UK REACH/CLP Regulation: Not classified as a substance of very high concern
Hazard Directives: Complies with hazard and risk phrase rules in EU (R22, R36/37/38)
Other Regulations: Not subject to special monitoring or reporting in most regions, but disposal and use must comply with pharmaceutical and environmental laws
